Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ERBB3
  • Mouse genes Erbb3
  • Rat genes Erbb3
  • Zfish genes erbb3a,erbb3b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Erbb3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0043125	ErbB-3 class receptor binding	ERBB3	IPI	UniProtKB:P04626	Human	PMID:12000754
Molecular Function	GO:0019838	growth factor binding	ERBB3	IPI	UniProtKB:Q02297-6	Human	PMID:11389077
Molecular Function	GO:0042802	identical protein binding	ERBB3	IPI	UniProtKB:P21860	Human	PMID:21575594
Molecular Function	GO:0042802	identical protein binding	ERBB3	IPI	UniProtKB:P21860	Human	PMID:23436906
Molecular Function	GO:0038132	neuregulin binding	ERBB3	IDA		Human	PMID:20682778
Molecular Function	GO:0038132	neuregulin binding	Erbb3	IMP		Rat	PMID:14711829|RGD:2289958
Molecular Function	GO:0038131	neuregulin receptor activity	Erbb3	IMP		Rat	PMID:14711829|RGD:2289958
Molecular Function	GO:0005515	protein binding	ERBB3	IPI	UniProtKB:P00533	Human	PMID:10572067
Molecular Function	GO:0005515	protein binding	ERBB3	IPI	UniProtKB:P04626	Human	PMID:10572067
Molecular Function	GO:0005515	protein binding	ERBB3	IPI	UniProtKB:P27986	Human	PMID:10572067
Molecular Function	GO:0005515	protein binding	ERBB3	IPI	UniProtKB:Q15303	Human	PMID:10572067
Molecular Function	GO:0005515	protein binding	ERBB3	IPI	UniProtKB:Q96JA1	Human	PMID:15282549
Molecular Function	GO:0005515	protein binding	ERBB3	IPI	UniProtKB:O00459	Human	PMID:16273093
Molecular Function	GO:0005515	protein binding	ERBB3	IPI	UniProtKB:O43639	Human	PMID:16273093
Molecular Function	GO:0005515	protein binding	ERBB3	IPI	UniProtKB:P08631	Human	PMID:16273093
Molecular Function	GO:0005515	protein binding	ERBB3	IPI	UniProtKB:P12931	Human	PMID:16273093
Molecular Function	GO:0005515	protein binding	ERBB3	IPI	UniProtKB:P19174	Human	PMID:16273093
Molecular Function	GO:0005515	protein binding	ERBB3	IPI	UniProtKB:P20936	Human	PMID:16273093
Molecular Function	GO:0005515	protein binding	ERBB3	IPI	UniProtKB:P27986	Human	PMID:16273093
Molecular Function	GO:0005515	protein binding	ERBB3	IPI	UniProtKB:P29353	Human	PMID:16273093
Molecular Function	GO:0005515	protein binding	ERBB3	IPI	UniProtKB:P42684	Human	PMID:16273093
Molecular Function	GO:0005515	protein binding	ERBB3	IPI	UniProtKB:P43405	Human	PMID:16273093
Molecular Function	GO:0005515	protein binding	ERBB3	IPI	UniProtKB:P46108	Human	PMID:16273093
Molecular Function	GO:0005515	protein binding	ERBB3	IPI	UniProtKB:P46109	Human	PMID:16273093
Molecular Function	GO:0005515	protein binding	ERBB3	IPI	UniProtKB:Q13671	Human	PMID:16273093
Molecular Function	GO:0005515	protein binding	ERBB3	IPI	UniProtKB:Q14451	Human	PMID:16273093
Molecular Function	GO:0005515	protein binding	ERBB3	IPI	UniProtKB:Q63HR2	Human	PMID:16273093
Molecular Function	GO:0005515	protein binding	ERBB3	IPI	UniProtKB:Q68CZ2	Human	PMID:16273093
Molecular Function	GO:0005515	protein binding	ERBB3	IPI	UniProtKB:Q92529	Human	PMID:16273093
Molecular Function	GO:0005515	protein binding	ERBB3	IPI	UniProtKB:Q92569	Human	PMID:16273093
Molecular Function	GO:0005515	protein binding	ERBB3	IPI	UniProtKB:Q9UQQ2	Human	PMID:16273093
Molecular Function	GO:0005515	protein binding	ERBB3	IPI	UniProtKB:Q9UQ80	Human	PMID:16832058
Molecular Function	GO:0005515	protein binding	ERBB3	IPI	UniProtKB:P04626	Human	PMID:16843263
Molecular Function	GO:0005515	protein binding	ERBB3	IPI	UniProtKB:P00533	Human	PMID:17148612
Molecular Function	GO:0005515	protein binding	ERBB3	IPI	UniProtKB:P04626	Human	PMID:17148612
Molecular Function	GO:0005515	protein binding	ERBB3	IPI	UniProtKB:P04626	Human	PMID:17426253
Molecular Function	GO:0005515	protein binding	ERBB3	IPI	UniProtKB:P04626	Human	PMID:19411071
Molecular Function	GO:0005515	protein binding	ERBB3	IPI	UniProtKB:P42336	Human	PMID:19411071
Molecular Function	GO:0005515	protein binding	ERBB3	IPI	UniProtKB:P27986	Human	PMID:20007781
Molecular Function	GO:0005515	protein binding	ERBB3	IPI	UniProtKB:P04626	Human	PMID:20227043
Molecular Function	GO:0005515	protein binding	ERBB3	IPI	UniProtKB:P27986	Human	PMID:20227043
Molecular Function	GO:0005515	protein binding	ERBB3	IPI	UniProtKB:Q15303	Human	PMID:20227043
Molecular Function	GO:0005515	protein binding	ERBB3	IPI	UniProtKB:P04626	Human	PMID:21075308
Molecular Function	GO:0005515	protein binding	ERBB3	IPI	UniProtKB:P27986	Human	PMID:21075308
Molecular Function	GO:0005515	protein binding	ERBB3	IPI	UniProtKB:P04626	Human	PMID:21203579
Molecular Function	GO:0005515	protein binding	ERBB3	IPI	UniProtKB:P00533	Human	PMID:21278786
Molecular Function	GO:0005515	protein binding	ERBB3	IPI	UniProtKB:P04626	Human	PMID:21278786
Molecular Function	GO:0005515	protein binding	ERBB3	IPI	UniProtKB:P27986	Human	PMID:21278786
Molecular Function	GO:0005515	protein binding	ERBB3	IPI	UniProtKB:P00533	Human	PMID:22439932
Molecular Function	GO:0005515	protein binding	ERBB3	IPI	UniProtKB:P27986	Human	PMID:22439932
Molecular Function	GO:0005515	protein binding	ERBB3	IPI	UniProtKB:P04626	Human	PMID:22733765
Molecular Function	GO:0005515	protein binding	ERBB3	IPI	UniProtKB:P04626	Human	PMID:22806884
Molecular Function	GO:0005515	protein binding	ERBB3	IPI	UniProtKB:P08238	Human	PMID:22939624
Molecular Function	GO:0005515	protein binding	ERBB3	IPI	UniProtKB:P00533	Human	PMID:23436906
Molecular Function	GO:0005515	protein binding	ERBB3	IPI	UniProtKB:P04626	Human	PMID:23436906
Molecular Function	GO:0005515	protein binding	ERBB3	IPI	UniProtKB:Q8R464	Human	PMID:23611113
Molecular Function	GO:0005515	protein binding	ERBB3	IPI	UniProtKB:P04626	Human	PMID:23680147
Molecular Function	GO:0005515	protein binding	ERBB3	IPI	UniProtKB:P04626	Human	PMID:23688700
Molecular Function	GO:0005515	protein binding	ERBB3	IPI	UniProtKB:P00533	Human	PMID:23866081
Molecular Function	GO:0005515	protein binding	ERBB3	IPI	UniProtKB:P04626	Human	PMID:23866081
Molecular Function	GO:0005515	protein binding	ERBB3	IPI	UniProtKB:O00459	Human	PMID:24189400
Molecular Function	GO:0005515	protein binding	ERBB3	IPI	UniProtKB:P00533	Human	PMID:24189400
Molecular Function	GO:0005515	protein binding	ERBB3	IPI	UniProtKB:P08238	Human	PMID:24189400
Molecular Function	GO:0005515	protein binding	ERBB3	IPI	UniProtKB:P27986	Human	PMID:24189400
Molecular Function	GO:0005515	protein binding	ERBB3	IPI	UniProtKB:P29353	Human	PMID:24189400
Molecular Function	GO:0005515	protein binding	ERBB3	IPI	UniProtKB:P42336	Human	PMID:24189400
Molecular Function	GO:0005515	protein binding	ERBB3	IPI	UniProtKB:P62993	Human	PMID:24189400
Molecular Function	GO:0005515	protein binding	ERBB3	IPI	UniProtKB:Q14451	Human	PMID:24189400
Molecular Function	GO:0005515	protein binding	ERBB3	IPI	UniProtKB:Q92569	Human	PMID:24189400
Molecular Function	GO:0005515	protein binding	ERBB3	IPI	UniProtKB:P04626	Human	PMID:24557338
Molecular Function	GO:0005515	protein binding	ERBB3	IPI	UniProtKB:P62993	Human	PMID:24658140
Molecular Function	GO:0005515	protein binding	ERBB3	IPI	UniProtKB:P04626	Human	PMID:25241761
Molecular Function	GO:0005515	protein binding	ERBB3	IPI	UniProtKB:P04626	Human	PMID:25326665
Molecular Function	GO:0005515	protein binding	ERBB3	IPI	UniProtKB:Q02297-6	Human	PMID:28988771
Molecular Function	GO:0005515	protein binding	ERBB3	IPI	UniProtKB:P26447	Human	PMID:30083275
Molecular Function	GO:0005515	protein binding	ERBB3	IPI	UniProtKB:Q13671	Human	PMID:31980649
Molecular Function	GO:0005515	protein binding	ERBB3	IPI	UniProtKB:P04271	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ERBB3	IPI	UniProtKB:P25098	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ERBB3	IPI	UniProtKB:P29353	Human	PMID:35384245
Molecular Function	GO:0005515	protein binding	ERBB3	IPI	UniProtKB:P04626	Human	PMID:7592681
Molecular Function	GO:0005515	protein binding	ERBB3	IPI	UniProtKB:Q02297-7	Human	PMID:7592681
Molecular Function	GO:0005515	protein binding	ERBB3	IPI	UniProtKB:Q14451	Human	PMID:9516479
Molecular Function	GO:0005515	protein binding	Erbb3	IPI	UniProtKB:P49615|UniProtKB:P61809	Mouse	MGI:MGI:3688080|PMID:11276227
Molecular Function	GO:0005515	protein binding	Erbb3	IPI	UniProtKB:O70624	Mouse	MGI:MGI:5527213|PMID:23897819
Molecular Function	GO:0005515	protein binding	Erbb3	IPI	UniProtKB:P70424	Mouse	MGI:MGI:4888096|PMID:20639901
Molecular Function	GO:0046982	protein heterodimerization activity	ERBB3	IPI	UniProtKB:P04626	Human	PMID:7556068
Molecular Function	GO:0030296	protein tyrosine kinase activator activity	ERBB3	IDA		Human	PMID:7556068
Molecular Function	GO:0038023	signaling receptor activity	Erbb3	IDA		Mouse	PMID:8702723
Molecular Function	GO:0004888	transmembrane signaling receptor activity	Erbb3	IDA		Mouse	PMID:9742126
Molecular Function	GO:0031625	ubiquitin protein ligase binding	ERBB3	IPI	UniProtKB:Q9H4P4	Human	PMID:27353365
Cellular Component	GO:0016324	apical plasma membrane	Erbb3	IDA		Mouse	PMID:15306553
Cellular Component	GO:0016323	basolateral plasma membrane	ERBB3	IDA		Human	PMID:12646923
Cellular Component	GO:0038143	ERBB3:ERBB2 complex	ERBB3	IDA		Human	PMID:12000754
Cellular Component	GO:0005615	extracellular space	ERBB3	IDA		Human	PMID:11389077
Cellular Component	GO:0016328	lateral plasma membrane	Erbb3	IDA		Mouse	PMID:15306553
Cellular Component	GO:0005634	nucleus	Erbb3	IDA		Rat	PMID:17553674|RGD:2289954
Cellular Component	GO:0005886	plasma membrane	Erbb3	IDA		Mouse	PMID:8702723
Cellular Component	GO:0005886	plasma membrane	Erbb3	IDA		Mouse	PMID:9742126
Cellular Component	GO:0045211	postsynaptic membrane	Erbb3	IDA		Rat	PMID:7589796|RGD:2289975
Cellular Component	GO:0043235	receptor complex	ERBB3	IDA		Human	PMID:23382219
Biological Process	GO:0007413	axonal fasciculation	erbb3b	IMP	ZFIN:ZDB-GENO-050512-3	Zfish	PMID:16875686
Biological Process	GO:0007409	axonogenesis	Erbb3	IEP		Rat	PMID:9030624|RGD:68774
Biological Process	GO:0032869	cellular response to insulin stimulus	Erbb3	IEP		Rat	PMID:9389501|RGD:2289971
Biological Process	GO:0007623	circadian rhythm	Erbb3	IEP		Rat	PMID:12454858|RGD:2289959
Biological Process	GO:0021545	cranial nerve development	Erbb3	IMP	MGI:MGI:1929598	Mouse	PMID:9338783
Biological Process	GO:0021545	cranial nerve development	Erbb3	IMP	MGI:MGI:1929072	Mouse	PMID:9338783
Biological Process	GO:0048066	developmental pigmentation	erbb3b	IMP	ZFIN:ZDB-GENO-080903-1	Zfish	PMID:18508863
Biological Process	GO:0048066	developmental pigmentation	erbb3b	IMP	ZFIN:ZDB-GENO-080827-1	Zfish	PMID:18508863
Biological Process	GO:0003197	endocardial cushion development	Erbb3	IMP	MGI:MGI:1928828	Mouse	PMID:9362461
Biological Process	GO:0007173	epidermal growth factor receptor signaling pathway	Erbb3	IMP		Rat	PMID:14711829|RGD:2289958
Biological Process	GO:0038133	ERBB2-ERBB3 signaling pathway	Erbb3	IDA		Mouse	PMID:8702723
Biological Process	GO:0038133	ERBB2-ERBB3 signaling pathway	Erbb3	IDA		Mouse	PMID:9742126
Biological Process	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	ERBB3	IMP		Human	PMID:17701904
Biological Process	GO:0031101	fin regeneration	erbb3b	IMP	ZFIN:ZDB-GENO-100802-2	Zfish	PMID:19133254
Biological Process	GO:0008347	glial cell migration	erbb3b	IMP	ZFIN:ZDB-GENO-050512-3	Zfish	PMID:15797019
Biological Process	GO:0048882	lateral line development	erbb3b	IMP	ZFIN:ZDB-GENO-980202-932	Zfish	PMID:9007244
Biological Process	GO:0060056	mammary gland involution	Erbb3	IEP		Rat	PMID:10653587|RGD:2290014
Biological Process	GO:0030318	melanocyte differentiation	erbb3b	IMP	ZFIN:ZDB-GENO-131108-137	Zfish	PMID:23364329
Biological Process	GO:0097049	motor neuron apoptotic process	Erbb3	IMP	MGI:MGI:1929072	Mouse	PMID:9338783
Biological Process	GO:0097049	motor neuron apoptotic process	Erbb3	IMP	MGI:MGI:1929598	Mouse	PMID:9338783
Biological Process	GO:0042552	myelination	erbb3b	IMP	ZFIN:ZDB-GENO-050512-4	Zfish	PMID:15797019
Biological Process	GO:0042552	myelination	erbb3b	IMP	ZFIN:ZDB-GENO-050512-3	Zfish	PMID:15797019
Biological Process	GO:0048914	myelination of anterior lateral line nerve axons	erbb3b	IMP	ZFIN:ZDB-GENO-050512-4	Zfish	PMID:16875686
Biological Process	GO:0048932	myelination of posterior lateral line nerve axons	erbb3b	IMP	ZFIN:ZDB-GENO-050512-3	Zfish	PMID:16875686
Biological Process	GO:0007162	negative regulation of cell adhesion	ERBB3	IDA		Human	PMID:7556068
Biological Process	GO:2000672	negative regulation of motor neuron apoptotic process	Erbb3	IMP	MGI:MGI:1929072	Mouse	PMID:9338783
Biological Process	GO:2000672	negative regulation of motor neuron apoptotic process	Erbb3	IMP	MGI:MGI:1929598	Mouse	PMID:9338783
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	Erbb3	IMP	MGI:MGI:1929072	Mouse	PMID:9338783
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	Erbb3	IMP	MGI:MGI:1929598	Mouse	PMID:9338783
Biological Process	GO:0051048	negative regulation of secretion	ERBB3	IDA		Human	PMID:10559227
Biological Process	GO:0009968	negative regulation of signal transduction	ERBB3	IDA		Human	PMID:11389077
Biological Process	GO:0014032	neural crest cell development	erbb3b	IMP	ZFIN:ZDB-GENO-080827-1	Zfish	PMID:18508863
Biological Process	GO:0014032	neural crest cell development	erbb3b	IMP	ZFIN:ZDB-GENO-080903-1	Zfish	PMID:18508863
Biological Process	GO:0001755	neural crest cell migration	erbb3b	IMP	ZFIN:ZDB-GENO-080218-1	Zfish	PMID:18599505
Biological Process	GO:0051402	neuron apoptotic process	ERBB3	IMP		Human	PMID:17701904
Biological Process	GO:0051402	neuron apoptotic process	Erbb3	IMP	MGI:MGI:1929072	Mouse	PMID:9338783
Biological Process	GO:0051402	neuron apoptotic process	Erbb3	IMP	MGI:MGI:1929598	Mouse	PMID:9338783
Biological Process	GO:0042476	odontogenesis	Erbb3	IEP		Rat	PMID:12112465|RGD:727391
Biological Process	GO:0007422	peripheral nervous system development	Erbb3	IMP	MGI:MGI:1928828	Mouse	PMID:9362461
Biological Process	GO:0014065	phosphatidylinositol 3-kinase signaling	ERBB3	IDA		Human	PMID:7556068
Biological Process	GO:0070886	positive regulation of calcineurin-NFAT signaling cascade	Erbb3	IGI	MGI:MGI:96083	Mouse	PMID:19179536
Biological Process	GO:0055025	positive regulation of cardiac muscle tissue development	Erbb3	IMP		Mouse	PMID:24364879
Biological Process	GO:0010628	positive regulation of gene expression	Erbb3	IMP		Mouse	PMID:24364879
Biological Process	GO:0046326	positive regulation of glucose import	Erbb3	IMP		Rat	PMID:14711829|RGD:2289958
Biological Process	GO:0061098	positive regulation of protein tyrosine kinase activity	ERBB3	IMP		Human	PMID:7556068
Biological Process	GO:0042127	regulation of cell population proliferation	ERBB3	IDA		Human	PMID:11389077
Biological Process	GO:0009611	response to wounding	Erbb3	IEP		Rat	PMID:9030624|RGD:68774
Biological Process	GO:0009410	response to xenobiotic stimulus	Erbb3	IEP		Rat	PMID:18184445|RGD:2289940
Biological Process	GO:0014044	Schwann cell development	erbb3b	IMP	ZFIN:ZDB-GENO-050512-3	Zfish	PMID:16875686
Biological Process	GO:0014044	Schwann cell development	erbb3b	IMP	ZFIN:ZDB-GENO-050512-4	Zfish	PMID:16875686
Biological Process	GO:0014037	Schwann cell differentiation	Erbb3	IMP	MGI:MGI:1929072	Mouse	PMID:9338783
Biological Process	GO:0014037	Schwann cell differentiation	Erbb3	IMP	MGI:MGI:1929598	Mouse	PMID:9338783
Biological Process	GO:0014037	Schwann cell differentiation	erbb3b	IMP	ZFIN:ZDB-GENO-050512-4	Zfish	PMID:16875686
Biological Process	GO:0014037	Schwann cell differentiation	erbb3b	IMP	ZFIN:ZDB-GENO-050512-3	Zfish	PMID:16875686
Biological Process	GO:0007165	signal transduction	ERBB3	IDA		Human	PMID:10572067
Biological Process	GO:0007519	skeletal muscle tissue development	Erbb3	IEP		Rat	PMID:8846777|RGD:2289973
Biological Process	GO:0001964	startle response	erbb3b	IMP	ZFIN:ZDB-GENO-050512-3,ZFIN:ZDB-GENO-050512-4	Zfish	PMID:16875686
Biological Process	GO:0043586	tongue development	Erbb3	IEP		Rat	PMID:10908606|RGD:2289970

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern