Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ERBB4
  • Mouse genes Erbb4
  • Rat genes Erbb4
  • Zfish genes erbb4a,erbb4b,si:ch73-383l1.1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Erbb4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005006	epidermal growth factor receptor activity	Erbb4	IGI	MGI:MGI:96070	Mouse	PMID:12621152
Molecular Function	GO:0005154	epidermal growth factor receptor binding	ERBB4	IPI	UniProtKB:P00533	Human	PMID:8617750
Molecular Function	GO:0050811	GABA receptor binding	Erbb4	IDA		Mouse	PMID:24218551
Molecular Function	GO:0038131	neuregulin receptor activity	ERBB4	IDA		Human	PMID:12466964
Molecular Function	GO:0038131	neuregulin receptor activity	ERBB4	IDA		Human	PMID:9275162
Molecular Function	GO:0038131	neuregulin receptor activity	Erbb4	IDA		Mouse	PMID:8702723
Molecular Function	GO:0038131	neuregulin receptor activity	Erbb4	IDA		Mouse	PMID:28822966
Molecular Function	GO:0038131	neuregulin receptor activity	Erbb4	IDA		Mouse	PMID:23033483
Molecular Function	GO:0038131	neuregulin receptor activity	Erbb4	IDA		Mouse	PMID:9168115
Molecular Function	GO:0038131	neuregulin receptor activity	Erbb4	IMP	MGI:MGI:2680217	Mouse	PMID:19632177
Molecular Function	GO:0038131	neuregulin receptor activity	Erbb4	IDA		Rat	PMID:26027736|RGD:11052272
Molecular Function	GO:0005515	protein binding	ERBB4	IPI	UniProtKB:P00533	Human	PMID:10572067
Molecular Function	GO:0005515	protein binding	ERBB4	IPI	UniProtKB:P04626	Human	PMID:10572067
Molecular Function	GO:0005515	protein binding	ERBB4	IPI	UniProtKB:P21860	Human	PMID:10572067
Molecular Function	GO:0005515	protein binding	ERBB4	IPI	UniProtKB:P78352	Human	PMID:10725395
Molecular Function	GO:0005515	protein binding	ERBB4	IPI	UniProtKB:Q9H4P4	Human	PMID:11867753
Molecular Function	GO:0005515	protein binding	ERBB4	IPI	UniProtKB:Q96JA1	Human	PMID:15282549
Molecular Function	GO:0005515	protein binding	ERBB4	IPI	UniProtKB:Q96JA1	Human	PMID:15345710
Molecular Function	GO:0005515	protein binding	ERBB4	IPI	UniProtKB:P29353	Human	PMID:16273093
Molecular Function	GO:0005515	protein binding	ERBB4	IPI	UniProtKB:P42684	Human	PMID:16273093
Molecular Function	GO:0005515	protein binding	ERBB4	IPI	UniProtKB:P04626	Human	PMID:16767099
Molecular Function	GO:0005515	protein binding	ERBB4	IPI	UniProtKB:P78352	Human	PMID:16767099
Molecular Function	GO:0005515	protein binding	ERBB4	IPI	UniProtKB:Q12815	Human	PMID:17360433
Molecular Function	GO:0005515	protein binding	ERBB4	IPI	UniProtKB:Q13895	Human	PMID:17360433
Molecular Function	GO:0005515	protein binding	ERBB4	IPI	UniProtKB:Q96J02-2	Human	PMID:18334649
Molecular Function	GO:0005515	protein binding	ERBB4	IPI	UniProtKB:Q8BZZ3	Human	PMID:19561640
Molecular Function	GO:0005515	protein binding	ERBB4	IPI	UniProtKB:P21860	Human	PMID:20227043
Molecular Function	GO:0005515	protein binding	ERBB4	IPI	UniProtKB:O00308	Human	PMID:20858735
Molecular Function	GO:0005515	protein binding	ERBB4	IPI	UniProtKB:O15042	Human	PMID:20858735
Molecular Function	GO:0005515	protein binding	ERBB4	IPI	UniProtKB:P19338	Human	PMID:20858735
Molecular Function	GO:0005515	protein binding	ERBB4	IPI	UniProtKB:P83876	Human	PMID:20858735
Molecular Function	GO:0005515	protein binding	ERBB4	IPI	UniProtKB:Q00839	Human	PMID:20858735
Molecular Function	GO:0005515	protein binding	ERBB4	IPI	UniProtKB:Q13263	Human	PMID:20858735
Molecular Function	GO:0005515	protein binding	ERBB4	IPI	UniProtKB:Q15029	Human	PMID:20858735
Molecular Function	GO:0005515	protein binding	ERBB4	IPI	UniProtKB:Q96J02	Human	PMID:20858735
Molecular Function	GO:0005515	protein binding	ERBB4	IPI	UniProtKB:Q9BUQ8	Human	PMID:20858735
Molecular Function	GO:0005515	protein binding	ERBB4	IPI	UniProtKB:Q9BXP5	Human	PMID:20858735
Molecular Function	GO:0005515	protein binding	ERBB4	IPI	UniProtKB:P04626	Human	PMID:21203579
Molecular Function	GO:0005515	protein binding	ERBB4	IPI	UniProtKB:P08238	Human	PMID:22939624
Molecular Function	GO:0005515	protein binding	ERBB4	IPI	UniProtKB:P04626	Human	PMID:24557338
Molecular Function	GO:0005515	protein binding	ERBB4	IPI	UniProtKB:P46937	Human	PMID:25283809
Molecular Function	GO:0005515	protein binding	ERBB4	IPI	UniProtKB:Q02297-6	Human	PMID:28988771
Molecular Function	GO:0005515	protein binding	ERBB4	IPI	UniProtKB:P26447	Human	PMID:30083275
Molecular Function	GO:0005515	protein binding	ERBB4	IPI	UniProtKB:P46937	Human	PMID:35044719
Molecular Function	GO:0005515	protein binding	ERBB4	IPI	UniProtKB:P00533	Human	PMID:35384245
Molecular Function	GO:0005515	protein binding	ERBB4	IPI	UniProtKB:P04626	Human	PMID:35384245
Molecular Function	GO:0005515	protein binding	ERBB4	IPI	UniProtKB:Q99075	Human	PMID:9135143
Molecular Function	GO:0005515	protein binding	ERBB4	IPI	UniProtKB:O14944	Human	PMID:9419975
Molecular Function	GO:0005515	protein binding	Erbb4	IPI	UniProtKB:Q9NZC7	Mouse	MGI:MGI:5294301|PMID:16061658
Molecular Function	GO:0005515	protein binding	Erbb4	IPI	UniProtKB:A0A0G2KB67	Rat	PMID:15219672|RGD:13601992
Molecular Function	GO:0005515	protein binding	Erbb4	IPI	RGD:3612	Rat	PMID:17018285|RGD:5688294
Molecular Function	GO:0005515	protein binding	Erbb4	IPI	RGD:3153	Rat	PMID:18523588|RGD:9686424
Molecular Function	GO:0042803	protein homodimerization activity	ERBB4	IPI	UniProtKB:Q15303	Human	PMID:18334220
Molecular Function	GO:0004713	protein tyrosine kinase activity	ERBB4	IDA		Human	PMID:18334220
Molecular Function	GO:0000976	transcription cis-regulatory region binding	ERBB4	IMP		Human	PMID:15534001
Molecular Function	GO:0004714	transmembrane receptor protein tyrosine kinase activity	ERBB4	IDA		Human	PMID:18334220
Molecular Function	GO:0004714	transmembrane receptor protein tyrosine kinase activity	Erbb4	IDA		Mouse	PMID:9556621
Molecular Function	GO:0004714	transmembrane receptor protein tyrosine kinase activity	Erbb4	IDA		Mouse	PMID:9168114
Cellular Component	GO:0016323	basolateral plasma membrane	ERBB4	IDA		Human	PMID:12646923
Cellular Component	GO:0005901	caveola	Erbb4	IDA		Rat	PMID:10381889|RGD:2290016
Cellular Component	GO:0005737	cytoplasm	Erbb4	IDA		Rat	PMID:15694257|RGD:2289956
Cellular Component	GO:0030425	dendrite	Erbb4	IDA		Rat	PMID:19793984|RGD:126790482
Cellular Component	GO:0098982	GABA-ergic synapse	Erbb4	IDA		Mouse	PMID:20393464
Cellular Component	GO:0098982	GABA-ergic synapse	Erbb4	IMP		Mouse	PMID:20393464
Cellular Component	GO:0098978	glutamatergic synapse	Erbb4	IDA		Mouse	PMID:20393464
Cellular Component	GO:0060077	inhibitory synapse	Erbb4	IDA		Rat	PMID:18819924|RGD:126790481
Cellular Component	GO:0045121	membrane raft	Erbb4	IDA		Rat	PMID:12716924|RGD:2289998
Cellular Component	GO:0005739	mitochondrion	ERBB4	IDA		Human	PMID:16778220
Cellular Component	GO:0031594	neuromuscular junction	Erbb4	IMP		Mouse	PMID:22184199
Cellular Component	GO:0031594	neuromuscular junction	Erbb4	IDA		Mouse	PMID:22184199
Cellular Component	GO:0043025	neuronal cell body	Erbb4	IDA		Rat	PMID:19793984|RGD:126790482
Cellular Component	GO:0005634	nucleus	ERBB4	IDA		Human	PMID:15534001
Cellular Component	GO:0005634	nucleus	Erbb4	IDA		Rat	PMID:17553674|RGD:2289954
Cellular Component	GO:0005886	plasma membrane	ERBB4	IDA		Human	PMID:12466964
Cellular Component	GO:0005886	plasma membrane	ERBB4	IDA		Human	PMID:9275162
Cellular Component	GO:0005886	plasma membrane	Erbb4	IDA		Mouse	PMID:24218551
Cellular Component	GO:0005886	plasma membrane	Erbb4	IDA		Mouse	PMID:8702723
Cellular Component	GO:0005886	plasma membrane	Erbb4	IDA		Mouse	PMID:19793984
Cellular Component	GO:0005886	plasma membrane	Erbb4	IDA		Mouse	PMID:28267150
Cellular Component	GO:0005886	plasma membrane	Erbb4	IDA		Mouse	PMID:23033483
Cellular Component	GO:0005886	plasma membrane	Erbb4	IDA		Mouse	PMID:12621152
Cellular Component	GO:0005886	plasma membrane	Erbb4	IDA		Mouse	PMID:9556621
Cellular Component	GO:0005886	plasma membrane	Erbb4	IDA		Mouse	PMID:9168115
Cellular Component	GO:0005886	plasma membrane	Erbb4	IDA		Mouse	PMID:9168114
Cellular Component	GO:0005886	plasma membrane	Erbb4	IDA		Rat	PMID:26027736|RGD:11052272
Cellular Component	GO:0005886	plasma membrane	Erbb4	IDA		Rat	PMID:15694257|RGD:2289956
Cellular Component	GO:0014069	postsynaptic density	Erbb4	IDA		Rat	PMID:12716924|RGD:2289998
Cellular Component	GO:0098839	postsynaptic density membrane	Erbb4	IDA		Mouse	PMID:24218551
Cellular Component	GO:0098839	postsynaptic density membrane	Erbb4	IDA		Mouse	PMID:20393464
Cellular Component	GO:0045211	postsynaptic membrane	Erbb4	IDA		Rat	PMID:15219672|RGD:13601992
Cellular Component	GO:0042734	presynaptic membrane	Erbb4	IDA		Mouse	PMID:20393464
Cellular Component	GO:0042734	presynaptic membrane	Erbb4	IDA		Mouse	PMID:24803543
Cellular Component	GO:0043235	receptor complex	ERBB4	IDA		Human	PMID:23382219
Biological Process	GO:0061026	cardiac muscle tissue regeneration	Erbb4	IMP		Mouse	MGI:MGI:4430666|PMID:19632177
Biological Process	GO:0045165	cell fate commitment	Erbb4	IDA		Mouse	PMID:12399441
Biological Process	GO:0016477	cell migration	ERBB4	IDA		Human	PMID:9135143
Biological Process	GO:0007166	cell surface receptor signaling pathway	Erbb4	IDA		Mouse	PMID:24218551
Biological Process	GO:0071364	cellular response to epidermal growth factor stimulus	Erbb4	IDA		Mouse	PMID:8702723
Biological Process	GO:0021551	central nervous system morphogenesis	Erbb4	IMP		Mouse	MGI:MGI:1352955|PMID:10655590
Biological Process	GO:0009880	embryonic pattern specification	Erbb4	IMP		Mouse	MGI:MGI:1352955|PMID:10655590
Biological Process	GO:0038135	ERBB2-ERBB4 signaling pathway	Erbb4	IGI	MGI:95410	Mouse	PMID:12621152
Biological Process	GO:0038135	ERBB2-ERBB4 signaling pathway	Erbb4	IDA		Mouse	PMID:9556621
Biological Process	GO:0038135	ERBB2-ERBB4 signaling pathway	Erbb4	IDA		Mouse	PMID:8702723
Biological Process	GO:0038130	ERBB4 signaling pathway	ERBB4	IDA		Human	PMID:12466964
Biological Process	GO:0038130	ERBB4 signaling pathway	ERBB4	IDA		Human	PMID:9275162
Biological Process	GO:0038130	ERBB4 signaling pathway	Erbb4	IMP	MGI:MGI:2680217,MGI:MGI:1934631	Mouse	PMID:28822966
Biological Process	GO:0038130	ERBB4 signaling pathway	Erbb4	IMP	MGI:MGI:2680217,MGI:MGI:2179048	Mouse	PMID:16446434
Biological Process	GO:0038130	ERBB4 signaling pathway	Erbb4	IDA		Rat	PMID:26027736|RGD:11052272
Biological Process	GO:0038138	ERBB4-ERBB4 signaling pathway	ERBB4	IDA		Human	PMID:12466964
Biological Process	GO:0038138	ERBB4-ERBB4 signaling pathway	ERBB4	IDA		Human	PMID:9275162
Biological Process	GO:0038138	ERBB4-ERBB4 signaling pathway	Erbb4	IDA		Mouse	PMID:28822966
Biological Process	GO:0038138	ERBB4-ERBB4 signaling pathway	Erbb4	IDA		Mouse	PMID:8702723
Biological Process	GO:0038138	ERBB4-ERBB4 signaling pathway	Erbb4	IDA		Mouse	PMID:23033483
Biological Process	GO:0038138	ERBB4-ERBB4 signaling pathway	Erbb4	IDA		Mouse	PMID:9556621
Biological Process	GO:0038138	ERBB4-ERBB4 signaling pathway	Erbb4	IDA		Mouse	PMID:9168115
Biological Process	GO:0038138	ERBB4-ERBB4 signaling pathway	Erbb4	IDA		Mouse	PMID:9168114
Biological Process	GO:0072046	establishment of planar polarity involved in nephron morphogenesis	Erbb4	IMP	MGI:MGI:2445461,MGI:MGI:2680217	Mouse	PMID:22076439
Biological Process	GO:0048699	generation of neurons	erbb4a	IMP	ZFIN:ZDB-MRPHLNO-151006-4	Zfish	PMID:26001123
Biological Process	GO:0007507	heart development	Erbb4	IMP	MGI:MGI:1929607	Mouse	PMID:7477376
Biological Process	GO:0007595	lactation	ERBB4	IMP		Human	PMID:15534001
Biological Process	GO:0007595	lactation	Erbb4	IMP		Mouse	MGI:MGI:5297795|PMID:10508857
Biological Process	GO:0060749	mammary gland alveolus development	Erbb4	IMP		Mouse	MGI:MGI:5297795|PMID:10508857
Biological Process	GO:0030879	mammary gland development	Erbb4	IEP		Rat	PMID:10653587|RGD:2290014
Biological Process	GO:0060644	mammary gland epithelial cell differentiation	Erbb4	IMP		Mouse	MGI:MGI:3689173|PMID:16837552
Biological Process	GO:0043653	mitochondrial fragmentation involved in apoptotic process	ERBB4	IMP		Human	PMID:16778220
Biological Process	GO:0008285	negative regulation of cell population proliferation	ERBB4	IMP		Human	PMID:17120616
Biological Process	GO:0010656	negative regulation of muscle cell apoptotic process	Erbb4	IMP		Rat	PMID:14654373|RGD:2289997
Biological Process	GO:0007399	nervous system development	Erbb4	IMP	MGI:MGI:1929607	Mouse	PMID:7477376
Biological Process	GO:0001755	neural crest cell migration	Erbb4	IMP		Mouse	MGI:MGI:1352955|PMID:10655590
Biological Process	GO:0099645	neurotransmitter receptor localization to postsynaptic specialization membrane	Erbb4	IDA		Mouse	PMID:22184199
Biological Process	GO:0099645	neurotransmitter receptor localization to postsynaptic specialization membrane	Erbb4	IMP		Mouse	PMID:22184199
Biological Process	GO:0042476	odontogenesis	Erbb4	IEP		Rat	PMID:12112465|RGD:727391
Biological Process	GO:0021889	olfactory bulb interneuron differentiation	Erbb4	IMP		Mouse	MGI:MGI:3527369|PMID:15543145
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	ERBB4	IDA		Human	PMID:18334220
Biological Process	GO:0060045	positive regulation of cardiac muscle cell proliferation	Erbb4	IMP		Mouse	MGI:MGI:4430666|PMID:19632177
Biological Process	GO:0030335	positive regulation of cell migration	Erbb4	IMP		Rat	PMID:15355992|RGD:2289957
Biological Process	GO:0008284	positive regulation of cell population proliferation	ERBB4	IMP		Human	PMID:8617750
Biological Process	GO:0008284	positive regulation of cell population proliferation	ERBB4	IMP		Human	PMID:9135143
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ERBB4	IMP		Human	PMID:15534001
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Erbb4	IMP		Mouse	MGI:MGI:3689173|PMID:16837552
Biological Process	GO:0050679	positive regulation of epithelial cell proliferation	Erbb4	IMP		Rat	PMID:17545485|RGD:2289988
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	ERBB4	IMP		Human	PMID:10348342
Biological Process	GO:0046326	positive regulation of glucose import	Erbb4	IMP		Rat	PMID:16740635|RGD:2289995
Biological Process	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	Erbb4	IGI	MGI:MGI:96083	Mouse	PMID:18458158
Biological Process	GO:0071073	positive regulation of phospholipid biosynthetic process	Erbb4	IMP		Rat	PMID:19191103|RGD:126790485
Biological Process	GO:2000010	positive regulation of protein localization to cell surface	Erbb4	IGI	MGI:MGI:96083	Mouse	PMID:18458158
Biological Process	GO:0046427	positive regulation of receptor signaling pathway via JAK-STAT	ERBB4	IMP		Human	PMID:15534001
Biological Process	GO:0046427	positive regulation of receptor signaling pathway via JAK-STAT	Erbb4	IMP		Mouse	MGI:MGI:3689173|PMID:16837552
Biological Process	GO:0032230	positive regulation of synaptic transmission, GABAergic	Erbb4	IMP		Rat	PMID:17521572|RGD:2289989
Biological Process	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	ERBB4	IMP		Human	PMID:16837552
Biological Process	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	Erbb4	IMP		Mouse	MGI:MGI:3689173|PMID:16837552
Biological Process	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	Erbb4	IMP		Mouse	MGI:MGI:5297795|PMID:10508857
Biological Process	GO:0046777	protein autophosphorylation	ERBB4	IDA		Human	PMID:18334220
Biological Process	GO:0030334	regulation of cell migration	Erbb4	IMP		Mouse	MGI:MGI:3527369|PMID:15543145
Biological Process	GO:0042542	response to hydrogen peroxide	Erbb4	IEP		Rat	PMID:15385548|RGD:2289996
Biological Process	GO:0032570	response to progesterone	Erbb4	IEP		Rat	PMID:17459743|RGD:2289991
Biological Process	GO:0009410	response to xenobiotic stimulus	Erbb4	IEP		Rat	PMID:18184445|RGD:2289940
Biological Process	GO:0007165	signal transduction	ERBB4	IDA		Human	PMID:10572067
Biological Process	GO:0043129	surfactant homeostasis	Erbb4	IMP		Rat	PMID:17545485|RGD:2289988
Biological Process	GO:0007416	synapse assembly	Erbb4	IDA		Mouse	PMID:20393464
Biological Process	GO:0007416	synapse assembly	Erbb4	IMP		Mouse	PMID:20393464
Biological Process	GO:0060074	synapse maturation	Erbb4	IMP		Rat	PMID:17521571|RGD:2289990
Biological Process	GO:0021537	telencephalon development	Erbb4	IEP		Rat	PMID:12571115|RGD:2290000
Biological Process	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	ERBB4	IDA		Human	PMID:10353604
Biological Process	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	ERBB4	IDA		Human	PMID:18334220

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern