Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ERCC1
  • Mouse genes Ercc1
  • Rat genes Ercc1
  • Zfish genes ercc1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ercc1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:1990599	3' overhang single-stranded DNA endodeoxyribonuclease activity	ERCC1	IMP		Human	PMID:14690602
Molecular Function	GO:0003684	damaged DNA binding	ERCC1	IDA		Human	PMID:17720715
Molecular Function	GO:0003677	DNA binding	ERCC1	IDA		Human	PMID:14734547
Molecular Function	GO:1990841	promoter-specific chromatin binding	Ercc1	IDA		Mouse	PMID:22323595
Molecular Function	GO:0005515	protein binding	ERCC1	IPI	UniProtKB:P23025	Human	PMID:11058119
Molecular Function	GO:0005515	protein binding	ERCC1	IPI	UniProtKB:Q15554	Human	PMID:14690602
Molecular Function	GO:0005515	protein binding	ERCC1	IPI	UniProtKB:P43246	Human	PMID:14706347
Molecular Function	GO:0005515	protein binding	ERCC1	IPI	UniProtKB:Q96S82	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	ERCC1	IPI	UniProtKB:Q92889	Human	PMID:16338413
Molecular Function	GO:0005515	protein binding	ERCC1	IPI	UniProtKB:P23025	Human	PMID:16491090
Molecular Function	GO:0005515	protein binding	ERCC1	IPI	UniProtKB:Q06609	Human	PMID:16756962
Molecular Function	GO:0005515	protein binding	ERCC1	IPI	UniProtKB:Q92889	Human	PMID:17055345
Molecular Function	GO:0005515	protein binding	ERCC1	IPI	UniProtKB:Q92889	Human	PMID:17289582
Molecular Function	GO:0005515	protein binding	ERCC1	IPI	UniProtKB:P23025	Human	PMID:17720715
Molecular Function	GO:0005515	protein binding	ERCC1	IPI	UniProtKB:P23025	Human	PMID:17948053
Molecular Function	GO:0005515	protein binding	ERCC1	IPI	UniProtKB:Q92889	Human	PMID:18812185
Molecular Function	GO:0005515	protein binding	ERCC1	IPI	UniProtKB:Q8IY92	Human	PMID:19596235
Molecular Function	GO:0005515	protein binding	ERCC1	IPI	UniProtKB:Q8IY92	Human	PMID:19596236
Molecular Function	GO:0005515	protein binding	ERCC1	IPI	UniProtKB:P00533	Human	PMID:24780295
Molecular Function	GO:0005515	protein binding	ERCC1	IPI	UniProtKB:Q92889	Human	PMID:24780295
Molecular Function	GO:0005515	protein binding	ERCC1	IPI	UniProtKB:P23025	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	ERCC1	IPI	UniProtKB:Q13064	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	ERCC1	IPI	UniProtKB:Q6NSB6	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	ERCC1	IPI	UniProtKB:Q8N6Y0	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	ERCC1	IPI	UniProtKB:Q96GJ1	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	ERCC1	IPI	UniProtKB:Q96S82	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	ERCC1	IPI	UniProtKB:Q9H9H4	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	ERCC1	IPI	UniProtKB:Q70EL2	Human	PMID:25538220
Molecular Function	GO:0005515	protein binding	ERCC1	IPI	UniProtKB:P23025	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	ERCC1	IPI	UniProtKB:Q92889	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	ERCC1	IPI	UniProtKB:Q9H9H4	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	ERCC1	IPI	UniProtKB:Q92889	Human	PMID:7559382
Molecular Function	GO:0005515	protein binding	ERCC1	IPI	UniProtKB:P23025	Human	PMID:8197175
Molecular Function	GO:0005515	protein binding	ERCC1	IPI	UniProtKB:P23025	Human	PMID:9013642
Molecular Function	GO:0005515	protein binding	ERCC1	IPI	UniProtKB:Q92889	Human	PMID:9722633
Molecular Function	GO:0005515	protein binding	Ercc1	IPI	PR:P29037	Mouse	PMID:22323595
Molecular Function	GO:0005515	protein binding	Ercc1	IPI	PR:Q8VE65	Mouse	PMID:22323595
Molecular Function	GO:0005515	protein binding	Ercc1	IPI	PR:Q8K387	Mouse	PMID:25538220
Molecular Function	GO:0005515	protein binding	Ercc1	IPI	PR:Q8K0H5	Mouse	PMID:22323595
Molecular Function	GO:0005515	protein binding	Ercc1	IPI	PR:Q62311	Mouse	PMID:22323595
Molecular Function	GO:0005515	protein binding	Ercc1	IPI	PR:Q9R1C0	Mouse	PMID:22323595
Molecular Function	GO:0003697	single-stranded DNA binding	ERCC1	IDA		Human	PMID:16076955
Molecular Function	GO:0003697	single-stranded DNA binding	ERCC1	IDA		Human	PMID:17720715
Molecular Function	GO:0000014	single-stranded DNA endodeoxyribonuclease activity	ERCC1	IDA		Human	PMID:7559382
Molecular Function	GO:0001094	TFIID-class transcription factor complex binding	Ercc1	IDA		Mouse	PMID:22323595
Cellular Component	GO:0000781	chromosome, telomeric region	ERCC1	IDA		Human	PMID:14690602
Cellular Component	GO:0070522	ERCC4-ERCC1 complex	ERCC1	IDA		Human	PMID:14690602
Cellular Component	GO:0070522	ERCC4-ERCC1 complex	ERCC1	IDA		Human	PMID:17055345
Cellular Component	GO:0005654	nucleoplasm	ERCC1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0000109	nucleotide-excision repair complex	ERCC1	IDA		Human	PMID:3290851
Cellular Component	GO:0000109	nucleotide-excision repair complex	ERCC1	IDA		Human	PMID:7559382
Cellular Component	GO:0000109	nucleotide-excision repair complex	ERCC1	IDA		Human	PMID:8197175
Cellular Component	GO:0000110	nucleotide-excision repair factor 1 complex	ERCC1	IDA		Human	PMID:10413517
Cellular Component	GO:0005634	nucleus	Ercc1	IPI	PR:Q8VE65	Mouse	PMID:22323595
Cellular Component	GO:0005634	nucleus	Ercc1	IPI	PR:P29037	Mouse	PMID:22323595
Cellular Component	GO:0005634	nucleus	Ercc1	IPI	PR:Q8K0H5	Mouse	PMID:22323595
Cellular Component	GO:0005634	nucleus	Ercc1	IPI	PR:Q62311	Mouse	PMID:22323595
Cellular Component	GO:0005634	nucleus	Ercc1	IPI	PR:Q9R1C0	Mouse	PMID:22323595
Cellular Component	GO:0005634	nucleus	Ercc1	IDA		Rat	PMID:19440222|RGD:2313668
Biological Process	GO:0048468	cell development	Ercc1	IMP	MGI:MGI:2158940	Mouse	PMID:10834928
Biological Process	GO:0008283	cell population proliferation	Ercc1	IMP	MGI:MGI:2183944	Mouse	PMID:15692571
Biological Process	GO:0051276	chromosome organization	Ercc1	IMP	MGI:MGI:2183944	Mouse	PMID:15199134
Biological Process	GO:0008340	determination of adult lifespan	Ercc1	IMP	MGI:MGI:2183944	Mouse	PMID:17183314
Biological Process	GO:0006974	DNA damage response	Ercc1	IMP	MGI:MGI:2183944	Mouse	PMID:15692571
Biological Process	GO:0006974	DNA damage response	Ercc1	IMP	MGI:MGI:2183944	Mouse	PMID:15979950
Biological Process	GO:0006974	DNA damage response	Ercc1	IMP	MGI:MGI:2183944	Mouse	PMID:11707424
Biological Process	GO:0006974	DNA damage response	Ercc1	IMP	MGI:MGI:2183945	Mouse	PMID:9197240
Biological Process	GO:0006310	DNA recombination	Ercc1	IMP	MGI:MGI:2183944	Mouse	PMID:11707424
Biological Process	GO:0006281	DNA repair	ERCC1	IMP		Human	PMID:25538220
Biological Process	GO:0006281	DNA repair	Ercc1	IMP	MGI:MGI:2158940	Mouse	PMID:12466203
Biological Process	GO:0006302	double-strand break repair	Ercc1	IMP	MGI:MGI:3617449	Mouse	PMID:17912366
Biological Process	GO:0006302	double-strand break repair	Ercc1	IMP	MGI:MGI:2183944	Mouse	PMID:15199134
Biological Process	GO:0006302	double-strand break repair	Ercc1	IMP	MGI:MGI:2158940	Mouse	PMID:17912366
Biological Process	GO:0006303	double-strand break repair via nonhomologous end joining	ERCC1	IMP		Human	PMID:14690602
Biological Process	GO:0048568	embryonic organ development	Ercc1	IEP		Rat	PMID:11425516|RGD:2313673
Biological Process	GO:0007281	germ cell development	Ercc1	IMP	MGI:MGI:3617449	Mouse	PMID:17912366
Biological Process	GO:0007281	germ cell development	Ercc1	IMP	MGI:MGI:2158940	Mouse	PMID:17912366
Biological Process	GO:0048009	insulin-like growth factor receptor signaling pathway	Ercc1	IMP	MGI:MGI:2183944	Mouse	PMID:17183314
Biological Process	GO:0036297	interstrand cross-link repair	Ercc1	IMP		Mouse	PMID:23637614
Biological Process	GO:0045190	isotype switching	Ercc1	IMP	MGI:MGI:2183944	Mouse	PMID:15280420
Biological Process	GO:0008584	male gonad development	Ercc1	IMP	MGI:MGI:3617449	Mouse	PMID:17912366
Biological Process	GO:0008584	male gonad development	Ercc1	IMP	MGI:MGI:2158940	Mouse	PMID:17912366
Biological Process	GO:0006312	mitotic recombination	ERCC1	IMP		Human	PMID:8811092
Biological Process	GO:0035264	multicellular organism growth	Ercc1	IGI	MGI:MGI:1100494	Mouse	PMID:22323595
Biological Process	GO:0035264	multicellular organism growth	Ercc1	IMP	MGI:MGI:2183944	Mouse	PMID:17183314
Biological Process	GO:0035264	multicellular organism growth	Ercc1	IGI	MGI:MGI:99135	Mouse	PMID:22323595
Biological Process	GO:0035264	multicellular organism growth	Ercc1	IMP	MGI:MGI:2183944	Mouse	PMID:22323595
Biological Process	GO:1905765	negative regulation of protection from non-homologous end joining at telomere	ERCC1	IMP		Human	PMID:14690602
Biological Process	GO:0032205	negative regulation of telomere maintenance	ERCC1	IMP		Human	PMID:17055345
Biological Process	GO:0006289	nucleotide-excision repair	ERCC1	IDA		Human	PMID:3290851
Biological Process	GO:0006289	nucleotide-excision repair	ERCC1	IMP		Human	PMID:7657672
Biological Process	GO:0006289	nucleotide-excision repair	Ercc1	IMP	MGI:MGI:2183944	Mouse	PMID:8275084
Biological Process	GO:0048477	oogenesis	Ercc1	IMP	MGI:MGI:2158940	Mouse	PMID:12466203
Biological Process	GO:1904431	positive regulation of t-circle formation	Ercc1	IMP		Mouse	MGI:MGI:5645200|PMID:22579284
Biological Process	GO:0060261	positive regulation of transcription initiation by RNA polymerase II	Ercc1	IMP		Mouse	PMID:22323595
Biological Process	GO:0035166	post-embryonic hemopoiesis	Ercc1	IMP	MGI:MGI:2183944	Mouse	PMID:15692571
Biological Process	GO:0000720	pyrimidine dimer repair by nucleotide-excision repair	Ercc1	IMP		Mouse	PMID:10454634
Biological Process	GO:0090399	replicative senescence	Ercc1	IMP	MGI:MGI:2183945	Mouse	PMID:9197240
Biological Process	GO:0090399	replicative senescence	Ercc1	IMP	MGI:MGI:2183944	Mouse	PMID:17173483
Biological Process	GO:0046686	response to cadmium ion	Ercc1	IEP		Rat	PMID:25729986|RGD:13207321
Biological Process	GO:0035902	response to immobilization stress	Ercc1	IEP		Rat	PMID:25726146|RGD:13207322
Biological Process	GO:0007584	response to nutrient	Ercc1	IEP		Rat	PMID:14670002|RGD:2316276
Biological Process	GO:0006979	response to oxidative stress	ERCC1	IMP		Human	PMID:17614221
Biological Process	GO:0006979	response to oxidative stress	ERCC1	IMP		Human	PMID:9256505
Biological Process	GO:0009744	response to sucrose	Ercc1	IEP		Rat	PMID:15145517|RGD:2313670
Biological Process	GO:0010165	response to X-ray	Ercc1	IMP	MGI:MGI:2183944	Mouse	PMID:15979950
Biological Process	GO:0007283	spermatogenesis	Ercc1	IMP	MGI:MGI:2158940	Mouse	PMID:12466203
Biological Process	GO:0006949	syncytium formation	Ercc1	IMP	MGI:MGI:2158940	Mouse	PMID:10834928
Biological Process	GO:0090656	t-circle formation	Ercc1	IMP		Mouse	MGI:MGI:5645200|PMID:22579284
Biological Process	GO:0061819	telomeric DNA-containing double minutes formation	ERCC1	IMP		Human	PMID:14690602
Biological Process	GO:0009650	UV protection	Ercc1	IMP		Mouse	PMID:10454634
Biological Process	GO:0009650	UV protection	Ercc1	IMP	MGI:MGI:3050065,MGI:MGI:3692923	Mouse	PMID:16682947
Biological Process	GO:0009650	UV protection	Ercc1	IMP	MGI:MGI:2158940	Mouse	PMID:8275084

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern