Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ERCC5
  • Mouse genes Ercc5
  • Rat genes Ercc5
  • Zfish genes ercc5
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ercc5

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0000405	bubble DNA binding	ERCC5	IDA		Human	PMID:16246722
Molecular Function	GO:0000405	bubble DNA binding	ERCC5	IDA		Human	PMID:32821917
Molecular Function	GO:0003684	damaged DNA binding	ERCC5	IDA		Human	PMID:32821917
Molecular Function	GO:0004520	DNA endonuclease activity	ERCC5	IDA		Human	PMID:12644470
Molecular Function	GO:0004520	DNA endonuclease activity	ERCC5	IDA		Human	PMID:8090225
Molecular Function	GO:0003690	double-stranded DNA binding	ERCC5	IDA		Human	PMID:12644470
Molecular Function	GO:0003690	double-stranded DNA binding	ERCC5	IDA		Human	PMID:8090225
Molecular Function	GO:0004519	endonuclease activity	ERCC5	IDA		Human	PMID:32522879
Molecular Function	GO:0004519	endonuclease activity	ERCC5	IDA		Human	PMID:32821917
Molecular Function	GO:0008047	enzyme activator activity	ERCC5	IDA		Human	PMID:9927729
Molecular Function	GO:0005515	protein binding	ERCC5	IPI	UniProtKB:P78549	Human	PMID:15358233
Molecular Function	GO:0005515	protein binding	ERCC5	IPI	UniProtKB:Q03468	Human	PMID:16246722
Molecular Function	GO:0005515	protein binding	ERCC5	IPI	UniProtKB:P24522	Human	PMID:17268471
Molecular Function	GO:0005515	protein binding	ERCC5	IPI	UniProtKB:P38398	Human	PMID:26833090
Molecular Function	GO:0005515	protein binding	ERCC5	IPI	UniProtKB:P51587,UniProtKB:P60896,UniProtKB:Q06609,UniProtKB:Q86YC2	Human	PMID:26833090
Molecular Function	GO:0005515	protein binding	ERCC5	IPI	UniProtKB:P18074	Human	PMID:8652557
Molecular Function	GO:0005515	protein binding	ERCC5	IPI	UniProtKB:P19447	Human	PMID:8652557
Molecular Function	GO:0005515	protein binding	ERCC5	IPI	UniProtKB:P32780	Human	PMID:8652557
Molecular Function	GO:0005515	protein binding	ERCC5	IPI	UniProtKB:Q03468	Human	PMID:8652557
Molecular Function	GO:0005515	protein binding	ERCC5	IPI	UniProtKB:Q13888	Human	PMID:8652557
Molecular Function	GO:0005515	protein binding	ERCC5	IPI	UniProtKB:P12004	Human	PMID:9305916
Molecular Function	GO:0005515	protein binding	ERCC5	IPI	UniProtKB:P78549	Human	PMID:9927729
Molecular Function	GO:0042803	protein homodimerization activity	ERCC5	IPI	UniProtKB:P28715	Human	PMID:10026181
Molecular Function	GO:0044877	protein-containing complex binding	ERCC5	IDA		Human	PMID:11259578
Molecular Function	GO:0000993	RNA polymerase II complex binding	ERCC5	IDA		Human	PMID:16246722
Molecular Function	GO:0003697	single-stranded DNA binding	ERCC5	IDA		Human	PMID:12644470
Cellular Component	GO:0000109	nucleotide-excision repair complex	ERCC5	IDA		Human	PMID:11259578
Cellular Component	GO:0005634	nucleus	ERCC5	IDA		Human	PMID:26833090
Cellular Component	GO:0005634	nucleus	ERCC5	IDA		Human	PMID:8710877
Cellular Component	GO:0032991	protein-containing complex	ERCC5	IDA		Human	PMID:26833090
Biological Process	GO:0006285	base-excision repair, AP site formation	ERCC5	IDA		Human	PMID:9927729
Biological Process	GO:0008340	determination of adult lifespan	Ercc5	IMP	MGI:MGI:3043589	Mouse	PMID:15082767
Biological Process	GO:0006281	DNA repair	Ercc5	IMP	MGI:MGI:3043589	Mouse	PMID:15082767
Biological Process	GO:0000724	double-strand break repair via homologous recombination	ERCC5	IMP		Human	PMID:26833090
Biological Process	GO:0035264	multicellular organism growth	Ercc5	IMP	MGI:MGI:2182793	Mouse	PMID:10022922
Biological Process	GO:0043066	negative regulation of apoptotic process	ERCC5	IMP		Human	PMID:16167068
Biological Process	GO:0006289	nucleotide-excision repair	ERCC5	IDA		Human	PMID:11259578
Biological Process	GO:0006289	nucleotide-excision repair	ERCC5	IDA		Human	PMID:32522879
Biological Process	GO:0006289	nucleotide-excision repair	ERCC5	IDA		Human	PMID:32821917
Biological Process	GO:0006289	nucleotide-excision repair	ERCC5	IMP		Human	PMID:7657672
Biological Process	GO:0006289	nucleotide-excision repair	ERCC5	IDA		Human	PMID:8090225
Biological Process	GO:0006289	nucleotide-excision repair	Ercc5	IMP	MGI:MGI:2182793	Mouse	PMID:10022922
Biological Process	GO:0050790	regulation of catalytic activity	ERCC5	IDA		Human	PMID:9927729
Biological Process	GO:0009411	response to UV	ERCC5	IMP		Human	PMID:16167068
Biological Process	GO:0009411	response to UV	ERCC5	IDA		Human	PMID:8710877
Biological Process	GO:0009411	response to UV	Ercc5	IMP	MGI:MGI:3043589	Mouse	PMID:15082767
Biological Process	GO:0010225	response to UV-C	ERCC5	IMP		Human	PMID:17208056
Biological Process	GO:0006283	transcription-coupled nucleotide-excision repair	ERCC5	IMP		Human	PMID:16246722
Biological Process	GO:0009650	UV protection	Ercc5	IMP		Mouse	PMID:7510366
Biological Process	GO:0009650	UV protection	Ercc5	IDA		Mouse	PMID:8703115

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern