Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ERCC6
  • Mouse genes Ercc6
  • Rat genes Ercc6
  • Zfish genes ercc6
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ercc6

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005524	ATP binding	ERCC6	IDA		Human	PMID:12560492
Molecular Function	GO:0005524	ATP binding	ERCC6	IDA		Human	PMID:16107709
Molecular Function	GO:0008094	ATP-dependent activity, acting on DNA	ERCC6	IDA		Human	PMID:12560492
Molecular Function	GO:0008094	ATP-dependent activity, acting on DNA	ERCC6	IDA		Human	PMID:16107709
Molecular Function	GO:0008094	ATP-dependent activity, acting on DNA	ERCC6	IMP		Human	PMID:25820262
Molecular Function	GO:0008094	ATP-dependent activity, acting on DNA	ERCC6	IDA		Human	PMID:8999876
Molecular Function	GO:0140658	ATP-dependent chromatin remodeler activity	ERCC6	IMP		Human	PMID:29203878
Molecular Function	GO:0003682	chromatin binding	ERCC6	IMP		Human	PMID:25820262
Molecular Function	GO:0003682	chromatin binding	ERCC6	IDA		Human	PMID:26620705
Molecular Function	GO:0003677	DNA binding	ERCC6	IDA		Human	PMID:12560492
Molecular Function	GO:0003677	DNA binding	ERCC6	IDA		Human	PMID:16107709
Molecular Function	GO:0003677	DNA binding	ERCC6	IDA		Human	PMID:8999876
Molecular Function	GO:0005515	protein binding	ERCC6	IPI	UniProtKB:Q9HCS7	Human	PMID:10944529
Molecular Function	GO:0005515	protein binding	ERCC6	IPI	UniProtKB:P09874	Human	PMID:16107709
Molecular Function	GO:0005515	protein binding	ERCC6	IPI	UniProtKB:P28715	Human	PMID:16246722
Molecular Function	GO:0005515	protein binding	ERCC6	IPI	UniProtKB:P00519	Human	PMID:17626041
Molecular Function	GO:0005515	protein binding	ERCC6	IPI	UniProtKB:Q2YD98	Human	PMID:22466612
Molecular Function	GO:0005515	protein binding	ERCC6	IPI	UniProtKB:Q12824	Human	PMID:24874740
Molecular Function	GO:0005515	protein binding	ERCC6	IPI	UniProtKB:O00232	Human	PMID:26030138
Molecular Function	GO:0005515	protein binding	ERCC6	IPI	UniProtKB:O00571	Human	PMID:26030138
Molecular Function	GO:0005515	protein binding	ERCC6	IPI	UniProtKB:O43172	Human	PMID:26030138
Molecular Function	GO:0005515	protein binding	ERCC6	IPI	UniProtKB:O43242	Human	PMID:26030138
Molecular Function	GO:0005515	protein binding	ERCC6	IPI	UniProtKB:O43395	Human	PMID:26030138
Molecular Function	GO:0005515	protein binding	ERCC6	IPI	UniProtKB:O94776	Human	PMID:26030138
Molecular Function	GO:0005515	protein binding	ERCC6	IPI	UniProtKB:P11387	Human	PMID:26030138
Molecular Function	GO:0005515	protein binding	ERCC6	IPI	UniProtKB:P11388	Human	PMID:26030138
Molecular Function	GO:0005515	protein binding	ERCC6	IPI	UniProtKB:P13010	Human	PMID:26030138
Molecular Function	GO:0005515	protein binding	ERCC6	IPI	UniProtKB:P17844	Human	PMID:26030138
Molecular Function	GO:0005515	protein binding	ERCC6	IPI	UniProtKB:P23246	Human	PMID:26030138
Molecular Function	GO:0005515	protein binding	ERCC6	IPI	UniProtKB:P28370	Human	PMID:26030138
Molecular Function	GO:0005515	protein binding	ERCC6	IPI	UniProtKB:P51531	Human	PMID:26030138
Molecular Function	GO:0005515	protein binding	ERCC6	IPI	UniProtKB:P62195	Human	PMID:26030138
Molecular Function	GO:0005515	protein binding	ERCC6	IPI	UniProtKB:Q00839	Human	PMID:26030138
Molecular Function	GO:0005515	protein binding	ERCC6	IPI	UniProtKB:Q05048	Human	PMID:26030138
Molecular Function	GO:0005515	protein binding	ERCC6	IPI	UniProtKB:Q09028	Human	PMID:26030138
Molecular Function	GO:0005515	protein binding	ERCC6	IPI	UniProtKB:Q13435	Human	PMID:26030138
Molecular Function	GO:0005515	protein binding	ERCC6	IPI	UniProtKB:Q13547	Human	PMID:26030138
Molecular Function	GO:0005515	protein binding	ERCC6	IPI	UniProtKB:Q15233	Human	PMID:26030138
Molecular Function	GO:0005515	protein binding	ERCC6	IPI	UniProtKB:Q6PD62	Human	PMID:26030138
Molecular Function	GO:0005515	protein binding	ERCC6	IPI	UniProtKB:Q7L5N1	Human	PMID:26030138
Molecular Function	GO:0005515	protein binding	ERCC6	IPI	UniProtKB:Q86VP6	Human	PMID:26030138
Molecular Function	GO:0005515	protein binding	ERCC6	IPI	UniProtKB:Q86YP4	Human	PMID:26030138
Molecular Function	GO:0005515	protein binding	ERCC6	IPI	UniProtKB:Q8WXI9	Human	PMID:26030138
Molecular Function	GO:0005515	protein binding	ERCC6	IPI	UniProtKB:Q92499	Human	PMID:26030138
Molecular Function	GO:0005515	protein binding	ERCC6	IPI	UniProtKB:Q92841	Human	PMID:26030138
Molecular Function	GO:0005515	protein binding	ERCC6	IPI	UniProtKB:Q93009	Human	PMID:26030138
Molecular Function	GO:0005515	protein binding	ERCC6	IPI	UniProtKB:Q9BT78	Human	PMID:26030138
Molecular Function	GO:0005515	protein binding	ERCC6	IPI	UniProtKB:Q9BUQ8	Human	PMID:26030138
Molecular Function	GO:0005515	protein binding	ERCC6	IPI	UniProtKB:Q9H2U1	Human	PMID:26030138
Molecular Function	GO:0005515	protein binding	ERCC6	IPI	UniProtKB:Q9UJV9	Human	PMID:26030138
Molecular Function	GO:0005515	protein binding	ERCC6	IPI	UniProtKB:Q9UNS2	Human	PMID:26030138
Molecular Function	GO:0005515	protein binding	ERCC6	IPI	UniProtKB:Q63187	Human	PMID:28292928
Molecular Function	GO:0005515	protein binding	ERCC6	IPI	UniProtKB:Q93034	Human	PMID:28292928
Molecular Function	GO:0005515	protein binding	ERCC6	IPI	UniProtKB:Q5UIP0	Human	PMID:29203878
Molecular Function	GO:0005515	protein binding	ERCC6	IPI	UniProtKB:P04637	Human	PMID:7663514
Molecular Function	GO:0005515	protein binding	ERCC6	IPI	UniProtKB:Q13216-1	Human	PMID:7664335
Molecular Function	GO:0005515	protein binding	ERCC6	IPI	UniProtKB:P23025	Human	PMID:8999876
Molecular Function	GO:0005515	protein binding	ERCC6	IPI	UniProtKB:P29084	Human	PMID:8999876
Molecular Function	GO:0030296	protein tyrosine kinase activator activity	ERCC6	IDA		Human	PMID:17626041
Cellular Component	GO:0110016	B-WICH complex	ERCC6	IDA		Human	PMID:16603771
Cellular Component	GO:0005730	nucleolus	ERCC6	IDA		Human	PMID:16107709
Cellular Component	GO:0005730	nucleolus	ERCC6	IDA		Human	PMID:17626041
Cellular Component	GO:0005654	nucleoplasm	ERCC6	IDA		Human	PMID:16107709
Cellular Component	GO:0005634	nucleus	ERCC6	IDA		Human	PMID:12560492
Cellular Component	GO:0005634	nucleus	ERCC6	IDA		Human	PMID:17626041
Cellular Component	GO:0090734	site of DNA damage	ERCC6	IDA		Human	PMID:28292928
Cellular Component	GO:0008023	transcription elongation factor complex	ERCC6	IDA		Human	PMID:9326587
Biological Process	GO:0006284	base-excision repair	ERCC6	IMP		Human	PMID:9973627
Biological Process	GO:0000077	DNA damage checkpoint signaling	ERCC6	IMP		Human	PMID:25820262
Biological Process	GO:0006974	DNA damage response	Ercc6	IMP	MGI:MGI:1932102	Mouse	PMID:11408355
Biological Process	GO:0006974	DNA damage response	Ercc6	IMP	MGI:MGI:1932102	Mouse	PMID:15979950
Biological Process	GO:0006974	DNA damage response	ercc6	IMP	ZFIN:ZDB-MRPHLNO-151009-5	Zfish	PMID:26100862
Biological Process	GO:0042262	DNA protection	Ercc6	IMP		Rat	PMID:31644904|RGD:126925983
Biological Process	GO:0006281	DNA repair	Ercc6	IGI	MGI:MGI:1097693	Mouse	PMID:12447686
Biological Process	GO:0006281	DNA repair	Ercc6	IGI	MGI:MGI:1097693	Mouse	PMID:17213818
Biological Process	GO:0006281	DNA repair	Ercc6	IMP	MGI:MGI:1932102	Mouse	PMID:10806208
Biological Process	GO:0097680	double-strand break repair via classical nonhomologous end joining	ERCC6	IDA		Human	PMID:29545921
Biological Process	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	Ercc6	IMP	MGI:MGI:1932102	Mouse	PMID:11005836
Biological Process	GO:0007254	JNK cascade	Ercc6	IMP	MGI:MGI:1932102	Mouse	PMID:16319174
Biological Process	GO:0035264	multicellular organism growth	Ercc6	IGI	MGI:MGI:99135	Mouse	PMID:22323595
Biological Process	GO:0035264	multicellular organism growth	Ercc6	IGI	MGI:MGI:95412	Mouse	PMID:22323595
Biological Process	GO:2001033	negative regulation of double-strand break repair via nonhomologous end joining	ERCC6	IMP		Human	PMID:25820262
Biological Process	GO:0022008	neurogenesis	ERCC6	IMP		Human	PMID:24874740
Biological Process	GO:0030182	neuron differentiation	ERCC6	IMP		Human	PMID:24874740
Biological Process	GO:0031175	neuron projection development	ERCC6	IMP		Human	PMID:24874740
Biological Process	GO:0045494	photoreceptor cell maintenance	Ercc6	IMP	MGI:MGI:1932102	Mouse	PMID:17145777
Biological Process	GO:0045739	positive regulation of DNA repair	ERCC6	IGI	UniProtKB:P0DP91	Human	PMID:22483866
Biological Process	GO:0045739	positive regulation of DNA repair	ERCC6	IMP		Human	PMID:22483866
Biological Process	GO:0032786	positive regulation of DNA-templated transcription, elongation	ERCC6	IDA		Human	PMID:9326587
Biological Process	GO:1905168	positive regulation of double-strand break repair via homologous recombination	ERCC6	IMP		Human	PMID:25820262
Biological Process	GO:0045945	positive regulation of transcription by RNA polymerase III	ERCC6	IDA		Human	PMID:16603771
Biological Process	GO:0060261	positive regulation of transcription initiation by RNA polymerase II	Ercc6	IGI	MGI:MGI:99135	Mouse	PMID:22323595
Biological Process	GO:0060261	positive regulation of transcription initiation by RNA polymerase II	Ercc6	IMP	MGI:MGI:1932102	Mouse	PMID:22323595
Biological Process	GO:0006290	pyrimidine dimer repair	Ercc6	IMP	MGI:MGI:1932102	Mouse	PMID:9150142
Biological Process	GO:0032784	regulation of DNA-templated transcription elongation	ERCC6	IDA		Human	PMID:9326587
Biological Process	GO:0034243	regulation of transcription elongation by RNA polymerase II	Ercc6	IMP		Rat	PMID:31644904|RGD:126925983
Biological Process	GO:0010332	response to gamma radiation	Ercc6	IMP	MGI:MGI:1932102	Mouse	PMID:15340056
Biological Process	GO:0006979	response to oxidative stress	ERCC6	IGI	UniProtKB:P00519	Human	PMID:17626041
Biological Process	GO:0006979	response to oxidative stress	ERCC6	IDA		Human	PMID:16107709
Biological Process	GO:0006979	response to oxidative stress	Ercc6	IMP	MGI:MGI:1932102	Mouse	PMID:12509265
Biological Process	GO:0000303	response to superoxide	Ercc6	IMP	MGI:MGI:1932102	Mouse	PMID:15340056
Biological Process	GO:0009636	response to toxic substance	Ercc6	IMP	MGI:MGI:1932102	Mouse	PMID:11408355
Biological Process	GO:0009411	response to UV	Ercc6	IMP	MGI:MGI:1932102	Mouse	PMID:15340056
Biological Process	GO:0009411	response to UV	Ercc6	IMP	MGI:MGI:1932102	Mouse	PMID:10843671
Biological Process	GO:0009411	response to UV	ercc6	IMP	ZFIN:ZDB-MRPHLNO-200331-2	Zfish	PMID:31546172
Biological Process	GO:0010224	response to UV-B	Ercc6	IMP	MGI:MGI:1932102	Mouse	PMID:10850428
Biological Process	GO:0010224	response to UV-B	Ercc6	IMP	MGI:MGI:1932102	Mouse	PMID:17145777
Biological Process	GO:0010165	response to X-ray	Ercc6	IMP	MGI:MGI:1932102	Mouse	PMID:15979950
Biological Process	GO:0010165	response to X-ray	Ercc6	IMP	MGI:MGI:1932102	Mouse	PMID:17145777
Biological Process	GO:0000012	single strand break repair	ERCC6	IDA		Human	PMID:29545921
Biological Process	GO:0006362	transcription elongation by RNA polymerase I	Ercc6	IMP	MGI:MGI:1932102	Mouse	PMID:23562818
Biological Process	GO:0006283	transcription-coupled nucleotide-excision repair	ERCC6	IMP		Human	PMID:10564257
Biological Process	GO:0006283	transcription-coupled nucleotide-excision repair	ERCC6	IMP		Human	PMID:26620705
Biological Process	GO:0006283	transcription-coupled nucleotide-excision repair	Ercc6	IMP	MGI:MGI:1932102	Mouse	PMID:9150142
Biological Process	GO:0006283	transcription-coupled nucleotide-excision repair	Ercc6	IMP	MGI:MGI:1932102	Mouse	PMID:12509265
Biological Process	GO:0006283	transcription-coupled nucleotide-excision repair	Ercc6	IMP		Rat	PMID:31644904|RGD:126925983

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern