Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ERCC8
  • Mouse genes Ercc8
  • Rat genes Ercc8
  • Zfish genes ercc8
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ercc8

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	ERCC8	IPI	UniProtKB:Q9HCS7	Human	PMID:10944529
Molecular Function	GO:0005515	protein binding	ERCC8	IPI	UniProtKB:Q16531	Human	PMID:12732143
Molecular Function	GO:0005515	protein binding	ERCC8	IPI	UniProtKB:Q13619,UniProtKB:Q16531	Human	PMID:16949367
Molecular Function	GO:0005515	protein binding	ERCC8	IPI	UniProtKB:Q16531	Human	PMID:16949367
Molecular Function	GO:0005515	protein binding	ERCC8	IPI	UniProtKB:Q2YD98	Human	PMID:22466612
Molecular Function	GO:0005515	protein binding	Ercc8	IPI	UniProtKB:Q3U4B1	Mouse	MGI:MGI:4455093|PMID:20211142
Molecular Function	GO:0044877	protein-containing complex binding	ERCC8	IDA		Human	PMID:16916636
Molecular Function	GO:0004842	ubiquitin-protein transferase activity	ERCC8	IDA		Human	PMID:12732143
Cellular Component	GO:0080008	Cul4-RING E3 ubiquitin ligase complex	ERCC8	IMP		Human	PMID:16949367
Cellular Component	GO:0031464	Cul4A-RING E3 ubiquitin ligase complex	ERCC8	IDA		Human	PMID:12732143
Cellular Component	GO:0005737	cytoplasm	Ercc8	IDA		Rat	PMID:22900489|RGD:13208225
Cellular Component	GO:0016363	nuclear matrix	ERCC8	IDA		Human	PMID:11782547
Cellular Component	GO:0016363	nuclear matrix	ERCC8	IDA		Human	PMID:26620705
Cellular Component	GO:0000109	nucleotide-excision repair complex	ERCC8	IDA		Human	PMID:12732143
Cellular Component	GO:0005634	nucleus	ERCC8	IDA		Human	PMID:11782547
Cellular Component	GO:0005634	nucleus	Ercc8	IDA		Rat	PMID:23022597|RGD:9590340
Cellular Component	GO:0043204	perikaryon	Ercc8	IDA		Rat	PMID:22900489|RGD:13208225
Cellular Component	GO:0032991	protein-containing complex	ERCC8	IDA		Human	PMID:12732143
Biological Process	GO:0006974	DNA damage response	ERCC8	IDA		Human	PMID:11782547
Biological Process	GO:0097680	double-strand break repair via classical nonhomologous end joining	ERCC8	IDA		Human	PMID:29545921
Biological Process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	ERCC8	IDA		Human	PMID:16751180
Biological Process	GO:0051865	protein autoubiquitination	ERCC8	IDA		Human	PMID:12732143
Biological Process	GO:0000209	protein polyubiquitination	ERCC8	IDA		Human	PMID:12732143
Biological Process	GO:0090262	regulation of transcription-coupled nucleotide-excision repair	ERCC8	IMP		Human	PMID:16916636
Biological Process	GO:0090262	regulation of transcription-coupled nucleotide-excision repair	ERCC8	IMP		Human	PMID:17297471
Biological Process	GO:0010996	response to auditory stimulus	Ercc8	IEP		Rat	PMID:23022597|RGD:9590340
Biological Process	GO:0014070	response to organic cyclic compound	Ercc8	IEP		Rat	PMID:22900489|RGD:13208225
Biological Process	GO:0006979	response to oxidative stress	ERCC8	IDA		Human	PMID:11782547
Biological Process	GO:0006979	response to oxidative stress	ERCC8	IMP		Human	PMID:17297471
Biological Process	GO:0009411	response to UV	ERCC8	IDA		Human	PMID:12732143
Biological Process	GO:0009411	response to UV	Ercc8	IMP	MGI:MGI:2449180	Mouse	PMID:15340056
Biological Process	GO:0009411	response to UV	ercc8	IMP	ZFIN:ZDB-MRPHLNO-200331-1	Zfish	PMID:31546172
Biological Process	GO:0010165	response to X-ray	Ercc8	IMP	MGI:MGI:2449180	Mouse	PMID:17145777
Biological Process	GO:0000012	single strand break repair	ERCC8	IDA		Human	PMID:29545921
Biological Process	GO:0006283	transcription-coupled nucleotide-excision repair	ERCC8	IDA		Human	PMID:12732143

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern