Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes EREG
  • Mouse genes Ereg
  • Rat genes Ereg
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ereg

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005154	epidermal growth factor receptor binding	Ereg	IDA		Mouse	MGI:MGI:3687425|PMID:7706296
Molecular Function	GO:0008083	growth factor activity	Ereg	IDA		Rat	PMID:9990076|RGD:632743
Molecular Function	GO:0005515	protein binding	EREG	IPI	UniProtKB:P00533	Human	PMID:28988771
Molecular Function	GO:0005515	protein binding	EREG	IPI	UniProtKB:Q07325	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	EREG	IPI	UniProtKB:Q5J8X5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	EREG	IPI	UniProtKB:Q6UX06	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	EREG	IPI	UniProtKB:Q9NZG7	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	EREG	IPI	UniProtKB:P00533	Human	PMID:9419975
Molecular Function	GO:0005515	protein binding	EREG	IPI	UniProtKB:Q15303	Human	PMID:9419975
Molecular Function	GO:0048018	receptor ligand activity	EREG	IDA		Human	PMID:28783046
Molecular Function	GO:0048018	receptor ligand activity	EREG	IDA		Human	PMID:9556621
Molecular Function	GO:0048018	receptor ligand activity	Ereg	IGI	MGI:MGI:95294	Mouse	PMID:28783046
Molecular Function	GO:0048018	receptor ligand activity	Ereg	IDA		Mouse	PMID:7706296
Molecular Function	GO:0030297	transmembrane receptor protein tyrosine kinase activator activity	EREG	IDA		Human	PMID:28783046
Molecular Function	GO:0030297	transmembrane receptor protein tyrosine kinase activator activity	EREG	IDA		Human	PMID:9556621
Cellular Component	GO:0005615	extracellular space	EREG	IDA		Human	PMID:28783046
Cellular Component	GO:0005615	extracellular space	EREG	IDA		Human	PMID:9556621
Cellular Component	GO:0005615	extracellular space	EREG	IDA		Human	PMID:14581411
Cellular Component	GO:0005615	extracellular space	EREG	IDA		Human	PMID:9337852
Cellular Component	GO:0005615	extracellular space	Ereg	IDA		Mouse	MGI:MGI:1333540|PMID:9337852
Cellular Component	GO:0005615	extracellular space	Ereg	IGI	MGI:MGI:95294	Mouse	PMID:28783046
Cellular Component	GO:0005615	extracellular space	Ereg	IDA		Rat	PMID:14570897|RGD:2316285
Biological Process	GO:0007267	cell-cell signaling	EREG	IDA		Human	PMID:14581411
Biological Process	GO:0019221	cytokine-mediated signaling pathway	EREG	IDA		Human	PMID:9419975
Biological Process	GO:0007173	epidermal growth factor receptor signaling pathway	EREG	IDA		Human	PMID:28783046
Biological Process	GO:0007173	epidermal growth factor receptor signaling pathway	EREG	IDA		Human	PMID:9556621
Biological Process	GO:0007173	epidermal growth factor receptor signaling pathway	Ereg	IDA		Mouse	PMID:7706296
Biological Process	GO:0007173	epidermal growth factor receptor signaling pathway	Ereg	IGI	MGI:MGI:95294	Mouse	PMID:28783046
Biological Process	GO:0038134	ERBB2-EGFR signaling pathway	EREG	IDA		Human	PMID:9556621
Biological Process	GO:0038135	ERBB2-ERBB4 signaling pathway	EREG	IDA		Human	PMID:9556621
Biological Process	GO:0038138	ERBB4-ERBB4 signaling pathway	EREG	IDA		Human	PMID:9556621
Biological Process	GO:0007143	female meiotic nuclear division	Ereg	IDA		Rat	PMID:15459120|RGD:2316284
Biological Process	GO:0043616	keratinocyte proliferation	EREG	IDA		Human	PMID:10681561
Biological Process	GO:0042700	luteinizing hormone signaling pathway	Ereg	IDA		Rat	PMID:15459120|RGD:2316284
Biological Process	GO:0009299	mRNA transcription	EREG	IDA		Human	PMID:10681561
Biological Process	GO:0008285	negative regulation of cell population proliferation	Ereg	IDA		Mouse	MGI:MGI:3687425|PMID:7706296
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	EREG	IDA		Human	PMID:14581411
Biological Process	GO:0051151	negative regulation of smooth muscle cell differentiation	EREG	IDA		Human	PMID:14581411
Biological Process	GO:0001556	oocyte maturation	Ereg	IDA		Rat	PMID:15459120|RGD:2316284
Biological Process	GO:0001550	ovarian cumulus expansion	Ereg	IDA		Rat	PMID:15459120|RGD:2316284
Biological Process	GO:0030728	ovulation	Ereg	IDA		Rat	PMID:15459120|RGD:2316284
Biological Process	GO:0008284	positive regulation of cell population proliferation	EREG	IDA		Human	PMID:10681561
Biological Process	GO:0008284	positive regulation of cell population proliferation	Ereg	IDA		Mouse	MGI:MGI:3687425|PMID:7706296
Biological Process	GO:0008284	positive regulation of cell population proliferation	Ereg	IDA		Rat	PMID:9990076|RGD:632743
Biological Process	GO:0001819	positive regulation of cytokine production	EREG	IDA		Human	PMID:10681561
Biological Process	GO:0001819	positive regulation of cytokine production	Ereg	IMP		Mouse	MGI:MGI:3604223|PMID:16182244
Biological Process	GO:0045740	positive regulation of DNA replication	EREG	IDA		Human	PMID:10681561
Biological Process	GO:0045740	positive regulation of DNA replication	EREG	IDA		Human	PMID:9337852
Biological Process	GO:0045740	positive regulation of DNA replication	Ereg	IDA		Mouse	MGI:MGI:3687425|PMID:7706296
Biological Process	GO:0045740	positive regulation of DNA replication	Ereg	IDA		Mouse	MGI:MGI:1333540|PMID:9337852
Biological Process	GO:0045740	positive regulation of DNA replication	Ereg	IDA		Rat	PMID:9990076|RGD:632743
Biological Process	GO:0045741	positive regulation of epidermal growth factor-activated receptor activity	Ereg	IDA		Rat	PMID:9990076|RGD:632743
Biological Process	GO:0048146	positive regulation of fibroblast proliferation	EREG	IDA		Human	PMID:12702554
Biological Process	GO:0045089	positive regulation of innate immune response	Ereg	IMP		Mouse	MGI:MGI:3604223|PMID:16182244
Biological Process	GO:0032755	positive regulation of interleukin-6 production	Ereg	IMP		Mouse	MGI:MGI:3604223|PMID:16182244
Biological Process	GO:0045840	positive regulation of mitotic nuclear division	Ereg	IDA		Mouse	MGI:MGI:3687425|PMID:7706296
Biological Process	GO:0045840	positive regulation of mitotic nuclear division	Ereg	IDA		Rat	PMID:9990076|RGD:632743
Biological Process	GO:0042327	positive regulation of phosphorylation	EREG	IDA		Human	PMID:10681561
Biological Process	GO:0042327	positive regulation of phosphorylation	EREG	IDA		Human	PMID:9419975
Biological Process	GO:0045860	positive regulation of protein kinase activity	EREG	IDA		Human	PMID:14581411
Biological Process	GO:0048661	positive regulation of smooth muscle cell proliferation	Ereg	IMP		Rat	PMID:14570897|RGD:2316285
Biological Process	GO:0048661	positive regulation of smooth muscle cell proliferation	Ereg	IDA		Rat	PMID:9990076|RGD:632743
Biological Process	GO:0048160	primary follicle stage	Ereg	IDA		Rat	PMID:15459120|RGD:2316284
Biological Process	GO:0043434	response to peptide hormone	Ereg	IEP		Rat	PMID:15459120|RGD:2316284

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern