Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ERN1
  • Mouse genes Ern1
  • Rat genes Ern1
  • Zfish genes ern1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ern1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0043531	ADP binding	ERN1	IDA		Human	PMID:21317875
Molecular Function	GO:0005524	ATP binding	ERN1	IDA		Human	PMID:9637683
Molecular Function	GO:0004519	endonuclease activity	Ern1	IDA		Mouse	MGI:MGI:3622319|PMID:11850408
Molecular Function	GO:0019899	enzyme binding	ERN1	IPI	UniProtKB:Q8N5Y8	Human	PMID:23103912
Molecular Function	GO:0030544	Hsp70 protein binding	ERN1	IPI	UniProtKB:P0DMV8	Human	PMID:20625543
Molecular Function	GO:0051879	Hsp90 protein binding	ERN1	IDA		Human	PMID:12446770
Molecular Function	GO:0051879	Hsp90 protein binding	Ern1	IDA		Rat	PMID:12446770|RGD:10047277
Molecular Function	GO:0042802	identical protein binding	ERN1	IPI	UniProtKB:O75460	Human	PMID:12637535
Molecular Function	GO:0042802	identical protein binding	ERN1	IPI	UniProtKB:O75460	Human	PMID:21317875
Molecular Function	GO:0000287	magnesium ion binding	ERN1	IDA		Human	PMID:9637683
Molecular Function	GO:0005161	platelet-derived growth factor receptor binding	ERN1	IPI	UniProtKB:P09619	Human	PMID:26315405
Molecular Function	GO:0005515	protein binding	ERN1	IPI	UniProtKB:Q12933	Human	PMID:11278723
Molecular Function	GO:0005515	protein binding	ERN1	IPI	UniProtKB:Q9H2K8	Human	PMID:11278723
Molecular Function	GO:0005515	protein binding	ERN1	IPI	UniProtKB:Q92905	Human	PMID:15234121
Molecular Function	GO:0005515	protein binding	ERN1	IPI	UniProtKB:O08734	Human	PMID:16645094
Molecular Function	GO:0005515	protein binding	ERN1	IPI	UniProtKB:P20029	Human	PMID:16645094
Molecular Function	GO:0005515	protein binding	ERN1	IPI	UniProtKB:Q07812	Human	PMID:16645094
Molecular Function	GO:0005515	protein binding	ERN1	IPI	UniProtKB:Q07813	Human	PMID:16645094
Molecular Function	GO:0005515	protein binding	ERN1	IPI	UniProtKB:Q86TM6	Human	PMID:18369366
Molecular Function	GO:0005515	protein binding	ERN1	IPI	UniProtKB:P54578	Human	PMID:19135427
Molecular Function	GO:0005515	protein binding	ERN1	IPI	UniProtKB:Q86TM6	Human	PMID:19135427
Molecular Function	GO:0005515	protein binding	ERN1	IPI	UniProtKB:Q96Q80	Human	PMID:19135427
Molecular Function	GO:0005515	protein binding	ERN1	IPI	UniProtKB:Q9BUN8	Human	PMID:19135427
Molecular Function	GO:0005515	protein binding	ERN1	IPI	UniProtKB:Q9UBV2	Human	PMID:19135427
Molecular Function	GO:0005515	protein binding	ERN1	IPI	UniProtKB:P55061	Human	PMID:19328063
Molecular Function	GO:0005515	protein binding	ERN1	IPI	UniProtKB:P63244	Human	PMID:20103773
Molecular Function	GO:0005515	protein binding	ERN1	IPI	UniProtKB:P35968	Human	PMID:23529610
Molecular Function	GO:0005515	protein binding	ERN1	IPI	UniProtKB:Q12933	Human	PMID:25241761
Molecular Function	GO:0005515	protein binding	ERN1	IPI	UniProtKB:Q969M3	Human	PMID:25742138
Molecular Function	GO:0005515	protein binding	ERN1	IPI	UniProtKB:P11021	Human	PMID:27238082
Molecular Function	GO:0005515	protein binding	ERN1	IPI	UniProtKB:Q96HY6	Human	PMID:28128204
Molecular Function	GO:0005515	protein binding	Ern1	IPI	UniProtKB:P70196	Mouse	MGI:MGI:5516130|PMID:23942232
Molecular Function	GO:0005515	protein binding	Ern1	IPI	UniProtKB:Q9D2C7	Mouse	MGI:MGI:3840374|PMID:19328063
Molecular Function	GO:0005515	protein binding	Ern1	IPI	UniProtKB:Q9JMA1	Mouse	MGI:MGI:3833760|PMID:19135427
Molecular Function	GO:0005515	protein binding	Ern1	IPI	UniProtKB:P39429,UniProtKB:Q3UHC7	Mouse	MGI:MGI:3796479|PMID:18281285
Molecular Function	GO:0005515	protein binding	Ern1	IPI	UniProtKB:Q3UHC7	Mouse	MGI:MGI:3796479|PMID:18281285
Molecular Function	GO:0005515	protein binding	Ern1	IPI	UniProtKB:P25118	Mouse	MGI:MGI:5508636|PMID:16680093
Molecular Function	GO:0005515	protein binding	Ern1	IPI	UniProtKB:B5DFH7	Rat	PMID:10650002|RGD:10047262
Molecular Function	GO:0042803	protein homodimerization activity	ERN1	IDA		Human	PMID:21317875
Molecular Function	GO:0042803	protein homodimerization activity	ERN1	IDA		Human	PMID:29198525
Molecular Function	GO:0042803	protein homodimerization activity	Ern1	IDA		Mouse	MGI:MGI:6114871|PMID:25164867
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ERN1	IDA		Human	PMID:21317875
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ERN1	IDA		Human	PMID:9637683
Molecular Function	GO:0004674	protein serine/threonine kinase activity	Ern1	IDA		Mouse	MGI:MGI:6114871|PMID:25164867
Molecular Function	GO:0004521	RNA endonuclease activity	ERN1	IDA		Human	PMID:11779465
Molecular Function	GO:0004521	RNA endonuclease activity	ERN1	IDA		Human	PMID:19328063
Molecular Function	GO:0004521	RNA endonuclease activity	ERN1	IDA		Human	PMID:21317875
Molecular Function	GO:0004521	RNA endonuclease activity	ERN1	IDA		Human	PMID:9637683
Molecular Function	GO:0004521	RNA endonuclease activity	Ern1	IDA		Mouse	PMID:25164867
Molecular Function	GO:0004521	RNA endonuclease activity	Ern1	IDA		Mouse	PMID:15601821
Cellular Component	GO:1990597	AIP1-IRE1 complex	Ern1	IPI	UniProtKB:Q3UHC7	Mouse	MGI:MGI:3796479|PMID:18281285
Cellular Component	GO:0005737	cytoplasm	ERN1	IDA		Human	PMID:19622636
Cellular Component	GO:0005783	endoplasmic reticulum	ERN1	IDA		Human	PMID:23529610
Cellular Component	GO:0005789	endoplasmic reticulum membrane	ERN1	IDA		Human	PMID:9637683
Cellular Component	GO:0005789	endoplasmic reticulum membrane	Ern1	IDA		Mouse	PMID:9755171
Cellular Component	GO:1990630	IRE1-RACK1-PP2A complex	ERN1	IDA		Human	PMID:20103773
Cellular Component	GO:1990604	IRE1-TRAF2-ASK1 complex	ERN1	IDA		Human	PMID:23000344
Cellular Component	GO:0005739	mitochondrion	Ern1	IDA		Mouse	PMID:23028046
Cellular Component	GO:0005637	nuclear inner membrane	Ern1	IDA		Mouse	MGI:MGI:3622319|PMID:11850408
Biological Process	GO:0071333	cellular response to glucose stimulus	ERN1	IDA		Human	PMID:20103773
Biological Process	GO:0071333	cellular response to glucose stimulus	Ern1	IEP		Rat	PMID:18286202|RGD:35315926
Biological Process	GO:0070301	cellular response to hydrogen peroxide	Ern1	IEP		Rat	PMID:29568958|RGD:34888236
Biological Process	GO:0071287	cellular response to manganese ion	Ern1	IEP		Rat	PMID:23934647|RGD:10047151
Biological Process	GO:0034620	cellular response to unfolded protein	ERN1	IDA		Human	PMID:19328063
Biological Process	GO:0034620	cellular response to unfolded protein	ERN1	IMP		Human	PMID:20625543
Biological Process	GO:0035924	cellular response to vascular endothelial growth factor stimulus	ERN1	IDA		Human	PMID:23529610
Biological Process	GO:0030968	endoplasmic reticulum unfolded protein response	Ern1	IDA		Mouse	PMID:15601821
Biological Process	GO:0030968	endoplasmic reticulum unfolded protein response	Ern1	IDA		Mouse	PMID:10882126
Biological Process	GO:0030968	endoplasmic reticulum unfolded protein response	Ern1	IDA		Mouse	PMID:11430819
Biological Process	GO:0001935	endothelial cell proliferation	ERN1	IDA		Human	PMID:23529610
Biological Process	GO:1901142	insulin metabolic process	ERN1	IDA		Human	PMID:20103773
Biological Process	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	Ern1	IMP		Mouse	MGI:MGI:3840374|PMID:19328063
Biological Process	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	Ern1	IDA		Mouse	PMID:11146108
Biological Process	GO:0036498	IRE1-mediated unfolded protein response	ERN1	IDA		Human	PMID:11779465
Biological Process	GO:0036498	IRE1-mediated unfolded protein response	ERN1	IDA		Human	PMID:19328063
Biological Process	GO:0036498	IRE1-mediated unfolded protein response	ERN1	IMP		Human	PMID:28128204
Biological Process	GO:0036498	IRE1-mediated unfolded protein response	ERN1	IDA		Human	PMID:29198525
Biological Process	GO:0036498	IRE1-mediated unfolded protein response	ERN1	IDA		Human	PMID:9637683
Biological Process	GO:0036498	IRE1-mediated unfolded protein response	Ern1	IDA		Mouse	MGI:MGI:6114871|PMID:25164867
Biological Process	GO:0036498	IRE1-mediated unfolded protein response	Ern1	IDA		Mouse	PMID:24508390
Biological Process	GO:0006379	mRNA cleavage	Ern1	IDA		Mouse	MGI:MGI:6114871|PMID:25164867
Biological Process	GO:0098787	mRNA cleavage involved in mRNA processing	ERN1	IDA		Human	PMID:21317875
Biological Process	GO:0070054	mRNA splicing, via endonucleolytic cleavage and ligation	ERN1	IDA		Human	PMID:11779464
Biological Process	GO:0070054	mRNA splicing, via endonucleolytic cleavage and ligation	ERN1	IDA		Human	PMID:19328063
Biological Process	GO:0070054	mRNA splicing, via endonucleolytic cleavage and ligation	ERN1	IDA		Human	PMID:19622636
Biological Process	GO:0070054	mRNA splicing, via endonucleolytic cleavage and ligation	ERN1	IMP		Human	PMID:20625543
Biological Process	GO:0070054	mRNA splicing, via endonucleolytic cleavage and ligation	ERN1	IDA		Human	PMID:21317875
Biological Process	GO:0070054	mRNA splicing, via endonucleolytic cleavage and ligation	ERN1	IMP		Human	PMID:21317875
Biological Process	GO:0036289	peptidyl-serine autophosphorylation	ERN1	IDA		Human	PMID:20103773
Biological Process	GO:1990579	peptidyl-serine trans-autophosphorylation	ERN1	IMP		Human	PMID:21317875
Biological Process	GO:1900103	positive regulation of endoplasmic reticulum unfolded protein response	ERN1	IMP		Human	PMID:16645094
Biological Process	GO:1900103	positive regulation of endoplasmic reticulum unfolded protein response	ERN1	IMP		Human	PMID:28128204
Biological Process	GO:0043507	positive regulation of JUN kinase activity	ERN1	IDA		Human	PMID:10650002
Biological Process	GO:0043507	positive regulation of JUN kinase activity	Ern1	IMP		Mouse	MGI:MGI:3777353|PMID:10650002
Biological Process	GO:0033120	positive regulation of RNA splicing	ERN1	IDA		Human	PMID:11779464
Biological Process	GO:0033120	positive regulation of RNA splicing	ERN1	IDA		Human	PMID:19622636
Biological Process	GO:0033120	positive regulation of RNA splicing	Ern1	IDA		Mouse	MGI:MGI:6114871|PMID:25164867
Biological Process	GO:1904707	positive regulation of vascular associated smooth muscle cell proliferation	ERN1	IMP		Human	PMID:26315405
Biological Process	GO:0046777	protein autophosphorylation	ERN1	IDA		Human	PMID:19328063
Biological Process	GO:0046777	protein autophosphorylation	ERN1	IDA		Human	PMID:9637683
Biological Process	GO:0046777	protein autophosphorylation	Ern1	IDA		Mouse	MGI:MGI:6114871|PMID:25164867
Biological Process	GO:0046777	protein autophosphorylation	Ern1	IDA		Mouse	PMID:11430819
Biological Process	GO:0006468	protein phosphorylation	ERN1	IDA		Human	PMID:9637683
Biological Process	GO:0034976	response to endoplasmic reticulum stress	ERN1	IDA		Human	PMID:10650002
Biological Process	GO:0001666	response to hypoxia	ern1	IDA		Zfish	PMID:25814654

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern