Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Esr1

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes ESR1
- Mouse genes Esr1
- Rat genes Esr1
- Zfish genes esr1
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Esr1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0051117	ATPase binding	ESR1	IDA		Human	PMID:12058073
Molecular Function	GO:0008013	beta-catenin binding	ESR1	IPI	UniProtKB:P35222	Human	PMID:15304487
Molecular Function	GO:0003682	chromatin binding	ESR1	IDA		Human	PMID:17505058
Molecular Function	GO:0003682	chromatin binding	ESR1	IDA		Human	PMID:20080953
Molecular Function	GO:0003682	chromatin binding	Esr1	IDA		Mouse	PMID:18202148
Molecular Function	GO:0003682	chromatin binding	Esr1	IDA		Mouse	PMID:24332041
Molecular Function	GO:0003677	DNA binding	Esr1	IMP		Rat	PMID:12372009\|RGD:1358611
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	ESR1	IDA		Human	PMID:12047722
Molecular Function	GO:0019899	enzyme binding	ESR1	IPI	UniProtKB:P55345	Human	PMID:12039952
Molecular Function	GO:0019899	enzyme binding	ESR1	IPI	UniProtKB:Q9Y2J8	Human	PMID:22853951
Molecular Function	GO:0019899	enzyme binding	Esr1	IPI	RGD:69231	Rat	PMID:19422801\|RGD:4890964
Molecular Function	GO:0019899	enzyme binding	Esr1	IPI	RGD:2053	Rat	PMID:23493398\|RGD:10413906
Molecular Function	GO:1903924	estradiol binding	esr1	IDA		Zfish	PMID:31437548
Molecular Function	GO:0034056	estrogen response element binding	ESR1	IDA		Human	PMID:15345745
Molecular Function	GO:0034056	estrogen response element binding	ESR1	IDA		Human	PMID:15831516
Molecular Function	GO:0034056	estrogen response element binding	ESR1	IDA		Human	PMID:17975005
Molecular Function	GO:0034056	estrogen response element binding	ESR1	IDA		Human	PMID:9841876
Molecular Function	GO:0042562	hormone binding	Esr1	IMP		Rat	PMID:15105439\|RGD:1580331
Molecular Function	GO:0042562	hormone binding	Esr1	IDA		Rat	PMID:17928626\|RGD:5128669
Molecular Function	GO:0042802	identical protein binding	ESR1	IPI	UniProtKB:P03372	Human	PMID:11265755
Molecular Function	GO:0042802	identical protein binding	ESR1	IPI	UniProtKB:P03372	Human	PMID:11682626
Molecular Function	GO:0042802	identical protein binding	ESR1	IPI	UniProtKB:P03372	Human	PMID:21182205
Molecular Function	GO:0042802	identical protein binding	ESR1	IPI	UniProtKB:P03372	Human	PMID:23065768
Molecular Function	GO:0042802	identical protein binding	ESR1	IPI	UniProtKB:P03372	Human	PMID:31527615
Molecular Function	GO:0030284	nuclear estrogen receptor activity	ESR1	IDA		Human	PMID:15831516
Molecular Function	GO:0030284	nuclear estrogen receptor activity	ESR1	IDA		Human	PMID:9841876
Molecular Function	GO:0030284	nuclear estrogen receptor activity	Esr1	IDA		Rat	PMID:15105439\|RGD:1580331
Molecular Function	GO:0030284	nuclear estrogen receptor activity	esr1	IDA		Zfish	PMID:31437548
Molecular Function	GO:0030284	nuclear estrogen receptor activity	esr1	IDA		Zfish	PMID:25106122
Molecular Function	GO:0030331	nuclear estrogen receptor binding	ESR1	IPI	UniProtKB:P03372	Human	PMID:9841876
Molecular Function	GO:0004879	nuclear receptor activity	ESR1	IDA		Human	PMID:15831516
Molecular Function	GO:0004879	nuclear receptor activity	ESR1	IGI	UniProtKB:Q8IX12	Human	PMID:18722177
Molecular Function	GO:0004879	nuclear receptor activity	Esr1	IDA		Mouse	PMID:15322135
Molecular Function	GO:0004879	nuclear receptor activity	esr1	IDA		Zfish	PMID:12021076
Molecular Function	GO:0004879	nuclear receptor activity	esr1	IDA		Zfish	PMID:25106122
Molecular Function	GO:0003707	nuclear steroid receptor activity	Esr1	IDA		Rat	PMID:17928626\|RGD:5128669
Molecular Function	GO:0003676	nucleic acid binding	ESR1	EXP		Human	PMID:16100953
Molecular Function	GO:0036312	phosphatidylinositol 3-kinase regulatory subunit binding	Esr1	IPI	RGD:3329	Rat	PMID:16971528\|RGD:1625219
Molecular Function	GO:1990841	promoter-specific chromatin binding	Esr1	IDA		Rat	PMID:24046281\|RGD:7364871
Molecular Function	GO:0005515	protein binding	ESR1	IPI	UniProtKB:Q99623	Human	PMID:10359819
Molecular Function	GO:0005515	protein binding	ESR1	IPI	UniProtKB:Q02447	Human	PMID:10816575
Molecular Function	GO:0005515	protein binding	ESR1	IPI	UniProtKB:Q9JLI4	Human	PMID:10866662
Molecular Function	GO:0005515	protein binding	ESR1	IPI	UniProtKB:P00523	Human	PMID:11032808
Molecular Function	GO:0005515	protein binding	ESR1	IPI	UniProtKB:Q00987	Human	PMID:11178989
Molecular Function	GO:0005515	protein binding	ESR1	IPI	UniProtKB:Q15596	Human	PMID:11265755
Molecular Function	GO:0005515	protein binding	ESR1	IPI	UniProtKB:Q96T76	Human	PMID:11279242
Molecular Function	GO:0005515	protein binding	ESR1	IPI	UniProtKB:Q12778	Human	PMID:11353774
Molecular Function	GO:0005515	protein binding	ESR1	IPI	UniProtKB:Q9Y6Q9	Human	PMID:11353774
Molecular Function	GO:0005515	protein binding	ESR1	IPI	UniProtKB:P05627	Human	PMID:11477071
Molecular Function	GO:0005515	protein binding	ESR1	IPI	UniProtKB:Q09472	Human	PMID:11581164
Molecular Function	GO:0005515	protein binding	ESR1	IPI	UniProtKB:Q99966	Human	PMID:11581164
Molecular Function	GO:0005515	protein binding	ESR1	IPI	UniProtKB:Q15788	Human	PMID:11682626
Molecular Function	GO:0005515	protein binding	ESR1	IPI	UniProtKB:O43251	Human	PMID:11875103
Molecular Function	GO:0005515	protein binding	ESR1	IPI	UniProtKB:P55345	Human	PMID:12039952
Molecular Function	GO:0005515	protein binding	ESR1	IPI	UniProtKB:P13056	Human	PMID:12093804
Molecular Function	GO:0005515	protein binding	ESR1	IPI	UniProtKB:P06401	Human	PMID:12612073
Molecular Function	GO:0005515	protein binding	ESR1	IPI	UniProtKB:P06401-1	Human	PMID:12612073
Molecular Function	GO:0005515	protein binding	ESR1	IPI	UniProtKB:Q14151	Human	PMID:12660241
Molecular Function	GO:0005515	protein binding	ESR1	IPI	UniProtKB:Q60974	Human	PMID:12904255
Molecular Function	GO:0005515	protein binding	ESR1	IPI	UniProtKB:Q96GM5	Human	PMID:12917342
Molecular Function	GO:0005515	protein binding	ESR1	IPI	UniProtKB:P53041	Human	PMID:14764652
Molecular Function	GO:0005515	protein binding	ESR1	IPI	UniProtKB:P12931	Human	PMID:14963108
Molecular Function	GO:0005515	protein binding	ESR1	IPI	UniProtKB:Q00403	Human	PMID:1517211
Molecular Function	GO:0005515	protein binding	ESR1	IPI	UniProtKB:Q16881-4	Human	PMID:15199063
Molecular Function	GO:0005515	protein binding	ESR1	IPI	UniProtKB:O43815	Human	PMID:15569929
Molecular Function	GO:0005515	protein binding	ESR1	IPI	UniProtKB:P38398	Human	PMID:15674350
Molecular Function	GO:0005515	protein binding	ESR1	IPI	UniProtKB:P63167	Human	PMID:15891768
Molecular Function	GO:0005515	protein binding	ESR1	IPI	UniProtKB:Q03989	Human	PMID:15941852
Molecular Function	GO:0005515	protein binding	ESR1	IPI	UniProtKB:Q15788	Human	PMID:16282588
Molecular Function	GO:0005515	protein binding	ESR1	IPI	UniProtKB:O14686	Human	PMID:16603732
Molecular Function	GO:0005515	protein binding	ESR1	IPI	UniProtKB:P59598	Human	PMID:16606617
Molecular Function	GO:0005515	protein binding	ESR1	IPI	UniProtKB:Q15788	Human	PMID:16606617
Molecular Function	GO:0005515	protein binding	ESR1	IPI	UniProtKB:Q8IXJ9	Human	PMID:16606617
Molecular Function	GO:0005515	protein binding	ESR1	IPI	UniProtKB:P51843	Human	PMID:16709599
Molecular Function	GO:0005515	protein binding	ESR1	IPI	UniProtKB:Q15466	Human	PMID:16709599
Molecular Function	GO:0005515	protein binding	ESR1	IPI	UniProtKB:Q05086,UniProtKB:Q969T9	Human	PMID:16772533
Molecular Function	GO:0005515	protein binding	ESR1	IPI	UniProtKB:Q15788	Human	PMID:16957778
Molecular Function	GO:0005515	protein binding	ESR1	IPI	UniProtKB:Q8NI77	Human	PMID:17006958
Molecular Function	GO:0005515	protein binding	ESR1	IPI	UniProtKB:P12931	Human	PMID:17043237
Molecular Function	GO:0005515	protein binding	ESR1	IPI	UniProtKB:Q96AQ6-1	Human	PMID:17043237
Molecular Function	GO:0005515	protein binding	ESR1	IPI	UniProtKB:Q8N895	Human	PMID:17085477
Molecular Function	GO:0005515	protein binding	ESR1	IPI	UniProtKB:P36873	Human	PMID:17274640
Molecular Function	GO:0005515	protein binding	ESR1	IPI	UniProtKB:P00533	Human	PMID:17284441
Molecular Function	GO:0005515	protein binding	ESR1	IPI	UniProtKB:P12931	Human	PMID:17284441
Molecular Function	GO:0005515	protein binding	ESR1	IPI	UniProtKB:Q9H467	Human	PMID:17347654
Molecular Function	GO:0005515	protein binding	ESR1	IPI	UniProtKB:O14497	Human	PMID:17363140
Molecular Function	GO:0005515	protein binding	ESR1	IPI	UniProtKB:Q15788	Human	PMID:17363140
Molecular Function	GO:0005515	protein binding	ESR1	IPI	UniProtKB:Q969G3	Human	PMID:17363140
Molecular Function	GO:0005515	protein binding	ESR1	IPI	UniProtKB:Q9H6U6	Human	PMID:17505058
Molecular Function	GO:0005515	protein binding	ESR1	IPI	UniProtKB:Q9Y3R0	Human	PMID:17545996
Molecular Function	GO:0005515	protein binding	ESR1	IPI	UniProtKB:Q15788	Human	PMID:17627277
Molecular Function	GO:0005515	protein binding	ESR1	IPI	UniProtKB:Q9BQ69	Human	PMID:17914104
Molecular Function	GO:0005515	protein binding	ESR1	IPI	UniProtKB:P00523	Human	PMID:17921256
Molecular Function	GO:0005515	protein binding	ESR1	IPI	UniProtKB:P12931	Human	PMID:17921256
Molecular Function	GO:0005515	protein binding	ESR1	IPI	UniProtKB:Q04206	Human	PMID:17932106
Molecular Function	GO:0005515	protein binding	ESR1	IPI	UniProtKB:Q9Y3R0	Human	PMID:17932106
Molecular Function	GO:0005515	protein binding	ESR1	IPI	UniProtKB:P15531	Human	PMID:17975005
Molecular Function	GO:0005515	protein binding	ESR1	IPI	UniProtKB:Q6PL18	Human	PMID:17998543
Molecular Function	GO:0005515	protein binding	ESR1	IPI	UniProtKB:P20290-2	Human	PMID:18025262
Molecular Function	GO:0005515	protein binding	ESR1	IPI	UniProtKB:O43524	Human	PMID:18312651
Molecular Function	GO:0005515	protein binding	ESR1	IPI	UniProtKB:Q15788	Human	PMID:18563714
Molecular Function	GO:0005515	protein binding	ESR1	IPI	UniProtKB:Q6P9F0	Human	PMID:18563714
Molecular Function	GO:0005515	protein binding	ESR1	IPI	UniProtKB:Q9BTK6	Human	PMID:19039327
Molecular Function	GO:0005515	protein binding	ESR1	IPI	UniProtKB:P19838:PRO_0000030311	Human	PMID:19350539
Molecular Function	GO:0005515	protein binding	ESR1	IPI	UniProtKB:Q04206	Human	PMID:19350539
Molecular Function	GO:0005515	protein binding	ESR1	IPI	UniProtKB:Q8WXU2	Human	PMID:19423554
Molecular Function	GO:0005515	protein binding	ESR1	IPI	UniProtKB:O95718-1	Human	PMID:19755138
Molecular Function	GO:0005515	protein binding	ESR1	IPI	UniProtKB:Q9BQ69	Human	PMID:20035625
Molecular Function	GO:0005515	protein binding	ESR1	IPI	UniProtKB:Q8N163	Human	PMID:20074560
Molecular Function	GO:0005515	protein binding	ESR1	IPI	UniProtKB:P10276	Human	PMID:20080953
Molecular Function	GO:0005515	protein binding	ESR1	IPI	UniProtKB:O75528	Human	PMID:20413580
Molecular Function	GO:0005515	protein binding	ESR1	IPI	UniProtKB:Q13188	Human	PMID:21104395
Molecular Function	GO:0005515	protein binding	ESR1	IPI	UniProtKB:O15164	Human	PMID:21164480
Molecular Function	GO:0005515	protein binding	ESR1	IPI	UniProtKB:O15164	Human	PMID:21182203
Molecular Function	GO:0005515	protein binding	ESR1	IPI	UniProtKB:Q9Y6Q9	Human	PMID:21182203
Molecular Function	GO:0005515	protein binding	ESR1	IPI	UniProtKB:P60660	Human	PMID:21182205
Molecular Function	GO:0005515	protein binding	ESR1	IPI	UniProtKB:O00165	Human	PMID:21217774
Molecular Function	GO:0005515	protein binding	ESR1	IPI	UniProtKB:O00429	Human	PMID:21217774
Molecular Function	GO:0005515	protein binding	ESR1	IPI	UniProtKB:O60869	Human	PMID:21217774
Molecular Function	GO:0005515	protein binding	ESR1	IPI	UniProtKB:P18846	Human	PMID:21217774
Molecular Function	GO:0005515	protein binding	ESR1	IPI	UniProtKB:P60660	Human	PMID:21217774
Molecular Function	GO:0005515	protein binding	ESR1	IPI	UniProtKB:P60763	Human	PMID:21217774
Molecular Function	GO:0005515	protein binding	ESR1	IPI	UniProtKB:P62952	Human	PMID:21217774
Molecular Function	GO:0005515	protein binding	ESR1	IPI	UniProtKB:Q96HI0	Human	PMID:21217774
Molecular Function	GO:0005515	protein binding	ESR1	IPI	UniProtKB:Q9UN36	Human	PMID:21217774
Molecular Function	GO:0005515	protein binding	ESR1	IPI	UniProtKB:Q9Y294	Human	PMID:21217774
Molecular Function	GO:0005515	protein binding	ESR1	IPI	UniProtKB:Q96Q04	Human	PMID:21602804
Molecular Function	GO:0005515	protein binding	ESR1	IPI	UniProtKB:P29279	Human	PMID:21629692
Molecular Function	GO:0005515	protein binding	ESR1	IPI	UniProtKB:O15054	Human	PMID:21841772
Molecular Function	GO:0005515	protein binding	ESR1	IPI	UniProtKB:P55345	Human	PMID:22093364
Molecular Function	GO:0005515	protein binding	ESR1	IPI	UniProtKB:P06401	Human	PMID:22396492
Molecular Function	GO:0005515	protein binding	ESR1	IPI	UniProtKB:P12931	Human	PMID:23065768
Molecular Function	GO:0005515	protein binding	ESR1	IPI	UniProtKB:Q86Y37	Human	PMID:23178685
Molecular Function	GO:0005515	protein binding	ESR1	IPI	UniProtKB:P62962	Human	PMID:23576398
Molecular Function	GO:0005515	protein binding	ESR1	IPI	UniProtKB:P12931	Human	PMID:24498420
Molecular Function	GO:0005515	protein binding	ESR1	IPI	UniProtKB:Q6NYC1	Human	PMID:24498420
Molecular Function	GO:0005515	protein binding	ESR1	IPI	UniProtKB:Q15650	Human	PMID:25219498
Molecular Function	GO:0005515	protein binding	ESR1	IPI	UniProtKB:Q6PL18	Human	PMID:25640309
Molecular Function	GO:0005515	protein binding	ESR1	IPI	UniProtKB:Q9BZ95	Human	PMID:25640309
Molecular Function	GO:0005515	protein binding	ESR1	IPI	UniProtKB:Q96RI1-3	Human	PMID:25675114
Molecular Function	GO:0005515	protein binding	ESR1	IPI	UniProtKB:P06401	Human	PMID:26153859
Molecular Function	GO:0005515	protein binding	ESR1	IPI	UniProtKB:Q9Y6Q9	Human	PMID:26153859
Molecular Function	GO:0005515	protein binding	ESR1	IPI	UniProtKB:Q8NEQ6	Human	PMID:27125460
Molecular Function	GO:0005515	protein binding	ESR1	IPI	UniProtKB:O95835	Human	PMID:28068668
Molecular Function	GO:0005515	protein binding	ESR1	IPI	UniProtKB:Q9NV06	Human	PMID:28068668
Molecular Function	GO:0005515	protein binding	ESR1	IPI	UniProtKB:Q9Y4B6	Human	PMID:28068668
Molecular Function	GO:0005515	protein binding	ESR1	IPI	UniProtKB:Q9UBK9	Human	PMID:28106301
Molecular Function	GO:0005515	protein binding	ESR1	IPI	UniProtKB:O60869	Human	PMID:31527615
Molecular Function	GO:0005515	protein binding	ESR1	IPI	UniProtKB:P17676	Human	PMID:31527615
Molecular Function	GO:0005515	protein binding	ESR1	IPI	UniProtKB:P18846	Human	PMID:31527615
Molecular Function	GO:0005515	protein binding	ESR1	IPI	UniProtKB:P36873	Human	PMID:31527615
Molecular Function	GO:0005515	protein binding	ESR1	IPI	UniProtKB:P38398	Human	PMID:31527615
Molecular Function	GO:0005515	protein binding	ESR1	IPI	UniProtKB:Q02447	Human	PMID:31527615
Molecular Function	GO:0005515	protein binding	ESR1	IPI	UniProtKB:Q04206	Human	PMID:31527615
Molecular Function	GO:0005515	protein binding	ESR1	IPI	UniProtKB:Q15648	Human	PMID:31527615
Molecular Function	GO:0005515	protein binding	ESR1	IPI	UniProtKB:Q6PL18	Human	PMID:31527615
Molecular Function	GO:0005515	protein binding	ESR1	IPI	UniProtKB:Q93009	Human	PMID:31527615
Molecular Function	GO:0005515	protein binding	ESR1	IPI	UniProtKB:Q9BZ95	Human	PMID:31527615
Molecular Function	GO:0005515	protein binding	ESR1	IPI	UniProtKB:Q9Y294	Human	PMID:31527615
Molecular Function	GO:0005515	protein binding	ESR1	IPI	UniProtKB:O76024	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ESR1	IPI	UniProtKB:Q6XD76	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ESR1	IPI	UniProtKB:Q6ZQX7-4	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	ESR1	IPI	UniProtKB:Q93009	Human	PMID:35044719
Molecular Function	GO:0005515	protein binding	ESR1	IPI	UniProtKB:P48552	Human	PMID:7641693
Molecular Function	GO:0005515	protein binding	ESR1	IPI	UniProtKB:P17676	Human	PMID:7651415
Molecular Function	GO:0005515	protein binding	ESR1	IPI	UniProtKB:P19838:PRO_0000030311	Human	PMID:7651415
Molecular Function	GO:0005515	protein binding	ESR1	IPI	UniProtKB:Q04206	Human	PMID:7651415
Molecular Function	GO:0005515	protein binding	ESR1	IPI	UniProtKB:P08047	Human	PMID:9328340
Molecular Function	GO:0005515	protein binding	ESR1	IPI	UniProtKB:Q12802	Human	PMID:9627117
Molecular Function	GO:0005515	protein binding	ESR1	IPI	UniProtKB:O88491	Human	PMID:9628876
Molecular Function	GO:0005515	protein binding	ESR1	IPI	UniProtKB:Q15648	Human	PMID:9653119
Molecular Function	GO:0005515	protein binding	Esr1	IPI	UniProtKB:O94763	Mouse	MGI:MGI:5614140\|PMID:25453901
Molecular Function	GO:0005515	protein binding	Esr1	IPI	UniProtKB:Q00175	Mouse	MGI:MGI:5819341\|PMID:22396492
Molecular Function	GO:0005515	protein binding	Esr1	IPI	UniProtKB:Q64127	Mouse	MGI:MGI:84614\|PMID:8978696
Molecular Function	GO:0005515	protein binding	Esr1	IPI	UniProtKB:Q15788	Mouse	MGI:MGI:5315377\|PMID:10207113
Molecular Function	GO:0005515	protein binding	Esr1	IPI	UniProtKB:P17208\|UniProtKB:Q63934-2	Mouse	MGI:MGI:5825439\|PMID:9448000
Molecular Function	GO:0005515	protein binding	Esr1	IPI	UniProtKB:O35129	Mouse	MGI:MGI:3687892\|PMID:12878603
Molecular Function	GO:0005515	protein binding	Esr1	IPI	UniProtKB:Q15788	Mouse	MGI:MGI:3610710\|PMID:16282588
Molecular Function	GO:0005515	protein binding	Esr1	IPI	PR:P27782	Mouse	PMID:18202148
Molecular Function	GO:0005515	protein binding	Esr1	IPI	PR:Q02248	Mouse	PMID:18202148
Molecular Function	GO:0005515	protein binding	Esr1	IPI	PR:Q6RI63	Mouse	PMID:17595322
Molecular Function	GO:0005515	protein binding	Esr1	IPI	PR:Q5IRJ6	Mouse	PMID:15988012
Molecular Function	GO:0005515	protein binding	Esr1	IPI	PR:Q9Z1J1	Mouse	PMID:18202148
Molecular Function	GO:0005515	protein binding	Esr1	IPI	RGD:620109	Rat	PMID:11818503\|RGD:634396
Molecular Function	GO:0005515	protein binding	Esr1	IPI	RGD:620795	Rat	PMID:14751567\|RGD:1581138
Molecular Function	GO:0005515	protein binding	Esr1	IPI	RGD:621827	Rat	PMID:18434427\|RGD:2311258
Molecular Function	GO:0005515	protein binding	Esr1	IPI	RGD:2156	Rat	PMID:19339617\|RGD:5509970
Molecular Function	GO:0005515	protein binding	Esr1	IPI	UniProtKB:Q5VJS5	Rat	PMID:19423554\|RGD:8553436
Molecular Function	GO:0005515	protein binding	Esr1	IPI	RGD:1309046	Rat	PMID:19460436\|RGD:5688174
Molecular Function	GO:0005515	protein binding	Esr1	IPI	RGD:1311850	Rat	PMID:19460436\|RGD:5688174
Molecular Function	GO:0005515	protein binding	Esr1	IPI	RGD:3612	Rat	PMID:19460436\|RGD:5688174
Molecular Function	GO:0005515	protein binding	Esr1	IPI	UniProtKB:P50503	Rat	PMID:21808025\|RGD:13432273
Molecular Function	GO:0019901	protein kinase binding	ESR1	IPI	UniProtKB:O95835	Human	PMID:28068668
Molecular Function	GO:0044877	protein-containing complex binding	Esr1	IDA		Rat	PMID:18434427\|RGD:2311258
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ESR1	IDA		Human	PMID:12047722
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ESR1	IDA		Human	PMID:15345745
Molecular Function	GO:0043565	sequence-specific DNA binding	Esr1	IDA		Mouse	MGI:MGI:5825439\|PMID:9448000
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	ESR1	IDA		Human	PMID:28473536
Molecular Function	GO:0005496	steroid binding	Esr1	IDA		Rat	PMID:15705806\|RGD:8553914
Molecular Function	GO:0005496	steroid binding	Esr1	IDA		Rat	PMID:17928626\|RGD:5128669
Molecular Function	GO:1990239	steroid hormone binding	esr1	IDA		Zfish	PMID:12021076
Molecular Function	GO:0017025	TBP-class protein binding	ESR1	IPI	UniProtKB:P13393	Human	PMID:11595744
Molecular Function	GO:0001093	TFIIB-class transcription factor binding	ESR1	IPI	UniProtKB:P03372	Human	PMID:9841876
Molecular Function	GO:0001223	transcription coactivator binding	ESR1	IPI	UniProtKB:Q969T9	Human	PMID:21642474
Molecular Function	GO:0001223	transcription coactivator binding	Esr1	IPI	RGD:620925	Rat	PMID:18511507\|RGD:4781450
Molecular Function	GO:0001221	transcription coregulator binding	ESR1	IPI	UniProtKB:Q6STE5	Human	PMID:14701856
Molecular Function	GO:0001222	transcription corepressor binding	ESR1	IPI	UniProtKB:Q96JN0	Human	PMID:12535528
Molecular Function	GO:0008134	transcription factor binding	Esr1	IPI	UniProtKB:O88470	Mouse	MGI:MGI:4430655\|PMID:19797124
Molecular Function	GO:0008134	transcription factor binding	Esr1	IPI	UniProtKB:O88470	Mouse	MGI:MGI:4429740\|PMID:20005806
Molecular Function	GO:0031798	type 1 metabotropic glutamate receptor binding	Esr1	IPI	RGD:2742	Rat	PMID:18948402\|RGD:4892069
Cellular Component	GO:0000785	chromatin	ESR1	IDA		Human	PMID:15831516
Cellular Component	GO:0000785	chromatin	ESR1	IDA		Human	PMID:20388878
Cellular Component	GO:0000785	chromatin	ESR1	IDA		Human	PMID:21131358
Cellular Component	GO:0005737	cytoplasm	ESR1	IDA		Human	PMID:17505058
Cellular Component	GO:0005737	cytoplasm	ESR1	IDA		Human	PMID:22693546
Cellular Component	GO:0005737	cytoplasm	Esr1	IDA		Mouse	PMID:14552897
Cellular Component	GO:0005737	cytoplasm	Esr1	IDA		Mouse	PMID:12845704
Cellular Component	GO:0005737	cytoplasm	Esr1	IDA		Rat	PMID:16122717\|RGD:1582179
Cellular Component	GO:0005737	cytoplasm	Esr1	IDA		Rat	PMID:16869728\|RGD:1601101
Cellular Component	GO:0000791	euchromatin	ESR1	IDA		Human	PMID:17505058
Cellular Component	GO:0005739	mitochondrion	Esr1	IDA		Rat	PMID:15994367\|RGD:2302405
Cellular Component	GO:0043005	neuron projection	Esr1	IDA		Rat	PMID:16122717\|RGD:1582179
Cellular Component	GO:0005634	nucleus	ESR1	IDA		Human	PMID:15569929
Cellular Component	GO:0005634	nucleus	ESR1	IDA		Human	PMID:17505058
Cellular Component	GO:0005634	nucleus	ESR1	IDA		Human	PMID:20074560
Cellular Component	GO:0005634	nucleus	ESR1	IDA		Human	PMID:20080953
Cellular Component	GO:0005634	nucleus	ESR1	IDA		Human	PMID:22693546
Cellular Component	GO:0005634	nucleus	ESR1	IDA		Human	PMID:9841876
Cellular Component	GO:0005634	nucleus	Esr1	IDA		Mouse	PMID:12845704
Cellular Component	GO:0005634	nucleus	Esr1	IDA		Mouse	PMID:18202148
Cellular Component	GO:0005634	nucleus	Esr1	IDA		Mouse	PMID:17065319
Cellular Component	GO:0005634	nucleus	Esr1	IDA		Mouse	PMID:8999954
Cellular Component	GO:0005634	nucleus	Esr1	IDA		Mouse	PMID:14502087
Cellular Component	GO:0005634	nucleus	Esr1	IDA		Mouse	PMID:11897499
Cellular Component	GO:0005634	nucleus	Esr1	IDA		Mouse	PMID:14552897
Cellular Component	GO:0005634	nucleus	Esr1	IDA		Rat	PMID:12372009\|RGD:1358611
Cellular Component	GO:0005634	nucleus	Esr1	IDA		Rat	PMID:15705806\|RGD:8553914
Cellular Component	GO:0005634	nucleus	Esr1	IDA		Rat	PMID:16122717\|RGD:1582179
Cellular Component	GO:0005634	nucleus	Esr1	IDA		Rat	PMID:16869728\|RGD:1601101
Cellular Component	GO:0005634	nucleus	Esr1	IDA		Rat	PMID:17928626\|RGD:5128669
Cellular Component	GO:0043204	perikaryon	Esr1	IDA		Rat	PMID:16122717\|RGD:1582179
Cellular Component	GO:0048471	perinuclear region of cytoplasm	Esr1	IDA		Rat	PMID:17928626\|RGD:5128669
Cellular Component	GO:0005886	plasma membrane	ESR1	IDA		Human	PMID:15569929
Cellular Component	GO:0005886	plasma membrane	Esr1	IDA		Rat	PMID:16876190\|RGD:1601102
Cellular Component	GO:0005886	plasma membrane	Esr1	IDA		Rat	PMID:17928626\|RGD:5128669
Cellular Component	GO:0005886	plasma membrane	Esr1	IDA		Rat	PMID:18489713\|RGD:4892089
Cellular Component	GO:0032991	protein-containing complex	ESR1	IMP		Human	PMID:11595744
Cellular Component	GO:0032991	protein-containing complex	ESR1	IDA		Human	PMID:20080953
Cellular Component	GO:0032991	protein-containing complex	Esr1	IDA		Rat	PMID:18434427\|RGD:2311258
Cellular Component	GO:0030315	T-tubule	Esr1	IDA		Rat	PMID:16876190\|RGD:1601102
Cellular Component	GO:0043195	terminal bouton	Esr1	IDA		Rat	PMID:17314305\|RGD:1601103
Cellular Component	GO:0005667	transcription regulator complex	ESR1	IPI		Human	PMID:11265755
Biological Process	GO:0008209	androgen metabolic process	Esr1	IMP	MGI:MGI:2150897	Mouse	PMID:18755802
Biological Process	GO:0001547	antral ovarian follicle growth	Esr1	IMP	MGI:MGI:2386760	Mouse	PMID:10976058
Biological Process	GO:1990375	baculum development	Esr1	IEP		Rat	PMID:21471296\|RGD:8552989
Biological Process	GO:0071392	cellular response to estradiol stimulus	ESR1	IDA		Human	PMID:12535528
Biological Process	GO:0071392	cellular response to estradiol stimulus	ESR1	IDA		Human	PMID:15831516
Biological Process	GO:0071392	cellular response to estradiol stimulus	Esr1	IDA		Mouse	MGI:MGI:5825439\|PMID:9448000
Biological Process	GO:0071392	cellular response to estradiol stimulus	Esr1	IDA		Rat	PMID:15705806\|RGD:8553914
Biological Process	GO:0071391	cellular response to estrogen stimulus	Esr1	IMP	MGI:MGI:2150897	Mouse	PMID:17901126
Biological Process	GO:0071391	cellular response to estrogen stimulus	Esr1	IEP		Rat	PMID:17272396\|RGD:152177689
Biological Process	GO:0071391	cellular response to estrogen stimulus	esr1	IDA		Zfish	PMID:18618001
Biological Process	GO:1904568	cellular response to wortmannin	Esr1	IEP		Rat	PMID:17272396\|RGD:152177689
Biological Process	GO:0046697	decidualization	Esr1	IEP		Rat	PMID:21248290\|RGD:8553214
Biological Process	GO:0002064	epithelial cell development	Esr1	IMP	MGI:MGI:2150897	Mouse	PMID:18755802
Biological Process	GO:0060750	epithelial cell proliferation involved in mammary gland duct elongation	Esr1	IMP	MGI:MGI:2150897	Mouse	PMID:12021201
Biological Process	GO:0048144	fibroblast proliferation	Esr1	IMP	MGI:MGI:2150897	Mouse	PMID:18755802
Biological Process	GO:0030520	intracellular estrogen receptor signaling pathway	ESR1	IDA		Human	PMID:9841876
Biological Process	GO:0030518	intracellular steroid hormone receptor signaling pathway	Esr1	IDA		Rat	PMID:15705806\|RGD:8553914
Biological Process	GO:0030518	intracellular steroid hormone receptor signaling pathway	Esr1	IDA		Rat	PMID:17928626\|RGD:5128669
Biological Process	GO:0008584	male gonad development	Esr1	IMP	MGI:MGI:2150897	Mouse	PMID:18755802
Biological Process	GO:0008584	male gonad development	Esr1	IEP		Rat	PMID:20951417\|RGD:8553220
Biological Process	GO:0060749	mammary gland alveolus development	Esr1	IMP	MGI:MGI:2150897	Mouse	PMID:10919287
Biological Process	GO:0060745	mammary gland branching involved in pregnancy	Esr1	IMP	MGI:MGI:2150897	Mouse	PMID:10919287
Biological Process	GO:0043433	negative regulation of DNA-binding transcription factor activity	ESR1	IDA		Human	PMID:10816575
Biological Process	GO:0010629	negative regulation of gene expression	ESR1	IDA		Human	PMID:21695196
Biological Process	GO:0046325	negative regulation of glucose import	Esr1	IDA		Rat	PMID:23871901\|RGD:8552990
Biological Process	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling	ESR1	IDA		Human	PMID:16043358
Biological Process	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling	ESR1	IDA		Human	PMID:7651415
Biological Process	GO:1902894	negative regulation of miRNA transcription	ESR1	IMP		Human	PMID:20388878
Biological Process	GO:1901215	negative regulation of neuron death	Esr1	IDA		Rat	PMID:15126114\|RGD:1582270
Biological Process	GO:0048662	negative regulation of smooth muscle cell proliferation	Esr1	IMP		Rat	PMID:22099601\|RGD:8553200
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ESR1	IMP		Human	PMID:20388878
Biological Process	GO:0090209	negative regulation of triglyceride metabolic process	Esr1	IDA		Rat	PMID:23871901\|RGD:8552990
Biological Process	GO:0002076	osteoblast development	Esr1	IEP		Rat	PMID:9528993\|RGD:2313676
Biological Process	GO:0007200	phospholipase C-activating G protein-coupled receptor signaling pathway	Esr1	IDA		Rat	PMID:15705806\|RGD:8553914
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration	Esr1	IDA		Rat	PMID:15705806\|RGD:8553914
Biological Process	GO:0051091	positive regulation of DNA-binding transcription factor activity	ESR1	IDA		Human	PMID:10681512
Biological Process	GO:0051091	positive regulation of DNA-binding transcription factor activity	ESR1	IDA		Human	PMID:9328340
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ESR1	IDA		Human	PMID:20074560
Biological Process	GO:0045742	positive regulation of epidermal growth factor receptor signaling pathway	Esr1	IMP		Rat	PMID:17928626\|RGD:5128669
Biological Process	GO:0050679	positive regulation of epithelial cell proliferation	Esr1	IMP		Rat	PMID:25004094\|RGD:10045877
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	Esr1	IDA		Rat	PMID:17928626\|RGD:5128669
Biological Process	GO:0048146	positive regulation of fibroblast proliferation	Esr1	IMP	MGI:MGI:2150897	Mouse	PMID:18755802
Biological Process	GO:0010863	positive regulation of phospholipase C activity	Esr1	IDA		Rat	PMID:15705806\|RGD:8553914
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ESR1	IDA		Human	PMID:11544182
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ESR1	IDA		Human	PMID:11265755
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ESR1	IDA		Human	PMID:12047722
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ESR1	IDA		Human	PMID:15345745
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ESR1	IDA		Human	PMID:15831516
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ESR1	IDA		Human	PMID:18563714
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ESR1	IDA		Human	PMID:9841876
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Esr1	IMP	MGI:MGI:2150897	Mouse	PMID:17901126
Biological Process	GO:0048920	posterior lateral line neuromast primordium migration	esr1	IMP	ZFIN:ZDB-MRPHLNO-100608-9	Zfish	PMID:20308561
Biological Process	GO:0048920	posterior lateral line neuromast primordium migration	esr1	IGI	ZFIN:ZDB-MRPHLNO-050324-1,ZFIN:ZDB-MRPHLNO-100608-9	Zfish	PMID:20308561
Biological Process	GO:0048920	posterior lateral line neuromast primordium migration	esr1	IGI	ZFIN:ZDB-GENO-071022-3,ZFIN:ZDB-MRPHLNO-100608-9	Zfish	PMID:20308561
Biological Process	GO:0060527	prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis	Esr1	IMP	MGI:MGI:2150897	Mouse	PMID:18535112
Biological Process	GO:0060523	prostate epithelial cord elongation	Esr1	IMP	MGI:MGI:2150897	Mouse	PMID:18535112
Biological Process	GO:0071168	protein localization to chromatin	ESR1	IMP		Human	PMID:20388878
Biological Process	GO:0060687	regulation of branching involved in prostate gland morphogenesis	Esr1	IMP	MGI:MGI:2150897	Mouse	PMID:15665095
Biological Process	GO:0060687	regulation of branching involved in prostate gland morphogenesis	Esr1	IMP	MGI:MGI:2150897	Mouse	PMID:18755802
Biological Process	GO:0006355	regulation of DNA-templated transcription	Esr1	IDA		Mouse	PMID:15322135
Biological Process	GO:1904035	regulation of epithelial cell apoptotic process	Esr1	IMP	MGI:MGI:2150897	Mouse	PMID:17901126
Biological Process	GO:0050727	regulation of inflammatory response	Esr1	IMP	MGI:MGI:2150897	Mouse	PMID:22659029
Biological Process	GO:0043523	regulation of neuron apoptotic process	Esr1	IDA		Rat	PMID:15126114\|RGD:1582270
Biological Process	GO:0034121	regulation of toll-like receptor signaling pathway	Esr1	IMP	MGI:MGI:2150897	Mouse	PMID:22659029
Biological Process	GO:0032355	response to estradiol	ESR1	IDA		Human	PMID:15304487
Biological Process	GO:0032355	response to estradiol	Esr1	IEP		Rat	PMID:9528993\|RGD:2313676
Biological Process	GO:0032355	response to estradiol	esr1	IDA		Zfish	PMID:19095286
Biological Process	GO:0043627	response to estrogen	ESR1	IDA		Human	PMID:11581164
Biological Process	GO:0043627	response to estrogen	esr1	IDA		Zfish	PMID:18801367
Biological Process	GO:0043627	response to estrogen	esr1	IDA		Zfish	PMID:25106122
Biological Process	GO:0009410	response to xenobiotic stimulus	esr1	IDA		Zfish	PMID:18416537
Biological Process	GO:0009410	response to xenobiotic stimulus	esr1	IDA		Zfish	PMID:19095286
Biological Process	GO:0051123	RNA polymerase II preinitiation complex assembly	ESR1	IDA		Human	PMID:9841876
Biological Process	GO:0060009	Sertoli cell development	Esr1	IEP		Rat	PMID:24056172\|RGD:7364870
Biological Process	GO:0060011	Sertoli cell proliferation	Esr1	IMP		Rat	PMID:17928626\|RGD:5128669
Biological Process	GO:0048863	stem cell differentiation	Esr1	IDA		Mouse	MGI:MGI:5634223\|PMID:25655704
Biological Process	GO:0006366	transcription by RNA polymerase II	Esr1	IMP	MGI:MGI:2150897	Mouse	PMID:17901126
Biological Process	GO:0060065	uterus development	Esr1	IGI	MGI:MGI:109392	Mouse	PMID:10976058
Biological Process	GO:0060068	vagina development	Esr1	IGI	MGI:MGI:109392	Mouse	PMID:10976058

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.