Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ESR2
  • Mouse genes Esr2
  • Rat genes Esr2
  • Zfish genes esr2a,esr2b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Esr2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003677	DNA binding	Esr2	IDA		Mouse	PMID:9058381
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Esr2	IDA		Rat	PMID:12047722|RGD:8661629
Molecular Function	GO:0019899	enzyme binding	ESR2	IPI	UniProtKB:P55345	Human	PMID:12039952
Molecular Function	GO:0019899	enzyme binding	Esr2	IPI	RGD:620979	Rat	PMID:19683557|RGD:8694315
Molecular Function	GO:1903924	estradiol binding	Esr2	IPI	CHEBI:23965	Rat	PMID:9292936|RGD:8694325
Molecular Function	GO:1903924	estradiol binding	esr2b	IDA		Zfish	PMID:31437548
Molecular Function	GO:1903924	estradiol binding	esr2a	IDA		Zfish	PMID:31437548
Molecular Function	GO:0099130	estrogen binding	Esr2	IPI	CHEBI:35071|CHEBI:17263|CHEBI:17160|CHEBI:34857|CHEBI:27974	Rat	PMID:9048584|RGD:8694130
Molecular Function	GO:0034056	estrogen response element binding	ESR2	IDA		Human	PMID:15345745
Molecular Function	GO:0034056	estrogen response element binding	ESR2	IDA		Human	PMID:19126643
Molecular Function	GO:0034056	estrogen response element binding	Esr2	IDA		Rat	PMID:9600083|RGD:728646
Molecular Function	GO:1901363	heterocyclic compound binding	Esr2	IPI	CHEBI:34881	Rat	PMID:9048584|RGD:8694130
Molecular Function	GO:1901363	heterocyclic compound binding	Esr2	IPI	CHEBI:28088	Rat	PMID:9292936|RGD:8694325
Molecular Function	GO:0042562	hormone binding	Esr2	IMP		Rat	PMID:15105439|RGD:1580331
Molecular Function	GO:0042562	hormone binding	Esr2	IDA		Rat	PMID:17928626|RGD:5128669
Molecular Function	GO:0042562	hormone binding	Esr2	IPI	CHEBI:41922	Rat	PMID:9048584|RGD:8694130
Molecular Function	GO:0030284	nuclear estrogen receptor activity	ESR2	IDA		Human	PMID:19126643
Molecular Function	GO:0030284	nuclear estrogen receptor activity	ESR2	IMP		Human	PMID:29261182
Molecular Function	GO:0030284	nuclear estrogen receptor activity	ESR2	IMP		Human	PMID:30113650
Molecular Function	GO:0030284	nuclear estrogen receptor activity	Esr2	IDA		Rat	PMID:15105439|RGD:1580331
Molecular Function	GO:0030284	nuclear estrogen receptor activity	Esr2	IMP		Rat	PMID:16904920|RGD:1626504
Molecular Function	GO:0030284	nuclear estrogen receptor activity	esr2b	IDA		Zfish	PMID:31437548
Molecular Function	GO:0030284	nuclear estrogen receptor activity	esr2a	IDA		Zfish	PMID:31437548
Molecular Function	GO:0030284	nuclear estrogen receptor activity	esr2b	IDA		Zfish	PMID:25106122
Molecular Function	GO:0030284	nuclear estrogen receptor activity	esr2a	IDA		Zfish	PMID:25106122
Molecular Function	GO:0004879	nuclear receptor activity	ESR2	IDA		Human	PMID:19126643
Molecular Function	GO:0004879	nuclear receptor activity	esr2b	IDA		Zfish	PMID:12021076
Molecular Function	GO:0004879	nuclear receptor activity	esr2b	IDA		Zfish	PMID:25106122
Molecular Function	GO:0004879	nuclear receptor activity	esr2a	IDA		Zfish	PMID:12021076
Molecular Function	GO:0004879	nuclear receptor activity	esr2a	IDA		Zfish	PMID:25106122
Molecular Function	GO:0003707	nuclear steroid receptor activity	Esr2	IDA		Rat	PMID:17928626|RGD:5128669
Molecular Function	GO:0097159	organic cyclic compound binding	Esr2	IPI	CHEBI:41774|CHEBI:31669|CHEBI:4518|CHEBI:6842|CHEBI:33216|CHEBI:28088|CHEBI:3752|CHEBI:28088|CHEBI:33216|CHEBI:6842	Rat	PMID:9048584|RGD:8694130
Molecular Function	GO:0097159	organic cyclic compound binding	Esr2	IPI	CHEBI:44616	Rat	PMID:9292936|RGD:8694325
Molecular Function	GO:0042975	peroxisome proliferator activated receptor binding	Esr2	IPI	RGD:3371	Rat	PMID:20689342|RGD:8553035
Molecular Function	GO:1990841	promoter-specific chromatin binding	Esr2	IDA		Rat	PMID:24046281|RGD:7364871
Molecular Function	GO:0005515	protein binding	ESR2	IPI	UniProtKB:Q96T76	Human	PMID:11279242
Molecular Function	GO:0005515	protein binding	ESR2	IPI	UniProtKB:Q60974	Human	PMID:12904255
Molecular Function	GO:0005515	protein binding	ESR2	IPI	UniProtKB:P53041	Human	PMID:14764652
Molecular Function	GO:0005515	protein binding	ESR2	IPI	UniProtKB:Q16881-4	Human	PMID:15199063
Molecular Function	GO:0005515	protein binding	ESR2	IPI	UniProtKB:O43524	Human	PMID:18312651
Molecular Function	GO:0005515	protein binding	ESR2	IPI	UniProtKB:P03372-1	Human	PMID:19022902
Molecular Function	GO:0005515	protein binding	ESR2	IPI	UniProtKB:Q6P9F0	Human	PMID:19126643
Molecular Function	GO:0005515	protein binding	ESR2	IPI	UniProtKB:Q8N163	Human	PMID:20074560
Molecular Function	GO:0005515	protein binding	ESR2	IPI	UniProtKB:P29279	Human	PMID:21629692
Molecular Function	GO:0005515	protein binding	ESR2	IPI	UniProtKB:P00533	Human	PMID:21951318
Molecular Function	GO:0005515	protein binding	ESR2	IPI	UniProtKB:P38398	Human	PMID:21951318
Molecular Function	GO:0005515	protein binding	ESR2	IPI	UniProtKB:O15162	Human	PMID:24722188
Molecular Function	GO:0005515	protein binding	ESR2	IPI	UniProtKB:O15162	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	Esr2	IPI	UniProtKB:P01101	Mouse	MGI:MGI:5013670|PMID:21565615
Molecular Function	GO:0005515	protein binding	Esr2	IPI	PR:Q8VH51	Mouse	PMID:11704680
Molecular Function	GO:0005515	protein binding	Esr2	IPI	RGD:3317	Rat	PMID:16020483|RGD:7248707
Molecular Function	GO:0005515	protein binding	Esr2	IPI	UniProtKB:Q5VJS5	Rat	PMID:19423554|RGD:8553436
Molecular Function	GO:0005515	protein binding	Esr2	IPI	RGD:1309046	Rat	PMID:19460436|RGD:5688174
Molecular Function	GO:0005515	protein binding	Esr2	IPI	RGD:1311850	Rat	PMID:19460436|RGD:5688174
Molecular Function	GO:0005515	protein binding	Esr2	IPI	RGD:3612	Rat	PMID:19460436|RGD:5688174
Molecular Function	GO:0005515	protein binding	Esr2	IPI	RGD:3269	Rat	PMID:19683557|RGD:8694315
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ESR2	IDA		Human	PMID:15345745
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Esr2	IDA		Rat	PMID:12047722|RGD:8661629
Molecular Function	GO:0043565	sequence-specific DNA binding	Esr2	IDA		Rat	PMID:12200235|RGD:1582280
Molecular Function	GO:0005496	steroid binding	Esr2	IDA		Rat	PMID:15705806|RGD:8553914
Molecular Function	GO:0005496	steroid binding	Esr2	IDA		Rat	PMID:17928626|RGD:5128669
Molecular Function	GO:1990239	steroid hormone binding	Esr2	IPI	CHEBI:27974|CHEBI:62845|CHEBI:17474|CHEBI:18329|CHEBI:34386|CHEBI:36713|CHEBI:16330|CHEBI:28689|CHEBI:7466|CHEBI:34895	Rat	PMID:9048584|RGD:8694130
Molecular Function	GO:1990239	steroid hormone binding	esr2b	IDA		Zfish	PMID:12021076
Molecular Function	GO:1990239	steroid hormone binding	esr2a	IDA		Zfish	PMID:12021076
Cellular Component	GO:0005929	cilium	Esr2	IDA		Rat	PMID:17374697|RGD:8694205
Cellular Component	GO:0005737	cytoplasm	Esr2	IDA		Mouse	PMID:14552897
Cellular Component	GO:0005737	cytoplasm	Esr2	IDA		Rat	PMID:16122717|RGD:1582179
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	ESR2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005739	mitochondrion	ESR2	IDA		Human	PMID:15024130
Cellular Component	GO:0005739	mitochondrion	Esr2	IDA		Rat	PMID:15024130|RGD:8554043
Cellular Component	GO:0043005	neuron projection	Esr2	IDA		Rat	PMID:16122717|RGD:1582179
Cellular Component	GO:0043025	neuronal cell body	Esr2	IDA		Rat	PMID:23701910|RGD:7364912
Cellular Component	GO:0005654	nucleoplasm	ESR2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	ESR2	IDA		Human	PMID:19126643
Cellular Component	GO:0005634	nucleus	ESR2	IDA		Human	PMID:20074560
Cellular Component	GO:0005634	nucleus	Esr2	IDA		Mouse	PMID:14502087
Cellular Component	GO:0005634	nucleus	Esr2	IDA		Mouse	PMID:14552897
Cellular Component	GO:0005634	nucleus	Esr2	IDA		Mouse	PMID:12801993
Cellular Component	GO:0005634	nucleus	Esr2	IDA		Rat	PMID:16122717|RGD:1582179
Cellular Component	GO:0005634	nucleus	Esr2	IDA		Rat	PMID:17928626|RGD:5128669
Cellular Component	GO:0043204	perikaryon	Esr2	IDA		Rat	PMID:16122717|RGD:1582179
Cellular Component	GO:0048471	perinuclear region of cytoplasm	Esr2	IDA		Rat	PMID:17928626|RGD:5128669
Cellular Component	GO:0005886	plasma membrane	Esr2	IDA		Rat	PMID:17928626|RGD:5128669
Cellular Component	GO:0005886	plasma membrane	Esr2	IDA		Rat	PMID:18489713|RGD:4892089
Cellular Component	GO:0032993	protein-DNA complex	Esr2	IDA		Rat	PMID:10342845|RGD:8694156
Biological Process	GO:0021764	amygdala development	Esr2	IEP		Rat	PMID:22791648|RGD:8694158
Biological Process	GO:0030521	androgen receptor signaling pathway	Esr2	IMP	MGI:MGI:2152217	Mouse	PMID:12370428
Biological Process	GO:0001662	behavioral fear response	Esr2	IDA		Rat	PMID:15514081|RGD:1582265
Biological Process	GO:0007420	brain development	Esr2	IMP	MGI:MGI:2152217	Mouse	PMID:12515851
Biological Process	GO:0008283	cell population proliferation	Esr2	IGI	MGI:MGI:88039	Mouse	PMID:18464259
Biological Process	GO:0071392	cellular response to estradiol stimulus	Esr2	IEP		Rat	PMID:17928626|RGD:5128669
Biological Process	GO:0071222	cellular response to lipopolysaccharide	Esr2	IMP		Rat	PMID:21127968|RGD:5508811
Biological Process	GO:0071259	cellular response to magnetism	Esr2	IEP		Rat	PMID:23469792|RGD:7365032
Biological Process	GO:0071407	cellular response to organic cyclic compound	Esr2	IEP		Rat	PMID:23596885|RGD:7364961
Biological Process	GO:0071466	cellular response to xenobiotic stimulus	Esr2	IEP		Rat	PMID:19279558|RGD:7364795
Biological Process	GO:0021549	cerebellum development	Esr2	IEP		Rat	PMID:16542644|RGD:1601098
Biological Process	GO:0060743	epithelial cell maturation involved in prostate gland development	Esr2	IMP	MGI:MGI:2152217	Mouse	PMID:15187231
Biological Process	GO:0050673	epithelial cell proliferation	Esr2	IMP	MGI:MGI:2152217	Mouse	PMID:15187231
Biological Process	GO:0050673	epithelial cell proliferation	Esr2	IMP	MGI:MGI:2152217	Mouse	PMID:12370428
Biological Process	GO:0044849	estrous cycle	Esr2	IMP		Rat	PMID:11854469|RGD:8694160
Biological Process	GO:0008585	female gonad development	Esr2	IEP		Rat	PMID:9927330|RGD:8694313
Biological Process	GO:0008628	hormone-mediated apoptotic signaling pathway	Esr2	IMP	MGI:MGI:2152217	Mouse	PMID:15187231
Biological Process	GO:0021854	hypothalamus development	Esr2	IEP		Rat	PMID:12960049|RGD:1582276
Biological Process	GO:0030520	intracellular estrogen receptor signaling pathway	Esr2	IMP	MGI:MGI:2152217	Mouse	PMID:12370428
Biological Process	GO:0030518	intracellular steroid hormone receptor signaling pathway	Esr2	IDA		Rat	PMID:17928626|RGD:5128669
Biological Process	GO:0007611	learning or memory	Esr2	IMP		Rat	PMID:16904920|RGD:1626504
Biological Process	GO:0008584	male gonad development	Esr2	IEP		Rat	PMID:15944240|RGD:8694153
Biological Process	GO:0008584	male gonad development	Esr2	IEP		Rat	PMID:23620208|RGD:7364949
Biological Process	GO:0060766	negative regulation of androgen receptor signaling pathway	Esr2	IMP	MGI:MGI:2152217	Mouse	PMID:12370428
Biological Process	GO:0048521	negative regulation of behavior	Esr2	IDA		Rat	PMID:15514081|RGD:1582265
Biological Process	GO:0008285	negative regulation of cell population proliferation	Esr2	IGI	MGI:MGI:88039	Mouse	PMID:18464259
Biological Process	GO:0050680	negative regulation of epithelial cell proliferation	Esr2	IMP	MGI:MGI:2152217	Mouse	PMID:12370428
Biological Process	GO:0050680	negative regulation of epithelial cell proliferation	Esr2	IMP	MGI:MGI:2152217	Mouse	PMID:15187231
Biological Process	GO:0050680	negative regulation of epithelial cell proliferation	Esr2	IDA		Rat	PMID:12370428|RGD:625746
Biological Process	GO:2000252	negative regulation of feeding behavior	Esr2	IMP		Rat	PMID:12119576|RGD:8694342
Biological Process	GO:1901215	negative regulation of neuron death	Esr2	IDA		Rat	PMID:15126114|RGD:1582270
Biological Process	GO:2000378	negative regulation of reactive oxygen species metabolic process	Esr2	IMP		Rat	PMID:23608653|RGD:7364951
Biological Process	GO:0048662	negative regulation of smooth muscle cell proliferation	Esr2	IMP		Rat	PMID:22099601|RGD:8553200
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ESR2	IDA		Human	PMID:15345745
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Esr2	IDA		Rat	PMID:9600083|RGD:728646
Biological Process	GO:0001764	neuron migration	Esr2	IMP	MGI:MGI:2152217	Mouse	PMID:12515851
Biological Process	GO:0001541	ovarian follicle development	Esr2	IMP	MGI:MGI:2152217	Mouse	PMID:9861029
Biological Process	GO:0001541	ovarian follicle development	Esr2	IMP	MGI:MGI:2386761	Mouse	PMID:10976058
Biological Process	GO:0001541	ovarian follicle development	Esr2	IEP		Rat	PMID:17971845|RGD:2289161
Biological Process	GO:0043065	positive regulation of apoptotic process	Esr2	IDA		Rat	PMID:22025007|RGD:8553211
Biological Process	GO:0051091	positive regulation of DNA-binding transcription factor activity	ESR2	IDA		Human	PMID:10681512
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ESR2	IDA		Human	PMID:20074560
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Esr2	IDA		Rat	PMID:15564578|RGD:1582269
Biological Process	GO:0045742	positive regulation of epidermal growth factor receptor signaling pathway	Esr2	IMP		Rat	PMID:17928626|RGD:5128669
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	Esr2	IDA		Rat	PMID:17928626|RGD:5128669
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	Esr2	IMP		Rat	PMID:24440742|RGD:10045880
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Esr2	IDA		Rat	PMID:12047722|RGD:8661629
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Esr2	IDA		Rat	PMID:15564578|RGD:1582269
Biological Process	GO:0030850	prostate gland development	Esr2	IEP		Rat	PMID:9492016|RGD:8694133
Biological Process	GO:0060740	prostate gland epithelium morphogenesis	Esr2	IMP	MGI:MGI:2152217	Mouse	PMID:15187231
Biological Process	GO:0060740	prostate gland epithelium morphogenesis	Esr2	IMP	MGI:MGI:2152217	Mouse	PMID:12370428
Biological Process	GO:0042127	regulation of cell population proliferation	Esr2	IMP	MGI:MGI:1857936	Mouse	PMID:9697695
Biological Process	GO:0043523	regulation of neuron apoptotic process	Esr2	IDA		Rat	PMID:15126114|RGD:1582270
Biological Process	GO:0014823	response to activity	Esr2	IEP		Rat	PMID:18516675|RGD:8694113
Biological Process	GO:1903925	response to bisphenol A	Esr2	IEP		Rat	PMID:22957036|RGD:9743854
Biological Process	GO:0071548	response to dexamethasone	Esr2	IEP		Rat	PMID:15087431|RGD:8694155
Biological Process	GO:0032355	response to estradiol	Esr2	IEP		Rat	PMID:19948032|RGD:5508718
Biological Process	GO:0043627	response to estrogen	Esr2	IEP		Rat	PMID:15667451|RGD:8694128
Biological Process	GO:0043627	response to estrogen	esr2b	IDA		Zfish	PMID:25106122
Biological Process	GO:0043627	response to estrogen	esr2a	IDA		Zfish	PMID:25106122
Biological Process	GO:0045471	response to ethanol	Esr2	IEP		Rat	PMID:23591044|RGD:7364963
Biological Process	GO:0033595	response to genistein	Esr2	IEP		Rat	PMID:19230619|RGD:7364797
Biological Process	GO:0009725	response to hormone	Esr2	IEP		Rat	PMID:23591044|RGD:7364963
Biological Process	GO:0044752	response to human chorionic gonadotropin	Esr2	IEP		Rat	PMID:10342845|RGD:8694156
Biological Process	GO:0017085	response to insecticide	Esr2	IEP		Rat	PMID:23943137|RGD:7364910
Biological Process	GO:0031667	response to nutrient levels	Esr2	IEP		Rat	PMID:18596125|RGD:8694126
Biological Process	GO:0014070	response to organic cyclic compound	Esr2	IEP		Rat	PMID:24070737|RGD:7364802
Biological Process	GO:1902074	response to salt	Esr2	IEP		Rat	PMID:12764114|RGD:8694168
Biological Process	GO:0033574	response to testosterone	Esr2	IMP		Rat	PMID:16904920|RGD:1626504
Biological Process	GO:0033574	response to testosterone	Esr2	IEP		Rat	PMID:23500659|RGD:7364973
Biological Process	GO:0009414	response to water deprivation	Esr2	IEP		Rat	PMID:15189329|RGD:8694206
Biological Process	GO:0009410	response to xenobiotic stimulus	Esr2	IEP		Rat	PMID:20686183|RGD:8694171
Biological Process	GO:0060009	Sertoli cell development	Esr2	IEP		Rat	PMID:24056172|RGD:7364870
Biological Process	GO:0060011	Sertoli cell proliferation	Esr2	IMP		Rat	PMID:17928626|RGD:5128669
Biological Process	GO:0007530	sex determination	esr2b	IMP	ZFIN:ZDB-GENO-100519-6	Zfish	PMID:26133072
Biological Process	GO:0043401	steroid hormone mediated signaling pathway	esr2b	IDA		Zfish	PMID:25106122|ZFIN:ZDB-PUB-140812-12
Biological Process	GO:0060065	uterus development	Esr2	IGI	MGI:MGI:1352467	Mouse	PMID:10976058
Biological Process	GO:0060068	vagina development	Esr2	IGI	MGI:MGI:1352467	Mouse	PMID:10976058
Biological Process	GO:0042311	vasodilation	Esr2	IMP		Rat	PMID:24440742|RGD:10045880

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern