Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ESRRA
  • Mouse genes Esrra
  • Rat genes Esrra
  • Zfish genes esrra
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Esrra

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Esrra	IDA		Mouse	MGI:MGI:3772483|PMID:18234909
Molecular Function	GO:0003700	DNA-binding transcription factor activity	ESRRA	IDA		Human	PMID:21190936
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Esrra	IDA		Mouse	PMID:18234909
Molecular Function	GO:0003700	DNA-binding transcription factor activity	esrra	IDA		Zfish	PMID:15088146
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	Esrra	IDA		Mouse	MGI:MGI:3772483|PMID:18234909
Molecular Function	GO:0005515	protein binding	ESRRA	IPI	UniProtKB:Q9UBK2	Human	PMID:12522104
Molecular Function	GO:0005515	protein binding	ESRRA	IPI	UniProtKB:Q9UBK2	Human	PMID:15337744
Molecular Function	GO:0005515	protein binding	ESRRA	IPI	UniProtKB:Q8N2W9	Human	PMID:18063693
Molecular Function	GO:0005515	protein binding	ESRRA	IPI	UniProtKB:Q9UBK2	Human	PMID:18063693
Molecular Function	GO:0005515	protein binding	ESRRA	IPI	UniProtKB:P48788	Human	PMID:18331830
Molecular Function	GO:0005515	protein binding	ESRRA	IPI	UniProtKB:Q9UBK2	Human	PMID:18441008
Molecular Function	GO:0005515	protein binding	ESRRA	IPI	UniProtKB:Q16665	Human	PMID:18509053
Molecular Function	GO:0005515	protein binding	ESRRA	IPI	UniProtKB:Q8TD08	Human	PMID:21190936
Molecular Function	GO:0005515	protein binding	ESRRA	IPI	UniProtKB:Q8N2W9	Human	PMID:21988832
Molecular Function	GO:0005515	protein binding	ESRRA	IPI	UniProtKB:P48788	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ESRRA	IPI	UniProtKB:P62508-3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ESRRA	IPI	UniProtKB:P78317	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ESRRA	IPI	UniProtKB:Q04864-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ESRRA	IPI	UniProtKB:Q8IZU1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ESRRA	IPI	UniProtKB:Q9UBK2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Esrra	IPI	UniProtKB:Q8TD08	Mouse	MGI:MGI:6158703|PMID:21190936
Molecular Function	GO:0019904	protein domain specific binding	ESRRA	IPI	UniProtKB:Q99698	Human	PMID:11984006
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Esrra	IDA		Mouse	PMID:18234909
Molecular Function	GO:0043565	sequence-specific DNA binding	ESRRA	IDA		Human	PMID:23836911
Molecular Function	GO:0043565	sequence-specific DNA binding	Esrra	IDA		Rat	PMID:20215575|RGD:10401858
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	ESRRA	IDA		Human	PMID:28473536
Cellular Component	GO:0005737	cytoplasm	ESRRA	IDA		Human	PMID:21190936
Cellular Component	GO:0001650	fibrillar center	ESRRA	IDA		Human	GO_REF:0000052
Cellular Component	GO:0045171	intercellular bridge	ESRRA	IDA		Human	GO_REF:0000052
Cellular Component	GO:0015630	microtubule cytoskeleton	ESRRA	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	ESRRA	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	ESRRA	IDA		Human	PMID:21190936
Cellular Component	GO:0005634	nucleus	Esrra	IDA		Mouse	PMID:18234909
Cellular Component	GO:0005634	nucleus	Esrra	IDA		Rat	PMID:20215575|RGD:10401858
Biological Process	GO:0051216	cartilage development	Esrra	IMP		Rat	PMID:17170100|RGD:1625657
Biological Process	GO:0042074	cell migration involved in gastrulation	esrra	IMP	ZFIN:ZDB-MRPHLNO-050511-1,ZFIN:ZDB-MRPHLNO-050511-2	Zfish	PMID:15848392
Biological Process	GO:0006351	DNA-templated transcription	esrra	IDA		Zfish	PMID:15088146
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Esrra	IDA		Mouse	MGI:MGI:3772483|PMID:18234909
Biological Process	GO:1900078	positive regulation of cellular response to insulin stimulus	Esrra	IMP		Rat	PMID:20215575|RGD:10401858
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Esrra	IMP		Rat	PMID:17170100|RGD:1625657
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Esrra	IMP		Mouse	MGI:MGI:4867337|PMID:21106753
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Esrra	IDA		Mouse	PMID:18234909
Biological Process	GO:0061035	regulation of cartilage development	esrra	IMP	ZFIN:ZDB-MRPHLNO-160218-2	Zfish	PMID:26657540
Biological Process	GO:0042127	regulation of cell population proliferation	Esrra	IMP		Rat	PMID:11381083|RGD:1625633
Biological Process	GO:0006355	regulation of DNA-templated transcription	ESRRA	IMP		Human	PMID:23836911
Biological Process	GO:0030278	regulation of ossification	Esrra	IMP		Rat	PMID:12193582|RGD:625668
Biological Process	GO:0045667	regulation of osteoblast differentiation	Esrra	IMP		Rat	PMID:11381083|RGD:1625633
Biological Process	GO:0045670	regulation of osteoclast differentiation	Esrra	IMP		Rat	PMID:12193582|RGD:625668
Biological Process	GO:0032355	response to estradiol	Esrra	IEP		Rat	PMID:15458797|RGD:10401860

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern