Comparative GO Graph (mouse, human)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ESX1
  • Mouse genes Esx1
  • Rat genes
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Esx1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	ESX1	IDA		Human	PMID:15897875
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	ESX1	IMP		Human	PMID:15897875
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	ESX1	IMP		Human	PMID:15897875
Molecular Function	GO:0043565	sequence-specific DNA binding	ESX1	IDA		Human	PMID:15897875
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	ESX1	IDA		Human	PMID:28473536
Cellular Component	GO:0005737	cytoplasm	ESX1	IDA		Human	PMID:15235584
Cellular Component	GO:0016607	nuclear speck	ESX1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	ESX1	IDA		Human	PMID:15235584
Cellular Component	GO:0005634	nucleus	Esx1	IDA		Mouse	PMID:19796622
Biological Process	GO:0001568	blood vessel development	Esx1	IMP	MGI:MGI:2153820	Mouse	PMID:9806555
Biological Process	GO:0060716	labyrinthine layer blood vessel development	Esx1	IMP	MGI:MGI:2153820	Mouse	PMID:9806555
Biological Process	GO:0060713	labyrinthine layer morphogenesis	Esx1	IMP	MGI:MGI:2153820	Mouse	PMID:9806555
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	ESX1	IDA		Human	PMID:15897875
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ESX1	IDA		Human	PMID:15897875
Biological Process	GO:0051726	regulation of cell cycle	ESX1	IDA		Human	PMID:15235584
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	Esx1	IDA		Mouse	PMID:19796622

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern