Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes EXT1
  • Mouse genes Ext1
  • Rat genes Ext1
  • Zfish genes ext1a,ext1b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ext1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0008375	acetylglucosaminyltransferase activity	EXT1	IDA		Human	PMID:12907669
Molecular Function	GO:0050508	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity	Ext1	IDA		Mouse	MGI:MGI:3687782|PMID:10639137
Molecular Function	GO:0050508	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity	Ext1	IGI	MGI:MGI:108050	Mouse	PMID:10639137
Molecular Function	GO:0015020	glucuronosyltransferase activity	EXT1	IDA		Human	PMID:12907669
Molecular Function	GO:0016757	glycosyltransferase activity	EXT1	IDA		Human	PMID:12907669
Molecular Function	GO:0016757	glycosyltransferase activity	Ext1	IMP		Mouse	PMID:10926768
Molecular Function	GO:0050509	N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity	Ext1	IDA		Mouse	MGI:MGI:3687782|PMID:10639137
Molecular Function	GO:0050509	N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity	Ext1	IGI	MGI:MGI:108050	Mouse	PMID:10639137
Molecular Function	GO:0005515	protein binding	EXT1	IPI	UniProtKB:P52848	Human	PMID:35137078
Molecular Function	GO:0046982	protein heterodimerization activity	EXT1	IPI	UniProtKB:Q93063	Human	PMID:12907669
Molecular Function	GO:0042803	protein homodimerization activity	EXT1	IDA		Human	PMID:12907669
Cellular Component	GO:0005783	endoplasmic reticulum	EXT1	IDA		Human	PMID:9620772
Cellular Component	GO:0005789	endoplasmic reticulum membrane	Ext1	IDA		Mouse	MGI:MGI:3687714|PMID:9620772
Cellular Component	GO:0005794	Golgi apparatus	EXT1	IDA		Human	PMID:10639137
Cellular Component	GO:0005794	Golgi apparatus	Ext1	IDA		Mouse	PMID:10639137
Biological Process	GO:0019882	antigen processing and presentation	Ext1	IMP		Mouse	PMID:23733868
Biological Process	GO:0007411	axon guidance	Ext1	IMP		Mouse	PMID:14605369
Biological Process	GO:0007411	axon guidance	Ext1	IMP		Mouse	PMID:21743013
Biological Process	GO:0007411	axon guidance	Ext1	IGI	MGI:MGI:1315205	Mouse	PMID:14605369
Biological Process	GO:0007411	axon guidance	Ext1	IMP	MGI:MGI:2176173,MGI:MGI:2682061	Mouse	PMID:14605369
Biological Process	GO:0071711	basement membrane organization	Ext1	IMP		Mouse	PMID:26024086
Biological Process	GO:0001974	blood vessel remodeling	Ext1	IMP		Mouse	PMID:26295701
Biological Process	GO:0030509	BMP signaling pathway	Ext1	IMP		Mouse	PMID:21148566
Biological Process	GO:0030509	BMP signaling pathway	Ext1	IMP		Mouse	PMID:22556407
Biological Process	GO:0030509	BMP signaling pathway	Ext1	IDA		Mouse	PMID:22556407
Biological Process	GO:0030509	BMP signaling pathway	Ext1	IMP		Mouse	PMID:23458899
Biological Process	GO:0030509	BMP signaling pathway	Ext1	IMP		Mouse	PMID:28445472
Biological Process	GO:0098868	bone growth	Ext1	IMP		Mouse	PMID:21185280
Biological Process	GO:0060349	bone morphogenesis	Ext1	IMP		Mouse	PMID:20404326
Biological Process	GO:0060349	bone morphogenesis	Ext1	IMP		Mouse	PMID:20080592
Biological Process	GO:0045453	bone resorption	Ext1	IMP		Mouse	PMID:29415886
Biological Process	GO:0007420	brain development	Ext1	IMP		Mouse	PMID:14605369
Biological Process	GO:0007420	brain development	Ext1	IMP	MGI:MGI:2176173,MGI:MGI:2682061	Mouse	PMID:14605369
Biological Process	GO:0007420	brain development	Ext1	IEP		Rat	PMID:22339633|RGD:13208511
Biological Process	GO:0060070	canonical Wnt signaling pathway	Ext1	IMP		Mouse	PMID:29545125
Biological Process	GO:0060351	cartilage development involved in endochondral bone morphogenesis	Ext1	IMP		Mouse	PMID:21185280
Biological Process	GO:0060351	cartilage development involved in endochondral bone morphogenesis	Ext1	IMP		Mouse	PMID:23958822
Biological Process	GO:0007155	cell adhesion	Ext1	IMP		Mouse	PMID:19850926
Biological Process	GO:0033627	cell adhesion mediated by integrin	Ext1	IMP		Mouse	PMID:21093315
Biological Process	GO:0045165	cell fate commitment	Ext1	IMP		Mouse	PMID:20022960
Biological Process	GO:0000902	cell morphogenesis	Ext1	IMP		Mouse	PMID:18480751
Biological Process	GO:0008283	cell population proliferation	Ext1	IMP		Mouse	PMID:21185280
Biological Process	GO:0008283	cell population proliferation	Ext1	IMP		Mouse	PMID:26024086
Biological Process	GO:0007166	cell surface receptor signaling pathway	Ext1	IMP		Mouse	PMID:10926768
Biological Process	GO:0007166	cell surface receptor signaling pathway	Ext1	IMP		Mouse	PMID:15177029
Biological Process	GO:0016043	cellular component organization	Ext1	IMP		Mouse	PMID:28445472
Biological Process	GO:0071773	cellular response to BMP stimulus	Ext1	IMP		Mouse	PMID:20404326
Biological Process	GO:0044344	cellular response to fibroblast growth factor stimulus	Ext1	IMP		Mouse	PMID:19850926
Biological Process	GO:0044344	cellular response to fibroblast growth factor stimulus	Ext1	IMP		Mouse	PMID:21310272
Biological Process	GO:0098586	cellular response to virus	Ext1	IMP		Mouse	PMID:25741008
Biological Process	GO:0032602	chemokine production	Ext1	IMP		Mouse	PMID:23733868
Biological Process	GO:0002062	chondrocyte differentiation	Ext1	IMP		Mouse	PMID:20080592
Biological Process	GO:0002062	chondrocyte differentiation	Ext1	IMP		Mouse	PMID:20404326
Biological Process	GO:0002062	chondrocyte differentiation	Ext1	IMP		Mouse	PMID:23458899
Biological Process	GO:0002062	chondrocyte differentiation	Ext1	IMP		Mouse	PMID:28768899
Biological Process	GO:0003415	chondrocyte hypertrophy	Ext1	IMP		Mouse	PMID:23958822
Biological Process	GO:0035988	chondrocyte proliferation	Ext1	IMP		Mouse	PMID:20080592
Biological Process	GO:0030204	chondroitin sulfate metabolic process	Ext1	IMP		Mouse	PMID:32201365
Biological Process	GO:0030199	collagen fibril organization	Ext1	IMP		Mouse	PMID:19850926
Biological Process	GO:1904888	cranial skeletal system development	Ext1	IMP		Mouse	PMID:28445472
Biological Process	GO:0070593	dendrite self-avoidance	Ext1	IMP		Mouse	PMID:21743013
Biological Process	GO:0036336	dendritic cell migration	Ext1	IMP		Mouse	PMID:21093315
Biological Process	GO:0060560	developmental growth involved in morphogenesis	Ext1	IMP		Mouse	PMID:23192691
Biological Process	GO:0060560	developmental growth involved in morphogenesis	Ext1	IMP		Mouse	PMID:23958822
Biological Process	GO:0048598	embryonic morphogenesis	Ext1	IMP		Mouse	PMID:10926768
Biological Process	GO:0072498	embryonic skeletal joint development	Ext1	IMP		Mouse	PMID:21185280
Biological Process	GO:0072498	embryonic skeletal joint development	Ext1	IMP	MGI:MGI:2682061	Mouse	PMID:21185280
Biological Process	GO:0003416	endochondral bone growth	Ext1	IMP		Mouse	PMID:23192691
Biological Process	GO:0060350	endochondral bone morphogenesis	Ext1	IMP		Mouse	PMID:21310272
Biological Process	GO:0060350	endochondral bone morphogenesis	Ext1	IGI	MGI:MGI:108050	Mouse	PMID:21310272
Biological Process	GO:0060350	endochondral bone morphogenesis	Ext1	IMP		Mouse	PMID:29545125
Biological Process	GO:0001958	endochondral ossification	Ext1	IMP		Mouse	PMID:21185280
Biological Process	GO:0001958	endochondral ossification	Ext1	IMP		Mouse	PMID:23958822
Biological Process	GO:0007492	endoderm development	Ext1	IMP		Mouse	PMID:10926768
Biological Process	GO:0007492	endoderm development	Ext1	IMP	MGI:MGI:1888710	Mouse	PMID:10926768
Biological Process	GO:0060441	epithelial tube branching involved in lung morphogenesis	Ext1	IMP		Mouse	PMID:28859094
Biological Process	GO:0060429	epithelium development	Ext1	IMP		Mouse	PMID:26024086
Biological Process	GO:0060429	epithelium development	Ext1	IMP		Mouse	PMID:29700203
Biological Process	GO:0042596	fear response	Ext1	IMP		Mouse	PMID:22411800
Biological Process	GO:0008543	fibroblast growth factor receptor signaling pathway	Ext1	IMP		Mouse	PMID:20022960
Biological Process	GO:0008543	fibroblast growth factor receptor signaling pathway	Ext1	IMP		Mouse	PMID:22556407
Biological Process	GO:0008543	fibroblast growth factor receptor signaling pathway	Ext1	IDA		Mouse	PMID:22556407
Biological Process	GO:0008543	fibroblast growth factor receptor signaling pathway	Ext1	IMP		Mouse	PMID:26295701
Biological Process	GO:0008543	fibroblast growth factor receptor signaling pathway	Ext1	IMP		Mouse	PMID:28859094
Biological Process	GO:0008543	fibroblast growth factor receptor signaling pathway	Ext1	IMP		Mouse	PMID:29545125
Biological Process	GO:0008543	fibroblast growth factor receptor signaling pathway	Ext1	IMP		Mouse	PMID:29700203
Biological Process	GO:0042044	fluid transport	Ext1	IGI	MGI:MGI:108050	Mouse	PMID:31365577
Biological Process	GO:0007369	gastrulation	Ext1	IMP		Mouse	PMID:10926768
Biological Process	GO:0007369	gastrulation	Ext1	IMP		Mouse	PMID:20080592
Biological Process	GO:0007369	gastrulation	Ext1	IMP	MGI:MGI:1888710	Mouse	PMID:10926768
Biological Process	GO:0010467	gene expression	Ext1	IMP		Mouse	PMID:20022960
Biological Process	GO:0010467	gene expression	Ext1	IMP		Mouse	PMID:23458899
Biological Process	GO:0010467	gene expression	Ext1	IMP		Mouse	PMID:23958822
Biological Process	GO:0010467	gene expression	Ext1	IMP		Mouse	PMID:25202142
Biological Process	GO:0010467	gene expression	Ext1	IMP		Mouse	PMID:28445472
Biological Process	GO:0010467	gene expression	Ext1	IMP		Mouse	PMID:28859094
Biological Process	GO:0010467	gene expression	Ext1	IMP		Mouse	PMID:29700203
Biological Process	GO:0010467	gene expression	Ext1	IMP		Mouse	PMID:32201365
Biological Process	GO:0002067	glandular epithelial cell differentiation	Ext1	IMP		Mouse	PMID:29700203
Biological Process	GO:0032836	glomerular basement membrane development	Ext1	IMP		Mouse	PMID:18480751
Biological Process	GO:0006024	glycosaminoglycan biosynthetic process	EXT1	IDA		Human	PMID:12907669
Biological Process	GO:0022405	hair cycle process	Ext1	IMP		Mouse	PMID:25053416
Biological Process	GO:0031069	hair follicle morphogenesis	Ext1	IMP		Mouse	PMID:25053416
Biological Process	GO:0060047	heart contraction	Ext1	IGI	MGI:MGI:108050	Mouse	PMID:31365577
Biological Process	GO:0003128	heart field specification	Ext1	IMP		Mouse	PMID:26295701
Biological Process	GO:0002244	hematopoietic progenitor cell differentiation	Ext1	IMP		Mouse	PMID:25202142
Biological Process	GO:0060218	hematopoietic stem cell differentiation	Ext1	IMP		Mouse	PMID:21148566
Biological Process	GO:0061484	hematopoietic stem cell homeostasis	Ext1	IMP		Mouse	PMID:25202142
Biological Process	GO:0097241	hematopoietic stem cell migration to bone marrow	Ext1	IMP		Mouse	PMID:25202142
Biological Process	GO:0015012	heparan sulfate proteoglycan biosynthetic process	EXT1	IDA		Human	PMID:10639137
Biological Process	GO:0015012	heparan sulfate proteoglycan biosynthetic process	EXT1	IDA		Human	PMID:9620772
Biological Process	GO:0015012	heparan sulfate proteoglycan biosynthetic process	Ext1	IDA		Mouse	MGI:MGI:3687782|PMID:10639137
Biological Process	GO:0015012	heparan sulfate proteoglycan biosynthetic process	Ext1	IMP		Mouse	PMID:20080592
Biological Process	GO:0015012	heparan sulfate proteoglycan biosynthetic process	Ext1	IMP		Mouse	PMID:10639137
Biological Process	GO:0015012	heparan sulfate proteoglycan biosynthetic process	Ext1	IMP		Mouse	PMID:30377379
Biological Process	GO:0015014	heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process	EXT1	IMP		Human	PMID:17761672
Biological Process	GO:0030210	heparin biosynthetic process	Ext1	IMP		Mouse	PMID:10926768
Biological Process	GO:0030210	heparin biosynthetic process	Ext1	IMP		Mouse	PMID:15161920
Biological Process	GO:0030210	heparin biosynthetic process	Ext1	IMP		Mouse	PMID:15177029
Biological Process	GO:0030210	heparin biosynthetic process	Ext1	IMP		Mouse	PMID:18480751
Biological Process	GO:0030210	heparin biosynthetic process	Ext1	IMP		Mouse	PMID:21148566
Biological Process	GO:0030210	heparin biosynthetic process	Ext1	IGI	MGI:MGI:108050	Mouse	PMID:21310272
Biological Process	GO:0030202	heparin metabolic process	Ext1	IMP		Mouse	PMID:26491162
Biological Process	GO:0030202	heparin metabolic process	Ext1	IMP		Mouse	PMID:32201365
Biological Process	GO:0002524	hypersensitivity	Ext1	IMP		Mouse	PMID:21093315
Biological Process	GO:0050901	leukocyte tethering or rolling	Ext1	IMP		Mouse	PMID:21093315
Biological Process	GO:0036022	limb joint morphogenesis	Ext1	IMP		Mouse	PMID:20404326
Biological Process	GO:0036339	lymphocyte adhesion to endothelial cell of high endothelial venule	Ext1	IMP		Mouse	PMID:21093315
Biological Process	GO:0097021	lymphocyte migration into lymphoid organs	Ext1	IMP		Mouse	PMID:21093315
Biological Process	GO:1901706	mesenchymal cell differentiation involved in bone development	Ext1	IMP		Mouse	PMID:20404326
Biological Process	GO:0060485	mesenchyme development	Ext1	IMP		Mouse	PMID:28859094
Biological Process	GO:0007498	mesoderm development	Ext1	IMP		Mouse	PMID:10926768
Biological Process	GO:0007498	mesoderm development	Ext1	IMP	MGI:MGI:1888710	Mouse	PMID:10926768
Biological Process	GO:0061744	motor behavior	Ext1	IMP		Mouse	PMID:22411800
Biological Process	GO:0035264	multicellular organism growth	Ext1	IMP		Mouse	PMID:23958822
Biological Process	GO:0050891	multicellular organismal-level water homeostasis	Ext1	IGI	MGI:MGI:108050	Mouse	PMID:31365577
Biological Process	GO:0014033	neural crest cell differentiation	Ext1	IMP		Mouse	PMID:26295701
Biological Process	GO:0031175	neuron projection development	Ext1	IMP		Mouse	PMID:21743013
Biological Process	GO:0021772	olfactory bulb development	Ext1	IMP	MGI:MGI:2176173,MGI:MGI:2682061	Mouse	PMID:14605369
Biological Process	GO:0021554	optic nerve development	Ext1	IMP		Mouse	PMID:21743013
Biological Process	GO:0001503	ossification	EXT1	IMP		Human	PMID:7550340
Biological Process	GO:0043931	ossification involved in bone maturation	Ext1	IMP		Mouse	PMID:29415886
Biological Process	GO:0061974	perichondral bone morphogenesis	Ext1	IMP		Mouse	PMID:28768899
Biological Process	GO:0072112	podocyte differentiation	Ext1	IMP		Mouse	PMID:18480751
Biological Process	GO:0000271	polysaccharide biosynthetic process	EXT1	IDA		Human	PMID:12907669
Biological Process	GO:0030163	protein catabolic process	Ext1	IMP		Mouse	PMID:22556407
Biological Process	GO:0065003	protein-containing complex assembly	Ext1	IMP		Mouse	PMID:29700203
Biological Process	GO:0030166	proteoglycan biosynthetic process	Ext1	IMP		Mouse	PMID:21185280
Biological Process	GO:0008217	regulation of blood pressure	Ext1	IGI	MGI:MGI:108050	Mouse	PMID:31365577
Biological Process	GO:0070848	response to growth factor	Ext1	IMP		Mouse	PMID:25202142
Biological Process	GO:0071503	response to heparin	Ext1	IMP		Mouse	PMID:21148566
Biological Process	GO:1990823	response to leukemia inhibitory factor	Ext1	IMP		Mouse	PMID:20022960
Biological Process	GO:0009642	response to light intensity	Ext1	IMP		Mouse	PMID:22411800
Biological Process	GO:0009615	response to virus	Ext1	IMP		Mouse	PMID:26491162
Biological Process	GO:0048733	sebaceous gland development	Ext1	IMP		Mouse	PMID:25053416
Biological Process	GO:0007224	smoothened signaling pathway	Ext1	IMP		Mouse	PMID:25053416
Biological Process	GO:0007224	smoothened signaling pathway	Ext1	IMP		Mouse	PMID:29545125
Biological Process	GO:0007224	smoothened signaling pathway	Ext1	IMP		Mouse	PMID:29700203
Biological Process	GO:0060506	smoothened signaling pathway involved in lung development	Ext1	IMP		Mouse	PMID:28859094
Biological Process	GO:0035176	social behavior	Ext1	IMP		Mouse	PMID:22411800
Biological Process	GO:0055078	sodium ion homeostasis	Ext1	IGI	MGI:MGI:108050	Mouse	PMID:31365577
Biological Process	GO:0017145	stem cell division	Ext1	IMP		Mouse	PMID:20022960
Biological Process	GO:0062094	stomach development	Ext1	IMP		Mouse	PMID:29700203
Biological Process	GO:0051923	sulfation	Ext1	IDA		Mouse	PMID:18337501
Biological Process	GO:0051923	sulfation	Ext1	IMP		Mouse	PMID:32201365
Biological Process	GO:0060792	sweat gland development	Ext1	IMP		Mouse	PMID:25053416
Biological Process	GO:0035249	synaptic transmission, glutamatergic	Ext1	IMP		Mouse	PMID:22411800
Biological Process	GO:0120193	tight junction organization	Ext1	IMP		Mouse	PMID:26024086
Biological Process	GO:0071847	TNFSF11-mediated signaling pathway	Ext1	IMP		Mouse	PMID:29415886
Biological Process	GO:0007033	vacuole organization	Ext1	IMP		Mouse	PMID:18480751
Biological Process	GO:0042311	vasodilation	Ext1	IGI	MGI:MGI:108050	Mouse	PMID:31365577
Biological Process	GO:0071625	vocalization behavior	Ext1	IMP		Mouse	PMID:22411800
Biological Process	GO:0042060	wound healing	Ext1	IMP		Mouse	PMID:26024086

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern