Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes EXT2
  • Mouse genes Ext2
  • Rat genes Ext2
  • Zfish genes ext2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ext2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0008375	acetylglucosaminyltransferase activity	EXT2	IDA		Human	PMID:12907669
Molecular Function	GO:0008375	acetylglucosaminyltransferase activity	Ext2	IDA		Mouse	MGI:MGI:3687782|PMID:10639137
Molecular Function	GO:0050508	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity	Ext2	IGI	MGI:MGI:894663	Mouse	PMID:10639137
Molecular Function	GO:0015020	glucuronosyltransferase activity	EXT2	IDA		Human	PMID:12907669
Molecular Function	GO:0015020	glucuronosyltransferase activity	Ext2	IDA		Mouse	MGI:MGI:3687782|PMID:10639137
Molecular Function	GO:0016757	glycosyltransferase activity	EXT2	IDA		Human	PMID:12907669
Molecular Function	GO:0050509	N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity	Ext2	IGI	MGI:MGI:894663	Mouse	PMID:10639137
Molecular Function	GO:0005515	protein binding	EXT2	IPI	UniProtKB:P52848	Human	PMID:18337501
Molecular Function	GO:0005515	protein binding	EXT2	IPI	UniProtKB:P52848	Human	PMID:35137078
Molecular Function	GO:0005515	protein binding	Ext2	IPI	UniProtKB:P52848	Mouse	PMID:18337501
Molecular Function	GO:0046982	protein heterodimerization activity	EXT2	IPI	UniProtKB:Q16394	Human	PMID:12907669
Molecular Function	GO:0042803	protein homodimerization activity	Ext2	IDA		Mouse	MGI:MGI:3687782|PMID:10639137
Cellular Component	GO:0005783	endoplasmic reticulum	Ext2	IDA		Mouse	MGI:MGI:3687782|PMID:10639137
Cellular Component	GO:0070062	extracellular exosome	EXT2	HDA		Human	PMID:19199708
Cellular Component	GO:0005794	Golgi apparatus	EXT2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005794	Golgi apparatus	Ext2	IDA		Mouse	PMID:10639137
Cellular Component	GO:0016020	membrane	EXT2	HDA		Human	PMID:19946888
Cellular Component	GO:0043541	UDP-N-acetylglucosamine transferase complex	EXT2	IDA		Human	PMID:12907669
Biological Process	GO:0051216	cartilage development	ext2	IMP	ZFIN:ZDB-GENO-980202-872	Zfish	PMID:21294126
Biological Process	GO:0051216	cartilage development	ext2	IMP	ZFIN:ZDB-GENO-980202-872	Zfish	PMID:18654627
Biological Process	GO:0044344	cellular response to fibroblast growth factor stimulus	Ext2	IMP		Mouse	PMID:21310272
Biological Process	GO:0002062	chondrocyte differentiation	Ext2	IMP	MGI:MGI:3608690	Mouse	PMID:16236767
Biological Process	GO:0050650	chondroitin sulfate proteoglycan biosynthetic process	ext2	IGI	ZFIN:ZDB-GENO-121010-7,ZFIN:ZDB-GENO-121129-2	Zfish	PMID:22869369
Biological Process	GO:0035118	embryonic pectoral fin morphogenesis	ext2	IMP	ZFIN:ZDB-GENO-980202-1195	Zfish	PMID:16221725
Biological Process	GO:0060350	endochondral bone morphogenesis	Ext2	IGI	MGI:MGI:894663	Mouse	PMID:21310272
Biological Process	GO:0030198	extracellular matrix organization	ext2	IGI	ZFIN:ZDB-GENO-121010-7,ZFIN:ZDB-GENO-121129-2	Zfish	PMID:22869369
Biological Process	GO:0030198	extracellular matrix organization	ext2	IMP	ZFIN:ZDB-GENO-980202-872	Zfish	PMID:21506131
Biological Process	GO:0008543	fibroblast growth factor receptor signaling pathway	ext2	IGI	ZFIN:ZDB-GENE-001006-1,ZFIN:ZDB-GENO-980202-872	Zfish	PMID:10976049
Biological Process	GO:0008543	fibroblast growth factor receptor signaling pathway	ext2	IGI	ZFIN:ZDB-GENE-001006-1,ZFIN:ZDB-GENO-980202-1195	Zfish	PMID:10976049
Biological Process	GO:0042044	fluid transport	Ext2	IGI	MGI:MGI:894663	Mouse	PMID:31365577
Biological Process	GO:0010467	gene expression	Ext2	IMP		Mouse	PMID:18337501
Biological Process	GO:0010467	gene expression	Ext2	IDA		Mouse	PMID:18337501
Biological Process	GO:0006024	glycosaminoglycan biosynthetic process	EXT2	IDA		Human	PMID:12907669
Biological Process	GO:0060047	heart contraction	Ext2	IGI	MGI:MGI:894663	Mouse	PMID:31365577
Biological Process	GO:0015012	heparan sulfate proteoglycan biosynthetic process	EXT2	IMP		Human	PMID:17761672
Biological Process	GO:0015012	heparan sulfate proteoglycan biosynthetic process	Ext2	IGI	MGI:MGI:894663	Mouse	PMID:10639137
Biological Process	GO:0015012	heparan sulfate proteoglycan biosynthetic process	Ext2	IMP	MGI:MGI:3608690	Mouse	PMID:16236767
Biological Process	GO:0015012	heparan sulfate proteoglycan biosynthetic process	ext2	IGI	ZFIN:ZDB-GENO-121010-7,ZFIN:ZDB-GENO-121129-2	Zfish	PMID:22869369
Biological Process	GO:0015012	heparan sulfate proteoglycan biosynthetic process	ext2	IMP	ZFIN:ZDB-GENO-121010-7	Zfish	PMID:22869369
Biological Process	GO:0015012	heparan sulfate proteoglycan biosynthetic process	ext2	IMP	ZFIN:ZDB-GENO-980202-872	Zfish	PMID:15603738
Biological Process	GO:0015014	heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process	EXT2	IMP		Human	PMID:17761672
Biological Process	GO:0030210	heparin biosynthetic process	Ext2	IGI	MGI:MGI:894663	Mouse	PMID:21310272
Biological Process	GO:0001707	mesoderm formation	Ext2	IMP	MGI:MGI:3608690	Mouse	PMID:16236767
Biological Process	GO:0050891	multicellular organismal-level water homeostasis	Ext2	IGI	MGI:MGI:894663	Mouse	PMID:31365577
Biological Process	GO:0042476	odontogenesis	ext2	IMP	ZFIN:ZDB-GENO-980202-872	Zfish	PMID:22253766
Biological Process	GO:0001503	ossification	EXT2	IMP		Human	PMID:9326317
Biological Process	GO:0001503	ossification	ext2	IMP	ZFIN:ZDB-GENO-980202-872	Zfish	PMID:21294126
Biological Process	GO:0001503	ossification	ext2	IMP	ZFIN:ZDB-GENO-980202-872	Zfish	PMID:22253766
Biological Process	GO:0001649	osteoblast differentiation	ext2	IMP	ZFIN:ZDB-GENO-980202-872	Zfish	PMID:18654627
Biological Process	GO:0033339	pectoral fin development	ext2	IMP		Zfish	PMID:9007245
Biological Process	GO:0033339	pectoral fin development	ext2	IMP	ZFIN:ZDB-GENO-980202-1195	Zfish	PMID:10976049
Biological Process	GO:0033339	pectoral fin development	ext2	IMP	ZFIN:ZDB-GENO-980202-872	Zfish	PMID:10976049
Biological Process	GO:0035138	pectoral fin morphogenesis	ext2	IMP	ZFIN:ZDB-GENO-980202-872	Zfish	PMID:15603738
Biological Process	GO:0000271	polysaccharide biosynthetic process	EXT2	IDA		Human	PMID:12907669
Biological Process	GO:0045743	positive regulation of fibroblast growth factor receptor signaling pathway	ext2	IMP	ZFIN:ZDB-GENO-980202-1195	Zfish	PMID:16221725
Biological Process	GO:0048920	posterior lateral line neuromast primordium migration	ext2	IMP	ZFIN:ZDB-GENO-980410-189	Zfish	PMID:25600875
Biological Process	GO:0048920	posterior lateral line neuromast primordium migration	ext2	IGI	ZFIN:ZDB-GENO-171115-4	Zfish	PMID:25600875
Biological Process	GO:0006487	protein N-linked glycosylation	Ext2	IDA		Mouse	PMID:18337501
Biological Process	GO:0030166	proteoglycan biosynthetic process	ext2	IMP	ZFIN:ZDB-GENO-980202-872	Zfish	PMID:21294126
Biological Process	GO:0030516	regulation of axon extension	ext2	IMP	ZFIN:ZDB-GENO-980202-872	Zfish	PMID:15603738
Biological Process	GO:0008217	regulation of blood pressure	Ext2	IGI	MGI:MGI:894663	Mouse	PMID:31365577
Biological Process	GO:0031290	retinal ganglion cell axon guidance	ext2	IMP	ZFIN:ZDB-GENO-980202-872	Zfish	PMID:9007260
Biological Process	GO:0031290	retinal ganglion cell axon guidance	ext2	IMP	ZFIN:ZDB-GENO-980202-1196	Zfish	PMID:9007260
Biological Process	GO:0031290	retinal ganglion cell axon guidance	ext2	IMP	ZFIN:ZDB-GENO-980202-1195	Zfish	PMID:9007260
Biological Process	GO:0097374	sensory neuron axon guidance	ext2	IGI	ZFIN:ZDB-GENO-130821-6,ZFIN:ZDB-MRPHLNO-120419-2	Zfish	PMID:22326027
Biological Process	GO:0097374	sensory neuron axon guidance	ext2	IMP	ZFIN:ZDB-GENO-130821-6	Zfish	PMID:22326027
Biological Process	GO:0097374	sensory neuron axon guidance	ext2	IGI	ZFIN:ZDB-GENO-130821-6,ZFIN:ZDB-MRPHLNO-120419-4	Zfish	PMID:22326027
Biological Process	GO:0001501	skeletal system development	ext2	IMP	ZFIN:ZDB-GENO-980202-872	Zfish	PMID:18654627
Biological Process	GO:0055078	sodium ion homeostasis	Ext2	IGI	MGI:MGI:894663	Mouse	PMID:31365577
Biological Process	GO:0051923	sulfation	Ext2	IDA		Mouse	PMID:18337501
Biological Process	GO:0048538	thymus development	ext2	IMP	ZFIN:ZDB-GENO-980202-872	Zfish	PMID:28148688
Biological Process	GO:0042311	vasodilation	Ext2	IGI	MGI:MGI:894663	Mouse	PMID:31365577

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern