Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes EYA1
  • Mouse genes Eya1
  • Rat genes Eya1
  • Zfish genes eya1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Eya1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0140793	histone H2Y142 phosphatase activity	EYA1	IDA		Human	PMID:19234442
Molecular Function	GO:0005515	protein binding	EYA1	IPI	UniProtKB:Q15475	Human	PMID:15141091
Molecular Function	GO:0005515	protein binding	EYA1	IPI	UniProtKB:Q15475	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	EYA1	IPI	UniProtKB:Q15475	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Eya1	IPI	UniProtKB:Q62232|UniProtKB:Q91WA6|UniProtKB:Q9WUB0	Mouse	MGI:MGI:5437425|PMID:20956555
Molecular Function	GO:0005515	protein binding	Eya1	IPI	UniProtKB:Q62231	Mouse	MGI:MGI:3044439|PMID:15141091
Molecular Function	GO:0005515	protein binding	Eya1	IPI	UniProtKB:Q62231|UniProtKB:Q62232	Mouse	MGI:MGI:3722498|PMID:11734542
Molecular Function	GO:0005515	protein binding	Eya1	IPI	PR:P70660	Mouse	PMID:22513373
Molecular Function	GO:0005515	protein binding	Eya1	IPI	PR:Q3TKT4	Mouse	PMID:22513373
Molecular Function	GO:0005515	protein binding	Eya1	IPI	PR:Q6PDG5	Mouse	PMID:22513373
Molecular Function	GO:0005515	protein binding	Eya1	IPI	PR:Q60867	Mouse	PMID:22513373
Molecular Function	GO:0004725	protein tyrosine phosphatase activity	Eya1	IDA		Mouse	PMID:14628052
Molecular Function	GO:0004725	protein tyrosine phosphatase activity	Eya1	IDA		Mouse	PMID:21385765
Molecular Function	GO:0003723	RNA binding	Eya1	IDA		Mouse	PMID:21936910
Cellular Component	GO:0005737	cytoplasm	EYA1	IDA		Human	PMID:19497856
Cellular Component	GO:0005737	cytoplasm	Eya1	IDA		Mouse	PMID:16024294
Cellular Component	GO:0016604	nuclear body	EYA1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	EYA1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	EYA1	IDA		Human	PMID:19234442
Cellular Component	GO:0005634	nucleus	EYA1	IDA		Human	PMID:19497856
Cellular Component	GO:0005634	nucleus	Eya1	IDA		Mouse	PMID:16024294
Cellular Component	GO:0032991	protein-containing complex	Eya1	IDA		Mouse	MGI:MGI:3768605|PMID:17785448
Cellular Component	GO:0032993	protein-DNA complex	Eya1	IDA		Mouse	MGI:MGI:3768605|PMID:17785448
Biological Process	GO:0021984	adenohypophysis development	eya1	IMP	ZFIN:ZDB-GENO-980202-1557	Zfish	PMID:16458879
Biological Process	GO:0021984	adenohypophysis development	eya1	IMP	ZFIN:ZDB-GENO-040716-6	Zfish	PMID:16458879
Biological Process	GO:0021984	adenohypophysis development	eya1	IGI	ZFIN:ZDB-GENO-980202-1557,ZFIN:ZDB-MRPHLNO-060606-5,ZFIN:ZDB-MRPHLNO-060606-6	Zfish	PMID:16458879
Biological Process	GO:0048856	anatomical structure development	Eya1	IGI	MGI:MGI:102780	Mouse	PMID:16530750
Biological Process	GO:0009887	animal organ morphogenesis	Eya1	IMP	MGI:MGI:2150426	Mouse	PMID:12070080
Biological Process	GO:0035909	aorta morphogenesis	Eya1	IMP	MGI:MGI:98493	Mouse	PMID:21364285
Biological Process	GO:0035909	aorta morphogenesis	Eya1	IMP	MGI:MGI:99604	Mouse	PMID:21364285
Biological Process	GO:0035909	aorta morphogenesis	Eya1	IMP	MGI:MGI:102780	Mouse	PMID:21364285
Biological Process	GO:0001658	branching involved in ureteric bud morphogenesis	Eya1	IGI	MGI:MGI:102780	Mouse	PMID:12783782
Biological Process	GO:0045165	cell fate commitment	Eya1	IMP	MGI:MGI:1857803	Mouse	PMID:15817220
Biological Process	GO:0045165	cell fate commitment	Eya1	IMP	MGI:MGI:2150426	Mouse	PMID:16018995
Biological Process	GO:0090103	cochlea morphogenesis	Eya1	IMP	MGI:MGI:1857803	Mouse	PMID:10072433
Biological Process	GO:0002065	columnar/cuboidal epithelial cell differentiation	Eya1	IGI	MGI:MGI:2443665	Mouse	PMID:21385765
Biological Process	GO:0002065	columnar/cuboidal epithelial cell differentiation	Eya1	IGI	MGI:MGI:1917942	Mouse	PMID:21385765
Biological Process	GO:0002065	columnar/cuboidal epithelial cell differentiation	Eya1	IGI	MGI:MGI:1923373	Mouse	PMID:21385765
Biological Process	GO:0002065	columnar/cuboidal epithelial cell differentiation	Eya1	IGI	MGI:MGI:107423	Mouse	PMID:21385765
Biological Process	GO:0006302	double-strand break repair	EYA1	IMP		Human	PMID:19234442
Biological Process	GO:0042471	ear morphogenesis	eya1	IMP	ZFIN:ZDB-GENO-980202-1547	Zfish	PMID:9007244
Biological Process	GO:0042471	ear morphogenesis	eya1	IMP	ZFIN:ZDB-GENO-980202-1558	Zfish	PMID:9007244
Biological Process	GO:0042471	ear morphogenesis	eya1	IMP	ZFIN:ZDB-GENO-980202-1531	Zfish	PMID:9007244
Biological Process	GO:0042471	ear morphogenesis	eya1	IMP	ZFIN:ZDB-GENO-980202-1557	Zfish	PMID:9007244
Biological Process	GO:0048704	embryonic skeletal system morphogenesis	Eya1	IMP	MGI:MGI:2150426	Mouse	PMID:10471511
Biological Process	GO:0050673	epithelial cell proliferation	Eya1	IMP	MGI:MGI:2150426	Mouse	PMID:16916509
Biological Process	GO:0000132	establishment of mitotic spindle orientation	Eya1	IMP	MGI:MGI:2150426	Mouse	PMID:21385765
Biological Process	GO:0000132	establishment of mitotic spindle orientation	Eya1	IGI	MGI:MGI:1917942	Mouse	PMID:21385765
Biological Process	GO:0000132	establishment of mitotic spindle orientation	Eya1	IGI	MGI:MGI:1923373	Mouse	PMID:21385765
Biological Process	GO:0000132	establishment of mitotic spindle orientation	Eya1	IGI	MGI:MGI:2443665	Mouse	PMID:21385765
Biological Process	GO:0035088	establishment or maintenance of apical/basal cell polarity	Eya1	IMP	MGI:MGI:2150426	Mouse	PMID:21385765
Biological Process	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	Eya1	IMP	MGI:MGI:1857803	Mouse	PMID:15817220
Biological Process	GO:0042472	inner ear morphogenesis	Eya1	IMP	MGI:MGI:2150426	Mouse	PMID:10471511
Biological Process	GO:0042472	inner ear morphogenesis	Eya1	IMP	MGI:MGI:1857803	Mouse	PMID:15817220
Biological Process	GO:0042472	inner ear morphogenesis	Eya1	IGI	MGI:MGI:97486	Mouse	PMID:16916509
Biological Process	GO:0042472	inner ear morphogenesis	eya1	IMP	ZFIN:ZDB-GENO-980202-1557	Zfish	PMID:15572137
Biological Process	GO:0060487	lung epithelial cell differentiation	Eya1	IGI	MGI:MGI:1917942	Mouse	PMID:21385765
Biological Process	GO:0060487	lung epithelial cell differentiation	Eya1	IGI	MGI:MGI:2443665	Mouse	PMID:21385765
Biological Process	GO:0060487	lung epithelial cell differentiation	Eya1	IGI	MGI:MGI:1923373	Mouse	PMID:21385765
Biological Process	GO:0060487	lung epithelial cell differentiation	Eya1	IGI	MGI:MGI:107423	Mouse	PMID:21385765
Biological Process	GO:0007501	mesodermal cell fate specification	Eya1	IDA		Mouse	MGI:MGI:3768605|PMID:17785448
Biological Process	GO:0001656	metanephros development	Eya1	IMP	MGI:MGI:2150426	Mouse	PMID:16018995
Biological Process	GO:0001656	metanephros development	Eya1	IMP	MGI:MGI:1857803	Mouse	PMID:10072433
Biological Process	GO:0042474	middle ear morphogenesis	Eya1	IMP	MGI:MGI:2150426	Mouse	PMID:10471511
Biological Process	GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	Eya1	IMP	MGI:MGI:1857803	Mouse	PMID:15817220
Biological Process	GO:0048665	neuron fate specification	Eya1	IGI	MGI:MGI:102780	Mouse	PMID:22513373
Biological Process	GO:0071599	otic vesicle development	Eya1	IGI	MGI:MGI:102780	Mouse	PMID:22513373
Biological Process	GO:0071600	otic vesicle morphogenesis	Eya1	IMP	MGI:MGI:2150426	Mouse	PMID:16916509
Biological Process	GO:0071600	otic vesicle morphogenesis	eya1	IMP	ZFIN:ZDB-MRPHLNO-050124-1	Zfish	PMID:20956555
Biological Process	GO:0048840	otolith development	eya1	IMP	ZFIN:ZDB-GENO-980202-1558	Zfish	PMID:9007244
Biological Process	GO:0048840	otolith development	eya1	IMP	ZFIN:ZDB-GENO-980202-1531	Zfish	PMID:9007244
Biological Process	GO:0048840	otolith development	eya1	IMP	ZFIN:ZDB-GENO-980202-1557	Zfish	PMID:9007244
Biological Process	GO:0048840	otolith development	eya1	IMP	ZFIN:ZDB-GENO-980202-1547	Zfish	PMID:9007244
Biological Process	GO:0042473	outer ear morphogenesis	Eya1	IMP	MGI:MGI:2150426	Mouse	PMID:10471511
Biological Process	GO:0003151	outflow tract morphogenesis	Eya1	IMP	MGI:MGI:102780	Mouse	PMID:21364285
Biological Process	GO:0003151	outflow tract morphogenesis	Eya1	IMP	MGI:MGI:98493	Mouse	PMID:21364285
Biological Process	GO:0003151	outflow tract morphogenesis	Eya1	IMP	MGI:MGI:99604	Mouse	PMID:21364285
Biological Process	GO:0007389	pattern specification process	Eya1	IGI	MGI:MGI:102780	Mouse	PMID:16530750
Biological Process	GO:0007389	pattern specification process	Eya1	IMP	MGI:MGI:2150426	Mouse	PMID:16916509
Biological Process	GO:0060037	pharyngeal system development	Eya1	IMP	MGI:MGI:98493	Mouse	PMID:21364285
Biological Process	GO:0060037	pharyngeal system development	Eya1	IMP	MGI:MGI:102780	Mouse	PMID:21364285
Biological Process	GO:0060037	pharyngeal system development	Eya1	IMP	MGI:MGI:99604	Mouse	PMID:21364285
Biological Process	GO:0045739	positive regulation of DNA repair	EYA1	IMP		Human	PMID:19234442
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Eya1	IDA		Mouse	MGI:MGI:3768605|PMID:17785448
Biological Process	GO:0050679	positive regulation of epithelial cell proliferation	Eya1	IMP	MGI:MGI:2150426	Mouse	PMID:16916509
Biological Process	GO:0045747	positive regulation of Notch signaling pathway	Eya1	IMP		Mouse	PMID:21385765
Biological Process	GO:0072513	positive regulation of secondary heart field cardioblast proliferation	Eya1	IGI	MGI:MGI:102780	Mouse	PMID:21364285
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Eya1	IGI	MGI:MGI:102780	Mouse	PMID:22513373
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Eya1	IGI	MGI:MGI:102780	Mouse	PMID:21364285
Biological Process	GO:0006470	protein dephosphorylation	Eya1	IDA		Mouse	PMID:14628052
Biological Process	GO:0008104	protein localization	Eya1	IMP	MGI:MGI:2150426	Mouse	PMID:21385765
Biological Process	GO:0016925	protein sumoylation	Eya1	IDA		Mouse	MGI:MGI:3663824|PMID:16990542
Biological Process	GO:0045664	regulation of neuron differentiation	Eya1	IGI	MGI:MGI:107754	Mouse	PMID:22513373
Biological Process	GO:0045664	regulation of neuron differentiation	Eya1	IGI	MGI:MGI:102780	Mouse	PMID:22513373
Biological Process	GO:0045664	regulation of neuron differentiation	Eya1	IGI	MGI:MGI:1339708	Mouse	PMID:22513373
Biological Process	GO:0045664	regulation of neuron differentiation	Eya1	IMP	MGI:MGI:2150426	Mouse	PMID:15496442
Biological Process	GO:0045664	regulation of neuron differentiation	Eya1	IGI	MGI:MGI:98364	Mouse	PMID:22513373
Biological Process	GO:0010212	response to ionizing radiation	EYA1	IDA		Human	PMID:19234442
Biological Process	GO:0048752	semicircular canal morphogenesis	Eya1	IMP	MGI:MGI:1857803	Mouse	PMID:10072433
Biological Process	GO:0014706	striated muscle tissue development	Eya1	IGI	MGI:MGI:109341	Mouse	PMID:17098221
Biological Process	GO:0001657	ureteric bud development	Eya1	IGI	MGI:MGI:97486	Mouse	PMID:16018995
Biological Process	GO:0001657	ureteric bud development	Eya1	IGI	MGI:MGI:102780	Mouse	PMID:16018995

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern