Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes EYA3
  • Mouse genes Eya3
  • Rat genes Eya3
  • Zfish genes eya3
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Eya3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003682	chromatin binding	Eya3	IGI	MGI:MGI:98310	Mouse	PMID:19008232
Molecular Function	GO:0003682	chromatin binding	Eya3	IGI	MGI:MGI:102780	Mouse	PMID:19008232
Molecular Function	GO:0140793	histone H2Y142 phosphatase activity	EYA3	IDA		Human	PMID:19234442
Molecular Function	GO:0140793	histone H2Y142 phosphatase activity	EYA3	IDA		Human	PMID:19351884
Molecular Function	GO:0005515	protein binding	EYA3	IPI	UniProtKB:P16104	Human	PMID:19234442
Molecular Function	GO:0005515	protein binding	EYA3	IPI	UniProtKB:D3DTS7	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	EYA3	IPI	UniProtKB:O60333-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	EYA3	IPI	UniProtKB:O76024	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	EYA3	IPI	UniProtKB:P07196	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	EYA3	IPI	UniProtKB:P10809	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	EYA3	IPI	UniProtKB:P13637	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	EYA3	IPI	UniProtKB:P16284	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	EYA3	IPI	UniProtKB:P26378-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	EYA3	IPI	UniProtKB:P42858	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	EYA3	IPI	UniProtKB:P50570-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	EYA3	IPI	UniProtKB:P51608	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	EYA3	IPI	UniProtKB:Q92870-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	EYA3	IPI	UniProtKB:Q9Y3C5	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Eya3	IPI	UniProtKB:Q62232	Mouse	MGI:MGI:5582180|PMID:12215533
Molecular Function	GO:0005515	protein binding	Eya3	IPI	UniProtKB:Q61321|UniProtKB:Q62231	Mouse	MGI:MGI:5582180|PMID:12215533
Molecular Function	GO:0005515	protein binding	Eya3	IPI	UniProtKB:P16104	Mouse	MGI:MGI:3840026|PMID:19234442
Molecular Function	GO:0005515	protein binding	Eya3	IPI	UniProtKB:P12755	Mouse	MGI:MGI:3839724|PMID:19008232
Molecular Function	GO:0005515	protein binding	Eya3	IPI	RGD:1305040	Rat	PMID:10490620|RGD:1303343
Molecular Function	GO:0004725	protein tyrosine phosphatase activity	EYA3	IDA		Human	PMID:19234442
Molecular Function	GO:0004725	protein tyrosine phosphatase activity	EYA3	IDA		Human	PMID:19351884
Molecular Function	GO:0004725	protein tyrosine phosphatase activity	Eya3	IDA		Mouse	PMID:14628052
Molecular Function	GO:0008138	protein tyrosine/serine/threonine phosphatase activity	Eya3	IDA		Mouse	PMID:14628042
Cellular Component	GO:0005813	centrosome	EYA3	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	EYA3	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	EYA3	IDA		Human	PMID:19234442
Cellular Component	GO:0005634	nucleus	Eya3	IDA		Mouse	PMID:14628042
Cellular Component	GO:0005634	nucleus	Eya3	IDA		Rat	PMID:10490620|RGD:1303343
Cellular Component	GO:0005667	transcription regulator complex	Eya3	IPI	PR:Q62231	Mouse	PMID:19008232
Cellular Component	GO:0005667	transcription regulator complex	Eya3	IPI	PR:Q60698	Mouse	PMID:19008232
Biological Process	GO:1904888	cranial skeletal system development	eya3	IMP	ZFIN:ZDB-MRPHLNO-220719-1	Zfish	PMID:33475861
Biological Process	GO:0006302	double-strand break repair	EYA3	IMP		Human	PMID:19234442
Biological Process	GO:0001654	eye development	eya3	IMP	ZFIN:ZDB-MRPHLNO-220719-1	Zfish	PMID:33475861
Biological Process	GO:0045739	positive regulation of DNA repair	EYA3	IMP		Human	PMID:19234442
Biological Process	GO:0006470	protein dephosphorylation	Eya3	IDA		Mouse	PMID:14628052
Biological Process	GO:0010212	response to ionizing radiation	EYA3	IDA		Human	PMID:19234442

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern