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Comparative GO Graph (mouse, human, rat, zebrafish)
Source
Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Ezr

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

Molecular Function


Cellular Component


Biological Process



Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ezr
Category ID Classification term Gene Evidence Inferred from Organism Reference
Molecular FunctionGO:0003779actin bindingEZRIDAHumanPMID:17825285
Molecular FunctionGO:0051015actin filament bindingEZRIDAHumanPMID:10793131
Molecular FunctionGO:0051117ATPase bindingEZRIPIUniProtKB:Q92887HumanPMID:17825285
Molecular FunctionGO:0045296cadherin bindingEZRHDAHumanPMID:25468996
Molecular FunctionGO:0050839cell adhesion molecule bindingEZRIPIUniProtKB:P19320HumanPMID:12082081
Molecular FunctionGO:0050839cell adhesion molecule bindingEZRIPIUniProtKB:P32942HumanPMID:12082081
Molecular FunctionGO:0050839cell adhesion molecule bindingEZRIPIUniProtKB:P16278HumanPMID:15498789
Molecular FunctionGO:0097718disordered domain specific bindingEzrIDAMouseMGI:MGI:5882886|PMID:18321067
Molecular FunctionGO:0042802identical protein bindingEZRIPIUniProtKB:P15311HumanPMID:21988832
Molecular FunctionGO:0042802identical protein bindingEZRIPIUniProtKB:P15311HumanPMID:29568061
Molecular FunctionGO:0042802identical protein bindingEZRIPIUniProtKB:P15311HumanPMID:31837246
Molecular FunctionGO:0008017microtubule bindingEZRIMPHumanPMID:23857773
Molecular FunctionGO:0005515protein bindingEZRIPIUniProtKB:P06396HumanPMID:10793131
Molecular FunctionGO:0005515protein bindingEZRIPIUniProtKB:P12814HumanPMID:10793131
Molecular FunctionGO:0005515protein bindingEZRIPIUniProtKB:P46940HumanPMID:10793131
Molecular FunctionGO:0005515protein bindingEZRIPIUniProtKB:Q9NZA1HumanPMID:10793131
Molecular FunctionGO:0005515protein bindingEZRIPIUniProtKB:Q92574HumanPMID:10806479
Molecular FunctionGO:0005515protein bindingEZRIPIUniProtKB:Q9EP53HumanPMID:10806479
Molecular FunctionGO:0005515protein bindingEZRIPIUniProtKB:Q8WX93HumanPMID:11598191
Molecular FunctionGO:0005515protein bindingEZRIPIUniProtKB:Q8IZE3HumanPMID:12651155
Molecular FunctionGO:0005515protein bindingEZRIPIUniProtKB:O14745HumanPMID:15020681
Molecular FunctionGO:0005515protein bindingEZRIPIUniProtKB:A6NDV4HumanPMID:15498789
Molecular FunctionGO:0005515protein bindingEZRIPIUniProtKB:Q86YL7HumanPMID:17046996
Molecular FunctionGO:0005515protein bindingEZRIPIUniProtKB:O14745HumanPMID:17242191
Molecular FunctionGO:0005515protein bindingEZRIPIUniProtKB:Q15599HumanPMID:17242191
Molecular FunctionGO:0005515protein bindingEZRIPIUniProtKB:P42858HumanPMID:17500595
Molecular FunctionGO:0005515protein bindingEZRIPIUniProtKB:O14745,UniProtKB:P41240,UniProtKB:Q9NWQ8HumanPMID:17911601
Molecular FunctionGO:0005515protein bindingEZRIPIUniProtKB:P07332HumanPMID:18046454
Molecular FunctionGO:0005515protein bindingEZRIPIUniProtKB:P23508HumanPMID:19555689
Molecular FunctionGO:0005515protein bindingEZRIPIUniProtKB:Q00987HumanPMID:20195357
Molecular FunctionGO:0005515protein bindingEZRIPIUniProtKB:O14745HumanPMID:20442317
Molecular FunctionGO:0005515protein bindingEZRIPIUniProtKB:O14986HumanPMID:20442317
Molecular FunctionGO:0005515protein bindingEZRIPIUniProtKB:Q12959HumanPMID:20551903
Molecular FunctionGO:0005515protein bindingEZRIPIUniProtKB:O14745HumanPMID:20937695
Molecular FunctionGO:0005515protein bindingEZRIPIUniProtKB:Q9H270HumanPMID:21148287
Molecular FunctionGO:0005515protein bindingEZRIPIUniProtKB:Q63155HumanPMID:21849478
Molecular FunctionGO:0005515protein bindingEZRIPIUniProtKB:P55011HumanPMID:22570591
Molecular FunctionGO:0005515protein bindingEZRIPIUniProtKB:P07384HumanPMID:22805611
Molecular FunctionGO:0005515protein bindingEZRIPIUniProtKB:O14745HumanPMID:23414517
Molecular FunctionGO:0005515protein bindingEZRIPIUniProtKB:P35241HumanPMID:23414517
Molecular FunctionGO:0005515protein bindingEZRIPIUniProtKB:P55011HumanPMID:24555568
Molecular FunctionGO:0005515protein bindingEZRIPIUniProtKB:P00533HumanPMID:24658140
Molecular FunctionGO:0005515protein bindingEZRIPIUniProtKB:P25815,UniProtKB:P46940HumanPMID:25554515
Molecular FunctionGO:0005515protein bindingEZRIPIUniProtKB:Q9NV70HumanPMID:25591774
Molecular FunctionGO:0005515protein bindingEZRIPIUniProtKB:P35241HumanPMID:26496610
Molecular FunctionGO:0005515protein bindingEZRIPIUniProtKB:Q8IVT2HumanPMID:28514442
Molecular FunctionGO:0005515protein bindingEZRIPIUniProtKB:O14745HumanPMID:29568061
Molecular FunctionGO:0005515protein bindingEZRIPIUniProtKB:P35241HumanPMID:29568061
Molecular FunctionGO:0005515protein bindingEZRIPIUniProtKB:P26447HumanPMID:31837246
Molecular FunctionGO:0005515protein bindingEZRIPIUniProtKB:P29034HumanPMID:31837246
Molecular FunctionGO:0005515protein bindingEZRIPIUniProtKB:P00533HumanPMID:31980649
Molecular FunctionGO:0005515protein bindingEZRIPIUniProtKB:Q8IVT2HumanPMID:32296183
Molecular FunctionGO:0005515protein bindingEZRIPIUniProtKB:Q8IZE3HumanPMID:32707033
Molecular FunctionGO:0005515protein bindingEZRIPIUniProtKB:P42858HumanPMID:32814053
Molecular FunctionGO:0005515protein bindingEZRIPIUniProtKB:Q14457HumanPMID:32814053
Molecular FunctionGO:0005515protein bindingEZRIPIUniProtKB:Q8N108-16HumanPMID:32814053
Molecular FunctionGO:0005515protein bindingEZRIPIUniProtKB:Q8WTV1HumanPMID:32814053
Molecular FunctionGO:0005515protein bindingEZRIPIUniProtKB:Q8WU43HumanPMID:32814053
Molecular FunctionGO:0005515protein bindingEZRIPIUniProtKB:Q8IZU9HumanPMID:34799561
Molecular FunctionGO:0005515protein bindingEZRIPIUniProtKB:P00533HumanPMID:35384245
Molecular FunctionGO:0005515protein bindingEZRIPIUniProtKB:P26038HumanPMID:7844168
Molecular FunctionGO:0005515protein bindingEZRIPIUniProtKB:Q5PQK5HumanPMID:7844168
Molecular FunctionGO:0005515protein bindingEZRIPIUniProtKB:Q5WQV5HumanPMID:7844168
Molecular FunctionGO:0005515protein bindingEzrIPIUniProtKB:P32004MouseMGI:MGI:5882886|PMID:18321067
Molecular FunctionGO:0005515protein bindingEzrIPIUniProtKB:P15702MouseMGI:MGI:5317032|PMID:21289089
Molecular FunctionGO:0005515protein bindingEzrIPIUniProtKB:P13838|UniProtKB:P15379|UniProtKB:P35330MouseMGI:MGI:6115186|PMID:9472040
Molecular FunctionGO:0005515protein bindingEzrIPIPR:Q8VI47MousePMID:12068294
Molecular FunctionGO:0005515protein bindingEzrIPIPR:B0V2N1MousePMID:24385580
Molecular FunctionGO:0005515protein bindingEzrIPIUniProtKB:Q9WTQ2RatPMID:11457882|RGD:634171
Molecular FunctionGO:0005515protein bindingEzrIPIRGD:621878RatPMID:11461930|RGD:7207839
Molecular FunctionGO:0005515protein bindingEzrIPIUniProtKB:Q62696RatPMID:11726633|RGD:8554011
Molecular FunctionGO:0005515protein bindingEzrIPIUniProtKB:Q9JJ19RatPMID:11726633|RGD:8554011
Molecular FunctionGO:0005515protein bindingEzrIPIRGD:2998RatPMID:15044370|RGD:1581827
Molecular FunctionGO:0005515protein bindingEzrIPIUniProtKB:P35952RatPMID:15044370|RGD:1581827
Molecular FunctionGO:0005515protein bindingEzrIPIRGD:628869RatPMID:17684062|RGD:2302243
Molecular FunctionGO:0005515protein bindingEzrIPIUniProtKB:Q63155RatPMID:21849478|RGD:14402440
Molecular FunctionGO:0019904protein domain specific bindingEZRIPIUniProtKB:P46940HumanPMID:25554515
Molecular FunctionGO:0019904protein domain specific bindingEzrIPIRGD:620911RatPMID:17045809|RGD:7207801
Molecular FunctionGO:0051018protein kinase A bindingEZRIPIUniProtKB:P10644HumanPMID:25097019
Molecular FunctionGO:0051018protein kinase A bindingEZRIPIUniProtKB:P13861HumanPMID:25097019
Molecular FunctionGO:0034236protein kinase A catalytic subunit bindingEZRIPIUniProtKB:P17612HumanPMID:17911601
Molecular FunctionGO:0034237protein kinase A regulatory subunit bindingEZRIPIUniProtKB:P10644HumanPMID:17911601
Molecular FunctionGO:0034237protein kinase A regulatory subunit bindingEZRIPIUniProtKB:P13861HumanPMID:17911601
Molecular FunctionGO:0044877protein-containing complex bindingEzrIPIRGD:3708|RGD:708538|RGD:70924RatPMID:21372499|RGD:7243126
Molecular FunctionGO:0003723RNA bindingEZRHDAHumanPMID:22658674
Molecular FunctionGO:0003723RNA bindingEZRHDAHumanPMID:22681889
Molecular FunctionGO:0044548S100 protein bindingEZRIPIUniProtKB:P25815HumanPMID:25554515
Cellular ComponentGO:0015629actin cytoskeletonEZRIDAHumanPMID:10793131
Cellular ComponentGO:0005884actin filamentEZRIDAHumanPMID:11598191
Cellular ComponentGO:0045177apical part of cellEZRIDAHumanPMID:12082081
Cellular ComponentGO:0045177apical part of cellEzrIDAMousePMID:9890997
Cellular ComponentGO:0045177apical part of cellEzrIDAMousePMID:14996907
Cellular ComponentGO:0016324apical plasma membraneEZRIDAHumanPMID:17825285
Cellular ComponentGO:0016324apical plasma membraneEZRIDAHumanPMID:22797597
Cellular ComponentGO:0016324apical plasma membraneEZRIDAHumanPMID:24862762
Cellular ComponentGO:0016324apical plasma membraneEzrIDAMousePMID:14625387
Cellular ComponentGO:0016324apical plasma membraneEzrIDARatPMID:11457882|RGD:634171
Cellular ComponentGO:0016324apical plasma membraneEzrIDARatPMID:11461930|RGD:7207839
Cellular ComponentGO:0097449astrocyte projectionEzrIDARatPMID:21753079|RGD:7207797
Cellular ComponentGO:0016323basolateral plasma membraneEzrIDARatPMID:11726633|RGD:8554011
Cellular ComponentGO:0005903brush borderEzrIDAMouseMGI:MGI:5621262|PMID:22114352
Cellular ComponentGO:0005903brush borderEzrIDAMousePMID:24284068
Cellular ComponentGO:0044297cell bodyEzrIDARatPMID:11461930|RGD:7207839
Cellular ComponentGO:0071944cell peripheryEZRIDAHumanPMID:22291017
Cellular ComponentGO:0042995cell projectionEZRIDAHumanPMID:25889165
Cellular ComponentGO:0051286cell tipEzrIDARatPMID:17061246|RGD:7207800
Cellular ComponentGO:0036064ciliary basal bodyEzrIDAMousePMID:14996907
Cellular ComponentGO:0005737cytoplasmEZRIDAHumanPMID:23106337
Cellular ComponentGO:0005737cytoplasmEZRIDAHumanPMID:25554515
Cellular ComponentGO:0005737cytoplasmEZRIDAHumanPMID:25591774
Cellular ComponentGO:0098592cytoplasmic side of apical plasma membraneEZRIDAHumanPMID:25591774
Cellular ComponentGO:0005829cytosolEZRIDAHumanPMID:9852149
Cellular ComponentGO:0005768endosomeEZRIDAHumanPMID:21148287
Cellular ComponentGO:0070062extracellular exosomeEZRHDAHumanPMID:20458337
Cellular ComponentGO:0070062extracellular exosomeEZRHDAHumanPMID:23533145
Cellular ComponentGO:0005615extracellular spaceEZRHDAHumanPMID:16502470
Cellular ComponentGO:0019898extrinsic component of membraneEZRIDAHumanPMID:7844168
Cellular ComponentGO:0001650fibrillar centerEZRIDAHumanGO_REF:0000052
Cellular ComponentGO:0030175filopodiumEZRIDAHumanPMID:12082081
Cellular ComponentGO:0030175filopodiumEZRIDAHumanPMID:23106337
Cellular ComponentGO:0030175filopodiumEzrIDARatPMID:21753079|RGD:7207797
Cellular ComponentGO:0005925focal adhesionEZRIDAHumanPMID:21282464
Cellular ComponentGO:0005925focal adhesionEZRHDAHumanPMID:21423176
Cellular ComponentGO:0001772immunological synapseEZRIDAHumanPMID:17911601
Cellular ComponentGO:0001772immunological synapseEZRIDAHumanPMID:20551903
Cellular ComponentGO:0005622intracellular anatomical structureEzrIDAMousePMID:17122142
Cellular ComponentGO:0016020membraneEZRHDAHumanPMID:19946888
Cellular ComponentGO:0045121membrane raftEzrIDARatPMID:21372499|RGD:7243126
Cellular ComponentGO:0044393microspikeEzrIDARatPMID:21753079|RGD:7207797
Cellular ComponentGO:0005902microvillusEZRIDAHumanPMID:12082081
Cellular ComponentGO:0005902microvillusEzrIDAMouseMGI:MGI:6115186|PMID:9472040
Cellular ComponentGO:0005902microvillusEzrIDAMousePMID:20551175
Cellular ComponentGO:0005902microvillusEzrIDAMousePMID:17138661
Cellular ComponentGO:0005902microvillusEzrIDAMousePMID:23284756
Cellular ComponentGO:0031528microvillus membraneEzrIDARatPMID:11726633|RGD:8554011
Cellular ComponentGO:0043209myelin sheathEzrHDAMouseMGI:MGI:3834050|PMID:17634366
Cellular ComponentGO:0048471perinuclear region of cytoplasmEZRIDAHumanPMID:24862762
Cellular ComponentGO:0005886plasma membraneEZRIDAHumanGO_REF:0000052
Cellular ComponentGO:0005886plasma membraneEZRIDAHumanPMID:23106337
Cellular ComponentGO:0005886plasma membraneEzrIDAMousePMID:24385580
Cellular ComponentGO:0005886plasma membraneEzrIDAMousePMID:21377456
Cellular ComponentGO:0005886plasma membraneEzrIDARatPMID:21753079|RGD:7207797
Cellular ComponentGO:0044853plasma membrane raftEZRIDAHumanPMID:17911601
Cellular ComponentGO:0032991protein-containing complexEZRIDAHumanPMID:25097019
Cellular ComponentGO:0001726ruffleEZRIDAHumanPMID:25554515
Cellular ComponentGO:0001726ruffleEZRIDAHumanPMID:9852149
Cellular ComponentGO:0097454Schwann cell microvillusEzrIDARatPMID:17045809|RGD:7207801
Cellular ComponentGO:0030315T-tubuleEzrIDARatPMID:19028724|RGD:7207798
Cellular ComponentGO:0001931uropodEzrIDAMousePMID:11728336
Cellular ComponentGO:0031982vesicleEZRHDAHumanPMID:19190083
Biological ProcessGO:0031532actin cytoskeleton reorganizationEZRIMPHumanPMID:23106337
Biological ProcessGO:0051017actin filament bundle assemblyEZRIDAHumanPMID:10793131
Biological ProcessGO:0030953astral microtubule organizationEZRIMPHumanPMID:20551903
Biological ProcessGO:0042074cell migration involved in gastrulationezrbIMPZFIN:ZDB-MRPHLNO-060919-3ZfishPMID:16638810
Biological ProcessGO:0042074cell migration involved in gastrulationezrbIMPZFIN:ZDB-MRPHLNO-060919-2ZfishPMID:16638810
Biological ProcessGO:0071320cellular response to cAMPEZRIMPHumanPMID:17911601
Biological ProcessGO:0060271cilium assemblyezrbIGIZFIN:ZDB-MRPHLNO-060919-3,ZFIN:ZDB-MRPHLNO-110310-2ZfishPMID:25516973
Biological ProcessGO:0043622cortical microtubule organizationEZRIMPHumanPMID:20551903
Biological ProcessGO:0090504epibolyezrbIMPZFIN:ZDB-MRPHLNO-060919-2ZfishPMID:26358752
Biological ProcessGO:0030855epithelial cell differentiationEzrIEPRatPMID:7640303|RGD:729995
Biological ProcessGO:0035850epithelial cell differentiation involved in kidney developmentezrbIMPZFIN:ZDB-MRPHLNO-060919-3ZfishPMID:27401686
Biological ProcessGO:0051660establishment of centrosome localizationEZRIMPHumanPMID:20551903
Biological ProcessGO:0061028establishment of endothelial barrierEZRIGIUniProtKB:P26038|UniProtKB:P35241HumanPMID:23264465
Biological ProcessGO:0035088establishment or maintenance of apical/basal cell polarityEzrIMPMGI:MGI:3052158MousePMID:15177033
Biological ProcessGO:0046847filopodium assemblyEZRIMPHumanPMID:23106337
Biological ProcessGO:0046847filopodium assemblyEzrIMPRatPMID:21753079|RGD:7207797
Biological ProcessGO:0001951intestinal D-glucose absorptionEzrIGIUniProtKB:Q3V0K9|UniProtKB:Q62468MouseMGI:MGI:5621262|PMID:22114352
Biological ProcessGO:0007159leukocyte cell-cell adhesionEZRIEPHumanPMID:12082081
Biological ProcessGO:0022614membrane to membrane dockingEZRIEPHumanPMID:12082081
Biological ProcessGO:0030033microvillus assemblyEZRIMPHumanPMID:22797597
Biological ProcessGO:0070373negative regulation of ERK1 and ERK2 cascadeEZRIMPHumanPMID:20551903
Biological ProcessGO:0032703negative regulation of interleukin-2 productionEZRIMPHumanPMID:17911601
Biological ProcessGO:1903753negative regulation of p38MAPK cascadeEZRIMPHumanPMID:20551903
Biological ProcessGO:0050860negative regulation of T cell receptor signaling pathwayEZRIMPHumanPMID:20551903
Biological ProcessGO:0000122negative regulation of transcription by RNA polymerase IIEZRIMPHumanPMID:20551903
Biological ProcessGO:0048015phosphatidylinositol-mediated signalingEZRIDAHumanPMID:25591774
Biological ProcessGO:2000643positive regulation of early endosome to late endosome transportEZRIGIUniProtKB:P26038|UniProtKB:P35241HumanPMID:21148287
Biological ProcessGO:2000643positive regulation of early endosome to late endosome transportEZRIMPHumanPMID:21148287
Biological ProcessGO:0010628positive regulation of gene expressionEZRIGIUniProtKB:Q96S97HumanPMID:23264465
Biological ProcessGO:0040018positive regulation of multicellular organism growthEzrIGIUniProtKB:Q3V0K9|UniProtKB:Q62468MouseMGI:MGI:5621262|PMID:22114352
Biological ProcessGO:0045732positive regulation of protein catabolic processEZRIGIUniProtKB:P26038|UniProtKB:P35241HumanPMID:21148287
Biological ProcessGO:1902966positive regulation of protein localization to early endosomeEZRIGIUniProtKB:P26038|UniProtKB:P35241HumanPMID:21148287
Biological ProcessGO:1903078positive regulation of protein localization to plasma membraneEzrIGIUniProtKB:Q3V0K9|UniProtKB:Q62468MouseMGI:MGI:5621262|PMID:22114352
Biological ProcessGO:0050714positive regulation of protein secretionEZRIMPHumanPMID:25591774
Biological ProcessGO:0098974postsynaptic actin cytoskeleton organizationEzrIDAMousePMID:29720403
Biological ProcessGO:0098974postsynaptic actin cytoskeleton organizationEzrIMPMousePMID:29720403
Biological ProcessGO:0010737protein kinase A signalingEZRIMPHumanPMID:17911601
Biological ProcessGO:0072697protein localization to cell cortexEZRIMPHumanPMID:25554515
Biological ProcessGO:0072659protein localization to plasma membraneEZRIMPHumanPMID:17825285
Biological ProcessGO:0072659protein localization to plasma membraneEZRIMPHumanPMID:17911601
Biological ProcessGO:0031503protein-containing complex localizationEZRIMPHumanPMID:20551903
Biological ProcessGO:0031623receptor internalizationEzrIMPMousePMID:16365167
Biological ProcessGO:0008360regulation of cell shapeEZRIMPHumanPMID:20551903
Biological ProcessGO:1902017regulation of cilium assemblyezrbIMPZFIN:ZDB-MRPHLNO-060919-3ZfishPMID:27401686
Biological ProcessGO:0032532regulation of microvillus lengthEzrIGIUniProtKB:Q3V0K9|UniProtKB:Q62468MouseMGI:MGI:5621262|PMID:22114352
Biological ProcessGO:1902115regulation of organelle assemblyEZRIGIUniProtKB:P26038|UniProtKB:P35241HumanPMID:21148287
Biological ProcessGO:1902115regulation of organelle assemblyEZRIMPHumanPMID:21148287
Biological ProcessGO:0003376sphingosine-1-phosphate receptor signaling pathwayEZRIMPHumanPMID:23106337
Biological ProcessGO:1902896terminal web assemblyEzrIGIUniProtKB:Q3V0K9|UniProtKB:Q62468MouseMGI:MGI:5621262|PMID:22114352

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IDA Inferred from direct assay
  IEP Inferred from expression pattern
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  HTP Inferred from High Throughput Experiment
  HDA Inferred from High Throughput Direct Assay
  HMP Inferred from High Throughput Mutant Phenotype
  HGI Inferred from High Throughput Genetic Interaction
  HEP Inferred from High Throughput Expression Pattern

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory