Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes F2
  • Mouse genes F2
  • Rat genes F2
  • Zfish genes f2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set F2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004175	endopeptidase activity	F2	IMP		Mouse	PMID:26742564
Molecular Function	GO:0008201	heparin binding	F2	IDA		Human	PMID:20421939
Molecular Function	GO:0001530	lipopolysaccharide binding	F2	IDA		Human	PMID:20421939
Molecular Function	GO:0140677	molecular function activator activity	F2	IMP		Mouse	PMID:26742564
Molecular Function	GO:0008233	peptidase activity	F2	IMP		Mouse	PMID:18305483
Molecular Function	GO:0005515	protein binding	F2	IPI	UniProtKB:P07204	Human	PMID:14691232
Molecular Function	GO:0005515	protein binding	F2	IPI	UniProtKB:Q846V4	Human	PMID:16230339
Molecular Function	GO:0005515	protein binding	F2	IPI	UniProtKB:Q846V4	Human	PMID:16230340
Molecular Function	GO:0005515	protein binding	F2	IPI	UniProtKB:P07093	Human	PMID:3279057
Molecular Function	GO:0005515	protein binding	F2	IPI	UniProtKB:P05067	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	F2	IPI	UniProtKB:P05154	Human	PMID:6323392
Molecular Function	GO:0005515	protein binding	F2	IPI	UniProtKB:P50452	Human	PMID:8530382
Molecular Function	GO:0005515	protein binding	F2	IPI	UniProtKB:P05121	Human	PMID:8626514
Molecular Function	GO:0005515	protein binding	F2	IPI	UniProtKB:Q07954	Human	PMID:8626514
Molecular Function	GO:0005515	protein binding	F2	IPI	UniProtKB:P02760:PRO_0000017886	Human	PMID:9183005
Molecular Function	GO:0005515	protein binding	F2	IPI	PR:Q60854	Mouse	PMID:7608171
Molecular Function	GO:0004252	serine-type endopeptidase activity	F2	IDA		Human	PMID:12855810
Molecular Function	GO:0004252	serine-type endopeptidase activity	F2	IDA		Human	PMID:1672265
Molecular Function	GO:0004252	serine-type endopeptidase activity	F2	IDA		Mouse	MGI:MGI:3810206|PMID:18398001
Molecular Function	GO:0004252	serine-type endopeptidase activity	F2	IDA		Mouse	PMID:18398001
Molecular Function	GO:0005102	signaling receptor binding	F2	IPI	UniProtKB:P07359	Human	PMID:12855810
Molecular Function	GO:0005102	signaling receptor binding	F2	IPI	UniProtKB:Q07954	Human	PMID:8626514
Molecular Function	GO:0070053	thrombospondin receptor activity	F2	IDA		Human	PMID:2435757
Cellular Component	GO:0072562	blood microparticle	F2	HDA		Human	PMID:22516433
Cellular Component	GO:0062023	collagen-containing extracellular matrix	F2	HDA		Human	PMID:28327460
Cellular Component	GO:0062023	collagen-containing extracellular matrix	F2	HDA		Mouse	MGI:MGI:6201853|PMID:28071719
Cellular Component	GO:0062023	collagen-containing extracellular matrix	F2	IDA		Rat	PMID:21191574|RGD:7387308
Cellular Component	GO:0009897	external side of plasma membrane	F2	IDA		Human	PMID:20421939
Cellular Component	GO:0070062	extracellular exosome	F2	HDA		Human	PMID:23533145
Cellular Component	GO:0005615	extracellular space	F2	HDA		Human	PMID:16502470
Cellular Component	GO:0005615	extracellular space	F2	IDA		Human	PMID:20421939
Cellular Component	GO:0005615	extracellular space	F2	IDA		Human	PMID:9639571
Cellular Component	GO:0005615	extracellular space	F2	IDA		Rat	PMID:16078333|RGD:1580343
Cellular Component	GO:0005615	extracellular space	F2	IDA		Rat	PMID:19719823|RGD:2313733
Biological Process	GO:0061844	antimicrobial humoral immune response mediated by antimicrobial peptide	F2	IDA		Human	PMID:20421939
Biological Process	GO:0007596	blood coagulation	F2	IDA		Rat	PMID:10048754|RGD:2290183
Biological Process	GO:0007596	blood coagulation	f2	IMP	ZFIN:ZDB-GENO-210304-6	Zfish	PMID:32132579
Biological Process	GO:0007596	blood coagulation	f2	IMP		Zfish	PMID:14757435
Biological Process	GO:0007596	blood coagulation	f2	IMP	ZFIN:ZDB-MRPHLNO-100428-7	Zfish	PMID:20002541
Biological Process	GO:0007166	cell surface receptor signaling pathway	F2	IDA		Human	PMID:1672265
Biological Process	GO:0071260	cellular response to mechanical stimulus	F2	IEP		Rat	PMID:22915765|RGD:6893464
Biological Process	GO:0051838	cytolysis by host of symbiont cells	F2	IDA		Human	PMID:20421939
Biological Process	GO:0042730	fibrinolysis	F2	IDA		Human	PMID:12855810
Biological Process	GO:0099105	ion channel modulating, G protein-coupled receptor signaling pathway	F2	IDA		Mouse	PMID:26742564
Biological Process	GO:0099105	ion channel modulating, G protein-coupled receptor signaling pathway	F2	IMP		Mouse	PMID:26742564
Biological Process	GO:1990806	ligand-gated ion channel signaling pathway	F2	IDA		Mouse	PMID:26742564
Biological Process	GO:1990806	ligand-gated ion channel signaling pathway	F2	IMP		Mouse	PMID:26742564
Biological Process	GO:0048712	negative regulation of astrocyte differentiation	F2	IDA		Human	PMID:1691280
Biological Process	GO:1900016	negative regulation of cytokine production involved in inflammatory response	F2	IDA		Human	PMID:20421939
Biological Process	GO:0045861	negative regulation of proteolysis	F2	IDA		Human	PMID:1695900
Biological Process	GO:0070945	neutrophil-mediated killing of gram-negative bacterium	F2	IDA		Human	PMID:20421939
Biological Process	GO:0030168	platelet activation	F2	IDA		Human	PMID:9038223
Biological Process	GO:0030168	platelet activation	F2	IDA		Mouse	PMID:17380206
Biological Process	GO:0030194	positive regulation of blood coagulation	F2	IDA		Human	PMID:9038223
Biological Process	GO:0030194	positive regulation of blood coagulation	F2	IMP		Rat	PMID:20664909|RGD:10449431
Biological Process	GO:0030307	positive regulation of cell growth	F2	IGI	MGI:MGI:101780	Mouse	PMID:18398001
Biological Process	GO:0008284	positive regulation of cell population proliferation	F2	IGI	MGI:MGI:101780	Mouse	PMID:18398001
Biological Process	GO:0032967	positive regulation of collagen biosynthetic process	F2	IDA		Human	PMID:9639571
Biological Process	GO:0032024	positive regulation of insulin secretion	F2	IMP		Mouse	PMID:26742564
Biological Process	GO:0032024	positive regulation of insulin secretion	F2	IDA		Mouse	PMID:26742564
Biological Process	GO:0090218	positive regulation of lipid kinase activity	F2	IDA		Human	PMID:11309392
Biological Process	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	F2	IGI	MGI:MGI:101802	Mouse	PMID:18398001
Biological Process	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	F2	IGI	MGI:MGI:101780	Mouse	PMID:18398001
Biological Process	GO:1900738	positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway	F2	IDA		Human	PMID:20164183
Biological Process	GO:1900182	positive regulation of protein localization to nucleus	F2	IDA		Human	PMID:11309392
Biological Process	GO:0001934	positive regulation of protein phosphorylation	F2	IDA		Human	PMID:7559487
Biological Process	GO:2000379	positive regulation of reactive oxygen species metabolic process	F2	IDA		Human	PMID:17275676
Biological Process	GO:0051281	positive regulation of release of sequestered calcium ion into cytosol	F2	IDA		Human	PMID:1672265
Biological Process	GO:0051281	positive regulation of release of sequestered calcium ion into cytosol	F2	IDA		Human	PMID:19052258
Biological Process	GO:0008360	regulation of cell shape	F2	IGI	MGI:MGI:101780	Mouse	PMID:18398001
Biological Process	GO:0051480	regulation of cytosolic calcium ion concentration	F2	IDA		Human	PMID:19052258
Biological Process	GO:0010468	regulation of gene expression	F2	IDA		Mouse	PMID:16720835
Biological Process	GO:0014854	response to inactivity	F2	IEP		Rat	PMID:16078333|RGD:1580343
Biological Process	GO:1904016	response to Thyroglobulin triiodothyronine	F2	IEP		Rat	PMID:18336749|RGD:2312311
Biological Process	GO:1905225	response to thyrotropin-releasing hormone	F2	IEP		Rat	PMID:18336749|RGD:2312311
Biological Process	GO:0097068	response to thyroxine	F2	IEP		Rat	PMID:18336749|RGD:2312311
Biological Process	GO:0009611	response to wounding	F2	IDA		Human	PMID:9639571

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern