Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes F3
  • Mouse genes F3
  • Rat genes F3
  • Zfish genes f3a,f3b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set F3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005543	phospholipid binding	F3	IDA		Human	PMID:17469850
Molecular Function	GO:0002020	protease binding	F3	IPI	UniProtKB:P08709	Human	PMID:3455766
Molecular Function	GO:0002020	protease binding	F3	IPI	RGD:628678	Rat	PMID:18315926|RGD:2312293
Molecular Function	GO:0005515	protein binding	F3	IPI	UniProtKB:P08709	Human	PMID:15522303
Molecular Function	GO:0005515	protein binding	F3	IPI	UniProtKB:P08709	Human	PMID:15664864
Molecular Function	GO:0005515	protein binding	F3	IPI	UniProtKB:P55085	Human	PMID:16959886
Molecular Function	GO:0005515	protein binding	F3	IPI	UniProtKB:Q9Y251	Human	PMID:20634491
Molecular Function	GO:0005515	protein binding	F3	IPI	UniProtKB:P08709	Human	PMID:25241761
Molecular Function	GO:0005515	protein binding	F3	IPI	UniProtKB:Q9UM19	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	F3	IPI	UniProtKB:P08709	Human	PMID:8598903
Molecular Function	GO:0005515	protein binding	F3	IPI	UniProtKB:P08709	Human	PMID:8940045
Molecular Function	GO:0005515	protein binding	F3	IPI	UniProtKB:P08709	Human	PMID:9414278
Molecular Function	GO:0004252	serine-type endopeptidase activity	F3	IDA		Human	PMID:24998411
Cellular Component	GO:0009986	cell surface	F3	IDA		Human	PMID:17898544
Cellular Component	GO:0009986	cell surface	F3	HDA		Human	PMID:19581412
Cellular Component	GO:0009986	cell surface	F3	IDA		Rat	PMID:16902157|RGD:2313746
Cellular Component	GO:0062023	collagen-containing extracellular matrix	F3	IDA		Human	PMID:2704749
Cellular Component	GO:0005737	cytoplasm	F3	IDA		Rat	PMID:16902157|RGD:2313746
Cellular Component	GO:0005615	extracellular space	F3	IDA		Human	PMID:19065458
Cellular Component	GO:0005615	extracellular space	F3	IDA		Rat	PMID:12083485|RGD:1299120
Cellular Component	GO:1905286	serine-type peptidase complex	F3	IPI	UniProtKB:P08709	Human	PMID:24998411
Biological Process	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	F3	IDA		Human	PMID:17898544
Biological Process	GO:0002541	activation of plasma proteins involved in acute inflammatory response	F3	IDA		Human	PMID:17469850
Biological Process	GO:0007568	aging	F3	IEP		Rat	PMID:9875493|RGD:2313773
Biological Process	GO:0007596	blood coagulation	F3	IDA		Human	PMID:24998411
Biological Process	GO:0007596	blood coagulation	F3	IDA		Human	PMID:8632006
Biological Process	GO:0070301	cellular response to hydrogen peroxide	F3	IEP		Rat	PMID:10190887|RGD:2313771
Biological Process	GO:0071404	cellular response to low-density lipoprotein particle stimulus	F3	IEP		Rat	PMID:10190887|RGD:2313771
Biological Process	GO:0007599	hemostasis	f3a	IMP	ZFIN:ZDB-MRPHLNO-221118-3	Zfish	PMID:35386206
Biological Process	GO:0045766	positive regulation of angiogenesis	F3	IDA		Human	PMID:17898544
Biological Process	GO:0001938	positive regulation of endothelial cell proliferation	F3	IDA		Human	PMID:17898544
Biological Process	GO:0010628	positive regulation of gene expression	F3	IMP		Human	PMID:22556343
Biological Process	GO:0032757	positive regulation of interleukin-8 production	F3	IMP		Human	PMID:22556343
Biological Process	GO:0010641	positive regulation of platelet-derived growth factor receptor signaling pathway	F3	IDA		Human	PMID:17991872
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	F3	IMP		Human	PMID:18612547
Biological Process	GO:0014911	positive regulation of smooth muscle cell migration	F3	IDA		Rat	PMID:10840019|RGD:2313761
Biological Process	GO:0016485	protein processing	F3	IDA		Human	PMID:24998411
Biological Process	GO:0032355	response to estradiol	F3	IEP		Rat	PMID:15481788|RGD:2313757
Biological Process	GO:0034405	response to fluid shear stress	F3	IEP		Rat	PMID:9974408|RGD:2313772
Biological Process	GO:0032496	response to lipopolysaccharide	F3	IEP		Rat	PMID:16113797|RGD:2313752
Biological Process	GO:0009612	response to mechanical stimulus	F3	IEP		Rat	PMID:15293323|RGD:2313758
Biological Process	GO:0009266	response to temperature stimulus	F3	IEP		Rat	PMID:16902157|RGD:2313746
Biological Process	GO:0009611	response to wounding	F3	IEP		Rat	PMID:10780328|RGD:2313770
Biological Process	GO:0002040	sprouting angiogenesis	f3a	IMP	ZFIN:ZDB-MRPHLNO-221118-3	Zfish	PMID:35386206
Biological Process	GO:0001944	vasculature development	f3b	IMP		Zfish	PMID:22057990

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern