Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes FADD
  • Mouse genes Fadd
  • Rat genes Fadd
  • Zfish genes fadd
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Fadd

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0089720	caspase binding	FADD	IDA		Human	PMID:24025841
Molecular Function	GO:0089720	caspase binding	FADD	IPI	UniProtKB:Q14790	Human	PMID:9343261
Molecular Function	GO:0035877	death effector domain binding	FADD	IPI	UniProtKB:Q14790	Human	PMID:11717445
Molecular Function	GO:0035877	death effector domain binding	FADD	IPI	UniProtKB:Q92851	Human	PMID:11717445
Molecular Function	GO:0005123	death receptor binding	Fadd	IPI	RGD:619831	Rat	PMID:17518537|RGD:2290177
Molecular Function	GO:0042802	identical protein binding	FADD	IPI	UniProtKB:Q13158	Human	PMID:25502805
Molecular Function	GO:0042802	identical protein binding	FADD	IPI	UniProtKB:Q13158	Human	PMID:30561431
Molecular Function	GO:0042802	identical protein binding	FADD	IPI	UniProtKB:Q13158	Human	PMID:31515488
Molecular Function	GO:0042802	identical protein binding	FADD	IPI	UniProtKB:Q13158	Human	PMID:32296183
Molecular Function	GO:0042802	identical protein binding	FADD	IPI	UniProtKB:Q13158	Human	PMID:7536190
Molecular Function	GO:0042802	identical protein binding	FADD	IPI	UniProtKB:Q13158	Human	PMID:8681376
Molecular Function	GO:0060090	molecular adaptor activity	FADD	IDA		Human	PMID:8565075
Molecular Function	GO:0002020	protease binding	FADD	IPI	UniProtKB:Q14790	Human	PMID:21785459
Molecular Function	GO:0002020	protease binding	FADD	IPI	UniProtKB:Q14790	Human	PMID:9208847
Molecular Function	GO:0002020	protease binding	Fadd	IPI	RGD:620945	Rat	PMID:17518537|RGD:2290177
Molecular Function	GO:0005515	protein binding	FADD	IPI	UniProtKB:Q15121	Human	PMID:10442631
Molecular Function	GO:0005515	protein binding	FADD	IPI	UniProtKB:Q99836	Human	PMID:10880445
Molecular Function	GO:0005515	protein binding	FADD	IPI	UniProtKB:Q15628	Human	PMID:11112409
Molecular Function	GO:0005515	protein binding	FADD	IPI	UniProtKB:O95243	Human	PMID:12702765
Molecular Function	GO:0005515	protein binding	FADD	IPI	UniProtKB:P48023	Human	PMID:12887920
Molecular Function	GO:0005515	protein binding	FADD	IPI	UniProtKB:Q14790	Human	PMID:12887920
Molecular Function	GO:0005515	protein binding	FADD	IPI	UniProtKB:Q14790	Human	PMID:14612908
Molecular Function	GO:0005515	protein binding	FADD	IPI	UniProtKB:Q9UNN5	Human	PMID:15688372
Molecular Function	GO:0005515	protein binding	FADD	IPI	UniProtKB:Q7Z434	Human	PMID:16127453
Molecular Function	GO:0005515	protein binding	FADD	IPI	UniProtKB:P25445	Human	PMID:16498403
Molecular Function	GO:0005515	protein binding	FADD	IPI	UniProtKB:P48023	Human	PMID:16498403
Molecular Function	GO:0005515	protein binding	FADD	IPI	UniProtKB:Q14790	Human	PMID:17047155
Molecular Function	GO:0005515	protein binding	FADD	IPI	UniProtKB:P25445	Human	PMID:17159907
Molecular Function	GO:0005515	protein binding	FADD	IPI	UniProtKB:Q14790	Human	PMID:17159907
Molecular Function	GO:0005515	protein binding	FADD	IPI	UniProtKB:P25445	Human	PMID:18328427
Molecular Function	GO:0005515	protein binding	FADD	IPI	UniProtKB:Q14790	Human	PMID:18485876
Molecular Function	GO:0005515	protein binding	FADD	IPI	UniProtKB:O14763	Human	PMID:18846110
Molecular Function	GO:0005515	protein binding	FADD	IPI	UniProtKB:Q14790	Human	PMID:19060883
Molecular Function	GO:0005515	protein binding	FADD	IPI	UniProtKB:P25445-1	Human	PMID:19118384
Molecular Function	GO:0005515	protein binding	FADD	IPI	UniProtKB:Q14790	Human	PMID:19176810
Molecular Function	GO:0005515	protein binding	FADD	IPI	UniProtKB:Q5S007	Human	PMID:19176810
Molecular Function	GO:0005515	protein binding	FADD	IPI	UniProtKB:Q14790	Human	PMID:19524512
Molecular Function	GO:0005515	protein binding	FADD	IPI	UniProtKB:Q13546	Human	PMID:19524513
Molecular Function	GO:0005515	protein binding	FADD	IPI	UniProtKB:Q14790	Human	PMID:20103630
Molecular Function	GO:0005515	protein binding	FADD	IPI	UniProtKB:P53350	Human	PMID:20890306
Molecular Function	GO:0005515	protein binding	FADD	IPI	UniProtKB:P25445-1	Human	PMID:20935634
Molecular Function	GO:0005515	protein binding	FADD	IPI	UniProtKB:P25446	Human	PMID:20935634
Molecular Function	GO:0005515	protein binding	FADD	IPI	UniProtKB:P25445	Human	PMID:21382479
Molecular Function	GO:0005515	protein binding	FADD	IPI	UniProtKB:Q13546	Human	PMID:21458669
Molecular Function	GO:0005515	protein binding	FADD	IPI	UniProtKB:Q14790	Human	PMID:21458669
Molecular Function	GO:0005515	protein binding	FADD	IPI	UniProtKB:Q13546	Human	PMID:21525013
Molecular Function	GO:0005515	protein binding	FADD	IPI	UniProtKB:Q14790	Human	PMID:21525013
Molecular Function	GO:0005515	protein binding	FADD	IPI	UniProtKB:P25445	Human	PMID:21625644
Molecular Function	GO:0005515	protein binding	FADD	IPI	UniProtKB:P25445-1	Human	PMID:21713032
Molecular Function	GO:0005515	protein binding	FADD	IPI	UniProtKB:O00220	Human	PMID:21785459
Molecular Function	GO:0005515	protein binding	FADD	IPI	UniProtKB:Q14790	Human	PMID:21785459
Molecular Function	GO:0005515	protein binding	FADD	IPI	UniProtKB:Q99497	Human	PMID:21785459
Molecular Function	GO:0005515	protein binding	FADD	IPI	UniProtKB:P25445	Human	PMID:21803845
Molecular Function	GO:0005515	protein binding	FADD	IPI	UniProtKB:Q14790	Human	PMID:21988832
Molecular Function	GO:0005515	protein binding	FADD	IPI	UniProtKB:Q99836	Human	PMID:21988832
Molecular Function	GO:0005515	protein binding	FADD	IPI	UniProtKB:Q14790	Human	PMID:22173242
Molecular Function	GO:0005515	protein binding	FADD	IPI	UniProtKB:Q14790	Human	PMID:22274400
Molecular Function	GO:0005515	protein binding	FADD	IPI	UniProtKB:P23396	Human	PMID:22510408
Molecular Function	GO:0005515	protein binding	FADD	IPI	UniProtKB:Q14790	Human	PMID:23955153
Molecular Function	GO:0005515	protein binding	FADD	IPI	UniProtKB:Q15628	Human	PMID:23955153
Molecular Function	GO:0005515	protein binding	FADD	IPI	UniProtKB:B7UI21	Human	PMID:24025841
Molecular Function	GO:0005515	protein binding	FADD	IPI	UniProtKB:P48023	Human	PMID:24025841
Molecular Function	GO:0005515	protein binding	FADD	IPI	UniProtKB:Q14790	Human	PMID:25043603
Molecular Function	GO:0005515	protein binding	FADD	IPI	UniProtKB:P25445	Human	PMID:25241761
Molecular Function	GO:0005515	protein binding	FADD	IPI	UniProtKB:P48023	Human	PMID:25241761
Molecular Function	GO:0005515	protein binding	FADD	IPI	UniProtKB:Q14790	Human	PMID:25911380
Molecular Function	GO:0005515	protein binding	FADD	IPI	UniProtKB:P25445-1	Human	PMID:26942442
Molecular Function	GO:0005515	protein binding	FADD	IPI	UniProtKB:Q13546	Human	PMID:30561431
Molecular Function	GO:0005515	protein binding	FADD	IPI	UniProtKB:Q14790	Human	PMID:30561431
Molecular Function	GO:0005515	protein binding	FADD	IPI	UniProtKB:Q15628	Human	PMID:30561431
Molecular Function	GO:0005515	protein binding	FADD	IPI	UniProtKB:B7ZLH0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	FADD	IPI	UniProtKB:O00560	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	FADD	IPI	UniProtKB:P62324	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	FADD	IPI	UniProtKB:P78317	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	FADD	IPI	UniProtKB:Q13546	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	FADD	IPI	UniProtKB:Q15560	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	FADD	IPI	UniProtKB:Q15628	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	FADD	IPI	UniProtKB:Q6PEW1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	FADD	IPI	UniProtKB:Q7KZS0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	FADD	IPI	UniProtKB:Q96D03	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	FADD	IPI	UniProtKB:Q9UJ78-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	FADD	IPI	UniProtKB:Q13546	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	FADD	IPI	UniProtKB:Q14790	Human	PMID:34591612
Molecular Function	GO:0005515	protein binding	FADD	IPI	UniProtKB:P25445	Human	PMID:7536190
Molecular Function	GO:0005515	protein binding	FADD	IPI	UniProtKB:P25446	Human	PMID:7536190
Molecular Function	GO:0005515	protein binding	FADD	IPI	UniProtKB:P25445	Human	PMID:7538907
Molecular Function	GO:0005515	protein binding	FADD	IPI	UniProtKB:Q14790-1	Human	PMID:8681376
Molecular Function	GO:0005515	protein binding	FADD	IPI	UniProtKB:Q14790-5	Human	PMID:8681376
Molecular Function	GO:0005515	protein binding	FADD	IPI	UniProtKB:O15519	Human	PMID:9208847
Molecular Function	GO:0005515	protein binding	FADD	IPI	UniProtKB:Q14790	Human	PMID:9343261
Molecular Function	GO:0005515	protein binding	Fadd	IPI	UniProtKB:O89110|UniProtKB:Q60855|UniProtKB:Q9QZL0	Mouse	MGI:MGI:5706670|PMID:26649818
Molecular Function	GO:0005515	protein binding	Fadd	IPI	UniProtKB:Q60855|UniProtKB:Q9QZL0	Mouse	MGI:MGI:4359574|PMID:19524513
Molecular Function	GO:0005515	protein binding	Fadd	IPI	UniProtKB:P25446	Mouse	MGI:MGI:5002421|PMID:21382479
Molecular Function	GO:0005515	protein binding	Fadd	IPI	UniProtKB:Q14790|UniProtKB:Q92851	Mouse	MGI:MGI:5526940|PMID:12884866
Molecular Function	GO:0005515	protein binding	Fadd	IPI	UniProtKB:Q62881	Mouse	MGI:MGI:5613476|PMID:15383280
Molecular Function	GO:0005515	protein binding	Fadd	IPI	UniProtKB:P25446	Mouse	MGI:MGI:5508614|PMID:17159908
Molecular Function	GO:0005515	protein binding	Fadd	IPI	UniProtKB:O89110|UniProtKB:Q60855	Mouse	MGI:MGI:5698536|PMID:26555174
Molecular Function	GO:0005515	protein binding	Fadd	IPI	UniProtKB:O89110|UniProtKB:Q60855	Mouse	MGI:MGI:6120592|PMID:29440439
Molecular Function	GO:0005515	protein binding	Fadd	IPI	UniProtKB:O89110|UniProtKB:Q60855	Mouse	MGI:MGI:6093208|PMID:18946037
Molecular Function	GO:0005515	protein binding	Fadd	IPI	UniProtKB:O89110|UniProtKB:Q60855|UniProtKB:Q9QZL0	Mouse	MGI:MGI:5566546|PMID:24557836
Molecular Function	GO:0005515	protein binding	Fadd	IPI	UniProtKB:P25446	Mouse	MGI:MGI:3810048|PMID:18455983
Molecular Function	GO:0005515	protein binding	Fadd	IPI	UniProtKB:Q60855	Mouse	MGI:MGI:6362574|PMID:31519887
Molecular Function	GO:0005515	protein binding	Fadd	IPI	UniProtKB:O89110	Mouse	MGI:MGI:3690188|PMID:16469705
Molecular Function	GO:0005515	protein binding	Fadd	IPI	UniProtKB:Q60855|UniProtKB:Q9QZL0	Mouse	MGI:MGI:4947443|PMID:21368763
Molecular Function	GO:0005515	protein binding	Fadd	IPI	UniProtKB:Q60855|UniProtKB:Q9QZL0	Mouse	MGI:MGI:5315337|PMID:21052097
Molecular Function	GO:0005515	protein binding	Fadd	IPI	UniProtKB:Q3U0V2	Mouse	MGI:MGI:6377951|PMID:30185824
Molecular Function	GO:0005515	protein binding	Fadd	IPI	UniProtKB:Q60855	Mouse	MGI:MGI:5926457|PMID:28842570
Molecular Function	GO:0005515	protein binding	Fadd	IPI	PR:A1KXC4	Mouse	PMID:15632112
Molecular Function	GO:0005515	protein binding	Fadd	IPI	PR:Q9ERV7	Mouse	PMID:16183742
Molecular Function	GO:0005515	protein binding	Fadd	IPI	UniProtKB:Q9JHX4	Rat	PMID:19001025|RGD:8553292
Molecular Function	GO:0044877	protein-containing complex binding	Fadd	IPI	RGD:620945|RGD:619831	Rat	PMID:17518537|RGD:2290177
Molecular Function	GO:0033612	receptor serine/threonine kinase binding	Fadd	IPI	RGD:1310158	Rat	PMID:26038570|RGD:11341801
Molecular Function	GO:0005164	tumor necrosis factor receptor binding	Fadd	IPI	RGD:621237	Rat	PMID:20649583|RGD:5130976
Molecular Function	GO:0032813	tumor necrosis factor receptor superfamily binding	FADD	IPI	UniProtKB:P25445	Human	PMID:21109225
Cellular Component	GO:0031265	CD95 death-inducing signaling complex	FADD	IDA		Human	PMID:20935634
Cellular Component	GO:0031265	CD95 death-inducing signaling complex	Fadd	IDA		Rat	PMID:16493077|RGD:4143200
Cellular Component	GO:0044297	cell body	Fadd	IDA		Rat	PMID:18096138|RGD:4142863
Cellular Component	GO:0005737	cytoplasm	FADD	IDA		Human	PMID:22510408
Cellular Component	GO:0005737	cytoplasm	Fadd	IDA		Rat	PMID:18096138|RGD:4142863
Cellular Component	GO:0005829	cytosol	FADD	IDA		Human	PMID:21785459
Cellular Component	GO:0031264	death-inducing signaling complex	FADD	IDA		Human	PMID:11101870
Cellular Component	GO:0031264	death-inducing signaling complex	FADD	IDA		Human	PMID:21803845
Cellular Component	GO:0031264	death-inducing signaling complex	Fadd	IDA		Rat	PMID:17518537|RGD:2290177
Cellular Component	GO:0045121	membrane raft	Fadd	IDA		Rat	PMID:15590916|RGD:1624191
Cellular Component	GO:0045121	membrane raft	Fadd	IDA		Rat	PMID:17518537|RGD:2290177
Cellular Component	GO:0043005	neuron projection	Fadd	IDA		Rat	PMID:18096138|RGD:4142863
Cellular Component	GO:0005634	nucleus	Fadd	IDA		Rat	PMID:18580876|RGD:11341804
Cellular Component	GO:0005886	plasma membrane	FADD	IDA		Human	PMID:22510408
Cellular Component	GO:0032991	protein-containing complex	Fadd	IDA		Rat	PMID:15590916|RGD:1624191
Cellular Component	GO:0097342	ripoptosome	FADD	IDA		Human	PMID:21737330
Biological Process	GO:0097202	activation of cysteine-type endopeptidase activity	FADD	IDA		Human	PMID:18387192
Biological Process	GO:0006915	apoptotic process	FADD	IMP		Human	PMID:22891283
Biological Process	GO:0097190	apoptotic signaling pathway	FADD	IDA		Human	PMID:11101870
Biological Process	GO:0097190	apoptotic signaling pathway	FADD	IDA		Human	PMID:8565075
Biological Process	GO:0048148	behavioral response to cocaine	Fadd	IEP		Rat	PMID:18580876|RGD:11341804
Biological Process	GO:0071260	cellular response to mechanical stimulus	FADD	IEP		Human	PMID:19593445
Biological Process	GO:0071550	death-inducing signaling complex assembly	FADD	IDA		Human	PMID:24025841
Biological Process	GO:0051607	defense response to virus	FADD	IMP		Human	PMID:21109225
Biological Process	GO:0097191	extrinsic apoptotic signaling pathway	FADD	IMP		Human	PMID:16611992
Biological Process	GO:0097191	extrinsic apoptotic signaling pathway	FADD	IDA		Human	PMID:21785459
Biological Process	GO:0097191	extrinsic apoptotic signaling pathway	Fadd	IDA		Mouse	PMID:10588860
Biological Process	GO:0097191	extrinsic apoptotic signaling pathway	Fadd	IGI	MGI:MGI:1889507	Mouse	PMID:16183742
Biological Process	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	Fadd	IMP		Mouse	PMID:13679421
Biological Process	GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors	FADD	IDA		Human	PMID:24025841
Biological Process	GO:0001822	kidney development	Fadd	IEP		Rat	PMID:27561622|RGD:13792500
Biological Process	GO:0048535	lymph node development	Fadd	IGI	UniProtKB:Q9QZL0	Mouse	MGI:MGI:5291865|PMID:21876153
Biological Process	GO:0097049	motor neuron apoptotic process	Fadd	IMP		Mouse	PMID:13679421
Biological Process	GO:0097527	necroptotic signaling pathway	FADD	IMP		Human	PMID:11101870
Biological Process	GO:0070236	negative regulation of activation-induced cell death of T cells	Fadd	IMP		Mouse	MGI:MGI:5291865|PMID:21876153
Biological Process	GO:0060546	negative regulation of necroptotic process	Fadd	IGI	MGI:MGI:104798	Mouse	PMID:22089168
Biological Process	GO:0060546	negative regulation of necroptotic process	Fadd	IGI	MGI:MGI:2154952	Mouse	PMID:22675671
Biological Process	GO:0042104	positive regulation of activated T cell proliferation	Fadd	IMP		Mouse	MGI:MGI:5291865|PMID:21876153
Biological Process	GO:0002821	positive regulation of adaptive immune response	Fadd	IMP		Mouse	MGI:MGI:5291865|PMID:21876153
Biological Process	GO:0043065	positive regulation of apoptotic process	FADD	IDA		Human	PMID:11821383
Biological Process	GO:0043065	positive regulation of apoptotic process	FADD	IMP		Human	PMID:20935634
Biological Process	GO:0043065	positive regulation of apoptotic process	fadd	IDA		Zfish	PMID:16888647
Biological Process	GO:2000454	positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation	Fadd	IMP		Mouse	MGI:MGI:5291865|PMID:21876153
Biological Process	GO:2001238	positive regulation of extrinsic apoptotic signaling pathway	FADD	IMP		Human	PMID:21525013
Biological Process	GO:2001238	positive regulation of extrinsic apoptotic signaling pathway	Fadd	IGI	MGI:MGI:2154952	Mouse	PMID:22675671
Biological Process	GO:2001238	positive regulation of extrinsic apoptotic signaling pathway	Fadd	IGI	MGI:MGI:1336166	Mouse	PMID:22675671
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	FADD	IEP		Human	PMID:12761501
Biological Process	GO:0032757	positive regulation of interleukin-8 production	FADD	IDA		Human	PMID:16127453
Biological Process	GO:0045651	positive regulation of macrophage differentiation	FADD	IMP		Human	PMID:17047155
Biological Process	GO:0045862	positive regulation of proteolysis	FADD	IDA		Human	PMID:18387192
Biological Process	GO:0001916	positive regulation of T cell mediated cytotoxicity	Fadd	IMP		Mouse	MGI:MGI:5291865|PMID:21876153
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	FADD	IDA		Human	PMID:16127453
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	FADD	IDA		Human	PMID:16127453
Biological Process	GO:0060340	positive regulation of type I interferon-mediated signaling pathway	FADD	IMP		Human	PMID:21109225
Biological Process	GO:0032729	positive regulation of type II interferon production	Fadd	IMP		Mouse	MGI:MGI:5291865|PMID:21876153
Biological Process	GO:0060544	regulation of necroptotic process	Fadd	IMP		Rat	PMID:26038570|RGD:11341801
Biological Process	GO:0042220	response to cocaine	Fadd	IEP		Rat	PMID:21925237|RGD:11341806
Biological Process	GO:0043278	response to morphine	Fadd	IDA		Rat	PMID:21088039|RGD:11341805
Biological Process	GO:0048536	spleen development	Fadd	IGI	UniProtKB:Q9QZL0	Mouse	MGI:MGI:5291865|PMID:21876153
Biological Process	GO:0033077	T cell differentiation in thymus	Fadd	IMP		Mouse	MGI:MGI:5291865|PMID:21876153
Biological Process	GO:0043029	T cell homeostasis	Fadd	IMP		Mouse	MGI:MGI:5291865|PMID:21876153
Biological Process	GO:0048538	thymus development	Fadd	IGI	UniProtKB:Q9QZL0	Mouse	MGI:MGI:5291865|PMID:21876153
Biological Process	GO:0036462	TRAIL-activated apoptotic signaling pathway	FADD	IDA		Human	PMID:21785459

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern