Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes FAM20C
  • Mouse genes Fam20c
  • Rat genes Fam20c
  • Zfish genes fam20ca,fam20cb
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Fam20c

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005509	calcium ion binding	Fam20c	IDA		Mouse	PMID:17369251
Molecular Function	GO:0030145	manganese ion binding	FAM20C	IDA		Human	PMID:23754375
Molecular Function	GO:0002020	protease binding	FAM20C	IPI	UniProtKB:Q14703	Human	PMID:34349020
Molecular Function	GO:0005515	protein binding	FAM20C	IPI	UniProtKB:O14791	Human	PMID:22582013
Molecular Function	GO:0005515	protein binding	FAM20C	IPI	UniProtKB:P01008	Human	PMID:22582013
Molecular Function	GO:0005515	protein binding	FAM20C	IPI	UniProtKB:P02666	Human	PMID:22582013
Molecular Function	GO:0005515	protein binding	FAM20C	IPI	UniProtKB:P02671	Human	PMID:22582013
Molecular Function	GO:0005515	protein binding	FAM20C	IPI	UniProtKB:P05060	Human	PMID:22582013
Molecular Function	GO:0005515	protein binding	FAM20C	IPI	UniProtKB:P10451	Human	PMID:22582013
Molecular Function	GO:0005515	protein binding	FAM20C	IPI	UniProtKB:P10451:PRO_0000020321	Human	PMID:22582013
Molecular Function	GO:0005515	protein binding	FAM20C	IPI	UniProtKB:P10451:PRO_0000020321	Human	PMID:25789606
Molecular Function	GO:0005515	protein binding	FAM20C	IPI	UniProtKB:Q6UX39	Human	PMID:25789606
Molecular Function	GO:0005515	protein binding	FAM20C	IPI	UniProtKB:Q96MK3	Human	PMID:25789606
Molecular Function	GO:0005515	protein binding	FAM20C	IPI	UniProtKB:Q9NP70	Human	PMID:25789606
Molecular Function	GO:0005515	protein binding	FAM20C	IPI	UniProtKB:Q9NRM1	Human	PMID:25789606
Molecular Function	GO:0005515	protein binding	FAM20C	IPI	UniProtKB:P02666	Human	PMID:26091039
Molecular Function	GO:0005515	protein binding	FAM20C	IPI	UniProtKB:P02671	Human	PMID:26091039
Molecular Function	GO:0005515	protein binding	FAM20C	IPI	UniProtKB:P02810	Human	PMID:26091039
Molecular Function	GO:0005515	protein binding	FAM20C	IPI	UniProtKB:P08833	Human	PMID:26091039
Molecular Function	GO:0005515	protein binding	FAM20C	IPI	UniProtKB:P10451	Human	PMID:26091039
Molecular Function	GO:0005515	protein binding	FAM20C	IPI	UniProtKB:O95486	Human	PMID:34349020
Molecular Function	GO:0005515	protein binding	FAM20C	IPI	UniProtKB:Q15436	Human	PMID:34349020
Molecular Function	GO:0004672	protein kinase activity	FAM20C	IDA		Human	PMID:34349020
Molecular Function	GO:0043621	protein self-association	FAM20C	IDA		Human	PMID:34349020
Molecular Function	GO:0004674	protein serine/threonine kinase activity	FAM20C	IDA		Human	PMID:22582013
Molecular Function	GO:0004674	protein serine/threonine kinase activity	FAM20C	IDA		Human	PMID:23754375
Molecular Function	GO:0004674	protein serine/threonine kinase activity	FAM20C	IDA		Human	PMID:25789606
Molecular Function	GO:0004674	protein serine/threonine kinase activity	FAM20C	IDA		Human	PMID:26091039
Molecular Function	GO:0004674	protein serine/threonine kinase activity	FAM20C	IDA		Human	PMID:29858230
Molecular Function	GO:0004674	protein serine/threonine kinase activity	Fam20c	IDA		Mouse	MGI:MGI:5644017|PMID:22900076
Molecular Function	GO:0004674	protein serine/threonine kinase activity	Fam20c	IDA		Rat	PMID:20067794|RGD:11560493
Cellular Component	GO:0005737	cytoplasm	Fam20c	IDA		Mouse	MGI:MGI:5574295|PMID:21549343
Cellular Component	GO:0005737	cytoplasm	Fam20c	IDA		Rat	PMID:27614627|RGD:11560492
Cellular Component	GO:0070062	extracellular exosome	FAM20C	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	FAM20C	HDA		Human	PMID:19199708
Cellular Component	GO:0005615	extracellular space	FAM20C	IDA		Human	PMID:22582013
Cellular Component	GO:0005615	extracellular space	FAM20C	IDA		Human	PMID:34349020
Cellular Component	GO:0005615	extracellular space	Fam20c	HDA		Mouse	MGI:MGI:5640941|PMID:24006456
Cellular Component	GO:0005615	extracellular space	Fam20c	IDA		Mouse	PMID:17369251
Cellular Component	GO:0005794	Golgi apparatus	FAM20C	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005794	Golgi apparatus	FAM20C	IDA		Human	PMID:22582013
Cellular Component	GO:0005794	Golgi apparatus	Fam20c	IDA		Mouse	MGI:MGI:5644017|PMID:22900076
Cellular Component	GO:0005794	Golgi apparatus	Fam20c	IDA		Rat	PMID:27614627|RGD:11560492
Cellular Component	GO:0000139	Golgi membrane	FAM20C	IDA		Human	PMID:34349020
Cellular Component	GO:0005654	nucleoplasm	FAM20C	IDA		Human	GO_REF:0000052
Biological Process	GO:0046034	ATP metabolic process	Fam20c	IDA		Rat	PMID:12927861|RGD:11560523
Biological Process	GO:0031214	biomineral tissue development	FAM20C	IMP		Human	PMID:22582013
Biological Process	GO:0031214	biomineral tissue development	FAM20C	IMP		Human	PMID:25789606
Biological Process	GO:0097187	dentinogenesis	Fam20c	IMP	MGI:MGI:5432377	Mouse	PMID:22732358
Biological Process	GO:0070166	enamel mineralization	Fam20c	IMP	MGI:MGI:5432377	Mouse	PMID:22732358
Biological Process	GO:0071895	odontoblast differentiation	Fam20c	IDA		Mouse	PMID:17369251
Biological Process	GO:0071895	odontoblast differentiation	Fam20c	IEP		Rat	PMID:17369251|RGD:11560522
Biological Process	GO:0036179	osteoclast maturation	Fam20c	IMP	MGI:MGI:2656539,MGI:MGI:5428020	Mouse	PMID:22615579
Biological Process	GO:0030501	positive regulation of bone mineralization	Fam20c	IDA		Mouse	PMID:22615579
Biological Process	GO:0030501	positive regulation of bone mineralization	Fam20c	IDA		Mouse	PMID:17369251
Biological Process	GO:0045669	positive regulation of osteoblast differentiation	Fam20c	IDA		Mouse	PMID:22615579
Biological Process	GO:0046777	protein autophosphorylation	FAM20C	IDA		Human	PMID:34349020
Biological Process	GO:0006468	protein phosphorylation	FAM20C	IDA		Human	PMID:23754375
Biological Process	GO:0006468	protein phosphorylation	FAM20C	IDA		Human	PMID:25789606
Biological Process	GO:0006468	protein phosphorylation	FAM20C	IDA		Human	PMID:26091039
Biological Process	GO:0006468	protein phosphorylation	FAM20C	IDA		Human	PMID:34349020
Biological Process	GO:0006468	protein phosphorylation	Fam20c	IDA		Mouse	MGI:MGI:5644017|PMID:22900076
Biological Process	GO:0006468	protein phosphorylation	Fam20c	IDA		Rat	PMID:20067794|RGD:11560493
Biological Process	GO:0040036	regulation of fibroblast growth factor receptor signaling pathway	Fam20c	IMP	MGI:MGI:2656539,MGI:MGI:5428020	Mouse	PMID:22615579
Biological Process	GO:0051174	regulation of phosphorus metabolic process	Fam20c	IMP	MGI:MGI:2656539,MGI:MGI:5428020	Mouse	PMID:22615579
Biological Process	GO:0001501	skeletal system development	Fam20c	IMP	MGI:MGI:5432377	Mouse	PMID:22732358
Biological Process	GO:0001501	skeletal system development	Fam20c	IMP	MGI:MGI:2656539,MGI:MGI:5428020	Mouse	PMID:22615579

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern