Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes FAP
  • Mouse genes Fap
  • Rat genes Fap
  • Zfish genes fap
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Fap

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0008239	dipeptidyl-peptidase activity	FAP	IDA		Human	PMID:10593948
Molecular Function	GO:0004175	endopeptidase activity	FAP	IDA		Human	PMID:17317851
Molecular Function	GO:0042802	identical protein binding	FAP	IPI	UniProtKB:Q12884	Human	PMID:9065413
Molecular Function	GO:0005178	integrin binding	FAP	IPI	UniProtKB:P05556	Human	PMID:10455171
Molecular Function	GO:0005178	integrin binding	FAP	IPI	UniProtKB:P26006	Human	PMID:10455171
Molecular Function	GO:0008233	peptidase activity	FAP	IDA		Human	PMID:10455171
Molecular Function	GO:0008233	peptidase activity	FAP	IDA		Human	PMID:9688278
Molecular Function	GO:0008233	peptidase activity	Fap	IDA		Mouse	PMID:9688278
Molecular Function	GO:0002020	protease binding	FAP	IPI	UniProtKB:P08697	Human	PMID:17317851
Molecular Function	GO:0005515	protein binding	FAP	IPI	UniProtKB:P27487	Human	PMID:16651416
Molecular Function	GO:0005515	protein binding	FAP	IPI	UniProtKB:P01275	Human	PMID:21314817
Molecular Function	GO:0005515	protein binding	FAP	IPI	UniProtKB:P01282	Human	PMID:21314817
Molecular Function	GO:0042803	protein homodimerization activity	FAP	IDA		Human	PMID:10455171
Molecular Function	GO:0004252	serine-type endopeptidase activity	FAP	IDA		Human	PMID:10593948
Molecular Function	GO:0008236	serine-type peptidase activity	FAP	IDA		Human	PMID:16651416
Molecular Function	GO:0008236	serine-type peptidase activity	FAP	IMP		Human	PMID:9065413
Cellular Component	GO:0045177	apical part of cell	Fap	IDA		Mouse	PMID:24038871
Cellular Component	GO:0045178	basal part of cell	Fap	IDA		Mouse	PMID:24038871
Cellular Component	GO:0009986	cell surface	Fap	IDA		Mouse	MGI:MGI:3047166|PMID:15133496
Cellular Component	GO:0005615	extracellular space	FAP	IDA		Human	PMID:17317851
Cellular Component	GO:0005925	focal adhesion	FAP	HDA		Human	PMID:21423176
Cellular Component	GO:0030027	lamellipodium	FAP	IDA		Human	PMID:16651416
Cellular Component	GO:0030027	lamellipodium	FAP	IDA		Human	PMID:9065413
Cellular Component	GO:1905368	peptidase complex	FAP	IMP		Human	PMID:9065413
Cellular Component	GO:0005886	plasma membrane	FAP	IDA		Human	PMID:10593948
Biological Process	GO:0030282	bone mineralization	fap	IGI	ZFIN:ZDB-MRPHLNO-210603-1,ZFIN:ZDB-MRPHLNO-210603-2	Zfish	PMID:33053358
Biological Process	GO:0043542	endothelial cell migration	FAP	IDA		Human	PMID:16651416
Biological Process	GO:1902362	melanocyte apoptotic process	Fap	IDA		Mouse	MGI:MGI:3047166|PMID:15133496
Biological Process	GO:0097325	melanocyte proliferation	Fap	IDA		Mouse	MGI:MGI:3047166|PMID:15133496
Biological Process	GO:0030502	negative regulation of bone mineralization	fap	IMP	ZFIN:ZDB-MRPHLNO-210603-2	Zfish	PMID:33053358
Biological Process	GO:0030502	negative regulation of bone mineralization	fap	IMP	ZFIN:ZDB-CRISPR-210603-3	Zfish	PMID:33053358
Biological Process	GO:0030502	negative regulation of bone mineralization	fap	IMP	ZFIN:ZDB-CRISPR-210603-4	Zfish	PMID:33053358
Biological Process	GO:0060244	negative regulation of cell proliferation involved in contact inhibition	Fap	IDA		Mouse	MGI:MGI:3047166|PMID:15133496
Biological Process	GO:0010716	negative regulation of extracellular matrix disassembly	FAP	IDA		Human	PMID:16651416
Biological Process	GO:1903054	negative regulation of extracellular matrix organization	FAP	IDA		Human	PMID:10455171
Biological Process	GO:1900119	positive regulation of execution phase of apoptosis	Fap	IDA		Mouse	MGI:MGI:3047166|PMID:15133496
Biological Process	GO:0006508	proteolysis	FAP	IDA		Human	PMID:10455171
Biological Process	GO:0006508	proteolysis	FAP	IMP		Human	PMID:9065413
Biological Process	GO:0051603	proteolysis involved in protein catabolic process	FAP	IDA		Human	PMID:10593948
Biological Process	GO:0051726	regulation of cell cycle	Fap	IDA		Mouse	MGI:MGI:3047166|PMID:15133496
Biological Process	GO:0010710	regulation of collagen catabolic process	FAP	IDA		Human	PMID:10455171

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern