Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes FASLG
  • Mouse genes Fasl
  • Rat genes Faslg
  • Zfish genes faslg
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Fasl

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005123	death receptor binding	Faslg	IPI	RGD:619831	Rat	PMID:15557468|RGD:1600357
Molecular Function	GO:0005123	death receptor binding	Faslg	IPI	RGD:619831	Rat	PMID:17959308|RGD:2290172
Molecular Function	GO:0005515	protein binding	FASLG	IPI	UniProtKB:Q14790	Human	PMID:12198154
Molecular Function	GO:0005515	protein binding	FASLG	IPI	UniProtKB:P25445	Human	PMID:12887920
Molecular Function	GO:0005515	protein binding	FASLG	IPI	UniProtKB:Q13158	Human	PMID:12887920
Molecular Function	GO:0005515	protein binding	FASLG	IPI	UniProtKB:Q14790	Human	PMID:12887920
Molecular Function	GO:0005515	protein binding	FASLG	IPI	UniProtKB:O43586	Human	PMID:16318909
Molecular Function	GO:0005515	protein binding	FASLG	IPI	UniProtKB:O75044	Human	PMID:16318909
Molecular Function	GO:0005515	protein binding	FASLG	IPI	UniProtKB:Q15642	Human	PMID:16318909
Molecular Function	GO:0005515	protein binding	FASLG	IPI	UniProtKB:Q96RU3	Human	PMID:16318909
Molecular Function	GO:0005515	protein binding	FASLG	IPI	UniProtKB:Q9BY11	Human	PMID:16318909
Molecular Function	GO:0005515	protein binding	FASLG	IPI	UniProtKB:Q9UKS6	Human	PMID:16318909
Molecular Function	GO:0005515	protein binding	FASLG	IPI	UniProtKB:Q9UNF0	Human	PMID:16318909
Molecular Function	GO:0005515	protein binding	FASLG	IPI	UniProtKB:Q13158	Human	PMID:16498403
Molecular Function	GO:0005515	protein binding	FASLG	IPI	UniProtKB:Q14790	Human	PMID:16498403
Molecular Function	GO:0005515	protein binding	FASLG	IPI	UniProtKB:P16333-1	Human	PMID:16595635
Molecular Function	GO:0005515	protein binding	FASLG	IPI	UniProtKB:Q91ZR2	Human	PMID:17761170
Molecular Function	GO:0005515	protein binding	FASLG	IPI	UniProtKB:Q9DBG3	Human	PMID:17761170
Molecular Function	GO:0005515	protein binding	FASLG	IPI	UniProtKB:O43586	Human	PMID:19807924
Molecular Function	GO:0005515	protein binding	FASLG	IPI	UniProtKB:O43639	Human	PMID:19807924
Molecular Function	GO:0005515	protein binding	FASLG	IPI	UniProtKB:O75044	Human	PMID:19807924
Molecular Function	GO:0005515	protein binding	FASLG	IPI	UniProtKB:P06241	Human	PMID:19807924
Molecular Function	GO:0005515	protein binding	FASLG	IPI	UniProtKB:P27986	Human	PMID:19807924
Molecular Function	GO:0005515	protein binding	FASLG	IPI	UniProtKB:Q08881	Human	PMID:19807924
Molecular Function	GO:0005515	protein binding	FASLG	IPI	UniProtKB:Q8WV41	Human	PMID:19807924
Molecular Function	GO:0005515	protein binding	FASLG	IPI	UniProtKB:Q9Y5X1	Human	PMID:19807924
Molecular Function	GO:0005515	protein binding	FASLG	IPI	UniProtKB:P25445	Human	PMID:21803845
Molecular Function	GO:0005515	protein binding	FASLG	IPI	UniProtKB:Q13158	Human	PMID:24025841
Molecular Function	GO:0005515	protein binding	FASLG	IPI	UniProtKB:Q14790	Human	PMID:24025841
Molecular Function	GO:0005515	protein binding	FASLG	IPI	UniProtKB:P06241	Human	PMID:25241761
Molecular Function	GO:0005515	protein binding	FASLG	IPI	UniProtKB:P25445	Human	PMID:25241761
Molecular Function	GO:0005515	protein binding	FASLG	IPI	UniProtKB:P27986	Human	PMID:25241761
Molecular Function	GO:0005515	protein binding	FASLG	IPI	UniProtKB:Q13158	Human	PMID:25241761
Molecular Function	GO:0005515	protein binding	FASLG	IPI	UniProtKB:O76081	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	FASLG	IPI	UniProtKB:O76081-6	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	FASLG	IPI	UniProtKB:Q15654	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	FASLG	IPI	UniProtKB:Q6A162	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	FASLG	IPI	UniProtKB:Q7Z3S9	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	FASLG	IPI	UniProtKB:A0A0S2Z4D7	Human	PMID:26871637
Molecular Function	GO:0005515	protein binding	FASLG	IPI	UniProtKB:Q8WV41	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	FASLG	IPI	UniProtKB:A8MQ03	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	FASLG	IPI	UniProtKB:O43639	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	FASLG	IPI	UniProtKB:O76081-6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	FASLG	IPI	UniProtKB:P60328	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	FASLG	IPI	UniProtKB:Q14525	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	FASLG	IPI	UniProtKB:Q15436	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	FASLG	IPI	UniProtKB:Q16610	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	FASLG	IPI	UniProtKB:Q63HR2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	FASLG	IPI	UniProtKB:Q8IUC1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	FASLG	IPI	UniProtKB:Q8IYA8	Human	PMID:32296183
Molecular Function	GO:0005164	tumor necrosis factor receptor binding	Faslg	IMP		Rat	PMID:16154149|RGD:1582433
Cellular Component	GO:0005901	caveola	Faslg	IDA		Rat	PMID:15541714|RGD:1358613
Cellular Component	GO:0009986	cell surface	Fasl	IDA		Mouse	MGI:MGI:5688840|PMID:20404348
Cellular Component	GO:0031410	cytoplasmic vesicle	Faslg	IDA		Rat	PMID:16563377|RGD:1582439
Cellular Component	GO:0009897	external side of plasma membrane	Fasl	IDA		Mouse	PMID:16973387
Cellular Component	GO:0070062	extracellular exosome	FASLG	IDA		Human	PMID:17076679
Cellular Component	GO:0005615	extracellular space	FASLG	IDA		Human	PMID:18835034
Cellular Component	GO:0045121	membrane raft	Faslg	IDA		Rat	PMID:17518537|RGD:2290177
Cellular Component	GO:0005634	nucleus	FASLG	IDA		Human	PMID:17557115
Cellular Component	GO:0048471	perinuclear region of cytoplasm	Faslg	IDA		Rat	PMID:16563377|RGD:1582439
Cellular Component	GO:0005886	plasma membrane	FASLG	IDA		Human	PMID:12201652
Biological Process	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	FASLG	IGI	UniProtKB:P18406	Human	PMID:19364818
Biological Process	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	FASLG	IMP		Human	PMID:18293083
Biological Process	GO:0097190	apoptotic signaling pathway	FASLG	IDA		Human	PMID:11101870
Biological Process	GO:0097190	apoptotic signaling pathway	Fasl	IDA		Mouse	PMID:15629131
Biological Process	GO:0097190	apoptotic signaling pathway	Fasl	IDA		Mouse	PMID:7511063
Biological Process	GO:0071346	cellular response to type II interferon	Faslg	IEP		Rat	PMID:10029626|RGD:14700709
Biological Process	GO:0048388	endosomal lumen acidification	Faslg	IDA		Rat	PMID:18045865|RGD:2315735
Biological Process	GO:0097191	extrinsic apoptotic signaling pathway	FASLG	IDA		Human	PMID:22891283
Biological Process	GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors	FASLG	IDA		Human	PMID:26582200
Biological Process	GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors	FASLG	IDA		Human	PMID:18835034
Biological Process	GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors	Fasl	IDA		Mouse	PMID:15039234
Biological Process	GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors	Fasl	IDA		Mouse	PMID:10588860
Biological Process	GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors	Faslg	IMP		Rat	PMID:16689665|RGD:1582444
Biological Process	GO:0006925	inflammatory cell apoptotic process	Faslg	IGI	UniProtKB:P25963	Rat	PMID:16154149|RGD:1582433
Biological Process	GO:0030644	intracellular chloride ion homeostasis	Faslg	IDA		Rat	PMID:18045865|RGD:2315735
Biological Process	GO:0070266	necroptotic process	FASLG	IDA		Human	PMID:11101870
Biological Process	GO:0097527	necroptotic signaling pathway	FASLG	IDA		Human	PMID:11101870
Biological Process	GO:0016525	negative regulation of angiogenesis	FASLG	IDA		Human	PMID:18835034
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	FASLG	IDA		Human	PMID:17557115
Biological Process	GO:0030903	notochord development	faslg	IMP	ZFIN:ZDB-MRPHLNO-141103-4	Zfish	PMID:25071022
Biological Process	GO:0030903	notochord development	faslg	IGI	ZFIN:ZDB-MRPHLNO-141103-3,ZFIN:ZDB-MRPHLNO-141103-4	Zfish	PMID:25071022
Biological Process	GO:0030903	notochord development	faslg	IGI	ZFIN:ZDB-MRPHLNO-141103-5,ZFIN:ZDB-MRPHLNO-141103-6	Zfish	PMID:25071022
Biological Process	GO:0043065	positive regulation of apoptotic process	FASLG	IDA		Human	PMID:14749367
Biological Process	GO:0043065	positive regulation of apoptotic process	FASLG	IDA		Human	PMID:21625644
Biological Process	GO:0008284	positive regulation of cell population proliferation	Faslg	IDA		Rat	PMID:18471522|RGD:2315731
Biological Process	GO:2000353	positive regulation of endothelial cell apoptotic process	FASLG	IDA		Human	PMID:18835034
Biological Process	GO:0045742	positive regulation of epidermal growth factor receptor signaling pathway	Faslg	IMP		Rat	PMID:18471522|RGD:2315731
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	FASLG	IEP		Human	PMID:12761501
Biological Process	GO:0043525	positive regulation of neuron apoptotic process	Faslg	IMP		Rat	PMID:9858598|RGD:2315725
Biological Process	GO:1905782	positive regulation of phosphatidylserine exposure on apoptotic cell surface	FASLG	IDA		Human	PMID:24904167
Biological Process	GO:1903514	release of sequestered calcium ion into cytosol by endoplasmic reticulum	FASLG	IDA		Human	PMID:26582200
Biological Process	GO:0070848	response to growth factor	Faslg	IEP		Rat	PMID:18692025|RGD:2315724
Biological Process	GO:0032496	response to lipopolysaccharide	Faslg	IEP		Rat	PMID:17899301|RGD:2290175
Biological Process	GO:0046666	retinal cell programmed cell death	Fasl	IMP	MGI:MGI:1856384	Mouse	PMID:14517994
Biological Process	GO:0070231	T cell apoptotic process	FASLG	IDA		Human	PMID:17076679

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern