Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes FAT1
  • Mouse genes Fat1
  • Rat genes Fat1
  • Zfish genes fat1a,fat1b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Fat1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	FAT1	IPI	UniProtKB:Q8N8S7	Human	PMID:16979624
Molecular Function	GO:0005515	protein binding	FAT1	IPI	UniProtKB:Q99JP6	Human	PMID:16979624
Molecular Function	GO:0005515	protein binding	FAT1	IPI	UniProtKB:Q9NSC5	Human	PMID:16979624
Molecular Function	GO:0005515	protein binding	FAT1	IPI	UniProtKB:P54259	Human	PMID:19131340
Molecular Function	GO:0005515	protein binding	FAT1	IPI	UniProtKB:Q9P2R6	Human	PMID:19131340
Molecular Function	GO:0005515	protein binding	Fat1	IPI	PR:Q03173	Mouse	PMID:15148305
Cellular Component	GO:0016324	apical plasma membrane	Fat1	IDA		Mouse	PMID:26114487
Cellular Component	GO:0030054	cell junction	Fat1	IDA		Mouse	PMID:15148305
Cellular Component	GO:0005911	cell-cell junction	FAT1	IDA		Human	PMID:15148305
Cellular Component	GO:0070062	extracellular exosome	FAT1	HDA		Human	PMID:19056867
Cellular Component	GO:0030175	filopodium	Fat1	IDA		Mouse	PMID:15148305
Cellular Component	GO:0005925	focal adhesion	FAT1	HDA		Human	PMID:21423176
Cellular Component	GO:0030027	lamellipodium	Fat1	IDA		Mouse	PMID:15148305
Cellular Component	GO:0005634	nucleus	FAT1	IDA		Human	PMID:15922730
Cellular Component	GO:0048471	perinuclear region of cytoplasm	FAT1	IDA		Human	PMID:15922730
Cellular Component	GO:0005886	plasma membrane	FAT1	IDA		Human	PMID:15922730
Cellular Component	GO:0005886	plasma membrane	Fat1	IDA		Mouse	PMID:26114487
Biological Process	GO:0007015	actin filament organization	Fat1	IMP		Mouse	PMID:15148305
Biological Process	GO:0043010	camera-type eye development	Fat1	IMP	MGI:2662293	Mouse	PMID:26114487
Biological Process	GO:0048593	camera-type eye morphogenesis	Fat1	IMP	MGI:2662293	Mouse	PMID:26114487
Biological Process	GO:0098609	cell-cell adhesion	Fat1	IMP		Mouse	PMID:15148305
Biological Process	GO:0061386	closure of optic fissure	fat1a	IMP	ZFIN:ZDB-CRISPR-200219-1	Zfish	PMID:30862798
Biological Process	GO:0061386	closure of optic fissure	fat1a	IMP	ZFIN:ZDB-MRPHLNO-190820-1	Zfish	PMID:30862798
Biological Process	GO:0003382	epithelial cell morphogenesis	Fat1	IMP	MGI:2662293	Mouse	PMID:26114487
Biological Process	GO:0003412	establishment of epithelial cell apical/basal polarity involved in camera-type eye morphogenesis	Fat1	IMP	MGI:2662293	Mouse	PMID:26114487
Biological Process	GO:0007163	establishment or maintenance of cell polarity	Fat1	IMP		Mouse	PMID:15148305
Biological Process	GO:0045197	establishment or maintenance of epithelial cell apical/basal polarity	Fat1	IMP	MGI:2662293	Mouse	PMID:26114487
Biological Process	GO:0021782	glial cell development	fat1b	IMP	ZFIN:ZDB-CRISPR-191008-17,ZFIN:ZDB-CRISPR-191008-19	Zfish	PMID:30924555
Biological Process	GO:0002088	lens development in camera-type eye	Fat1	IMP	MGI:2662293	Mouse	PMID:26114487
Biological Process	GO:0048793	pronephros development	fat1a	IMP	ZFIN:ZDB-MRPHLNO-090609-6	Zfish	PMID:26905694
Biological Process	GO:0060041	retina development in camera-type eye	fat1b	IMP	ZFIN:ZDB-CRISPR-191008-17,ZFIN:ZDB-CRISPR-191008-19	Zfish	PMID:30924555

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern