Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes FBN1
  • Mouse genes Fbn1
  • Rat genes Fbn1
  • Zfish genes fbn1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Fbn1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005509	calcium ion binding	FBN1	IDA		Human	PMID:15062093
Molecular Function	GO:0005509	calcium ion binding	FBN1	IDA		Human	PMID:7691719
Molecular Function	GO:0005201	extracellular matrix structural constituent	FBN1	IDA		Human	PMID:3536967
Molecular Function	GO:0008201	heparin binding	FBN1	IDA		Human	PMID:11461921
Molecular Function	GO:0005179	hormone activity	Fbn1	IDA		Mouse	MGI:MGI:6865806|PMID:32337066
Molecular Function	GO:0005179	hormone activity	Fbn1	IDA		Mouse	MGI:MGI:6810708|PMID:31798959
Molecular Function	GO:0005179	hormone activity	Fbn1	IDA		Mouse	MGI:MGI:6357396|PMID:31230984
Molecular Function	GO:0005179	hormone activity	Fbn1	IDA		Mouse	MGI:MGI:6103363|PMID:29106398
Molecular Function	GO:0005179	hormone activity	Fbn1	IDA		Mouse	MGI:MGI:6442875|PMID:30997682
Molecular Function	GO:0042802	identical protein binding	FBN1	IPI	UniProtKB:P35555	Human	PMID:18448684
Molecular Function	GO:0042802	identical protein binding	FBN1	IPI	UniProtKB:P35555	Human	PMID:24035709
Molecular Function	GO:0042802	identical protein binding	FBN1	IPI	UniProtKB:P35555	Human	PMID:25034023
Molecular Function	GO:0005178	integrin binding	FBN1	IPI	UniProtKB:P05106|UniProtKB:P06756	Human	PMID:12807887
Molecular Function	GO:0005178	integrin binding	FBN1	IPI	UniProtKB:P05556|UniProtKB:P08648	Human	PMID:12807887
Molecular Function	GO:0005178	integrin binding	FBN1	IPI	UniProtKB:P05106	Human	PMID:15062093
Molecular Function	GO:0005178	integrin binding	FBN1	IPI	UniProtKB:P05556|UniProtKB:P08648	Human	PMID:17158881
Molecular Function	GO:0005178	integrin binding	FBN1	IPI	UniProtKB:P06756|UniProtKB:P18564	Human	PMID:17158881
Molecular Function	GO:0005515	protein binding	FBN1	IPI	UniProtKB:B7ZLY3	Human	PMID:12429738
Molecular Function	GO:0005515	protein binding	FBN1	IPI	UniProtKB:Q14766	Human	PMID:12429738
Molecular Function	GO:0005515	protein binding	FBN1	IPI	UniProtKB:Q14766-2	Human	PMID:12429738
Molecular Function	GO:0005515	protein binding	FBN1	IPI	UniProtKB:Q8N2S1	Human	PMID:12429738
Molecular Function	GO:0005515	protein binding	FBN1	IPI	UniProtKB:P27424	Human	PMID:15131124
Molecular Function	GO:0005515	protein binding	FBN1	IPI	UniProtKB:Q28022	Human	PMID:15131124
Molecular Function	GO:0005515	protein binding	FBN1	IPI	UniProtKB:Q07092	Human	PMID:15165854
Molecular Function	GO:0005515	protein binding	FBN1	IPI	UniProtKB:P15502	Human	PMID:15790312
Molecular Function	GO:0005515	protein binding	FBN1	IPI	UniProtKB:Q9UBX5	Human	PMID:15790312
Molecular Function	GO:0005515	protein binding	FBN1	IPI	UniProtKB:Q14766,UniProtKB:Q14767	Human	PMID:17293099
Molecular Function	GO:0005515	protein binding	FBN1	IPI	UniProtKB:O95393	Human	PMID:18339631
Molecular Function	GO:0005515	protein binding	FBN1	IPI	UniProtKB:P12643	Human	PMID:18339631
Molecular Function	GO:0005515	protein binding	FBN1	IPI	UniProtKB:P12644	Human	PMID:18339631
Molecular Function	GO:0005515	protein binding	FBN1	IPI	UniProtKB:P18075	Human	PMID:18339631
Molecular Function	GO:0005515	protein binding	FBN1	IPI	UniProtKB:P43026	Human	PMID:18339631
Molecular Function	GO:0005515	protein binding	FBN1	IPI	UniProtKB:O95967	Human	PMID:19349279
Molecular Function	GO:0005515	protein binding	FBN1	IPI	UniProtKB:P98095|UniProtKB:Q14766|UniProtKB:Q8N2S1|UniProtKB:Q9UBX5	Human	PMID:19349279
Molecular Function	GO:0005515	protein binding	FBN1	IPI	UniProtKB:O95967	Human	PMID:19570982
Molecular Function	GO:0005515	protein binding	FBN1	IPI	UniProtKB:P28300	Human	PMID:19570982
Molecular Function	GO:0005515	protein binding	FBN1	IPI	UniProtKB:Q9UBX5	Human	PMID:19570982
Molecular Function	GO:0005515	protein binding	FBN1	IPI	UniProtKB:Q9H324	Human	PMID:21402694
Molecular Function	GO:0005515	protein binding	FBN1	IPI	UniProtKB:P55083	Human	PMID:22355679
Molecular Function	GO:0005515	protein binding	FBN1	IPI	UniProtKB:O35235	Human	PMID:24039232
Molecular Function	GO:0005515	protein binding	FBN1	IPI	UniProtKB:P02751	Human	PMID:25034023
Molecular Function	GO:0005515	protein binding	FBN1	IPI	UniProtKB:P35556	Human	PMID:25034023
Molecular Function	GO:0005515	protein binding	FBN1	IPI	UniProtKB:P55083	Human	PMID:26601954
Molecular Function	GO:0005515	protein binding	FBN1	IPI	UniProtKB:O14964	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	FBN1	IPI	UniProtKB:Q7L5D6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	FBN1	IPI	UniProtKB:Q96EQ0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Fbn1	IPI	PR:Q3UTY6	Mouse	PMID:19940141
Molecular Function	GO:0005515	protein binding	Fbn1	IPI	PR:Q7TSK7	Mouse	PMID:25762570
Molecular Function	GO:0044877	protein-containing complex binding	FBN1	IPI	UniProtKB:P05106	Human	PMID:15062093
Cellular Component	GO:0005604	basement membrane	FBN1	IDA		Human	PMID:3536967
Cellular Component	GO:0062023	collagen-containing extracellular matrix	FBN1	HDA		Human	PMID:20551380
Cellular Component	GO:0062023	collagen-containing extracellular matrix	FBN1	HDA		Human	PMID:23658023
Cellular Component	GO:0062023	collagen-containing extracellular matrix	FBN1	HDA		Human	PMID:23979707
Cellular Component	GO:0062023	collagen-containing extracellular matrix	FBN1	HDA		Human	PMID:27559042
Cellular Component	GO:0062023	collagen-containing extracellular matrix	FBN1	HDA		Human	PMID:28327460
Cellular Component	GO:0062023	collagen-containing extracellular matrix	FBN1	HDA		Human	PMID:25037231
Cellular Component	GO:0062023	collagen-containing extracellular matrix	FBN1	HDA		Human	PMID:28675934
Cellular Component	GO:0062023	collagen-containing extracellular matrix	Fbn1	HDA		Mouse	MGI:MGI:6201834|PMID:22159717
Cellular Component	GO:0062023	collagen-containing extracellular matrix	Fbn1	HDA		Mouse	MGI:MGI:6201853|PMID:28071719
Cellular Component	GO:0062023	collagen-containing extracellular matrix	Fbn1	HDA		Mouse	MGI:MGI:5582867|PMID:23658023
Cellular Component	GO:0062023	collagen-containing extracellular matrix	Fbn1	IDA		Mouse	MGI:MGI:5795811|PMID:24039232
Cellular Component	GO:0062023	collagen-containing extracellular matrix	Fbn1	IDA		Mouse	PMID:17099216
Cellular Component	GO:0062023	collagen-containing extracellular matrix	Fbn1	IDA		Rat	PMID:15849235|RGD:1601147
Cellular Component	GO:0031012	extracellular matrix	FBN1	IDA		Human	PMID:3536967
Cellular Component	GO:0005576	extracellular region	FBN1	IDA		Human	PMID:11461921
Cellular Component	GO:0005576	extracellular region	FBN1	HDA		Human	PMID:27068509
Cellular Component	GO:0005576	extracellular region	FBN1	IDA		Human	PMID:34411563
Cellular Component	GO:0005576	extracellular region	Fbn1	IDA		Rat	PMID:17200203|RGD:7365047
Cellular Component	GO:0005615	extracellular space	FBN1	HDA		Human	PMID:20551380
Cellular Component	GO:0005615	extracellular space	FBN1	IDA		Human	PMID:3536967
Cellular Component	GO:0005615	extracellular space	Fbn1	HDA		Mouse	MGI:MGI:5640941|PMID:24006456
Cellular Component	GO:0005615	extracellular space	Fbn1	IDA		Mouse	MGI:MGI:6103363|PMID:29106398
Cellular Component	GO:0001527	microfibril	FBN1	IDA		Human	PMID:10424889
Cellular Component	GO:0001527	microfibril	FBN1	IDA		Human	PMID:12429738
Cellular Component	GO:0001527	microfibril	FBN1	IDA		Human	PMID:1860873
Cellular Component	GO:0001527	microfibril	FBN1	IDA		Human	PMID:22355679
Cellular Component	GO:0001527	microfibril	FBN1	IDA		Human	PMID:3536967
Cellular Component	GO:0001527	microfibril	FBN1	IDA		Human	PMID:7534784
Cellular Component	GO:0001527	microfibril	FBN1	IDA		Human	PMID:8120105
Cellular Component	GO:0001527	microfibril	Fbn1	IDA		Mouse	PMID:26405179
Biological Process	GO:0043010	camera-type eye development	FBN1	IEP		Human	PMID:25406291
Biological Process	GO:0048593	camera-type eye morphogenesis	fbn1	IMP	ZFIN:ZDB-GENO-221221-4	Zfish	PMID:35285860
Biological Process	GO:0033627	cell adhesion mediated by integrin	FBN1	IDA		Human	PMID:12807887
Biological Process	GO:0033627	cell adhesion mediated by integrin	FBN1	IDA		Human	PMID:17158881
Biological Process	GO:1990314	cellular response to insulin-like growth factor stimulus	Fbn1	IEP		Rat	PMID:17200203|RGD:7365047
Biological Process	GO:0071560	cellular response to transforming growth factor beta stimulus	Fbn1	IEP		Rat	PMID:11012893|RGD:7387263
Biological Process	GO:0048048	embryonic eye morphogenesis	FBN1	IEP		Human	PMID:25406291
Biological Process	GO:0007507	heart development	FBN1	IMP		Human	PMID:15781745
Biological Process	GO:0001822	kidney development	Fbn1	IEP		Rat	PMID:9815129|RGD:632672
Biological Process	GO:0001822	kidney development	Fbn1	IMP		Rat	PMID:9815129|RGD:632672
Biological Process	GO:0001656	metanephros development	Fbn1	IMP		Rat	PMID:9815129|RGD:632672
Biological Process	GO:1903444	negative regulation of brown fat cell differentiation	Fbn1	IMP		Mouse	MGI:MGI:6828895|PMID:33705351
Biological Process	GO:0046676	negative regulation of insulin secretion	Fbn1	IDA		Mouse	MGI:MGI:6442875|PMID:30997682
Biological Process	GO:2001205	negative regulation of osteoclast development	FBN1	IDA		Human	PMID:24039232
Biological Process	GO:2001205	negative regulation of osteoclast development	Fbn1	IDA		Mouse	MGI:MGI:5795811|PMID:24039232
Biological Process	GO:0045671	negative regulation of osteoclast differentiation	FBN1	IDA		Human	PMID:24039232
Biological Process	GO:0045671	negative regulation of osteoclast differentiation	Fbn1	IDA		Mouse	MGI:MGI:5795811|PMID:24039232
Biological Process	GO:0032100	positive regulation of appetite	Fbn1	IDA		Mouse	MGI:MGI:6103363|PMID:29106398
Biological Process	GO:0048050	post-embryonic eye morphogenesis	FBN1	IEP		Human	PMID:25406291
Biological Process	GO:0035582	sequestering of BMP in extracellular matrix	Fbn1	IMP		Mouse	MGI:MGI:4836762|PMID:20855508
Biological Process	GO:0035583	sequestering of TGFbeta in extracellular matrix	Fbn1	IMP		Mouse	MGI:MGI:4836762|PMID:20855508
Biological Process	GO:0001501	skeletal system development	FBN1	IMP		Human	PMID:8188302

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern