Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes FBN2
  • Mouse genes Fbn2
  • Rat genes Fbn2
  • Zfish genes fbn2a,fbn2b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Fbn2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005179	hormone activity	Fbn2	IDA		Mouse	MGI:MGI:6448811|PMID:32329225
Molecular Function	GO:0005515	protein binding	FBN2	IPI	UniProtKB:B7ZLY3	Human	PMID:12429738
Molecular Function	GO:0005515	protein binding	FBN2	IPI	UniProtKB:Q14766	Human	PMID:12429738
Molecular Function	GO:0005515	protein binding	FBN2	IPI	UniProtKB:P27424	Human	PMID:15131124
Molecular Function	GO:0005515	protein binding	FBN2	IPI	UniProtKB:Q28022	Human	PMID:15131124
Molecular Function	GO:0005515	protein binding	FBN2	IPI	UniProtKB:O95393	Human	PMID:18339631
Molecular Function	GO:0005515	protein binding	FBN2	IPI	UniProtKB:P12643	Human	PMID:18339631
Molecular Function	GO:0005515	protein binding	FBN2	IPI	UniProtKB:P12644	Human	PMID:18339631
Molecular Function	GO:0005515	protein binding	FBN2	IPI	UniProtKB:P18075	Human	PMID:18339631
Molecular Function	GO:0005515	protein binding	FBN2	IPI	UniProtKB:P43026	Human	PMID:18339631
Molecular Function	GO:0005515	protein binding	FBN2	IPI	UniProtKB:P02751	Human	PMID:25034023
Molecular Function	GO:0005515	protein binding	FBN2	IPI	UniProtKB:P35555	Human	PMID:25034023
Molecular Function	GO:0005515	protein binding	FBN2	IPI	UniProtKB:P55083	Human	PMID:26601954
Molecular Function	GO:0005515	protein binding	Fbn2	IPI	PR:Q7TSK7	Mouse	PMID:25762570
Cellular Component	GO:0062023	collagen-containing extracellular matrix	FBN2	HDA		Human	PMID:23658023
Cellular Component	GO:0062023	collagen-containing extracellular matrix	FBN2	HDA		Human	PMID:28327460
Cellular Component	GO:0062023	collagen-containing extracellular matrix	FBN2	HDA		Human	PMID:28675934
Cellular Component	GO:0062023	collagen-containing extracellular matrix	Fbn2	HDA		Mouse	MGI:MGI:6201853|PMID:28071719
Cellular Component	GO:0062023	collagen-containing extracellular matrix	Fbn2	HDA		Mouse	MGI:MGI:5582867|PMID:23658023
Cellular Component	GO:0005576	extracellular region	Fbn2	IDA		Mouse	PMID:24348270
Cellular Component	GO:0001527	microfibril	FBN2	IDA		Human	PMID:8120105
Cellular Component	GO:0001527	microfibril	Fbn2	IDA		Mouse	PMID:24348270
Cellular Component	GO:0001527	microfibril	Fbn2	IDA		Mouse	PMID:26405179
Biological Process	GO:0060346	bone trabecula formation	Fbn2	IMP		Mouse	MGI:MGI:4836762|PMID:20855508
Biological Process	GO:0043010	camera-type eye development	FBN2	IEP		Human	PMID:25406291
Biological Process	GO:0007155	cell adhesion	fbn2b	IGI	ZFIN:ZDB-GENO-130718-5	Zfish	PMID:22841646
Biological Process	GO:0048048	embryonic eye morphogenesis	FBN2	IEP		Human	PMID:25406291
Biological Process	GO:0030326	embryonic limb morphogenesis	Fbn2	IMP	MGI:MGI:1935122	Mouse	PMID:11285249
Biological Process	GO:0030326	embryonic limb morphogenesis	Fbn2	IMP	MGI:MGI:1935123	Mouse	PMID:11285249
Biological Process	GO:0030326	embryonic limb morphogenesis	Fbn2	IMP	MGI:MGI:2157491	Mouse	PMID:11350121
Biological Process	GO:0060958	endocardial cell development	fbn2b	IGI	ZFIN:ZDB-GENO-130718-5	Zfish	PMID:23418350
Biological Process	GO:0003160	endocardium morphogenesis	fbn2b	IGI	ZFIN:ZDB-GENO-130718-5	Zfish	PMID:22841646
Biological Process	GO:0042593	glucose homeostasis	Fbn2	IDA		Mouse	MGI:MGI:6448811|PMID:32329225
Biological Process	GO:0003007	heart morphogenesis	fbn2b	IGI	ZFIN:ZDB-GENO-130718-5	Zfish	PMID:9007249
Biological Process	GO:0003007	heart morphogenesis	fbn2b	IMP	ZFIN:ZDB-GENO-070808-31	Zfish	PMID:9007249
Biological Process	GO:0035108	limb morphogenesis	Fbn2	IMP	MGI:MGI:2157491	Mouse	PMID:10700192
Biological Process	GO:0048570	notochord morphogenesis	fbn2b	IMP	ZFIN:ZDB-GENO-090113-1	Zfish	PMID:18816837
Biological Process	GO:0048570	notochord morphogenesis	fbn2b	IMP	ZFIN:ZDB-MRPHLNO-090112-2	Zfish	PMID:18816837
Biological Process	GO:0048570	notochord morphogenesis	fbn2b	IGI	ZFIN:ZDB-GENO-090113-1,ZFIN:ZDB-MRPHLNO-070919-4	Zfish	PMID:18816837
Biological Process	GO:0048570	notochord morphogenesis	fbn2b	IMP	ZFIN:ZDB-MRPHLNO-090112-3	Zfish	PMID:18816837
Biological Process	GO:0030501	positive regulation of bone mineralization	Fbn2	IMP		Mouse	MGI:MGI:4836762|PMID:20855508
Biological Process	GO:0045669	positive regulation of osteoblast differentiation	Fbn2	IMP		Mouse	MGI:MGI:4836762|PMID:20855508
Biological Process	GO:0003250	regulation of cell proliferation involved in heart valve morphogenesis	fbn2b	IGI	ZFIN:ZDB-GENO-130718-5	Zfish	PMID:23418350
Biological Process	GO:0035583	sequestering of TGFbeta in extracellular matrix	Fbn2	IMP		Mouse	MGI:MGI:4836762|PMID:20855508
Biological Process	GO:0001570	vasculogenesis	fbn2b	IMP	ZFIN:ZDB-MRPHLNO-090112-3	Zfish	PMID:18816837
Biological Process	GO:0001570	vasculogenesis	fbn2b	IMP	ZFIN:ZDB-GENO-090113-1	Zfish	PMID:18816837
Biological Process	GO:0001570	vasculogenesis	fbn2b	IMP	ZFIN:ZDB-MRPHLNO-090112-2	Zfish	PMID:18816837

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern