Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes FBXO5
  • Mouse genes Fbxo5
  • Rat genes Fbxo5
  • Zfish genes fbxo5
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Fbxo5

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0010997	anaphase-promoting complex binding	FBXO5	IDA		Human	PMID:16921029
Molecular Function	GO:0010997	anaphase-promoting complex binding	FBXO5	IDA		Human	PMID:26083744
Molecular Function	GO:0140678	molecular function inhibitor activity	FBXO5	IDA		Human	PMID:23708605
Molecular Function	GO:0140678	molecular function inhibitor activity	FBXO5	IMP		Human	PMID:23708605
Molecular Function	GO:0005515	protein binding	FBXO5	IPI	UniProtKB:Q12834	Human	PMID:11988738
Molecular Function	GO:0005515	protein binding	FBXO5	IPI	UniProtKB:Q9UM11	Human	PMID:11988738
Molecular Function	GO:0005515	protein binding	FBXO5	IPI	UniProtKB:Q9Y297	Human	PMID:12791267
Molecular Function	GO:0005515	protein binding	FBXO5	IPI	UniProtKB:O60447	Human	PMID:16439210
Molecular Function	GO:0005515	protein binding	FBXO5	IPI	UniProtKB:Q9UM11	Human	PMID:16921029
Molecular Function	GO:0005515	protein binding	FBXO5	IPI	UniProtKB:P63208	Human	PMID:17380122
Molecular Function	GO:0005515	protein binding	FBXO5	IPI	UniProtKB:P30260	Human	PMID:17719540
Molecular Function	GO:0005515	protein binding	FBXO5	IPI	UniProtKB:P30260	Human	PMID:18662541
Molecular Function	GO:0005515	protein binding	FBXO5	IPI	UniProtKB:O75496|UniProtKB:P30260|UniProtKB:Q9UJX2|UniProtKB:Q9UJX6|UniProtKB:Q9UM11	Human	PMID:23708001
Molecular Function	GO:0005515	protein binding	FBXO5	IPI	UniProtKB:P63208	Human	PMID:27705803
Molecular Function	GO:0005515	protein binding	FBXO5	IPI	UniProtKB:P63208	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Fbxo5	IPI	PR:Q9WUT3	Mouse	PMID:15526037
Molecular Function	GO:0005515	protein binding	Fbxo5	IPI	PR:Q9JJ66	Mouse	PMID:15526037
Molecular Function	GO:0019901	protein kinase binding	FBXO5	IPI	UniProtKB:P06493	Human	PMID:15148369
Molecular Function	GO:0019901	protein kinase binding	FBXO5	IPI	UniProtKB:P53350	Human	PMID:15148369
Molecular Function	GO:1990948	ubiquitin ligase inhibitor activity	FBXO5	IDA		Human	PMID:15148369
Cellular Component	GO:0005737	cytoplasm	FBXO5	IDA		Human	PMID:11988738
Cellular Component	GO:0005737	cytoplasm	Fbxo5	IDA		Mouse	PMID:15526037
Cellular Component	GO:0072687	meiotic spindle	Fbxo5	IDA		Mouse	MGI:MGI:3521521|PMID:15526037
Cellular Component	GO:0005654	nucleoplasm	FBXO5	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	FBXO5	IDA		Human	PMID:11988738
Cellular Component	GO:0005819	spindle	FBXO5	IDA		Human	PMID:15469984
Biological Process	GO:0051301	cell division	fbxo5	IMP	ZFIN:ZDB-GENO-130618-3	Zfish	PMID:20146251
Biological Process	GO:0051276	chromosome organization	fbxo5	IMP	ZFIN:ZDB-GENO-110811-1	Zfish	PMID:19704007
Biological Process	GO:0006974	DNA damage response	FBXO5	IMP		Human	PMID:17875940
Biological Process	GO:0030097	hemopoiesis	fbxo5	IMP	ZFIN:ZDB-GENO-110811-1	Zfish	PMID:19704007
Biological Process	GO:0046785	microtubule polymerization	Fbxo5	IDA		Mouse	PMID:17190794
Biological Process	GO:0000278	mitotic cell cycle	fbxo5	IMP	ZFIN:ZDB-MRPHLNO-121203-1	Zfish	PMID:23082190
Biological Process	GO:0000281	mitotic cytokinesis	fbxo5	IMP	ZFIN:ZDB-GENO-130618-3	Zfish	PMID:20146251
Biological Process	GO:2000773	negative regulation of cellular senescence	FBXO5	IMP		Human	PMID:17875940
Biological Process	GO:0032876	negative regulation of DNA endoreduplication	FBXO5	IMP		Human	PMID:17875940
Biological Process	GO:0045835	negative regulation of meiotic nuclear division	Fbxo5	IDA		Mouse	PMID:15526037
Biological Process	GO:0045841	negative regulation of mitotic metaphase/anaphase transition	FBXO5	IDA		Human	PMID:11988738
Biological Process	GO:0045841	negative regulation of mitotic metaphase/anaphase transition	FBXO5	IDA		Human	PMID:16921029
Biological Process	GO:0045839	negative regulation of mitotic nuclear division	fbxo5	IMP	ZFIN:ZDB-GENO-081024-7	Zfish	PMID:18480162
Biological Process	GO:1904667	negative regulation of ubiquitin protein ligase activity	FBXO5	IDA		Human	PMID:11988738
Biological Process	GO:1904667	negative regulation of ubiquitin protein ligase activity	FBXO5	IDA		Human	PMID:16921029
Biological Process	GO:1904667	negative regulation of ubiquitin protein ligase activity	FBXO5	IMP		Human	PMID:23708605
Biological Process	GO:1904667	negative regulation of ubiquitin protein ligase activity	FBXO5	IMP		Human	PMID:29875408
Biological Process	GO:0051444	negative regulation of ubiquitin-protein transferase activity	FBXO5	IDA		Human	PMID:23708001
Biological Process	GO:0001556	oocyte maturation	Fbxo5	IDA		Mouse	PMID:15526037
Biological Process	GO:0001556	oocyte maturation	Fbxo5	IMP		Mouse	PMID:15526037
Biological Process	GO:0070169	positive regulation of biomineral tissue development	FBXO5	IMP		Human	PMID:29850565
Biological Process	GO:0008284	positive regulation of cell population proliferation	FBXO5	IMP		Human	PMID:17234884
Biological Process	GO:0010971	positive regulation of G2/M transition of mitotic cell cycle	FBXO5	IMP		Human	PMID:17485488
Biological Process	GO:1905322	positive regulation of mesenchymal stem cell migration	FBXO5	IMP		Human	PMID:29850565
Biological Process	GO:0045669	positive regulation of osteoblast differentiation	FBXO5	IMP		Human	PMID:29850565
Biological Process	GO:0051726	regulation of cell cycle	fbxo5	IMP	ZFIN:ZDB-GENO-110811-1,ZFIN:ZDB-GENO-121004-3	Zfish	PMID:19704007
Biological Process	GO:0006275	regulation of DNA replication	FBXO5	IMP		Human	PMID:17234884
Biological Process	GO:0006275	regulation of DNA replication	FBXO5	IMP		Human	PMID:17485488
Biological Process	GO:0040020	regulation of meiotic nuclear division	Fbxo5	IDA		Mouse	PMID:17190794
Biological Process	GO:0007346	regulation of mitotic cell cycle	Fbxo5	IMP		Mouse	MGI:MGI:3640016|PMID:16809773
Biological Process	GO:0051225	spindle assembly	Fbxo5	IDA		Mouse	PMID:17190794
Biological Process	GO:0007057	spindle assembly involved in female meiosis I	Fbxo5	IDA		Mouse	PMID:17190794
Biological Process	GO:0016050	vesicle organization	Fbxo5	IDA		Mouse	PMID:17190794

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern