Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes FCER1A
  • Mouse genes Fcer1a
  • Rat genes Fcer1a
  • Zfish genes zgc:154125
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Fcer1a

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0019768	high-affinity IgE receptor activity	FCER1A	IDA		Human	PMID:8114916
Molecular Function	GO:0019768	high-affinity IgE receptor activity	FCER1A	IDA		Human	PMID:8551243
Molecular Function	GO:0019863	IgE binding	FCER1A	IDA		Human	PMID:10917520
Molecular Function	GO:0019863	IgE binding	Fcer1a	IMP	MGI:MGI:2383982	Mouse	PMID:8252632
Molecular Function	GO:0019863	IgE binding	Fcer1a	IDA		Mouse	PMID:2527850
Molecular Function	GO:0019767	IgE receptor activity	Fcer1a	IDA		Mouse	PMID:9000133
Molecular Function	GO:0019767	IgE receptor activity	Fcer1a	IMP	MGI:MGI:2383982	Mouse	PMID:8252632
Molecular Function	GO:0005515	protein binding	FCER1A	IPI	UniProtKB:P01854	Human	PMID:10917520
Molecular Function	GO:0005515	protein binding	FCER1A	IPI	UniProtKB:Q14696	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Fcer1a	IPI	PR:P49710	Mouse	PMID:7506729
Cellular Component	GO:0009986	cell surface	FCER1A	IDA		Human	PMID:1535625
Cellular Component	GO:0009897	external side of plasma membrane	Fcer1a	IDA		Mouse	PMID:9000133
Cellular Component	GO:0009897	external side of plasma membrane	Fcer1a	IDA		Mouse	PMID:2527850
Cellular Component	GO:0005886	plasma membrane	FCER1A	IDA		Human	PMID:8114916
Cellular Component	GO:0005886	plasma membrane	FCER1A	IDA		Human	PMID:8551243
Cellular Component	GO:0005886	plasma membrane	Fcer1a	IDA		Mouse	PMID:2527850
Biological Process	GO:0019722	calcium-mediated signaling	Fcer1a	IDA		Mouse	PMID:9000133
Biological Process	GO:0007166	cell surface receptor signaling pathway	Fcer1a	IDA		Mouse	PMID:9000133
Biological Process	GO:0007166	cell surface receptor signaling pathway	Fcer1a	IMP	MGI:MGI:2383982	Mouse	PMID:8252632
Biological Process	GO:0043308	eosinophil degranulation	FCER1A	IDA		Human	PMID:8114916
Biological Process	GO:0051649	establishment of localization in cell	Fcer1a	IDA		Mouse	PMID:9000133
Biological Process	GO:0038095	Fc-epsilon receptor signaling pathway	Fcer1a	IMP	MGI:MGI:2383982	Mouse	MGI:MGI:86632|PMID:8252632
Biological Process	GO:0032604	granulocyte macrophage colony-stimulating factor production	Fcer1a	IDA		Mouse	PMID:9000133
Biological Process	GO:0032632	interleukin-3 production	Fcer1a	IDA		Mouse	PMID:9000133
Biological Process	GO:0019370	leukotriene biosynthetic process	Fcer1a	IDA		Mouse	PMID:9000133
Biological Process	GO:0032762	mast cell cytokine production	Fcer1a	IDA		Mouse	PMID:9000133
Biological Process	GO:0043303	mast cell degranulation	FCER1A	IMP		Human	PMID:8551243
Biological Process	GO:0043303	mast cell degranulation	Fcer1a	IDA		Mouse	PMID:9000133
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	Fcer1a	IDA		Mouse	PMID:9000133
Biological Process	GO:0050850	positive regulation of calcium-mediated signaling	Fcer1a	IDA		Mouse	PMID:9000133
Biological Process	GO:0032725	positive regulation of granulocyte macrophage colony-stimulating factor production	Fcer1a	IDA		Mouse	PMID:9000133
Biological Process	GO:0032752	positive regulation of interleukin-3 production	Fcer1a	IDA		Mouse	PMID:9000133
Biological Process	GO:0043507	positive regulation of JUN kinase activity	Fcer1a	IDA		Mouse	PMID:9000133
Biological Process	GO:0043406	positive regulation of MAP kinase activity	Fcer1a	IDA		Mouse	PMID:9000133
Biological Process	GO:0032765	positive regulation of mast cell cytokine production	Fcer1a	IDA		Mouse	PMID:9000133
Biological Process	GO:0043306	positive regulation of mast cell degranulation	Fcer1a	IDA		Mouse	PMID:9000133
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	Fcer1a	IDA		Mouse	PMID:7506729
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	Fcer1a	IDA		Mouse	PMID:9000133
Biological Process	GO:0001812	positive regulation of type I hypersensitivity	Fcer1a	IMP	MGI:MGI:2383982	Mouse	PMID:8252632
Biological Process	GO:0001820	serotonin secretion	Fcer1a	IDA		Mouse	PMID:9000133
Biological Process	GO:0001820	serotonin secretion	Fcer1a	IMP	MGI:MGI:2383982	Mouse	PMID:8252632
Biological Process	GO:0007165	signal transduction	Fcer1a	IDA		Mouse	PMID:12192036
Biological Process	GO:0042092	type 2 immune response	FCER1A	IDA		Human	PMID:8114916
Biological Process	GO:0016068	type I hypersensitivity	FCER1A	IMP		Human	PMID:8551243

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern