Comparative GO Graph (mouse, human, rat)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Fcgr2b

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes FCGR2A,FCGR2B,FCGR2C
- Mouse genes Fcgr2b
- Rat genes Fcgr2b
- Zfish genes
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Fcgr2b

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0001540	amyloid-beta binding	FCGR2B	IPI	UniProtKB:P05067:PRO_0000000092	Human	PMID:23921129
Molecular Function	GO:0019864	IgG binding	FCGR2B	IDA		Human	PMID:2142460
Molecular Function	GO:0019864	IgG binding	Fcgr2b	IDA		Mouse	PMID:9551950
Molecular Function	GO:0019864	IgG binding	Fcgr2b	IDA		Rat	PMID:7590913\|RGD:9588567
Molecular Function	GO:0019865	immunoglobulin binding	Fcgr2b	IDA		Rat	PMID:18295888\|RGD:9588565
Molecular Function	GO:0019772	low-affinity IgG receptor activity	FCGR2B	IDA		Human	PMID:2142460
Molecular Function	GO:0005515	protein binding	FCGR2A	IPI	UniProtKB:Q9UMX0	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	FCGR2A	IPI	UniProtKB:Q9UMX0-2	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	FCGR2B	IPI	UniProtKB:Q92835	Human	PMID:10382761
Molecular Function	GO:0005515	protein binding	FCGR2B	IPI	UniProtKB:P01857	Human	PMID:11567028
Molecular Function	GO:0005515	protein binding	FCGR2B	IPI	UniProtKB:P16333	Human	PMID:17474147
Molecular Function	GO:0005515	protein binding	FCGR2B	IPI	UniProtKB:P19174	Human	PMID:17474147
Molecular Function	GO:0005515	protein binding	FCGR2B	IPI	UniProtKB:Q92835	Human	PMID:24642916
Molecular Function	GO:0005515	protein binding	FCGR2B	IPI	UniProtKB:Q92876	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	FCGR2B	IPI	UniProtKB:P29350	Human	PMID:8577729
Molecular Function	GO:0005515	protein binding	FCGR2B	IPI	UniProtKB:P29350	Human	PMID:9148918
Molecular Function	GO:0005515	protein binding	FCGR2B	IPI	UniProtKB:Q92835	Human	PMID:9148918
Molecular Function	GO:0005515	protein binding	FCGR2B	IPI	UniProtKB:P29350	Human	PMID:9603468
Molecular Function	GO:0005515	protein binding	FCGR2C	IPI	UniProtKB:P16333	Human	PMID:17474147
Molecular Function	GO:0005515	protein binding	FCGR2C	IPI	UniProtKB:P02741	Human	PMID:17785206
Molecular Function	GO:0005515	protein binding	Fcgr2b	IPI	PR:Q9ES52	Mouse	PMID:12893283
Molecular Function	GO:0044877	protein-containing complex binding	FCGR2B	IPI	ComplexPortal:CPX-1134	Human	PMID:23921129
Cellular Component	GO:0044297	cell body	Fcgr2b	IDA		Mouse	MGI:MGI:3718938\|PMID:17502348
Cellular Component	GO:0009986	cell surface	Fcgr2b	IDA		Rat	PMID:18295888\|RGD:9588565
Cellular Component	GO:0043197	dendritic spine	Fcgr2b	IDA		Mouse	MGI:MGI:3718938\|PMID:17502348
Cellular Component	GO:0009897	external side of plasma membrane	Fcgr2b	IDA		Mouse	PMID:8552190
Cellular Component	GO:0009897	external side of plasma membrane	Fcgr2b	IDA		Mouse	PMID:8769481
Cellular Component	GO:0005794	Golgi apparatus	FCGR2A	IDA		Human	GO_REF:0000052
Cellular Component	GO:0016020	membrane	Fcgr2b	IDA		Mouse	PMID:8552190
Cellular Component	GO:0045121	membrane raft	Fcgr2b	IDA		Rat	PMID:17680646\|RGD:9588617
Cellular Component	GO:0005886	plasma membrane	FCGR2A	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	FCGR2B	IDA		Human	PMID:2142460
Cellular Component	GO:0005886	plasma membrane	FCGR2B	IDA		Human	PMID:23921129
Cellular Component	GO:0005886	plasma membrane	Fcgr2b	IDA		Mouse	MGI:MGI:3718938\|PMID:17502348
Cellular Component	GO:0005886	plasma membrane	Fcgr2b	IDA		Mouse	MGI:MGI:5904203\|PMID:28389502
Cellular Component	GO:0055037	recycling endosome	Fcgr2b	IDA		Rat	PMID:17680646\|RGD:9588617
Biological Process	GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II	Fcgr2b	IMP	MGI:MGI:1857166	Mouse	PMID:14643301
Biological Process	GO:0042100	B cell proliferation	Fcgr2b	IMP	MGI:MGI:1857166	Mouse	PMID:12385742
Biological Process	GO:0007166	cell surface receptor signaling pathway	Fcgr2b	IMP	MGI:MGI:1857166	Mouse	PMID:8552190
Biological Process	GO:1904646	cellular response to amyloid-beta	Fcgr2b	IMP		Mouse	MGI:MGI:5514474\|PMID:23921129
Biological Process	GO:1904646	cellular response to amyloid-beta	Fcgr2b	IMP		Rat	PMID:23921129\|RGD:12910988
Biological Process	GO:0071222	cellular response to lipopolysaccharide	Fcgr2b	IEP		Rat	PMID:19106808\|RGD:5147925
Biological Process	GO:0071219	cellular response to molecule of bacterial origin	Fcgr2b	IMP	MGI:MGI:1857166	Mouse	PMID:12385742
Biological Process	GO:0021549	cerebellum development	Fcgr2b	IMP		Mouse	MGI:MGI:3718938\|PMID:17502348
Biological Process	GO:0006952	defense response	Fcgr2b	IMP	MGI:MGI:1857166	Mouse	PMID:11994421
Biological Process	GO:0016358	dendrite development	Fcgr2b	IMP		Mouse	MGI:MGI:3718938\|PMID:17502348
Biological Process	GO:0032456	endocytic recycling	Fcgr2b	IDA		Rat	PMID:17680646\|RGD:9588617
Biological Process	GO:0051649	establishment of localization in cell	Fcgr2b	IMP	MGI:MGI:1857166	Mouse	PMID:12385742
Biological Process	GO:0160006	Fc receptor-mediated immune complex endocytosis	Fcgr2b	IDA		Mouse	MGI:MGI:5904203\|PMID:28389502
Biological Process	GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis	FCGR2B	IDA		Human	PMID:2142460
Biological Process	GO:0002434	immune complex clearance	Fcgr2b	IDA		Rat	PMID:17680646\|RGD:9588617
Biological Process	GO:0016064	immunoglobulin mediated immune response	Fcgr2b	IMP	MGI:MGI:1857166	Mouse	PMID:10395649
Biological Process	GO:0016064	immunoglobulin mediated immune response	Fcgr2b	IMP	MGI:MGI:1857166	Mouse	PMID:14643301
Biological Process	GO:0002377	immunoglobulin production	Fcgr2b	IMP	MGI:MGI:1857166	Mouse	PMID:12385742
Biological Process	GO:0032613	interleukin-10 production	Fcgr2b	IMP	MGI:MGI:1857166	Mouse	PMID:12385742
Biological Process	GO:0002865	negative regulation of acute inflammatory response to antigenic stimulus	Fcgr2b	IMP	MGI:MGI:1857166	Mouse	PMID:12385742
Biological Process	GO:0030889	negative regulation of B cell proliferation	Fcgr2b	IMP	MGI:MGI:1857166	Mouse	PMID:12385742
Biological Process	GO:0030889	negative regulation of B cell proliferation	Fcgr2b	IMP	MGI:MGI:1857166	Mouse	PMID:8552190
Biological Process	GO:0050859	negative regulation of B cell receptor signaling pathway	FCGR2B	IMP		Human	PMID:24169826
Biological Process	GO:0002924	negative regulation of humoral immune response mediated by circulating immunoglobulin	Fcgr2b	IMP	MGI:MGI:1857166	Mouse	PMID:12385742
Biological Process	GO:0050777	negative regulation of immune response	Fcgr2b	IMP	MGI:MGI:1857166	Mouse	PMID:10395649
Biological Process	GO:0050777	negative regulation of immune response	Fcgr2b	IMP	MGI:MGI:1857166	Mouse	PMID:8552190
Biological Process	GO:0050777	negative regulation of immune response	Fcgr2b	IMP	MGI:MGI:1857166	Mouse	PMID:11994421
Biological Process	GO:0002638	negative regulation of immunoglobulin production	Fcgr2b	IMP	MGI:MGI:1857166	Mouse	PMID:12385742
Biological Process	GO:0002862	negative regulation of inflammatory response to antigenic stimulus	Fcgr2b	IMP	MGI:MGI:1857166	Mouse	PMID:16492738
Biological Process	GO:0032693	negative regulation of interleukin-10 production	Fcgr2b	IMP	MGI:MGI:1857166	Mouse	PMID:12385742
Biological Process	GO:0033030	negative regulation of neutrophil apoptotic process	Fcgr2b	IMP		Rat	PMID:19106808\|RGD:5147925
Biological Process	GO:0050765	negative regulation of phagocytosis	Fcgr2b	IMP	MGI:MGI:1857166	Mouse	PMID:12385742
Biological Process	GO:0001811	negative regulation of type I hypersensitivity	Fcgr2b	IMP	MGI:MGI:1857166	Mouse	PMID:8552190
Biological Process	GO:0006909	phagocytosis	Fcgr2b	IMP	MGI:MGI:1857166	Mouse	PMID:12385742
Biological Process	GO:0006911	phagocytosis, engulfment	Fcgr2b	IDA		Mouse	PMID:8769481
Biological Process	GO:0051091	positive regulation of DNA-binding transcription factor activity	Fcgr2b	IMP		Mouse	MGI:MGI:5514474\|PMID:23921129
Biological Process	GO:0046330	positive regulation of JNK cascade	Fcgr2b	IMP		Mouse	MGI:MGI:5514474\|PMID:23921129
Biological Process	GO:1901216	positive regulation of neuron death	Fcgr2b	IMP		Mouse	MGI:MGI:5514474\|PMID:23921129
Biological Process	GO:1901216	positive regulation of neuron death	Fcgr2b	IMP		Rat	PMID:23921129\|RGD:12910988
Biological Process	GO:0050766	positive regulation of phagocytosis	Fcgr2b	IDA		Mouse	PMID:8769481
Biological Process	GO:1905898	positive regulation of response to endoplasmic reticulum stress	Fcgr2b	IMP		Mouse	MGI:MGI:5514474\|PMID:23921129
Biological Process	GO:1905898	positive regulation of response to endoplasmic reticulum stress	Fcgr2b	IMP		Rat	PMID:23921129\|RGD:12910988
Biological Process	GO:0006898	receptor-mediated endocytosis	FCGR2B	IDA		Human	PMID:2142460
Biological Process	GO:0006898	receptor-mediated endocytosis	Fcgr2b	IDA		Rat	PMID:17680646\|RGD:9588617
Biological Process	GO:1902950	regulation of dendritic spine maintenance	FCGR2B	IGI	UniProtKB:P05067:PRO_0000000092	Human	PMID:23921129
Biological Process	GO:1902950	regulation of dendritic spine maintenance	Fcgr2b	IMP		Mouse	MGI:MGI:5514474\|PMID:23921129
Biological Process	GO:0048169	regulation of long-term neuronal synaptic plasticity	Fcgr2b	IMP		Mouse	MGI:MGI:5514474\|PMID:23921129
Biological Process	GO:0009617	response to bacterium	Fcgr2b	IMP	MGI:MGI:1857166	Mouse	PMID:12385742
Biological Process	GO:0032355	response to estradiol	Fcgr2b	IEP		Rat	PMID:21774811\|RGD:9588605

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.