Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes FCGR3A,FCGR3B
  • Mouse genes Fcgr4
  • Rat genes Fcgr3a
  • Zfish genes zgc:154125
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Fcgr4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0034235	GPI anchor binding	FCGR3B	IDA		Human	PMID:1825220
Molecular Function	GO:0019767	IgE receptor activity	Fcgr4	IDA		Mouse	MGI:MGI:3718147|PMID:17558411
Molecular Function	GO:0019767	IgE receptor activity	Fcgr4	IDA		Mouse	MGI:MGI:3831439|PMID:18949059
Molecular Function	GO:0019770	IgG receptor activity	Fcgr4	IDA		Mouse	MGI:MGI:3718147|PMID:17558411
Molecular Function	GO:0019770	IgG receptor activity	Fcgr4	IDA		Mouse	MGI:MGI:3588817|PMID:16039578
Molecular Function	GO:0140375	immune receptor activity	FCGR3A	IDA		Human	PMID:10318937
Molecular Function	GO:0019772	low-affinity IgG receptor activity	FCGR3A	IDA		Human	PMID:11711607
Molecular Function	GO:0005515	protein binding	FCGR3A	IPI	UniProtKB:P06729	Human	PMID:23006327
Molecular Function	GO:0005515	protein binding	FCGR3A	IPI	UniProtKB:P26447	Human	PMID:23024279
Molecular Function	GO:0005515	protein binding	FCGR3A	IPI	UniProtKB:P20963	Human	PMID:2532305
Molecular Function	GO:0005515	protein binding	FCGR3A	IPI	UniProtKB:Q99706	Human	PMID:34158475
Cellular Component	GO:0009986	cell surface	Fcgr4	IDA		Mouse	MGI:MGI:3718147|PMID:17558411
Cellular Component	GO:0009986	cell surface	Fcgr3a	IDA		Rat	PMID:19106808|RGD:5147925
Cellular Component	GO:0009897	external side of plasma membrane	FCGR3A	IDA		Human	PMID:10706735
Cellular Component	GO:0009897	external side of plasma membrane	FCGR3A	IDA		Human	PMID:24942581
Cellular Component	GO:0070062	extracellular exosome	FCGR3B	HDA		Human	PMID:23533145
Cellular Component	GO:0070062	extracellular exosome	FCGR3A	HDA		Human	PMID:23533145
Cellular Component	GO:0005615	extracellular space	FCGR3A	IDA		Human	PMID:24337742
Cellular Component	GO:0033001	Fc-gamma receptor III complex	FCGR3A	IDA		Human	PMID:1825220
Cellular Component	GO:0033001	Fc-gamma receptor III complex	FCGR3A	IDA		Human	PMID:28652325
Cellular Component	GO:0005886	plasma membrane	FCGR3B	IDA		Human	PMID:1825220
Cellular Component	GO:0005886	plasma membrane	FCGR3A	IDA		Human	PMID:1825220
Cellular Component	GO:0005886	plasma membrane	FCGR3A	IDA		Human	PMID:23006327
Cellular Component	GO:0005886	plasma membrane	FCGR3A	IDA		Human	PMID:24337742
Cellular Component	GO:0005886	plasma membrane	FCGR3A	IDA		Human	PMID:2532305
Cellular Component	GO:0005886	plasma membrane	FCGR3A	IDA		Human	PMID:27670158
Cellular Component	GO:0005886	plasma membrane	FCGR3A	IDA		Human	PMID:28652325
Cellular Component	GO:0005886	plasma membrane	Fcgr4	IDA		Mouse	MGI:MGI:5904203|PMID:28389502
Biological Process	GO:0001788	antibody-dependent cellular cytotoxicity	FCGR3A	IDA		Human	PMID:11711607
Biological Process	GO:0001788	antibody-dependent cellular cytotoxicity	FCGR3A	IDA		Human	PMID:27670158
Biological Process	GO:0001788	antibody-dependent cellular cytotoxicity	FCGR3A	IDA		Human	PMID:28652325
Biological Process	GO:0019722	calcium-mediated signaling	FCGR3A	IDA		Human	PMID:23024279
Biological Process	GO:0071222	cellular response to lipopolysaccharide	Fcgr3a	IDA		Rat	PMID:19106808|RGD:5147925
Biological Process	GO:0002468	dendritic cell antigen processing and presentation	Fcgr4	IMP		Mouse	MGI:MGI:5904203|PMID:28389502
Biological Process	GO:0160006	Fc receptor-mediated immune complex endocytosis	Fcgr4	IDA		Mouse	MGI:MGI:5904203|PMID:28389502
Biological Process	GO:0038094	Fc-gamma receptor signaling pathway	FCGR3A	IDA		Human	PMID:23024279
Biological Process	GO:0038094	Fc-gamma receptor signaling pathway	FCGR3A	IDA		Human	PMID:8478617
Biological Process	GO:0042116	macrophage activation	FCGR3A	IDA		Human	PMID:10728755
Biological Process	GO:0030101	natural killer cell activation	FCGR3A	IMP		Human	PMID:23006327
Biological Process	GO:0030101	natural killer cell activation	FCGR3A	IDA		Human	PMID:9916693
Biological Process	GO:0043320	natural killer cell degranulation	FCGR3A	IDA		Human	PMID:25786175
Biological Process	GO:0043320	natural killer cell degranulation	FCGR3A	IDA		Human	PMID:28652325
Biological Process	GO:0042267	natural killer cell mediated cytotoxicity	FCGR3A	IDA		Human	PMID:10318937
Biological Process	GO:0042267	natural killer cell mediated cytotoxicity	FCGR3A	IDA		Human	PMID:23006327
Biological Process	GO:0042119	neutrophil activation	Fcgr4	IMP		Mouse	MGI:MGI:3772527|PMID:18097064
Biological Process	GO:0014065	phosphatidylinositol 3-kinase signaling	FCGR3A	IDA		Human	PMID:23024279
Biological Process	GO:0045780	positive regulation of bone resorption	Fcgr4	IMP		Mouse	MGI:MGI:5641770|PMID:25824719
Biological Process	GO:0032819	positive regulation of natural killer cell proliferation	FCGR3A	IDA		Human	PMID:9916693
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	FCGR3A	IDA		Human	PMID:10728755
Biological Process	GO:0051930	regulation of sensory perception of pain	Fcgr3a	IMP		Rat	PMID:20589683|RGD:5508377
Biological Process	GO:0042060	wound healing	Fcgr3a	IEP		Rat	PMID:16939567|RGD:2316289

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern