Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes FDX1
  • Mouse genes Fdx1
  • Rat genes Fdx1
  • Zfish genes fdx1,fdx1b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Fdx1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0051537	2 iron, 2 sulfur cluster binding	FDX1	IDA		Human	PMID:21636783
Molecular Function	GO:0008386	cholesterol monooxygenase (side-chain-cleaving) activity	Fdx1	IDA		Rat	PMID:8789462|RGD:2326068
Molecular Function	GO:0009055	electron transfer activity	FDX1	IDA		Human	PMID:21636783
Molecular Function	GO:0009055	electron transfer activity	Fdx1	IDA		Rat	PMID:8789462|RGD:2326068
Molecular Function	GO:0019899	enzyme binding	Fdx1	IPI	RGD:621648	Rat	PMID:10525147|RGD:727285
Molecular Function	GO:0005506	iron ion binding	Fdx1	IDA		Rat	PMID:8789462|RGD:2326068
Molecular Function	GO:0015039	NADPH-adrenodoxin reductase activity	Fdx1	IDA		Rat	PMID:8789462|RGD:2326068
Cellular Component	GO:0030061	mitochondrial crista	Fdx1	IDA		Rat	PMID:16139340|RGD:4145663
Cellular Component	GO:0005759	mitochondrial matrix	Fdx1	IDA		Rat	PMID:2170421|RGD:13506267
Cellular Component	GO:0005739	mitochondrion	FDX1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005739	mitochondrion	Fdx1	HDA		Mouse	PMID:14651853
Cellular Component	GO:0005739	mitochondrion	Fdx1	HDA		Mouse	PMID:18614015
Cellular Component	GO:0005739	mitochondrion	Fdx1	IDA		Rat	PMID:8789462|RGD:2326068
Biological Process	GO:0030325	adrenal gland development	Fdx1	IEP		Rat	PMID:8097866|RGD:4145970
Biological Process	GO:0071320	cellular response to cAMP	Fdx1	IDA		Mouse	PMID:7495857
Biological Process	GO:0071872	cellular response to epinephrine stimulus	Fdx1	IEP		Rat	PMID:11064152|RGD:4145763
Biological Process	GO:1904322	cellular response to forskolin	Fdx1	IDA		Mouse	PMID:7495857
Biological Process	GO:0044320	cellular response to leptin stimulus	Fdx1	IEP		Rat	PMID:10098510|RGD:4145764
Biological Process	GO:0071407	cellular response to organic cyclic compound	Fdx1	IEP		Rat	PMID:11064152|RGD:4145763
Biological Process	GO:0008203	cholesterol metabolic process	FDX1	IDA		Human	PMID:21636783
Biological Process	GO:0034651	cortisol biosynthetic process	fdx1b	IMP	ZFIN:ZDB-GENO-151019-2	Zfish	PMID:30266295
Biological Process	GO:0034651	cortisol biosynthetic process	fdx1b	IMP	ZFIN:ZDB-GENO-151019-2	Zfish	PMID:26650568
Biological Process	GO:0042446	hormone biosynthetic process	FDX1	IDA		Human	PMID:21636783
Biological Process	GO:0070995	NADPH oxidation	Fdx1	IDA		Rat	PMID:10525147|RGD:727285
Biological Process	GO:1904087	negative regulation of epiboly involved in gastrulation with mouth forming second	fdx1	IMP	ZFIN:ZDB-MRPHLNO-160429-1	Zfish	PMID:26650568
Biological Process	GO:0051353	positive regulation of oxidoreductase activity	Fdx1	IMP		Rat	PMID:11325963|RGD:4145669
Biological Process	GO:0050790	regulation of catalytic activity	Fdx1	IDA		Rat	PMID:10525147|RGD:727285
Biological Process	GO:0050790	regulation of catalytic activity	Fdx1	IDA		Rat	PMID:8789462|RGD:2326068
Biological Process	GO:0034698	response to gonadotropin	Fdx1	IEP		Rat	PMID:16139340|RGD:4145663
Biological Process	GO:0044321	response to leptin	Fdx1	IEP		Rat	PMID:11604238|RGD:4145667
Biological Process	GO:0006694	steroid biosynthetic process	fdx1b	IMP	ZFIN:ZDB-GENO-151019-2	Zfish	PMID:26650568

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern