Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes FEN1
  • Mouse genes Fen1
  • Rat genes Fen1
  • Zfish genes fen1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Fen1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0008409	5'-3' exonuclease activity	FEN1	IDA		Human	PMID:7961795
Molecular Function	GO:0017108	5'-flap endonuclease activity	FEN1	IMP		Human	PMID:11986308
Molecular Function	GO:0017108	5'-flap endonuclease activity	FEN1	IDA		Human	PMID:18995831
Molecular Function	GO:0017108	5'-flap endonuclease activity	FEN1	IMP		Human	PMID:8621570
Molecular Function	GO:0003677	DNA binding	FEN1	IMP		Human	PMID:11986308
Molecular Function	GO:0003677	DNA binding	Fen1	IDA		Mouse	PMID:12162748
Molecular Function	GO:0004527	exonuclease activity	Fen1	IDA		Mouse	PMID:12162748
Molecular Function	GO:0048256	flap endonuclease activity	FEN1	IDA		Human	PMID:18499658
Molecular Function	GO:0048256	flap endonuclease activity	Fen1	IDA		Mouse	PMID:12162748
Molecular Function	GO:0000287	magnesium ion binding	Fen1	IDA		Mouse	PMID:12162748
Molecular Function	GO:0030145	manganese ion binding	Fen1	IDA		Mouse	PMID:12162748
Molecular Function	GO:0005515	protein binding	FEN1	IPI	UniProtKB:Q09472	Human	PMID:11430825
Molecular Function	GO:0005515	protein binding	FEN1	IPI	UniProtKB:Q14191	Human	PMID:11598021
Molecular Function	GO:0005515	protein binding	FEN1	IPI	UniProtKB:P12004	Human	PMID:14657243
Molecular Function	GO:0005515	protein binding	FEN1	IPI	UniProtKB:Q14191	Human	PMID:14657243
Molecular Function	GO:0005515	protein binding	FEN1	IPI	UniProtKB:P54132	Human	PMID:14688284
Molecular Function	GO:0005515	protein binding	FEN1	IPI	UniProtKB:Q14191	Human	PMID:14688284
Molecular Function	GO:0005515	protein binding	FEN1	IPI	UniProtKB:P12004	Human	PMID:15576034
Molecular Function	GO:0005515	protein binding	FEN1	IPI	UniProtKB:Q96FC9	Human	PMID:18499658
Molecular Function	GO:0005515	protein binding	FEN1	IPI	UniProtKB:P12004	Human	PMID:18692475
Molecular Function	GO:0005515	protein binding	FEN1	IPI	UniProtKB:Q96NY9	Human	PMID:22551069
Molecular Function	GO:0005515	protein binding	FEN1	IPI	UniProtKB:P12004	Human	PMID:26030842
Molecular Function	GO:0005515	protein binding	FEN1	IPI	UniProtKB:P12004	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	FEN1	IPI	UniProtKB:P12004	Human	PMID:26751069
Molecular Function	GO:0005515	protein binding	FEN1	IPI	UniProtKB:P57081	Human	PMID:26751069
Molecular Function	GO:0005515	protein binding	FEN1	IPI	UniProtKB:P12004	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	FEN1	IPI	UniProtKB:P12004	Human	PMID:29997244
Molecular Function	GO:0005515	protein binding	FEN1	IPI	UniProtKB:P12004	Human	PMID:31467278
Molecular Function	GO:0005515	protein binding	FEN1	IPI	UniProtKB:P12004	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	FEN1	IPI	UniProtKB:P12004	Human	PMID:9305916
Molecular Function	GO:0004523	RNA-DNA hybrid ribonuclease activity	FEN1	IDA		Human	PMID:7961795
Cellular Component	GO:0000781	chromosome, telomeric region	FEN1	IDA		Human	PMID:24270157
Cellular Component	GO:0000781	chromosome, telomeric region	FEN1	HDA		Human	PMID:19135898
Cellular Component	GO:0016020	membrane	FEN1	HDA		Human	PMID:19946888
Cellular Component	GO:0005739	mitochondrion	FEN1	IDA		Human	PMID:18995831
Cellular Component	GO:0005730	nucleolus	FEN1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	FEN1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	FEN1	IDA		Human	PMID:12427278
Cellular Component	GO:0005634	nucleus	FEN1	IDA		Human	PMID:18995831
Cellular Component	GO:0005634	nucleus	FEN1	IDA		Human	PMID:7961795
Cellular Component	GO:0005634	nucleus	Fen1	IDA		Rat	PMID:19420241|RGD:6484211
Cellular Component	GO:0032991	protein-containing complex	FEN1	IDA		Human	PMID:25378300
Biological Process	GO:0006281	DNA repair	Fen1	IMP	MGI:MGI:2670036	Mouse	PMID:12861020
Biological Process	GO:0006260	DNA replication	Fen1	IMP	MGI:MGI:2670036	Mouse	PMID:12861020
Biological Process	GO:0043137	DNA replication, removal of RNA primer	FEN1	IDA		Human	PMID:18995831
Biological Process	GO:0007613	memory	Fen1	IMP		Rat	PMID:19420241|RGD:6484211
Biological Process	GO:0090305	nucleic acid phosphodiester bond hydrolysis	FEN1	IDA		Human	PMID:18499658
Biological Process	GO:0045876	positive regulation of sister chromatid cohesion	FEN1	IMP		Human	PMID:18499658
Biological Process	GO:0060041	retina development in camera-type eye	fen1	IMP	ZFIN:ZDB-GENO-040831-3	Zfish	PMID:15716491

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern