Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes FERMT2
  • Mouse genes Fermt2
  • Rat genes Fermt2
  • Zfish genes fermt2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Fermt2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003779	actin binding	FERMT2	IMP		Human	PMID:29496737
Molecular Function	GO:0051015	actin filament binding	Fermt2	IDA		Mouse	PMID:16876785
Molecular Function	GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding	FERMT2	IDA		Human	PMID:21325030
Molecular Function	GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding	FERMT2	IDA		Human	PMID:22030399
Molecular Function	GO:0005515	protein binding	FERMT2	IPI	UniProtKB:P15884	Human	PMID:22699938
Molecular Function	GO:0005515	protein binding	FERMT2	IPI	UniProtKB:P35222	Human	PMID:22699938
Molecular Function	GO:0019901	protein kinase binding	FERMT2	IPI	UniProtKB:Q13418	Human	PMID:30254023
Molecular Function	GO:0046332	SMAD binding	FERMT2	IPI	UniProtKB:P84022	Human	PMID:23723426
Molecular Function	GO:0034713	type I transforming growth factor beta receptor binding	FERMT2	IPI	UniProtKB:P36897	Human	PMID:23723426
Cellular Component	GO:0005912	adherens junction	FERMT2	IDA		Human	PMID:28799653
Cellular Component	GO:0030054	cell junction	FERMT2	IDA		Human	PMID:30382829
Cellular Component	GO:0005737	cytoplasm	FERMT2	IDA		Human	PMID:22699938
Cellular Component	GO:0005737	cytoplasm	FERMT2	IDA		Human	PMID:18528435
Cellular Component	GO:0005737	cytoplasm	FERMT2	IDA		Human	PMID:28799653
Cellular Component	GO:0005829	cytosol	FERMT2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	FERMT2	IDA		Human	PMID:23723426
Cellular Component	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane	FERMT2	IDA		Human	PMID:21325030
Cellular Component	GO:0005925	focal adhesion	FERMT2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005925	focal adhesion	FERMT2	IDA		Human	PMID:21325030
Cellular Component	GO:0005925	focal adhesion	FERMT2	HDA		Human	PMID:21423176
Cellular Component	GO:0005925	focal adhesion	FERMT2	IDA		Human	PMID:29162887
Cellular Component	GO:0005925	focal adhesion	FERMT2	IDA		Human	PMID:18528435
Cellular Component	GO:0005925	focal adhesion	FERMT2	IDA		Human	PMID:29496737
Cellular Component	GO:0014704	intercalated disc	fermt2	IMP	ZFIN:ZDB-MRPHLNO-080708-1	Zfish	PMID:18174465
Cellular Component	GO:0005654	nucleoplasm	FERMT2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	FERMT2	IDA		Human	PMID:22699938
Cellular Component	GO:0005886	plasma membrane	FERMT2	IDA		Human	PMID:23723426
Cellular Component	GO:0005886	plasma membrane	FERMT2	IDA		Human	PMID:30382829
Cellular Component	GO:0001725	stress fiber	Fermt2	IDA		Mouse	PMID:16876785
Biological Process	GO:0034334	adherens junction maintenance	FERMT2	IMP		Human	PMID:28799653
Biological Process	GO:0034334	adherens junction maintenance	Fermt2	IMP		Mouse	MGI:MGI:6467695|PMID:28799653
Biological Process	GO:0001525	angiogenesis	fermt2	IMP	ZFIN:ZDB-MRPHLNO-080708-1,ZFIN:ZDB-MRPHLNO-080708-2	Zfish	PMID:21378273
Biological Process	GO:0055008	cardiac muscle tissue morphogenesis	fermt2	IMP	ZFIN:ZDB-MRPHLNO-080708-2	Zfish	PMID:18174465
Biological Process	GO:0055008	cardiac muscle tissue morphogenesis	fermt2	IMP	ZFIN:ZDB-MRPHLNO-080708-1	Zfish	PMID:18174465
Biological Process	GO:0007155	cell adhesion	FERMT2	IGI	UniProtKB:Q9BQL6	Human	PMID:21356350
Biological Process	GO:0007155	cell adhesion	FERMT2	IMP		Human	PMID:30382829
Biological Process	GO:0016477	cell migration	fermt2	IGI	ZFIN:ZDB-MRPHLNO-080708-2,ZFIN:ZDB-MRPHLNO-101102-1	Zfish	PMID:24599960
Biological Process	GO:0016477	cell migration	fermt2	IGI	ZFIN:ZDB-MRPHLNO-080708-1,ZFIN:ZDB-MRPHLNO-101102-1	Zfish	PMID:24599960
Biological Process	GO:0007160	cell-matrix adhesion	FERMT2	IMP		Human	PMID:21325030
Biological Process	GO:0007160	cell-matrix adhesion	Fermt2	IMP		Mouse	MGI:MGI:3789779|PMID:18483218
Biological Process	GO:0007010	cytoskeleton organization	fermt2	IMP	ZFIN:ZDB-MRPHLNO-080708-1	Zfish	PMID:18174465
Biological Process	GO:0007010	cytoskeleton organization	fermt2	IMP	ZFIN:ZDB-MRPHLNO-080708-2	Zfish	PMID:18174465
Biological Process	GO:0048041	focal adhesion assembly	FERMT2	IMP		Human	PMID:21356350
Biological Process	GO:0048041	focal adhesion assembly	Fermt2	IMP		Mouse	MGI:MGI:3789779|PMID:18483218
Biological Process	GO:0033622	integrin activation	FERMT2	IMP		Human	PMID:22030399
Biological Process	GO:0033622	integrin activation	Fermt2	IMP		Mouse	MGI:MGI:3789779|PMID:18483218
Biological Process	GO:0007229	integrin-mediated signaling pathway	FERMT2	IMP		Human	PMID:21325030
Biological Process	GO:0060173	limb development	Fermt2	IMP		Mouse	MGI:MGI:6149626|PMID:29496737
Biological Process	GO:0060548	negative regulation of cell death	FERMT2	IMP		Human	PMID:29496737
Biological Process	GO:0045599	negative regulation of fat cell differentiation	FERMT2	IMP		Human	PMID:29496737
Biological Process	GO:0045599	negative regulation of fat cell differentiation	Fermt2	IMP		Mouse	MGI:MGI:6149626|PMID:29496737
Biological Process	GO:0043116	negative regulation of vascular permeability	FERMT2	IMP		Human	PMID:28799653
Biological Process	GO:0043116	negative regulation of vascular permeability	Fermt2	IMP		Mouse	MGI:MGI:6467695|PMID:28799653
Biological Process	GO:0030335	positive regulation of cell migration	FERMT2	IMP		Human	PMID:30382829
Biological Process	GO:0010718	positive regulation of epithelial to mesenchymal transition	FERMT2	IDA		Human	PMID:24226523
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	FERMT2	IDA		Human	PMID:24226523
Biological Process	GO:0051894	positive regulation of focal adhesion assembly	FERMT2	IMP		Human	PMID:29496737
Biological Process	GO:0043547	positive regulation of GTPase activity	FERMT2	IMP		Human	PMID:29496737
Biological Process	GO:0033625	positive regulation of integrin activation	FERMT2	IGI	UniProtKB:Q9BQL6	Human	PMID:21356350
Biological Process	GO:1902462	positive regulation of mesenchymal stem cell proliferation	FERMT2	IMP		Human	PMID:29496737
Biological Process	GO:0035505	positive regulation of myosin light chain kinase activity	FERMT2	IMP		Human	PMID:29496737
Biological Process	GO:0045669	positive regulation of osteoblast differentiation	FERMT2	IMP		Human	PMID:29496737
Biological Process	GO:0045669	positive regulation of osteoblast differentiation	Fermt2	IMP		Mouse	MGI:MGI:6149626|PMID:29496737
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	FERMT2	IDA		Human	PMID:24226523
Biological Process	GO:1900182	positive regulation of protein localization to nucleus	FERMT2	IDA		Human	PMID:23723426
Biological Process	GO:0051496	positive regulation of stress fiber assembly	FERMT2	IMP		Human	PMID:29496737
Biological Process	GO:1900026	positive regulation of substrate adhesion-dependent cell spreading	FERMT2	IGI	UniProtKB:Q13418	Human	PMID:30254023
Biological Process	GO:1903691	positive regulation of wound healing, spreading of epidermal cells	FERMT2	IMP		Human	PMID:21356350
Biological Process	GO:1902414	protein localization to cell junction	FERMT2	IMP		Human	PMID:30254023
Biological Process	GO:0072657	protein localization to membrane	Fermt2	IMP		Mouse	MGI:MGI:3789779|PMID:18483218
Biological Process	GO:0022604	regulation of cell morphogenesis	FERMT2	IMP		Human	PMID:30254023
Biological Process	GO:0034446	substrate adhesion-dependent cell spreading	Fermt2	IMP		Mouse	MGI:MGI:3789779|PMID:18483218
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	FERMT2	IMP		Human	PMID:21325030
Biological Process	GO:0016055	Wnt signaling pathway	FERMT2	IMP		Human	PMID:22699938

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern