Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes FFAR4
  • Mouse genes Ffar4
  • Rat genes Ffar4
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ffar4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005504	fatty acid binding	Ffar4	IDA		Mouse	MGI:MGI:4839696|PMID:20813258
Molecular Function	GO:0005504	fatty acid binding	Ffar4	IDA		Mouse	PMID:15619630
Molecular Function	GO:0004930	G protein-coupled receptor activity	Ffar4	IDA		Mouse	PMID:15619630
Molecular Function	GO:0005515	protein binding	Ffar4	IPI	UniProtKB:Q91YI4	Mouse	MGI:MGI:4839696|PMID:20813258
Molecular Function	GO:0008527	taste receptor activity	Ffar4	IMP		Mouse	MGI:MGI:4459568|PMID:20573884
Cellular Component	GO:0005929	cilium	FFAR4	IDA		Human	PMID:31761534
Cellular Component	GO:0005929	cilium	Ffar4	IDA		Mouse	MGI:MGI:6383338|PMID:31761534
Cellular Component	GO:0030139	endocytic vesicle	Ffar4	IDA		Mouse	PMID:15619630
Cellular Component	GO:0005886	plasma membrane	FFAR4	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	Ffar4	IDA		Mouse	MGI:MGI:4839696|PMID:20813258
Cellular Component	GO:0005886	plasma membrane	Ffar4	IDA		Mouse	PMID:15619630
Biological Process	GO:0050873	brown fat cell differentiation	Ffar4	IMP		Mouse	MGI:MGI:5888836|PMID:27853148
Biological Process	GO:0045444	fat cell differentiation	Ffar4	IMP		Mouse	MGI:MGI:5316157|PMID:22343897
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	Ffar4	IDA		Mouse	PMID:15619630
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	Ffar4	IDA		Rat	PMID:22279596|RGD:10047213
Biological Process	GO:0036321	ghrelin secretion	Ffar4	IMP		Mouse	MGI:MGI:6383312|PMID:24222669
Biological Process	GO:0046879	hormone secretion	Ffar4	IDA		Mouse	PMID:15619630
Biological Process	GO:0043066	negative regulation of apoptotic process	Ffar4	IMP		Mouse	MGI:MGI:3582120|PMID:15774482
Biological Process	GO:0001818	negative regulation of cytokine production	Ffar4	IDA		Mouse	MGI:MGI:4839696|PMID:20813258
Biological Process	GO:0001818	negative regulation of cytokine production	Ffar4	IMP		Mouse	PMID:26828067
Biological Process	GO:0050728	negative regulation of inflammatory response	Ffar4	IDA		Mouse	MGI:MGI:4839696|PMID:20813258
Biological Process	GO:0032691	negative regulation of interleukin-1 beta production	FFAR4	IMP		Human	PMID:23809162
Biological Process	GO:0090275	negative regulation of somatostatin secretion	Ffar4	IMP		Mouse	MGI:MGI:5575837|PMID:24663807
Biological Process	GO:0007200	phospholipase C-activating G protein-coupled receptor signaling pathway	Ffar4	IMP		Mouse	MGI:MGI:6203732|PMID:27852822
Biological Process	GO:0090336	positive regulation of brown fat cell differentiation	Ffar4	IMP		Mouse	MGI:MGI:6155359|PMID:29343498
Biological Process	GO:0043950	positive regulation of cAMP-mediated signaling	Ffar4	IDA		Mouse	MGI:MGI:6383338|PMID:31761534
Biological Process	GO:0120162	positive regulation of cold-induced thermogenesis	Ffar4	IMP		Mouse	MGI:MGI:5888836|PMID:27853148
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration	Ffar4	IMP		Mouse	MGI:MGI:6203732|PMID:27852822
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	Ffar4	IMP		Mouse	MGI:MGI:3582120|PMID:15774482
Biological Process	GO:0070094	positive regulation of glucagon secretion	Ffar4	IMP		Mouse	MGI:MGI:5588067|PMID:24742677
Biological Process	GO:0045669	positive regulation of osteoblast differentiation	Ffar4	IMP		Mouse	MGI:MGI:6220333|PMID:26365922
Biological Process	GO:0010827	regulation of glucose transmembrane transport	Ffar4	IDA		Mouse	MGI:MGI:4839696|PMID:20813258
Biological Process	GO:0050872	white fat cell differentiation	FFAR4	IDA		Human	PMID:31761534
Biological Process	GO:0050872	white fat cell differentiation	Ffar4	IDA		Mouse	MGI:MGI:6383338|PMID:31761534

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern