Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes FGF21
  • Mouse genes Fgf21
  • Rat genes Fgf21
  • Zfish genes fgf21
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Fgf21

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	FGF21	IPI	UniProtKB:Q86Z14	Human	PMID:18829467
Molecular Function	GO:0005515	protein binding	FGF21	IPI	UniProtKB:Q86Z14	Human	PMID:19059246
Molecular Function	GO:0005515	protein binding	FGF21	IPI	UniProtKB:Q86Z14	Human	PMID:19117008
Molecular Function	GO:0005515	protein binding	FGF21	IPI	UniProtKB:O43765	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	FGF21	IPI	UniProtKB:Q96EQ0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	FGF21	IPI	UniProtKB:O14645	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	FGF21	IPI	UniProtKB:O14901	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	FGF21	IPI	UniProtKB:P13473-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	FGF21	IPI	UniProtKB:P46379-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	FGF21	IPI	UniProtKB:P54652	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	FGF21	IPI	UniProtKB:P55212	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	FGF21	IPI	UniProtKB:Q0VDC6	Human	PMID:32814053
Cellular Component	GO:0005615	extracellular space	Fgf21	IDA		Mouse	MGI:MGI:6380950|PMID:30605666
Cellular Component	GO:0005615	extracellular space	Fgf21	IDA		Rat	PMID:22166524|RGD:10401877
Biological Process	GO:0071377	cellular response to glucagon stimulus	Fgf21	IEP		Rat	PMID:23262585|RGD:10401916
Biological Process	GO:0071333	cellular response to glucose stimulus	Fgf21	IEP		Rat	PMID:19660458|RGD:10401884
Biological Process	GO:0071404	cellular response to low-density lipoprotein particle stimulus	Fgf21	IEP		Rat	PMID:22166524|RGD:10401877
Biological Process	GO:0071466	cellular response to xenobiotic stimulus	Fgf21	IEP		Rat	PMID:23118742|RGD:10401886
Biological Process	GO:0030968	endoplasmic reticulum unfolded protein response	Fgf21	IEP		Rat	PMID:23123503|RGD:10401883
Biological Process	GO:0072577	endothelial cell apoptotic process	Fgf21	IEP		Rat	PMID:22166524|RGD:10401877
Biological Process	GO:0030218	erythrocyte differentiation	fgf21	IMP	ZFIN:ZDB-MRPHLNO-060623-1	Zfish	PMID:23183322
Biological Process	GO:0030218	erythrocyte differentiation	fgf21	IGI	ZFIN:ZDB-GENE-030131-9	Zfish	PMID:23183322
Biological Process	GO:0030099	myeloid cell differentiation	fgf21	IMP	ZFIN:ZDB-MRPHLNO-060623-1	Zfish	PMID:16612391
Biological Process	GO:2000352	negative regulation of endothelial cell apoptotic process	Fgf21	IMP		Rat	PMID:22166524|RGD:10401877
Biological Process	GO:1901215	negative regulation of neuron death	Fgf21	IMP		Rat	PMID:24468826|RGD:10401923
Biological Process	GO:0008284	positive regulation of cell population proliferation	Fgf21	IGI	MGI:MGI:95522	Mouse	PMID:18187602
Biological Process	GO:0008284	positive regulation of cell population proliferation	Fgf21	IGI	MGI:MGI:1932466	Mouse	PMID:18187602
Biological Process	GO:0008284	positive regulation of cell population proliferation	Fgf21	IGI	MGI:MGI:95524	Mouse	PMID:18187602
Biological Process	GO:0120162	positive regulation of cold-induced thermogenesis	Fgf21	IMP		Mouse	MGI:MGI:5311061|PMID:22302939
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	FGF21	IDA		Human	PMID:17623664
Biological Process	GO:0046326	positive regulation of glucose import	FGF21	IDA		Human	PMID:17623664
Biological Process	GO:0090080	positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway	Fgf21	IGI	MGI:MGI:1932466	Mouse	PMID:18187602
Biological Process	GO:0090080	positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway	Fgf21	IGI	MGI:MGI:95522	Mouse	PMID:18187602
Biological Process	GO:0090080	positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway	Fgf21	IGI	MGI:MGI:95524	Mouse	PMID:18187602
Biological Process	GO:0010898	positive regulation of triglyceride catabolic process	Fgf21	IMP		Rat	PMID:23262585|RGD:10401916
Biological Process	GO:0014823	response to activity	Fgf21	IEP		Rat	PMID:22891896|RGD:10401895
Biological Process	GO:1904640	response to methionine	Fgf21	IEP		Rat	PMID:23052097|RGD:10401915
Biological Process	GO:0031667	response to nutrient levels	Fgf21	IEP		Rat	PMID:25133427|RGD:10401894

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern