Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes FGF4
  • Mouse genes Fgf4
  • Rat genes Fgf4
  • Zfish genes fgf4
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Fgf4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	Fgf4	IPI	PR:P21803	Mouse	PMID:8393815
Biological Process	GO:0006915	apoptotic process	Fgf4	IGI	MGI:MGI:99604	Mouse	PMID:16245339
Biological Process	GO:0060561	apoptotic process involved in morphogenesis	Fgf4	IGI	MGI:MGI:96970	Mouse	PMID:15649466
Biological Process	GO:0001502	cartilage condensation	Fgf4	IGI	MGI:MGI:98726	Mouse	PMID:8565825
Biological Process	GO:0008283	cell population proliferation	Fgf4	IGI	MGI:MGI:99604	Mouse	PMID:16245339
Biological Process	GO:1990830	cellular response to leukemia inhibitory factor	Fgf4	IEP		Mouse	PMID:20439489
Biological Process	GO:0060591	chondroblast differentiation	FGF4	IDA		Human	PMID:17167778
Biological Process	GO:0060271	cilium assembly	fgf4	IMP	ZFIN:ZDB-MRPHLNO-100511-1	Zfish	PMID:19481538
Biological Process	GO:0060363	cranial suture morphogenesis	Fgf4	IDA		Mouse	PMID:9477322
Biological Process	GO:0007368	determination of left/right symmetry	fgf4	IMP	ZFIN:ZDB-MRPHLNO-100511-1	Zfish	PMID:19481538
Biological Process	GO:0007368	determination of left/right symmetry	fgf4	IMP	ZFIN:ZDB-MRPHLNO-060831-4	Zfish	PMID:19481538
Biological Process	GO:0007368	determination of left/right symmetry	fgf4	IGI	ZFIN:ZDB-MRPHLNO-050714-1,ZFIN:ZDB-MRPHLNO-100511-1	Zfish	PMID:19481538
Biological Process	GO:0035116	embryonic hindlimb morphogenesis	Fgf4	IGI	MGI:MGI:99604	Mouse	PMID:16245339
Biological Process	GO:0030326	embryonic limb morphogenesis	Fgf4	IGI	MGI:MGI:99604	Mouse	PMID:15328019
Biological Process	GO:1904019	epithelial cell apoptotic process	Fgf4	IGI	MGI:MGI:96970	Mouse	PMID:15649466
Biological Process	GO:0008543	fibroblast growth factor receptor signaling pathway	FGF4	IGI	UniProtKB:P11362	Human	PMID:8663044
Biological Process	GO:0008543	fibroblast growth factor receptor signaling pathway	FGF4	IGI	UniProtKB:P21802	Human	PMID:8663044
Biological Process	GO:0070121	Kupffer's vesicle development	fgf4	IMP	ZFIN:ZDB-MRPHLNO-100511-1	Zfish	PMID:19481538
Biological Process	GO:0010463	mesenchymal cell proliferation	FGF4	IDA		Human	PMID:11023873
Biological Process	GO:0043066	negative regulation of apoptotic process	Fgf4	IGI	MGI:MGI:99604	Mouse	PMID:16245339
Biological Process	GO:0042475	odontogenesis of dentin-containing tooth	Fgf4	IDA		Mouse	PMID:12502739
Biological Process	GO:0048339	paraxial mesoderm development	fgf4	IGI	ZFIN:ZDB-MRPHLNO-050714-1	Zfish	PMID:32345657
Biological Process	GO:0048339	paraxial mesoderm development	fgf4	IGI	ZFIN:ZDB-MRPHLNO-201021-2	Zfish	PMID:32345657
Biological Process	GO:0008284	positive regulation of cell population proliferation	FGF4	IGI	UniProtKB:P11362	Human	PMID:8663044
Biological Process	GO:0008284	positive regulation of cell population proliferation	FGF4	IGI	UniProtKB:P21802	Human	PMID:8663044
Biological Process	GO:0008284	positive regulation of cell population proliferation	Fgf4	IDA		Mouse	PMID:17951031
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	FGF4	IDA		Human	PMID:17167778
Biological Process	GO:0010628	positive regulation of gene expression	Fgf4	IDA		Mouse	PMID:9244299
Biological Process	GO:0001934	positive regulation of protein phosphorylation	Fgf4	IDA		Mouse	PMID:19289495
Biological Process	GO:2000648	positive regulation of stem cell proliferation	Fgf4	IGI	MGI:MGI:99604	Mouse	PMID:16245339
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Fgf4	IDA		Mouse	PMID:9477322
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Fgf4	IGI	MGI:MGI:97168	Mouse	PMID:8898217
Biological Process	GO:2000544	regulation of endothelial cell chemotaxis to fibroblast growth factor	FGF4	IDA		Human	PMID:16756958
Biological Process	GO:0010468	regulation of gene expression	Fgf4	IDA		Mouse	PMID:19289495
Biological Process	GO:0035019	somatic stem cell population maintenance	Fgf4	IGI	MGI:MGI:97359	Mouse	PMID:15328412
Biological Process	GO:0060063	Spemann organizer formation at the embryonic shield	fgf4	IGI	ZFIN:ZDB-MRPHLNO-050221-3	Zfish	PMID:32345657
Biological Process	GO:0019827	stem cell population maintenance	Fgf4	IGI	MGI:MGI:97359	Mouse	PMID:15328412
Biological Process	GO:0072089	stem cell proliferation	Fgf4	IGI	MGI:MGI:99604	Mouse	PMID:16245339

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern