Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes FGR
  • Mouse genes Fgr
  • Rat genes Fgr
  • Zfish genes yrk
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Fgr

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0034988	Fc-gamma receptor I complex binding	FGR	IDA		Human	PMID:8327512
Molecular Function	GO:0034987	immunoglobulin receptor binding	Fgr	IDA		Mouse	MGI:MGI:5294498|PMID:21746961
Molecular Function	GO:0004715	non-membrane spanning protein tyrosine kinase activity	FGR	IDA		Human	PMID:8327512
Molecular Function	GO:0004715	non-membrane spanning protein tyrosine kinase activity	Fgr	IDA		Mouse	MGI:MGI:3513574|PMID:15561106
Molecular Function	GO:0001784	phosphotyrosine residue binding	FGR	IPI	UniProtKB:Q6GX35	Human	PMID:20624904
Molecular Function	GO:0001784	phosphotyrosine residue binding	Fgr	IDA		Mouse	MGI:MGI:3640451|PMID:11672534
Molecular Function	GO:0005515	protein binding	FGR	IPI	UniProtKB:P04626	Human	PMID:16273093
Molecular Function	GO:0005515	protein binding	FGR	IPI	UniProtKB:P08238	Human	PMID:22939624
Molecular Function	GO:0005515	protein binding	FGR	IPI	UniProtKB:P00533	Human	PMID:24658140
Molecular Function	GO:0005515	protein binding	FGR	IPI	UniProtKB:P08581	Human	PMID:24728074
Molecular Function	GO:0005515	protein binding	FGR	IPI	UniProtKB:P10275	Human	PMID:24728074
Molecular Function	GO:0005515	protein binding	FGR	IPI	UniProtKB:P10721	Human	PMID:24728074
Molecular Function	GO:0005515	protein binding	FGR	IPI	UniProtKB:P09917	Human	PMID:24860872
Molecular Function	GO:0005515	protein binding	FGR	IPI	UniProtKB:P00533	Human	PMID:31980649
Molecular Function	GO:0005515	protein binding	FGR	IPI	UniProtKB:P08238	Human	PMID:31980649
Molecular Function	GO:0005515	protein binding	Fgr	IPI	UniProtKB:Q9QZE2	Mouse	MGI:MGI:3774350|PMID:16439675
Molecular Function	GO:0005515	protein binding	Fgr	IPI	RGD:1304754	Rat	PMID:7744027|RGD:2315070
Molecular Function	GO:0019901	protein kinase binding	Fgr	IPI	UniProtKB:P48025	Mouse	MGI:MGI:3640451|PMID:11672534
Molecular Function	GO:0019901	protein kinase binding	Fgr	IDA		Mouse	MGI:MGI:3640451|PMID:11672534
Molecular Function	GO:0004713	protein tyrosine kinase activity	FGR	EXP		Human	PMID:10861086
Molecular Function	GO:0004713	protein tyrosine kinase activity	FGR	EXP		Human	PMID:16921024
Molecular Function	GO:0004713	protein tyrosine kinase activity	FGR	IDA		Human	PMID:7519620
Molecular Function	GO:0004713	protein tyrosine kinase activity	Fgr	IDA		Rat	PMID:15282299|RGD:1302342
Cellular Component	GO:0015629	actin cytoskeleton	Fgr	IDA		Mouse	MGI:MGI:3513574|PMID:15561106
Cellular Component	GO:0016235	aggresome	FGR	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005856	cytoskeleton	FGR	IDA		Human	PMID:8603737
Cellular Component	GO:0005829	cytosol	Fgr	IDA		Rat	PMID:9116282|RGD:1600232
Cellular Component	GO:0070062	extracellular exosome	FGR	HDA		Human	PMID:20458337
Cellular Component	GO:0005886	plasma membrane	FGR	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	Fgr	IDA		Mouse	MGI:MGI:5294498|PMID:21746961
Cellular Component	GO:0005886	plasma membrane	Fgr	IDA		Mouse	MGI:MGI:3513574|PMID:15561106
Cellular Component	GO:0005886	plasma membrane	Fgr	IDA		Rat	PMID:9116282|RGD:1600232
Cellular Component	GO:0032587	ruffle membrane	Fgr	IDA		Mouse	MGI:MGI:3513574|PMID:15561106
Biological Process	GO:0030282	bone mineralization	Fgr	IMP	MGI:MGI:3665439	Mouse	PMID:16964445
Biological Process	GO:0050830	defense response to Gram-positive bacterium	Fgr	IMP		Mouse	MGI:MGI:65050|PMID:8125254
Biological Process	GO:0050830	defense response to Gram-positive bacterium	Fgr	IGI	MGI:MGI:96052	Mouse	PMID:8125254
Biological Process	GO:0007229	integrin-mediated signaling pathway	FGR	IMP		Human	PMID:10739672
Biological Process	GO:0007229	integrin-mediated signaling pathway	FGR	IMP		Human	PMID:7519620
Biological Process	GO:0007229	integrin-mediated signaling pathway	Fgr	IMP		Mouse	MGI:MGI:3640451|PMID:11672534
Biological Process	GO:0048246	macrophage chemotaxis	yrk	IMP	ZFIN:ZDB-MRPHLNO-150224-5	Zfish	PMID:25488917
Biological Process	GO:0048246	macrophage chemotaxis	yrk	IMP	ZFIN:ZDB-MRPHLNO-150224-4	Zfish	PMID:25488917
Biological Process	GO:0051450	myoblast proliferation	Fgr	IEP		Rat	PMID:2425941|RGD:151667421
Biological Process	GO:0032815	negative regulation of natural killer cell activation	Fgr	IMP		Mouse	MGI:MGI:3774350|PMID:16439675
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	FGR	IDA		Human	PMID:7519620
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	FGR	IDA		Human	PMID:8327512
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	Fgr	IDA		Mouse	MGI:MGI:3513574|PMID:15561106
Biological Process	GO:0030335	positive regulation of cell migration	Fgr	IMP		Mouse	MGI:MGI:3513574|PMID:15561106
Biological Process	GO:0001819	positive regulation of cytokine production	Fgr	IDA		Mouse	MGI:MGI:5294498|PMID:21746961
Biological Process	GO:0043306	positive regulation of mast cell degranulation	Fgr	IDA		Mouse	MGI:MGI:5294498|PMID:21746961
Biological Process	GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity	FGR	IMP		Human	PMID:10739672
Biological Process	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	FGR	IMP		Human	PMID:10739672
Biological Process	GO:0046777	protein autophosphorylation	FGR	IDA		Human	PMID:2181286
Biological Process	GO:0046777	protein autophosphorylation	FGR	IDA		Human	PMID:8327512
Biological Process	GO:0008360	regulation of cell shape	Fgr	IMP		Mouse	MGI:MGI:3640451|PMID:11672534
Biological Process	GO:0045088	regulation of innate immune response	Fgr	IMP		Mouse	MGI:MGI:5294498|PMID:21746961
Biological Process	GO:0050764	regulation of phagocytosis	Fgr	IMP		Mouse	MGI:MGI:3640451|PMID:11672534
Biological Process	GO:0045859	regulation of protein kinase activity	Fgr	IDA		Mouse	MGI:MGI:3640451|PMID:11672534
Biological Process	GO:0048705	skeletal system morphogenesis	Fgr	IMP	MGI:MGI:3665439	Mouse	PMID:16964445

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern