Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes FH
  • Mouse genes Fh1
  • Rat genes Fh
  • Zfish genes fh
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Fh1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004333	fumarate hydratase activity	FH	IMP		Human	PMID:29456767
Molecular Function	GO:0004333	fumarate hydratase activity	FH	IDA		Human	PMID:30761759
Molecular Function	GO:0004333	fumarate hydratase activity	Fh1	IMP		Mouse	MGI:MGI:5496931|PMID:23643539
Molecular Function	GO:0004333	fumarate hydratase activity	Fh1	IMP		Mouse	PMID:20660115
Molecular Function	GO:0004333	fumarate hydratase activity	Fh	IMP		Rat	PMID:2914923|RGD:632664
Molecular Function	GO:0004333	fumarate hydratase activity	Fh	IDA		Rat	PMID:938457|RGD:2306828
Molecular Function	GO:0005515	protein binding	FH	IPI	UniProtKB:P11309	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	FH	IPI	UniProtKB:P0C0S5	Human	PMID:26237645
Molecular Function	GO:0005515	protein binding	FH	IPI	UniProtKB:O14787-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	FH	IPI	UniProtKB:O15160	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	FH	IPI	UniProtKB:P21673	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	FH	IPI	UniProtKB:Q03252	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	FH	IPI	UniProtKB:Q14129	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	FH	IPI	UniProtKB:Q2TAC2-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	FH	IPI	UniProtKB:Q68D86	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	FH	IPI	UniProtKB:Q6DKK2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	FH	IPI	UniProtKB:Q8WZ60	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	FH	IPI	UniProtKB:Q9H6J7-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	FH	IPI	UniProtKB:Q9NQT4	Human	PMID:32296183
Cellular Component	GO:0070062	extracellular exosome	FH	HDA		Human	PMID:20458337
Cellular Component	GO:0005759	mitochondrial matrix	Fh1	IDA		Mouse	PMID:31648943
Cellular Component	GO:0005739	mitochondrion	FH	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005739	mitochondrion	FH	HDA		Human	PMID:20833797
Cellular Component	GO:0005739	mitochondrion	Fh1	HDA		Mouse	PMID:18614015
Cellular Component	GO:0005739	mitochondrion	Fh1	HDA		Mouse	PMID:14651853
Cellular Component	GO:0005739	mitochondrion	Fh	IDA		Rat	PMID:938457|RGD:2306828
Biological Process	GO:0006106	fumarate metabolic process	FH	IDA		Human	PMID:30761759
Biological Process	GO:0006106	fumarate metabolic process	Fh1	IMP		Mouse	MGI:MGI:5496931|PMID:23643539
Biological Process	GO:0006106	fumarate metabolic process	Fh	IDA		Rat	PMID:938457|RGD:2306828
Biological Process	GO:0048873	homeostasis of number of cells within a tissue	Fh1	IMP	MGI:MGI:2665300,MGI:MGI:3710112	Mouse	PMID:17418408
Biological Process	GO:0006108	malate metabolic process	FH	IDA		Human	PMID:30761759
Biological Process	GO:0006108	malate metabolic process	Fh	IDA		Rat	PMID:938457|RGD:2306828
Biological Process	GO:0120162	positive regulation of cold-induced thermogenesis	Fh1	IMP		Mouse	MGI:MGI:5922846|PMID:27554470
Biological Process	GO:0000821	regulation of arginine metabolic process	Fh1	IMP		Mouse	MGI:MGI:5496931|PMID:23643539
Biological Process	GO:0006099	tricarboxylic acid cycle	Fh1	IMP	MGI:MGI:3710112	Mouse	PMID:22405071
Biological Process	GO:0006099	tricarboxylic acid cycle	Fh	IDA		Rat	PMID:938457|RGD:2306828
Biological Process	GO:0000050	urea cycle	Fh1	IMP		Mouse	MGI:MGI:5496931|PMID:23643539

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern