Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes FIG4
  • Mouse genes Fig4
  • Rat genes Fig4
  • Zfish genes fig4a
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Fig4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0034593	phosphatidylinositol bisphosphate phosphatase activity	Fig4	IDA		Rat	PMID:17909536|RGD:2312411
Molecular Function	GO:0004438	phosphatidylinositol-3-phosphate phosphatase activity	Fig4	IDA		Rat	PMID:17909536|RGD:2312411
Molecular Function	GO:0043812	phosphatidylinositol-4-phosphate phosphatase activity	Fig4	IDA		Rat	PMID:17909536|RGD:2312411
Molecular Function	GO:0005515	protein binding	FIG4	IPI	UniProtKB:Q9Y2I7	Human	PMID:17556371
Molecular Function	GO:0005515	protein binding	FIG4	IPI	UniProtKB:Q9Z1T6	Human	PMID:17556371
Molecular Function	GO:0005515	protein binding	FIG4	IPI	UniProtKB:Q08AM6	Human	PMID:19037259
Molecular Function	GO:0005515	protein binding	FIG4	IPI	UniProtKB:Q08AM6	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	FIG4	IPI	UniProtKB:Q08AM6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	FIG4	IPI	UniProtKB:Q9H8Y8	Human	PMID:32296183
Cellular Component	GO:0005783	endoplasmic reticulum	Fig4	IDA		Rat	PMID:17909536|RGD:2312411
Cellular Component	GO:0010008	endosome membrane	FIG4	IDA		Human	PMID:17556371
Cellular Component	GO:0005794	Golgi apparatus	Fig4	IDA		Rat	PMID:17909536|RGD:2312411
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	FIG4	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005811	lipid droplet	FIG4	IDA		Human	GO_REF:0000052
Cellular Component	GO:0055037	recycling endosome	Fig4	IDA		Rat	PMID:17909536|RGD:2312411
Biological Process	GO:0007626	locomotory behavior	Fig4	IMP	MGI:MGI:3716838	Mouse	PMID:17572665
Biological Process	GO:0007041	lysosomal transport	fig4a	IMP	ZFIN:ZDB-GENO-220421-19	Zfish	PMID:33909505
Biological Process	GO:0007041	lysosomal transport	fig4a	IMP	ZFIN:ZDB-GENO-220421-22	Zfish	PMID:33909505
Biological Process	GO:0032288	myelin assembly	Fig4	IGI	MGI:MGI:1924366	Mouse	PMID:22028665
Biological Process	GO:0042552	myelination	Fig4	IMP	MGI:MGI:3716838	Mouse	PMID:22028665
Biological Process	GO:0042552	myelination	Fig4	IGI	MGI:MGI:1924366	Mouse	PMID:22028665
Biological Process	GO:0031642	negative regulation of myelination	Fig4	IGI	MGI:MGI:1924366	Mouse	PMID:22028665
Biological Process	GO:0031642	negative regulation of myelination	Fig4	IMP	MGI:MGI:3716838	Mouse	PMID:22028665
Biological Process	GO:0048666	neuron development	Fig4	IMP	MGI:MGI:3716838	Mouse	PMID:17572665
Biological Process	GO:0048666	neuron development	Fig4	IMP	MGI:MGI:3716838	Mouse	PMID:22028665
Biological Process	GO:0048666	neuron development	Fig4	IGI	MGI:MGI:1924366	Mouse	PMID:22028665
Biological Process	GO:0046488	phosphatidylinositol metabolic process	Fig4	IMP	MGI:MGI:3716838	Mouse	PMID:17572665
Biological Process	GO:0046488	phosphatidylinositol metabolic process	Fig4	IMP	MGI:MGI:3716838	Mouse	PMID:22028665
Biological Process	GO:0043473	pigmentation	Fig4	IMP	MGI:MGI:3716838	Mouse	PMID:22028665
Biological Process	GO:0043473	pigmentation	Fig4	IMP	MGI:MGI:3716838	Mouse	PMID:17572665
Biological Process	GO:0010976	positive regulation of neuron projection development	Fig4	IMP		Rat	PMID:17909536|RGD:2312411
Biological Process	GO:0007033	vacuole organization	Fig4	IMP	MGI:MGI:3716838	Mouse	PMID:17572665

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern