Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes FIS1
  • Mouse genes Fis1
  • Rat genes Fis1
  • Zfish genes fis1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Fis1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0042802	identical protein binding	FIS1	IPI	UniProtKB:Q9Y3D6	Human	PMID:18353969
Molecular Function	GO:0042802	identical protein binding	FIS1	IPI	UniProtKB:Q9Y3D6	Human	PMID:18845145
Molecular Function	GO:0008289	lipid binding	FIS1	EXP		Human	PMID:14623186
Molecular Function	GO:0060090	molecular adaptor activity	FIS1	EXP		Human	PMID:14623186
Molecular Function	GO:0005515	protein binding	FIS1	IPI	UniProtKB:O00429	Human	PMID:12861026
Molecular Function	GO:0005515	protein binding	FIS1	IPI	UniProtKB:Q9NX47	Human	PMID:16874301
Molecular Function	GO:0005515	protein binding	FIS1	IPI	UniProtKB:O96011	Human	PMID:17408615
Molecular Function	GO:0005515	protein binding	FIS1	IPI	UniProtKB:P40855	Human	PMID:18782765
Molecular Function	GO:0005515	protein binding	FIS1	IPI	UniProtKB:O75192	Human	PMID:20826455
Molecular Function	GO:0005515	protein binding	FIS1	IPI	UniProtKB:O96011	Human	PMID:20826455
Molecular Function	GO:0005515	protein binding	FIS1	IPI	UniProtKB:Q96HA9	Human	PMID:20826455
Molecular Function	GO:0005515	protein binding	FIS1	IPI	UniProtKB:O00429	Human	PMID:21149567
Molecular Function	GO:0005515	protein binding	FIS1	IPI	UniProtKB:P51572	Human	PMID:21183955
Molecular Function	GO:0005515	protein binding	FIS1	IPI	UniProtKB:Q9HC29	Human	PMID:21699783
Molecular Function	GO:0005515	protein binding	FIS1	IPI	UniProtKB:Q9NQG6	Human	PMID:21701560
Molecular Function	GO:0005515	protein binding	FIS1	IPI	UniProtKB:Q8N6L0	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	FIS1	IPI	UniProtKB:O00429	Human	PMID:29464060
Molecular Function	GO:0005515	protein binding	FIS1	IPI	UniProtKB:O15552	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	FIS1	IPI	UniProtKB:P48051	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	FIS1	IPI	UniProtKB:P57054	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	FIS1	IPI	UniProtKB:Q13336-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	FIS1	IPI	UniProtKB:Q15125	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	FIS1	IPI	UniProtKB:Q3KNW5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	FIS1	IPI	UniProtKB:Q5JX71	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	FIS1	IPI	UniProtKB:Q6P5S7	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	FIS1	IPI	UniProtKB:Q6ZT21	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	FIS1	IPI	UniProtKB:Q8N4V1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	FIS1	IPI	UniProtKB:Q8N5M9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	FIS1	IPI	UniProtKB:Q96BI3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	FIS1	IPI	UniProtKB:Q96KR6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	FIS1	IPI	UniProtKB:Q9BV23	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	FIS1	IPI	UniProtKB:Q9NUH8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	FIS1	IPI	UniProtKB:Q9NY72	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	FIS1	IPI	UniProtKB:Q9Y282	Human	PMID:32296183
Cellular Component	GO:0016020	membrane	FIS1	HDA		Human	PMID:19946888
Cellular Component	GO:0005741	mitochondrial outer membrane	FIS1	IDA		Human	PMID:14996942
Cellular Component	GO:0005741	mitochondrial outer membrane	Fis1	IDA		Rat	PMID:15979461|RGD:12738370
Cellular Component	GO:0005739	mitochondrion	FIS1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005739	mitochondrion	FIS1	IDA		Human	PMID:17408615
Cellular Component	GO:0005739	mitochondrion	FIS1	IDA		Human	PMID:17545159
Cellular Component	GO:0005739	mitochondrion	FIS1	IDA		Human	PMID:18782765
Cellular Component	GO:0005739	mitochondrion	FIS1	IDA		Human	PMID:19864424
Cellular Component	GO:0005739	mitochondrion	FIS1	IDA		Human	PMID:20451243
Cellular Component	GO:0005739	mitochondrion	FIS1	IDA		Human	PMID:21183955
Cellular Component	GO:0005739	mitochondrion	Fis1	HDA		Mouse	PMID:18614015
Cellular Component	GO:0005739	mitochondrion	Fis1	HDA		Mouse	PMID:14651853
Cellular Component	GO:0005739	mitochondrion	Fis1	IDA		Mouse	PMID:17035996
Cellular Component	GO:0005739	mitochondrion	Fis1	IDA		Rat	PMID:27045873|RGD:12436727
Cellular Component	GO:0005778	peroxisomal membrane	FIS1	IDA		Human	PMID:16107562
Cellular Component	GO:0005778	peroxisomal membrane	FIS1	IDA		Human	PMID:17408615
Cellular Component	GO:0005778	peroxisomal membrane	Fis1	IDA		Rat	PMID:16107562|RGD:12738367
Cellular Component	GO:0005777	peroxisome	FIS1	IDA		Human	PMID:18782765
Cellular Component	GO:0005777	peroxisome	FIS1	IDA		Human	PMID:20451243
Cellular Component	GO:0005777	peroxisome	FIS1	IDA		Human	PMID:23921378
Cellular Component	GO:0005777	peroxisome	Fis1	IDA		Rat	PMID:14561759|RGD:1580664
Cellular Component	GO:0032991	protein-containing complex	FIS1	IDA		Human	PMID:17408615
Cellular Component	GO:0032991	protein-containing complex	FIS1	IDA		Human	PMID:18353969
Cellular Component	GO:0032991	protein-containing complex	FIS1	IDA		Human	PMID:20826455
Biological Process	GO:0000422	autophagy of mitochondrion	FIS1	IDA		Human	PMID:18515060
Biological Process	GO:0035584	calcium-mediated signaling using intracellular calcium source	FIS1	IMP		Human	PMID:21183955
Biological Process	GO:0071333	cellular response to glucose stimulus	Fis1	IEP		Rat	PMID:27684054|RGD:12436725
Biological Process	GO:0071396	cellular response to lipid	Fis1	IEP		Rat	PMID:18006463|RGD:12738362
Biological Process	GO:1901653	cellular response to peptide	Fis1	IDA		Rat	PMID:24103571|RGD:12738206
Biological Process	GO:0097237	cellular response to toxic substance	Fis1	IEP		Rat	PMID:26732598|RGD:12436726
Biological Process	GO:0055088	lipid homeostasis	fis1	IMP	ZFIN:ZDB-MRPHLNO-170131-2	Zfish	PMID:27497958
Biological Process	GO:0000266	mitochondrial fission	FIS1	IDA		Human	PMID:16118244
Biological Process	GO:0000266	mitochondrial fission	FIS1	IDA		Human	PMID:18845145
Biological Process	GO:0000266	mitochondrial fission	FIS1	IMP		Human	PMID:19864424
Biological Process	GO:0000266	mitochondrial fission	Fis1	IMP		Mouse	MGI:MGI:5508698|PMID:23283981
Biological Process	GO:0043653	mitochondrial fragmentation involved in apoptotic process	FIS1	IDA		Human	PMID:16118244
Biological Process	GO:0043653	mitochondrial fragmentation involved in apoptotic process	FIS1	IDA		Human	PMID:17545159
Biological Process	GO:0043653	mitochondrial fragmentation involved in apoptotic process	FIS1	IMP		Human	PMID:18353969
Biological Process	GO:0043653	mitochondrial fragmentation involved in apoptotic process	FIS1	IMP		Human	PMID:19864424
Biological Process	GO:0043653	mitochondrial fragmentation involved in apoptotic process	Fis1	IMP		Rat	PMID:18940801|RGD:2314538
Biological Process	GO:0008053	mitochondrial fusion	FIS1	IMP		Human	PMID:23921378
Biological Process	GO:0070584	mitochondrion morphogenesis	FIS1	IMP		Human	PMID:21149567
Biological Process	GO:0070584	mitochondrion morphogenesis	FIS1	IMP		Human	PMID:18845145
Biological Process	GO:1903579	negative regulation of ATP metabolic process	FIS1	IMP		Human	PMID:32521232
Biological Process	GO:0032471	negative regulation of endoplasmic reticulum calcium ion concentration	FIS1	IMP		Human	PMID:21183955
Biological Process	GO:2000192	negative regulation of fatty acid transport	FIS1	IMP		Human	PMID:32521232
Biological Process	GO:0016559	peroxisome fission	FIS1	IDA		Human	PMID:16107562
Biological Process	GO:0016559	peroxisome fission	FIS1	IDA		Human	PMID:17408615
Biological Process	GO:0016559	peroxisome fission	FIS1	IMP		Human	PMID:20826455
Biological Process	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	FIS1	IMP		Human	PMID:21183955
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration	FIS1	IMP		Human	PMID:21183955
Biological Process	GO:2001244	positive regulation of intrinsic apoptotic signaling pathway	FIS1	IMP		Human	PMID:21183955
Biological Process	GO:0051561	positive regulation of mitochondrial calcium ion concentration	FIS1	IMP		Human	PMID:21183955
Biological Process	GO:0090141	positive regulation of mitochondrial fission	FIS1	IDA		Human	PMID:23283981
Biological Process	GO:0090141	positive regulation of mitochondrial fission	Fis1	IMP		Rat	PMID:15979461|RGD:12738370
Biological Process	GO:0090141	positive regulation of mitochondrial fission	Fis1	IMP		Rat	PMID:17443673|RGD:12738363
Biological Process	GO:0043525	positive regulation of neuron apoptotic process	Fis1	IMP		Rat	PMID:18940801|RGD:2314538
Biological Process	GO:0090314	positive regulation of protein targeting to membrane	FIS1	IDA		Human	PMID:23283981
Biological Process	GO:0006626	protein targeting to mitochondrion	FIS1	IMP		Human	PMID:18845145
Biological Process	GO:0010821	regulation of mitochondrion organization	FIS1	IMP		Human	PMID:18353969
Biological Process	GO:0010821	regulation of mitochondrion organization	FIS1	IMP		Human	PMID:21149567
Biological Process	GO:0001836	release of cytochrome c from mitochondria	FIS1	IMP		Human	PMID:19864424
Biological Process	GO:0034976	response to endoplasmic reticulum stress	Fis1	IMP		Rat	PMID:17443673|RGD:12738363
Biological Process	GO:1905395	response to flavonoid	Fis1	IEP		Rat	PMID:24637344|RGD:12738213
Biological Process	GO:1902617	response to fluoride	Fis1	IEP		Rat	PMID:23007560|RGD:12738230
Biological Process	GO:1990910	response to hypobaric hypoxia	Fis1	IEP		Rat	PMID:24361501|RGD:12738138
Biological Process	GO:0014850	response to muscle activity	Fis1	IEP		Rat	PMID:24943897|RGD:12437082
Biological Process	GO:0031667	response to nutrient levels	Fis1	IEP		Rat	PMID:25336449|RGD:12880438

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern