Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes FITM2
  • Mouse genes Fitm2
  • Rat genes Fitm2
  • Zfish genes fitm2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Fitm2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0106399	acyl-coenzyme A diphosphatase activity	FITM2	IMP		Human	PMID:32915949
Molecular Function	GO:0019992	diacylglycerol binding	Fitm2	IDA		Mouse	MGI:MGI:6478052|PMID:22106267
Molecular Function	GO:0005515	protein binding	FITM2	IPI	UniProtKB:Q53HI1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	FITM2	IPI	UniProtKB:Q9BUP3-3	Human	PMID:32296183
Molecular Function	GO:0017129	triglyceride binding	Fitm2	IDA		Mouse	MGI:MGI:6478052|PMID:22106267
Cellular Component	GO:0005789	endoplasmic reticulum membrane	Fitm2	IDA		Mouse	MGI:MGI:3772596|PMID:18160536
Cellular Component	GO:0005789	endoplasmic reticulum membrane	Fitm2	IDA		Mouse	MGI:MGI:4943823|PMID:20520733
Cellular Component	GO:0005739	mitochondrion	Fitm2	HDA		Mouse	PMID:18614015
Biological Process	GO:0007010	cytoskeleton organization	FITM2	IMP		Human	PMID:21834987
Biological Process	GO:0031018	endocrine pancreas development	fitm2	IMP	ZFIN:ZDB-MRPHLNO-160621-20	Zfish	PMID:26963759
Biological Process	GO:0036115	fatty-acyl-CoA catabolic process	FITM2	IMP		Human	PMID:32915949
Biological Process	GO:0042593	glucose homeostasis	fitm2	IMP	ZFIN:ZDB-MRPHLNO-160621-20	Zfish	PMID:26963759
Biological Process	GO:0035356	intracellular triglyceride homeostasis	Fitm2	IMP		Mouse	MGI:MGI:3772596|PMID:18160536
Biological Process	GO:0140042	lipid droplet formation	FITM2	IMP		Human	PMID:32915949
Biological Process	GO:0140042	lipid droplet formation	Fitm2	IDA		Mouse	MGI:MGI:6478052|PMID:22106267
Biological Process	GO:0140042	lipid droplet formation	Fitm2	IMP		Mouse	MGI:MGI:5763334|PMID:26504167
Biological Process	GO:0034389	lipid droplet organization	Fitm2	IMP		Mouse	MGI:MGI:4943823|PMID:20520733
Biological Process	GO:0034389	lipid droplet organization	Fitm2	IDA		Mouse	MGI:MGI:3772596|PMID:18160536
Biological Process	GO:0055088	lipid homeostasis	FITM2	IMP		Human	PMID:32915949
Biological Process	GO:0019915	lipid storage	fitm2	IMP	ZFIN:ZDB-MRPHLNO-080424-1	Zfish	PMID:18160536
Biological Process	GO:0019915	lipid storage	fitm2	IMP	ZFIN:ZDB-MRPHLNO-080424-2	Zfish	PMID:18160536
Biological Process	GO:1990798	pancreas regeneration	fitm2	IMP	ZFIN:ZDB-MRPHLNO-160621-20	Zfish	PMID:26963759
Biological Process	GO:0010890	positive regulation of sequestering of triglyceride	Fitm2	IDA		Mouse	MGI:MGI:3772596|PMID:18160536
Biological Process	GO:0022604	regulation of cell morphogenesis	FITM2	IMP		Human	PMID:21834987
Biological Process	GO:0010866	regulation of triglyceride biosynthetic process	Fitm2	IMP		Mouse	MGI:MGI:3772596|PMID:18160536
Biological Process	GO:0030730	sequestering of triglyceride	Fitm2	IMP	MGI:MGI:2386686,MGI:MGI:5621176	Mouse	PMID:24519944
Biological Process	GO:0003323	type B pancreatic cell development	fitm2	IMP	ZFIN:ZDB-MRPHLNO-160621-20	Zfish	PMID:26963759

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern