Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes FKBP1A,FKBP1C
  • Mouse genes Fkbp1a
  • Rat genes Fkbp1a
  • Zfish genes fkbp1aa,fkbp1ab
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Fkbp1a

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0048185	activin binding	FKBP1A	IPI	UniProtKB:P36896	Human	PMID:16720724
Molecular Function	GO:0019899	enzyme binding	Fkbp1a	IPI	RGD:3337|RGD:2553	Rat	PMID:17877381|RGD:2302074
Molecular Function	GO:0005528	FK506 binding	FKBP1A	IDA		Human	PMID:7592869
Molecular Function	GO:0005528	FK506 binding	FKBP1A	IDA		Human	PMID:9880681
Molecular Function	GO:0005528	FK506 binding	Fkbp1a	IDA		Mouse	PMID:1722474
Molecular Function	GO:0005528	FK506 binding	Fkbp1a	IDA		Rat	PMID:9013543|RGD:61587
Molecular Function	GO:0030544	Hsp70 protein binding	Fkbp1a	IPI	RGD:621725	Rat	PMID:17877381|RGD:2302074
Molecular Function	GO:0042802	identical protein binding	Fkbp1a	IPI	PR:P26883	Mouse	PMID:22750946
Molecular Function	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	FKBP1A	IDA		Human	PMID:1696686
Molecular Function	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	FKBP1A	IDA		Human	PMID:1701173
Molecular Function	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	FKBP1A	IDA		Human	PMID:2477715
Molecular Function	GO:0005515	protein binding	FKBP1A	IPI	UniProtKB:P36897	Human	PMID:10025408
Molecular Function	GO:0005515	protein binding	FKBP1A	IPI	UniProtKB:P42345	Human	PMID:10089303
Molecular Function	GO:0005515	protein binding	FKBP1A	IPI	UniProtKB:Q9TS33	Human	PMID:10358090
Molecular Function	GO:0005515	protein binding	FKBP1A	IPI	UniProtKB:Q92736	Human	PMID:11237759
Molecular Function	GO:0005515	protein binding	FKBP1A	IPI	UniProtKB:Q92990	Human	PMID:12604780
Molecular Function	GO:0005515	protein binding	FKBP1A	IPI	UniProtKB:P11716	Human	PMID:12629052
Molecular Function	GO:0005515	protein binding	FKBP1A	IPI	UniProtKB:O15105	Human	PMID:16720724
Molecular Function	GO:0005515	protein binding	FKBP1A	IPI	UniProtKB:P36896	Human	PMID:16720724
Molecular Function	GO:0005515	protein binding	FKBP1A	IPI	UniProtKB:P42345	Human	PMID:17148612
Molecular Function	GO:0005515	protein binding	FKBP1A	IPI	UniProtKB:P0C6X7:PRO_0000037309	Human	PMID:22046132
Molecular Function	GO:0005515	protein binding	FKBP1A	IPI	UniProtKB:P0C6X7:PRO_0000037312	Human	PMID:22046132
Molecular Function	GO:0005515	protein binding	FKBP1A	IPI	UniProtKB:P42345	Human	PMID:22664266
Molecular Function	GO:0005515	protein binding	FKBP1A	IPI	UniProtKB:P05067	Human	PMID:24499793
Molecular Function	GO:0005515	protein binding	FKBP1A	IPI	UniProtKB:P36897	Human	PMID:24658140
Molecular Function	GO:0005515	protein binding	FKBP1A	IPI	UniProtKB:Q9NZD4	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	FKBP1A	IPI	UniProtKB:P42345	Human	PMID:29997244
Molecular Function	GO:0005515	protein binding	FKBP1A	IPI	UniProtKB:P05067	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	FKBP1A	IPI	UniProtKB:P11716	Human	PMID:9857007
Molecular Function	GO:0005515	protein binding	Fkbp1a	IPI	UniProtKB:E9PZQ0	Mouse	MGI:MGI:5438859|PMID:22939628
Molecular Function	GO:0005515	protein binding	Fkbp1a	IPI	UniProtKB:E9PZQ0	Mouse	MGI:MGI:3775502|PMID:18268335
Molecular Function	GO:0005515	protein binding	Fkbp1a	IPI	PR:E9PZQ0	Mouse	PMID:15289441
Molecular Function	GO:0005515	protein binding	Fkbp1a	IPI	PR:E9PZQ0	Mouse	PMID:12704193
Molecular Function	GO:0005515	protein binding	Fkbp1a	IPI	PR:E9PZQ0	Mouse	PMID:14592808
Molecular Function	GO:0005515	protein binding	Fkbp1a	IPI	RGD:71005	Rat	PMID:17877381|RGD:2302074
Molecular Function	GO:0046332	SMAD binding	FKBP1A	IPI	UniProtKB:O15105	Human	PMID:16720724
Molecular Function	GO:0005160	transforming growth factor beta receptor binding	Fkbp1a	IDA		Rat	PMID:7518616|RGD:8554044
Molecular Function	GO:0044325	transmembrane transporter binding	Fkbp1a	IPI	UniProtKB:E9PZQ0	Mouse	MGI:MGI:3837615|PMID:19198614
Molecular Function	GO:0034713	type I transforming growth factor beta receptor binding	FKBP1A	IPI	UniProtKB:P36897	Human	PMID:11583628
Molecular Function	GO:0034713	type I transforming growth factor beta receptor binding	Fkbp1a	IDA		Rat	PMID:7518616|RGD:8554044
Cellular Component	GO:0043679	axon terminus	Fkbp1a	IDA		Rat	PMID:12494287|RGD:1580386
Cellular Component	GO:0005737	cytoplasm	FKBP1A	IDA		Human	PMID:12443530
Cellular Component	GO:0005829	cytosol	FKBP1A	IDA		Human	PMID:1701173
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	Fkbp1a	IDA		Rat	PMID:9013543|RGD:61587
Cellular Component	GO:0016020	membrane	FKBP1A	IDA		Human	PMID:12443530
Cellular Component	GO:0016020	membrane	Fkbp1a	IDA		Mouse	PMID:12704193
Cellular Component	GO:0033017	sarcoplasmic reticulum membrane	Fkbp1a	IDA		Mouse	PMID:14592808
Cellular Component	GO:0045202	synapse	Fkbp1a	EXP		Mouse	PMID:24534009
Cellular Component	GO:0045202	synapse	Fkbp1a	IDA		Mouse	PMID:24534009
Cellular Component	GO:0030018	Z disc	FKBP1A	IDA		Human	PMID:20431056
Biological Process	GO:1990000	amyloid fibril formation	FKBP1A	IDA		Human	PMID:18346205
Biological Process	GO:0019221	cytokine-mediated signaling pathway	Fkbp1a	IMP	MGI:MGI:2158807	Mouse	PMID:14605212
Biological Process	GO:0003007	heart morphogenesis	Fkbp1a	IMP		Mouse	MGI:MGI:1195585|PMID:9461216
Biological Process	GO:0060347	heart trabecula formation	Fkbp1a	IMP		Mouse	MGI:MGI:1195585|PMID:9461216
Biological Process	GO:0006936	muscle contraction	Fkbp1a	IMP	MGI:MGI:2182095,MGI:MGI:3514012	Mouse	PMID:15289441
Biological Process	GO:0032515	negative regulation of phosphoprotein phosphatase activity	FKBP1A	IDA		Human	PMID:7592869
Biological Process	GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	FKBP1A	IDA		Human	PMID:11583628
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	FKBP1A	HMP		Human	PMID:12761501
Biological Process	GO:0032092	positive regulation of protein binding	FKBP1A	IDA		Human	PMID:18346205
Biological Process	GO:0031398	positive regulation of protein ubiquitination	FKBP1A	IDA		Human	PMID:16720724
Biological Process	GO:0000413	protein peptidyl-prolyl isomerization	FKBP1A	IDA		Human	PMID:1696686
Biological Process	GO:0032925	regulation of activin receptor signaling pathway	FKBP1A	IDA		Human	PMID:16720724
Biological Process	GO:1902991	regulation of amyloid precursor protein catabolic process	FKBP1A	IGI	UniProtKB:P05067	Human	PMID:24499793
Biological Process	GO:0050776	regulation of immune response	FKBP1A	IMP		Human	PMID:2477715
Biological Process	GO:0032880	regulation of protein localization	FKBP1A	IGI	UniProtKB:P05067	Human	PMID:24499793
Biological Process	GO:0060314	regulation of ryanodine-sensitive calcium-release channel activity	FKBP1A	IDA		Human	PMID:7592869
Biological Process	GO:0060314	regulation of ryanodine-sensitive calcium-release channel activity	Fkbp1a	IMP		Mouse	MGI:MGI:1195585|PMID:9461216
Biological Process	GO:0051209	release of sequestered calcium ion into cytosol	Fkbp1a	IMP	MGI:MGI:2182095,MGI:MGI:3514012	Mouse	PMID:15289441
Biological Process	GO:0051209	release of sequestered calcium ion into cytosol	Fkbp1a	IDA		Mouse	PMID:12704193
Biological Process	GO:0031000	response to caffeine	Fkbp1a	IMP	MGI:MGI:2182095,MGI:MGI:3514012	Mouse	PMID:15289441
Biological Process	GO:0010039	response to iron ion	Fkbp1a	IEP		Rat	PMID:17546681|RGD:2302076
Biological Process	GO:0007183	SMAD protein complex assembly	FKBP1A	IDA		Human	PMID:16720724
Biological Process	GO:0097435	supramolecular fiber organization	FKBP1A	IDA		Human	PMID:18346205
Biological Process	GO:0042098	T cell proliferation	Fkbp1a	IMP	MGI:MGI:2158807	Mouse	PMID:14605212
Biological Process	GO:0055010	ventricular cardiac muscle tissue morphogenesis	Fkbp1a	IMP		Mouse	MGI:MGI:1195585|PMID:9461216

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern