Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes FKBP1B
  • Mouse genes Fkbp1b
  • Rat genes Fkbp1b
  • Zfish genes fkbp1b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Fkbp1b

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0019855	calcium channel inhibitor activity	FKBP1B	IDA		Human	PMID:12443530
Molecular Function	GO:0019855	calcium channel inhibitor activity	FKBP1B	IDA		Human	PMID:20431056
Molecular Function	GO:0030551	cyclic nucleotide binding	Fkbp1b	IDA		Rat	PMID:9013543|RGD:61587
Molecular Function	GO:0005528	FK506 binding	FKBP1B	IDA		Human	PMID:7592869
Molecular Function	GO:0005528	FK506 binding	Fkbp1b	IDA		Mouse	PMID:14592808
Molecular Function	GO:0005528	FK506 binding	Fkbp1b	IDA		Rat	PMID:9013543|RGD:61587
Molecular Function	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	FKBP1B	IDA		Human	PMID:7592869
Molecular Function	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	Fkbp1b	IDA		Mouse	PMID:16481613
Molecular Function	GO:0005515	protein binding	FKBP1B	IPI	UniProtKB:Q92736	Human	PMID:10830164
Molecular Function	GO:0005515	protein binding	FKBP1B	IPI	UniProtKB:Q92736	Human	PMID:11237759
Molecular Function	GO:0005515	protein binding	FKBP1B	IPI	UniProtKB:Q92736	Human	PMID:23233753
Molecular Function	GO:0005515	protein binding	FKBP1B	IPI	UniProtKB:Q04864	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	FKBP1B	IPI	UniProtKB:Q13557	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	FKBP1B	IPI	UniProtKB:Q15323	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	FKBP1B	IPI	UniProtKB:Q53SE7	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	FKBP1B	IPI	UniProtKB:Q6A162	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	FKBP1B	IPI	UniProtKB:Q6UY14-3	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	FKBP1B	IPI	UniProtKB:Q86WT6	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	FKBP1B	IPI	UniProtKB:Q8WN72	Human	PMID:7592869
Molecular Function	GO:0005515	protein binding	Fkbp1b	IPI	UniProtKB:E9Q401	Mouse	MGI:MGI:5438859|PMID:22939628
Molecular Function	GO:0005515	protein binding	Fkbp1b	IPI	PR:E9Q401	Mouse	PMID:14592808
Molecular Function	GO:0005515	protein binding	Fkbp1b	IPI	PR:E9Q401	Mouse	PMID:16481613
Molecular Function	GO:0005102	signaling receptor binding	FKBP1B	IPI	UniProtKB:Q92736	Human	PMID:10830164
Molecular Function	GO:0005102	signaling receptor binding	FKBP1B	IPI	UniProtKB:Q92736	Human	PMID:17921453
Molecular Function	GO:0044325	transmembrane transporter binding	Fkbp1b	IPI	UniProtKB:E9Q401	Mouse	MGI:MGI:4420848|PMID:20080623
Molecular Function	GO:0044325	transmembrane transporter binding	Fkbp1b	IPI	UniProtKB:E9Q401	Mouse	MGI:MGI:3690823|PMID:16213210
Molecular Function	GO:0044325	transmembrane transporter binding	Fkbp1b	IPI	PR:E9Q401	Mouse	PMID:21788490
Cellular Component	GO:0034704	calcium channel complex	FKBP1B	IDA		Human	PMID:10830164
Cellular Component	GO:0034704	calcium channel complex	Fkbp1b	IDA		Mouse	MGI:MGI:3690823|PMID:16213210
Cellular Component	GO:0005737	cytoplasm	FKBP1B	IDA		Human	PMID:12443530
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	Fkbp1b	IDA		Rat	PMID:9013543|RGD:61587
Cellular Component	GO:0016020	membrane	FKBP1B	IDA		Human	PMID:12443530
Cellular Component	GO:0016529	sarcoplasmic reticulum	Fkbp1b	IDA		Mouse	PMID:19578067
Cellular Component	GO:0016529	sarcoplasmic reticulum	Fkbp1b	IDA		Mouse	PMID:21788490
Cellular Component	GO:0033017	sarcoplasmic reticulum membrane	Fkbp1b	IDA		Mouse	PMID:16481613
Cellular Component	GO:0033017	sarcoplasmic reticulum membrane	Fkbp1b	IDA		Mouse	PMID:14592808
Cellular Component	GO:0030018	Z disc	FKBP1B	IDA		Human	PMID:20431056
Biological Process	GO:0030073	insulin secretion	Fkbp1b	IMP	MGI:MGI:3720261,MGI:MGI:3796253	Mouse	PMID:18466757
Biological Process	GO:0035773	insulin secretion involved in cellular response to glucose stimulus	Fkbp1b	IMP	MGI:MGI:2182644	Mouse	PMID:19805579
Biological Process	GO:0010459	negative regulation of heart rate	Fkbp1b	IMP		Mouse	MGI:MGI:3621834|PMID:12837242
Biological Process	GO:0061179	negative regulation of insulin secretion involved in cellular response to glucose stimulus	Fkbp1b	IMP	MGI:MGI:2182644	Mouse	PMID:19805579
Biological Process	GO:0032515	negative regulation of phosphoprotein phosphatase activity	FKBP1B	IDA		Human	PMID:7592869
Biological Process	GO:0051280	negative regulation of release of sequestered calcium ion into cytosol	FKBP1B	IDA		Human	PMID:12443530
Biological Process	GO:0060315	negative regulation of ryanodine-sensitive calcium-release channel activity	FKBP1B	IDA		Human	PMID:12443530
Biological Process	GO:0019227	neuronal action potential propagation	Fkbp1b	IMP	MGI:MGI:2182644	Mouse	PMID:14605212
Biological Process	GO:0048680	positive regulation of axon regeneration	Fkbp1b	IDA		Rat	PMID:9512405|RGD:7205517
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration	Fkbp1b	IMP	MGI:MGI:2182644	Mouse	PMID:19805579
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration	Fkbp1b	IDA		Rat	PMID:9013543|RGD:61587
Biological Process	GO:0051284	positive regulation of sequestering of calcium ion	FKBP1B	IDA		Human	PMID:12443530
Biological Process	GO:0000413	protein peptidyl-prolyl isomerization	FKBP1B	IDA		Human	PMID:7592869
Biological Process	GO:0010881	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion	Fkbp1b	IMP		Mouse	MGI:MGI:3621834|PMID:12837242
Biological Process	GO:0051480	regulation of cytosolic calcium ion concentration	FKBP1B	IDA		Human	PMID:20431056
Biological Process	GO:0051480	regulation of cytosolic calcium ion concentration	FKBP1B	IGI	UniProtKB:Q9Z2I2	Human	PMID:22087651
Biological Process	GO:0051480	regulation of cytosolic calcium ion concentration	Fkbp1b	IMP		Mouse	MGI:MGI:5499717|PMID:22087651
Biological Process	GO:0002027	regulation of heart rate	Fkbp1b	IMP	MGI:MGI:3623214	Mouse	PMID:16672364
Biological Process	GO:0010880	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	FKBP1B	IDA		Human	PMID:20431056
Biological Process	GO:0010880	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	Fkbp1b	IMP	MGI:MGI:2182644	Mouse	PMID:19578067
Biological Process	GO:0010880	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	Fkbp1b	IMP	MGI:MGI:2182644	Mouse	PMID:14592808
Biological Process	GO:0010880	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	Fkbp1b	IMP	MGI:MGI:3623214	Mouse	PMID:16672364
Biological Process	GO:0060314	regulation of ryanodine-sensitive calcium-release channel activity	FKBP1B	IDA		Human	PMID:20431056
Biological Process	GO:0060314	regulation of ryanodine-sensitive calcium-release channel activity	FKBP1B	IMP		Human	PMID:7592869
Biological Process	GO:0060314	regulation of ryanodine-sensitive calcium-release channel activity	Fkbp1b	IMP		Mouse	MGI:MGI:3621834|PMID:12837242
Biological Process	GO:0051209	release of sequestered calcium ion into cytosol	Fkbp1b	IMP	MGI:MGI:2182644	Mouse	PMID:15024040
Biological Process	GO:0009749	response to glucose	Fkbp1b	IMP	MGI:MGI:3720261,MGI:MGI:3796253	Mouse	PMID:18466757
Biological Process	GO:0042542	response to hydrogen peroxide	Fkbp1b	IEP		Rat	PMID:18611397|RGD:2302078
Biological Process	GO:0010033	response to organic substance	Fkbp1b	IEP		Rat	PMID:19000375|RGD:2302065
Biological Process	GO:0051775	response to redox state	FKBP1B	IDA		Human	PMID:19226252
Biological Process	GO:0033197	response to vitamin E	Fkbp1b	IEP		Rat	PMID:18611397|RGD:2302078
Biological Process	GO:0006939	smooth muscle contraction	Fkbp1b	IMP	MGI:MGI:2182644	Mouse	PMID:14592808
Biological Process	GO:0042098	T cell proliferation	Fkbp1b	IMP	MGI:MGI:2182644	Mouse	PMID:14605212

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern