Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes FLI1
  • Mouse genes Fli1
  • Rat genes Fli1
  • Zfish genes fli1,fli1rs
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Fli1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003682	chromatin binding	Fli1	IDA		Mouse	PMID:16757682
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Fli1	IDA		Mouse	MGI:MGI:3721210|PMID:17606295
Molecular Function	GO:0005515	protein binding	FLI1	IPI	UniProtKB:P84022	Human	PMID:20211142
Molecular Function	GO:0005515	protein binding	FLI1	IPI	UniProtKB:O94993	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	FLI1	IPI	UniProtKB:P56545-3	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	FLI1	IPI	UniProtKB:Q8IUQ4	Human	PMID:25416956
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Fli1	IDA		Mouse	MGI:MGI:3721210|PMID:17606295
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Fli1	IDA		Mouse	PMID:17962413
Molecular Function	GO:0043565	sequence-specific DNA binding	Fli1	IDA		Mouse	PMID:21867929
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	FLI1	IDA		Human	PMID:28473536
Molecular Function	GO:0000976	transcription cis-regulatory region binding	FLI1	IDA		Human	PMID:31146003
Cellular Component	GO:0005829	cytosol	FLI1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0016604	nuclear body	FLI1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	FLI1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	FLI1	IDA		Human	PMID:28255014
Cellular Component	GO:0005634	nucleus	Fli1	IDA		Mouse	PMID:12527908
Biological Process	GO:0001525	angiogenesis	fli1rs	IGI	ZFIN:ZDB-GENE-050622-14	Zfish	PMID:25722433
Biological Process	GO:0001525	angiogenesis	fli1	IGI	ZFIN:ZDB-MRPHLNO-081231-1,ZFIN:ZDB-MRPHLNO-090602-4	Zfish	PMID:18832752
Biological Process	GO:0009887	animal organ morphogenesis	Fli1	IMP	MGI:MGI:1888942	Mouse	PMID:10981960
Biological Process	GO:0008015	blood circulation	Fli1	IMP	MGI:MGI:1888942	Mouse	PMID:10981960
Biological Process	GO:0048514	blood vessel morphogenesis	fli1rs	IGI	ZFIN:ZDB-MRPHLNO-070605-1,ZFIN:ZDB-MRPHLNO-070605-4,ZFIN:ZDB-MRPHLNO-070605-5	Zfish	PMID:17125762
Biological Process	GO:0048514	blood vessel morphogenesis	fli1rs	IGI	ZFIN:ZDB-MRPHLNO-070605-4,ZFIN:ZDB-MRPHLNO-070605-5,ZFIN:ZDB-MRPHLNO-070605-6	Zfish	PMID:17125762
Biological Process	GO:0048514	blood vessel morphogenesis	fli1rs	IGI	ZFIN:ZDB-MRPHLNO-070605-1,ZFIN:ZDB-MRPHLNO-070605-5,ZFIN:ZDB-MRPHLNO-070605-6	Zfish	PMID:17125762
Biological Process	GO:0048514	blood vessel morphogenesis	fli1	IGI	ZFIN:ZDB-MRPHLNO-070605-1,ZFIN:ZDB-MRPHLNO-070605-4,ZFIN:ZDB-MRPHLNO-070605-6	Zfish	PMID:17125762
Biological Process	GO:0048514	blood vessel morphogenesis	fli1	IGI	ZFIN:ZDB-MRPHLNO-070605-1,ZFIN:ZDB-MRPHLNO-070605-5,ZFIN:ZDB-MRPHLNO-070605-6	Zfish	PMID:17125762
Biological Process	GO:0048514	blood vessel morphogenesis	fli1	IGI	ZFIN:ZDB-MRPHLNO-070605-4,ZFIN:ZDB-MRPHLNO-070605-5,ZFIN:ZDB-MRPHLNO-070605-6	Zfish	PMID:17125762
Biological Process	GO:0035855	megakaryocyte development	Fli1	IMP	MGI:MGI:2386167	Mouse	PMID:16757682
Biological Process	GO:0051091	positive regulation of DNA-binding transcription factor activity	fli1	IMP		Zfish	PMID:15893977
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	FLI1	IDA		Human	PMID:26316623
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	FLI1	IMP		Human	PMID:31146003
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Fli1	IDA		Mouse	MGI:MGI:3721210|PMID:17606295
Biological Process	GO:0006355	regulation of DNA-templated transcription	Fli1	IMP	MGI:MGI:1888942	Mouse	PMID:10981960
Biological Process	GO:0006355	regulation of DNA-templated transcription	fli1rs	IDA		Zfish	PMID:25722433
Biological Process	GO:0001570	vasculogenesis	fli1rs	IGI	ZFIN:ZDB-GENE-050622-14	Zfish	PMID:25722433

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern