Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Flna

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes FLNA
- Mouse genes Flna
- Rat genes Flna
- Zfish genes flna
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Flna

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0051015	actin filament binding	FLNA	IDA		Human	PMID:2391361
Molecular Function	GO:0051015	actin filament binding	FLNA	IDA		Human	PMID:25358863
Molecular Function	GO:0051015	actin filament binding	FLNA	IDA		Human	PMID:3138234
Molecular Function	GO:0051015	actin filament binding	FLNA	IDA		Human	PMID:4044584
Molecular Function	GO:0045296	cadherin binding	FLNA	HDA		Human	PMID:25468996
Molecular Function	GO:0140297	DNA-binding transcription factor binding	FLNA	IPI	UniProtKB:Q12948	Human	PMID:15684392
Molecular Function	GO:0034988	Fc-gamma receptor I complex binding	FLNA	IDA		Human	PMID:1833070
Molecular Function	GO:0001664	G protein-coupled receptor binding	FLNA	IPI	UniProtKB:P04201\|UniProtKB:P25100\|UniProtKB:P30556\|UniProtKB:P35462	Human	PMID:26460884
Molecular Function	GO:0001664	G protein-coupled receptor binding	FLNA	IPI	UniProtKB:P25095	Human	PMID:26460884
Molecular Function	GO:0051020	GTPase binding	FLNA	IPI	UniProtKB:P11233	Human	PMID:16291724
Molecular Function	GO:0019900	kinase binding	FLNA	IPI	UniProtKB:P43405	Human	PMID:20713593
Molecular Function	GO:0031852	mu-type opioid receptor binding	Flna	IMP		Rat	PMID:19172190\|RGD:7207406
Molecular Function	GO:0015459	potassium channel regulator activity	FLNA	IDA		Human	PMID:24951510
Molecular Function	GO:0015459	potassium channel regulator activity	Flna	IMP		Mouse	MGI:MGI:5578267\|PMID:24951510
Molecular Function	GO:0005515	protein binding	FLNA	IPI	UniProtKB:P11233	Human	PMID:10051605
Molecular Function	GO:0005515	protein binding	FLNA	IPI	UniProtKB:P60953	Human	PMID:10051605
Molecular Function	GO:0005515	protein binding	FLNA	IPI	UniProtKB:P61586	Human	PMID:10051605
Molecular Function	GO:0005515	protein binding	FLNA	IPI	UniProtKB:P63000	Human	PMID:10051605
Molecular Function	GO:0005515	protein binding	FLNA	IPI	UniProtKB:P14416	Human	PMID:10692483
Molecular Function	GO:0005515	protein binding	FLNA	IPI	UniProtKB:P35462	Human	PMID:10692483
Molecular Function	GO:0005515	protein binding	FLNA	IPI	UniProtKB:O75369	Human	PMID:12393796
Molecular Function	GO:0005515	protein binding	FLNA	IPI	UniProtKB:P62993	Human	PMID:12577067
Molecular Function	GO:0005515	protein binding	FLNA	IPI	UniProtKB:P35372	Human	PMID:14573758
Molecular Function	GO:0005515	protein binding	FLNA	IPI	UniProtKB:Q12948	Human	PMID:15684392
Molecular Function	GO:0005515	protein binding	FLNA	IPI	UniProtKB:Q9NP98	Human	PMID:16076904
Molecular Function	GO:0005515	protein binding	FLNA	IPI	UniProtKB:Q9UBF9	Human	PMID:16076904
Molecular Function	GO:0005515	protein binding	FLNA	IPI	UniProtKB:P13688	Human	PMID:16291724
Molecular Function	GO:0005515	protein binding	FLNA	IPI	UniProtKB:Q8N264	Human	PMID:16862148
Molecular Function	GO:0005515	protein binding	FLNA	IPI	UniProtKB:O95067	Human	PMID:17408621
Molecular Function	GO:0005515	protein binding	FLNA	IPI	UniProtKB:P46108	Human	PMID:17474147
Molecular Function	GO:0005515	protein binding	FLNA	IPI	UniProtKB:P62993	Human	PMID:17474147
Molecular Function	GO:0005515	protein binding	FLNA	IPI	UniProtKB:P05556	Human	PMID:17690686
Molecular Function	GO:0005515	protein binding	FLNA	IPI	UniProtKB:P26010	Human	PMID:17690686
Molecular Function	GO:0005515	protein binding	FLNA	IPI	UniProtKB:P05556	Human	PMID:18177638
Molecular Function	GO:0005515	protein binding	FLNA	IPI	UniProtKB:P12314	Human	PMID:18322202
Molecular Function	GO:0005515	protein binding	FLNA	IPI	UniProtKB:P05107\|UniProtKB:P07359\|UniProtKB:P26010\|UniProtKB:Q8WUP2	Human	PMID:19828450
Molecular Function	GO:0005515	protein binding	FLNA	IPI	UniProtKB:Q86SQ0	Human	PMID:20236936
Molecular Function	GO:0005515	protein binding	FLNA	IPI	UniProtKB:P97358	Human	PMID:21228480
Molecular Function	GO:0005515	protein binding	FLNA	IPI	UniProtKB:Q80WQ8	Human	PMID:21228480
Molecular Function	GO:0005515	protein binding	FLNA	IPI	UniProtKB:P26010\|UniProtKB:Q8WUP2	Human	PMID:21524097
Molecular Function	GO:0005515	protein binding	FLNA	IPI	UniProtKB:P51114	Human	PMID:21653829
Molecular Function	GO:0005515	protein binding	FLNA	IPI	UniProtKB:Q9BYB0	Human	PMID:21653829
Molecular Function	GO:0005515	protein binding	FLNA	IPI	UniProtKB:Q9WMX2:PRO_0000037548	Human	PMID:21914078
Molecular Function	GO:0005515	protein binding	FLNA	IPI	UniProtKB:Q9WMX2:PRO_0000037551	Human	PMID:21914078
Molecular Function	GO:0005515	protein binding	FLNA	IPI	UniProtKB:P26010-1	Human	PMID:21926999
Molecular Function	GO:0005515	protein binding	FLNA	IPI	UniProtKB:Q5HYA8	Human	PMID:22121117
Molecular Function	GO:0005515	protein binding	FLNA	IPI	UniProtKB:O14786	Human	PMID:24021649
Molecular Function	GO:0005515	protein binding	FLNA	IPI	UniProtKB:P46108	Human	PMID:25241761
Molecular Function	GO:0005515	protein binding	FLNA	IPI	UniProtKB:O14531	Human	PMID:25358863
Molecular Function	GO:0005515	protein binding	FLNA	IPI	UniProtKB:Q14194	Human	PMID:25358863
Molecular Function	GO:0005515	protein binding	FLNA	IPI	UniProtKB:Q14195	Human	PMID:25358863
Molecular Function	GO:0005515	protein binding	FLNA	IPI	UniProtKB:P07359	Human	PMID:25666618
Molecular Function	GO:0005515	protein binding	FLNA	IPI	UniProtKB:P05106	Human	PMID:25849143
Molecular Function	GO:0005515	protein binding	FLNA	IPI	UniProtKB:P08514-1	Human	PMID:25849143
Molecular Function	GO:0005515	protein binding	FLNA	IPI	UniProtKB:Q86SQ0	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	FLNA	IPI	UniProtKB:P13224	Human	PMID:4044584
Molecular Function	GO:0005515	protein binding	FLNA	IPI	UniProtKB:P05556	Human	PMID:9722563
Molecular Function	GO:0005515	protein binding	FLNA	IPI	UniProtKB:P07228	Human	PMID:9722563
Molecular Function	GO:0005515	protein binding	Flna	IPI	UniProtKB:Q8CIH5	Mouse	MGI:MGI:3688344\|PMID:15102471
Molecular Function	GO:0005515	protein binding	Flna	IPI	PR:P23188	Mouse	PMID:9412467
Molecular Function	GO:0005515	protein binding	Flna	IPI	PR:E9Q9D5	Mouse	PMID:23055941
Molecular Function	GO:0005515	protein binding	Flna	IPI	PR:Q8VHG2	Mouse	PMID:18824598
Molecular Function	GO:0005515	protein binding	Flna	IPI	PR:Q9JK37	Mouse	PMID:11114196
Molecular Function	GO:0005515	protein binding	Flna	IPI	PR:Q80X90	Mouse	PMID:12393796
Molecular Function	GO:0005515	protein binding	Flna	IPI	PR:Q5SVD0	Mouse	PMID:24436304
Molecular Function	GO:0005515	protein binding	Flna	IPI	PR:Q61990	Mouse	PMID:8871564
Molecular Function	GO:0005515	protein binding	Flna	IPI	PR:Q7TS73	Mouse	PMID:24436304
Molecular Function	GO:0005515	protein binding	Flna	IPI	RGD:1359203	Rat	PMID:15505042\|RGD:1359754
Molecular Function	GO:0005515	protein binding	Flna	IPI	RGD:2914	Rat	PMID:15661894\|RGD:2312435
Molecular Function	GO:0005515	protein binding	Flna	IPI	UniProtKB:Q62950	Rat	PMID:25358863\|RGD:11059585
Molecular Function	GO:0042803	protein homodimerization activity	FLNA	IDA		Human	PMID:2391361
Molecular Function	GO:0005080	protein kinase C binding	Flna	IDA		Mouse	PMID:12704190
Molecular Function	GO:0044877	protein-containing complex binding	Flna	IPI	RGD:1590969\|RGD:620688	Rat	PMID:22948144\|RGD:9686140
Molecular Function	GO:0003723	RNA binding	FLNA	HDA		Human	PMID:22658674
Molecular Function	GO:0003723	RNA binding	FLNA	HDA		Human	PMID:22681889
Molecular Function	GO:0046332	SMAD binding	Flna	IPI	RGD:3033	Rat	PMID:20167606\|RGD:7207405
Molecular Function	GO:0031267	small GTPase binding	FLNA	IDA		Human	PMID:10051605
Molecular Function	GO:0044325	transmembrane transporter binding	FLNA	IPI	UniProtKB:Q9H2S1	Human	PMID:24951510
Cellular Component	GO:0015629	actin cytoskeleton	FLNA	IDA		Human	GO_REF:0000052
Cellular Component	GO:0015629	actin cytoskeleton	FLNA	IDA		Human	PMID:25358863
Cellular Component	GO:0015629	actin cytoskeleton	Flna	IDA		Mouse	MGI:MGI:5770037\|PMID:25358863
Cellular Component	GO:0015629	actin cytoskeleton	Flna	IDA		Rat	PMID:20167606\|RGD:7207405
Cellular Component	GO:0005884	actin filament	Flna	IDA		Rat	PMID:22872576\|RGD:7207404
Cellular Component	GO:0005884	actin filament	Flna	IDA		Rat	PMID:15661894\|RGD:2312435
Cellular Component	GO:0032432	actin filament bundle	Flna	IDA		Mouse	PMID:24436304
Cellular Component	GO:0097440	apical dendrite	Flna	IDA		Rat	PMID:22434607\|RGD:7207403
Cellular Component	GO:0044295	axonal growth cone	Flna	IDA		Mouse	MGI:MGI:6378072\|PMID:26157139
Cellular Component	GO:0005903	brush border	Flna	IDA		Mouse	MGI:MGI:5621262\|PMID:22114352
Cellular Component	GO:0005938	cell cortex	Flna	IDA		Rat	PMID:22872576\|RGD:7207404
Cellular Component	GO:0005911	cell-cell junction	FLNA	IDA		Human	PMID:16291724
Cellular Component	GO:0030863	cortical cytoskeleton	Flna	IDA		Rat	PMID:15661894\|RGD:2312435
Cellular Component	GO:0005737	cytoplasm	FLNA	IDA		Human	PMID:15684392
Cellular Component	GO:0005737	cytoplasm	FLNA	IDA		Human	PMID:21914078
Cellular Component	GO:0005737	cytoplasm	FLNA	IDA		Human	PMID:25468996
Cellular Component	GO:0005829	cytosol	FLNA	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	Flna	IDA		Rat	PMID:15661894\|RGD:2312435
Cellular Component	GO:0043198	dendritic shaft	Flna	IDA		Rat	PMID:22434607\|RGD:7207403
Cellular Component	GO:0070062	extracellular exosome	FLNA	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	FLNA	HDA		Human	PMID:20458337
Cellular Component	GO:0070062	extracellular exosome	FLNA	HDA		Human	PMID:21362503
Cellular Component	GO:0070062	extracellular exosome	FLNA	HDA		Human	PMID:23533145
Cellular Component	GO:0005925	focal adhesion	FLNA	HDA		Human	PMID:21423176
Cellular Component	GO:0098978	glutamatergic synapse	Flna	IDA		Rat	PMID:26972007\|RGD:11537084
Cellular Component	GO:0030426	growth cone	Flna	IDA		Mouse	MGI:MGI:5770037\|PMID:25358863
Cellular Component	GO:0016020	membrane	FLNA	HDA		Human	PMID:19946888
Cellular Component	GO:0031523	Myb complex	FLNA	IDA		Human	PMID:18548008
Cellular Component	GO:0043025	neuronal cell body	Flna	IDA		Rat	PMID:22434607\|RGD:7207403
Cellular Component	GO:0005730	nucleolus	FLNA	IMP		Human	PMID:22307607
Cellular Component	GO:0005634	nucleus	FLNA	IDA		Human	PMID:15684392
Cellular Component	GO:0005634	nucleus	Flna	IDA		Rat	PMID:20167606\|RGD:7207405
Cellular Component	GO:0048471	perinuclear region of cytoplasm	Flna	IDA		Rat	PMID:20167606\|RGD:7207405
Cellular Component	GO:0048471	perinuclear region of cytoplasm	Flna	IDA		Rat	PMID:22872576\|RGD:7207404
Cellular Component	GO:0005886	plasma membrane	FLNA	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	FLNA	IDA		Human	PMID:18322202
Cellular Component	GO:0098794	postsynapse	Flna	IDA		Rat	PMID:26972007\|RGD:11537084
Cellular Component	GO:0005802	trans-Golgi network	Flna	IDA		Mouse	PMID:9412467
Cellular Component	GO:0030018	Z disc	Flna	IDA		Mouse	MGI:MGI:5578267\|PMID:24951510
Biological Process	GO:0051764	actin crosslink formation	FLNA	IDA		Human	PMID:10051605
Biological Process	GO:0030036	actin cytoskeleton organization	Flna	IGI	MGI:MGI:1923816	Mouse	PMID:21709252
Biological Process	GO:0031532	actin cytoskeleton reorganization	FLNA	IDA		Human	PMID:10051605
Biological Process	GO:0007195	adenylate cyclase-inhibiting dopamine receptor signaling pathway	FLNA	IMP		Human	PMID:10692483
Biological Process	GO:0001525	angiogenesis	Flna	IMP		Mouse	MGI:MGI:3699024\|PMID:17172441
Biological Process	GO:0001974	blood vessel remodeling	Flna	IMP		Mouse	MGI:MGI:3699024\|PMID:17172441
Biological Process	GO:0045216	cell-cell junction organization	Flna	IMP		Mouse	MGI:MGI:3699024\|PMID:17172441
Biological Process	GO:0021987	cerebral cortex development	Flna	IEP		Rat	PMID:22076441\|RGD:11564351
Biological Process	GO:0060271	cilium assembly	FLNA	IMP		Human	PMID:22121117
Biological Process	GO:0051220	cytoplasmic sequestering of protein	FLNA	IMP		Human	PMID:17536008
Biological Process	GO:0061371	determination of heart left/right asymmetry	flna	IMP	ZFIN:ZDB-CRISPR-210719-1	Zfish	PMID:32738303
Biological Process	GO:0045022	early endosome to late endosome transport	Flna	IDA		Mouse	PMID:9412467
Biological Process	GO:0001837	epithelial to mesenchymal transition	Flna	IGI	MGI:MGI:1923816	Mouse	PMID:21709252
Biological Process	GO:0045184	establishment of protein localization	FLNA	IDA		Human	PMID:18322202
Biological Process	GO:0097368	establishment of Sertoli cell barrier	Flna	IMP		Rat	PMID:22872576\|RGD:7207404
Biological Process	GO:0021943	formation of radial glial scaffolds	Flna	IMP		Rat	PMID:22076441\|RGD:11564351
Biological Process	GO:0003007	heart morphogenesis	Flna	IMP		Mouse	MGI:MGI:3699024\|PMID:17172441
Biological Process	GO:0090307	mitotic spindle assembly	FLNA	IDA		Human	PMID:18548008
Biological Process	GO:0042789	mRNA transcription by RNA polymerase II	Flna	IMP		Rat	PMID:20167606\|RGD:7207405
Biological Process	GO:0043066	negative regulation of apoptotic process	FLNA	IMP		Human	PMID:18177638
Biological Process	GO:0043433	negative regulation of DNA-binding transcription factor activity	FLNA	IDA		Human	PMID:15684392
Biological Process	GO:0010977	negative regulation of neuron projection development	Flna	IGI	UniProtKB:Q14194	Mouse	MGI:MGI:5770037\|PMID:25358863
Biological Process	GO:0042177	negative regulation of protein catabolic process	FLNA	IMP		Human	PMID:18322202
Biological Process	GO:0016479	negative regulation of transcription by RNA polymerase I	FLNA	IDA		Human	PMID:22307607
Biological Process	GO:0070527	platelet aggregation	FLNA	HMP		Human	PMID:23382103
Biological Process	GO:0032233	positive regulation of actin filament bundle assembly	Flna	IMP		Rat	PMID:22872576\|RGD:7207404
Biological Process	GO:0048680	positive regulation of axon regeneration	Flna	IMP		Mouse	MGI:MGI:6378072\|PMID:26157139
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	FLNA	HMP		Human	PMID:12761501
Biological Process	GO:2001046	positive regulation of integrin-mediated signaling pathway	FLNA	IMP		Human	PMID:18177638
Biological Process	GO:2000179	positive regulation of neural precursor cell proliferation	Flna	IMP		Rat	PMID:22076441\|RGD:11564351
Biological Process	GO:2001224	positive regulation of neuron migration	Flna	IMP		Rat	PMID:22076441\|RGD:11564351
Biological Process	GO:1901381	positive regulation of potassium ion transmembrane transport	FLNA	IDA		Human	PMID:24951510
Biological Process	GO:1901381	positive regulation of potassium ion transmembrane transport	Flna	IMP		Mouse	MGI:MGI:5578267\|PMID:24951510
Biological Process	GO:0042307	positive regulation of protein import into nucleus	FLNA	IMP		Human	PMID:15684392
Biological Process	GO:1900026	positive regulation of substrate adhesion-dependent cell spreading	FLNA	IMP		Human	PMID:18177638
Biological Process	GO:1902396	protein localization to bicellular tight junction	Flna	IMP		Rat	PMID:22872576\|RGD:7207404
Biological Process	GO:0034394	protein localization to cell surface	FLNA	IDA		Human	PMID:18322202
Biological Process	GO:0072659	protein localization to plasma membrane	FLNA	IDA		Human	PMID:24951510
Biological Process	GO:0072659	protein localization to plasma membrane	Flna	IMP		Mouse	MGI:MGI:5578267\|PMID:24951510
Biological Process	GO:0050821	protein stabilization	FLNA	IMP		Human	PMID:18322202
Biological Process	GO:0043113	receptor clustering	FLNA	IDA		Human	PMID:10692483
Biological Process	GO:0032231	regulation of actin filament bundle assembly	Flna	IMP		Mouse	MGI:MGI:4838360\|PMID:20713593
Biological Process	GO:0030334	regulation of cell migration	FLNA	IDA		Human	PMID:16291724
Biological Process	GO:1905031	regulation of membrane repolarization during cardiac muscle cell action potential	Flna	IMP		Mouse	MGI:MGI:5578267\|PMID:24951510
Biological Process	GO:0071526	semaphorin-plexin signaling pathway	FLNA	IGI	UniProtKB:O08665,UniProtKB:Q8BTM8	Human	PMID:25358863
Biological Process	GO:0071526	semaphorin-plexin signaling pathway	Flna	IEP		Mouse	MGI:MGI:5770037\|PMID:25358863
Biological Process	GO:0071526	semaphorin-plexin signaling pathway	Flna	IGI	UniProtKB:O08665	Mouse	MGI:MGI:5770037\|PMID:25358863
Biological Process	GO:0050808	synapse organization	Flna	IDA		Mouse	PMID:26972007
Biological Process	GO:0050808	synapse organization	Flna	IMP		Mouse	PMID:26972007
Biological Process	GO:0090042	tubulin deacetylation	FLNA	IMP		Human	PMID:26157139
Biological Process	GO:0044319	wound healing, spreading of cells	FLNA	IDA		Human	PMID:16291724

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.