Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes FLNC
  • Mouse genes Flnc
  • Rat genes Flnc
  • Zfish genes flnca,flncb
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Flnc

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0030506	ankyrin binding	FLNC	IPI	UniProtKB:O70511	Human	PMID:21223964
Molecular Function	GO:0030506	ankyrin binding	Flnc	IPI	UniProtKB:O70511	Rat	PMID:21223964|RGD:8554309
Molecular Function	GO:0008092	cytoskeletal protein binding	FLNC	IPI	UniProtKB:O76041	Human	PMID:17987659
Molecular Function	GO:0008092	cytoskeletal protein binding	FLNC	IPI	UniProtKB:Q90684	Human	PMID:17987659
Molecular Function	GO:0005515	protein binding	FLNC	IPI	UniProtKB:Q9UBF9	Human	PMID:11038172
Molecular Function	GO:0005515	protein binding	FLNC	IPI	UniProtKB:P05556	Human	PMID:16076904
Molecular Function	GO:0005515	protein binding	FLNC	IPI	UniProtKB:Q9NP98	Human	PMID:16076904
Molecular Function	GO:0005515	protein binding	FLNC	IPI	UniProtKB:Q9UBF9	Human	PMID:16076904
Molecular Function	GO:0005515	protein binding	FLNC	IPI	UniProtKB:Q702N8	Human	PMID:16631741
Molecular Function	GO:0005515	protein binding	FLNC	IPI	UniProtKB:P00519	Human	PMID:17474147
Molecular Function	GO:0005515	protein binding	FLNC	IPI	UniProtKB:P46108	Human	PMID:17474147
Molecular Function	GO:0005515	protein binding	FLNC	IPI	UniProtKB:P62993	Human	PMID:17474147
Molecular Function	GO:0005515	protein binding	FLNC	IPI	UniProtKB:O70511-7	Human	PMID:21223964
Cellular Component	GO:0005737	cytoplasm	FLNC	IDA		Human	PMID:12393796
Cellular Component	GO:0005737	cytoplasm	FLNC	IDA		Human	PMID:25351925
Cellular Component	GO:0005829	cytosol	FLNC	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005925	focal adhesion	FLNC	HDA		Human	PMID:21423176
Cellular Component	GO:0045171	intercellular bridge	FLNC	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	FLNC	IDA		Human	GO_REF:0000052
Cellular Component	GO:0042383	sarcolemma	FLNC	IDA		Human	PMID:21223964
Cellular Component	GO:0042383	sarcolemma	Flnc	IDA		Rat	PMID:21223964|RGD:8554309
Cellular Component	GO:0016528	sarcoplasm	Flnc	IDA		Rat	PMID:21223964|RGD:8554309
Biological Process	GO:0060271	cilium assembly	flncb	IMP	ZFIN:ZDB-MRPHLNO-120320-1	Zfish	PMID:22121117
Biological Process	GO:0060271	cilium assembly	flncb	IGI	ZFIN:ZDB-MRPHLNO-080716-5,ZFIN:ZDB-MRPHLNO-120320-1	Zfish	PMID:22121117
Biological Process	GO:0007507	heart development	flncb	IMP	ZFIN:ZDB-MRPHLNO-121018-1	Zfish	PMID:28008423
Biological Process	GO:0007626	locomotory behavior	flncb	IMP	ZFIN:ZDB-MRPHLNO-150622-6	Zfish	PMID:25866181
Biological Process	GO:0007626	locomotory behavior	flnca	IMP	ZFIN:ZDB-MRPHLNO-150622-5	Zfish	PMID:25866181
Biological Process	GO:0046716	muscle cell cellular homeostasis	flncb	IGI	ZFIN:ZDB-MRPHLNO-121018-1,ZFIN:ZDB-MRPHLNO-121018-2	Zfish	PMID:22706277
Biological Process	GO:0046716	muscle cell cellular homeostasis	flncb	IMP	ZFIN:ZDB-GENO-050323-3	Zfish	PMID:22706277
Biological Process	GO:0046716	muscle cell cellular homeostasis	flnca	IGI	ZFIN:ZDB-MRPHLNO-121018-1,ZFIN:ZDB-MRPHLNO-121018-2	Zfish	PMID:22706277
Biological Process	GO:0046716	muscle cell cellular homeostasis	flnca	IMP	ZFIN:ZDB-MRPHLNO-121018-2	Zfish	PMID:22706277
Biological Process	GO:0055001	muscle cell development	Flnc	IDA		Mouse	MGI:MGI:3655755|PMID:16914736
Biological Process	GO:0045214	sarcomere organization	FLNC	IMP		Human	PMID:34405687
Biological Process	GO:0045214	sarcomere organization	flncb	IMP	ZFIN:ZDB-MRPHLNO-121018-1	Zfish	PMID:28008423

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern