Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes FLOT2
  • Mouse genes Flot2
  • Rat genes Flot2
  • Zfish genes flot2a,flot2b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Flot2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0035255	ionotropic glutamate receptor binding	Flot2	IPI	RGD:2737|RGD:2738|RGD:2736	Rat	PMID:19298817|RGD:2326007
Molecular Function	GO:0002020	protease binding	Flot2	IPI	UniProtKB:P56817	Rat	PMID:24612608|RGD:8693369
Molecular Function	GO:0005515	protein binding	FLOT2	IPI	UniProtKB:O75955	Human	PMID:17113085
Molecular Function	GO:0005515	protein binding	FLOT2	IPI	UniProtKB:Q9HAQ2	Human	PMID:21119006
Molecular Function	GO:0005515	protein binding	FLOT2	IPI	UniProtKB:O75955	Human	PMID:21696602
Molecular Function	GO:0005515	protein binding	FLOT2	IPI	UniProtKB:O75955	Human	PMID:24167781
Molecular Function	GO:0005515	protein binding	FLOT2	IPI	UniProtKB:O75955	Human	PMID:24809731
Molecular Function	GO:0005515	protein binding	FLOT2	IPI	UniProtKB:Q6FHG5	Human	PMID:25229320
Molecular Function	GO:0005515	protein binding	FLOT2	IPI	UniProtKB:O75955	Human	PMID:30021884
Molecular Function	GO:0005515	protein binding	Flot2	IPI	RGD:70991	Rat	PMID:19298817|RGD:2326007
Cellular Component	GO:0002080	acrosomal membrane	Flot2	IDA		Mouse	PMID:19144954
Cellular Component	GO:0005912	adherens junction	FLOT2	IDA		Human	PMID:24046456
Cellular Component	GO:0016323	basolateral plasma membrane	FLOT2	IDA		Human	PMID:23983584
Cellular Component	GO:0005901	caveola	FLOT2	IDA		Human	PMID:24013648
Cellular Component	GO:0005901	caveola	Flot2	IDA		Mouse	PMID:9153235
Cellular Component	GO:0005901	caveola	Flot2	IDA		Rat	PMID:9858255|RGD:70739
Cellular Component	GO:0044291	cell-cell contact zone	FLOT2	IDA		Human	PMID:23983584
Cellular Component	GO:0030864	cortical actin cytoskeleton	FLOT2	IDA		Human	PMID:24046456
Cellular Component	GO:0031410	cytoplasmic vesicle	FLOT2	IDA		Human	PMID:23983584
Cellular Component	GO:0031410	cytoplasmic vesicle	FLOT2	IDA		Human	PMID:25105415
Cellular Component	GO:0031410	cytoplasmic vesicle	Flot2	IDA		Mouse	MGI:MGI:5634873|PMID:25105415
Cellular Component	GO:0030139	endocytic vesicle	FLOT2	IDA		Human	PMID:20682791
Cellular Component	GO:0005768	endosome	FLOT2	IDA		Human	PMID:20682791
Cellular Component	GO:0070062	extracellular exosome	FLOT2	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	FLOT2	HDA		Human	PMID:20458337
Cellular Component	GO:0070062	extracellular exosome	FLOT2	HDA		Human	PMID:23533145
Cellular Component	GO:0016600	flotillin complex	FLOT2	IDA		Human	PMID:21696602
Cellular Component	GO:0016600	flotillin complex	FLOT2	IDA		Human	PMID:24046456
Cellular Component	GO:0016600	flotillin complex	FLOT2	IDA		Human	PMID:25204797
Cellular Component	GO:0016600	flotillin complex	Flot2	IDA		Mouse	MGI:MGI:5634880|PMID:24046456
Cellular Component	GO:0016600	flotillin complex	Flot2	IDA		Mouse	PMID:17600709
Cellular Component	GO:0016600	flotillin complex	Flot2	IDA		Rat	PMID:9858255|RGD:70739
Cellular Component	GO:0005925	focal adhesion	FLOT2	HDA		Human	PMID:21423176
Cellular Component	GO:0098978	glutamatergic synapse	Flot2	IMP		Mouse	PMID:27993509
Cellular Component	GO:0098978	glutamatergic synapse	Flot2	IDA		Mouse	PMID:27993509
Cellular Component	GO:0098978	glutamatergic synapse	Flot2	EXP		Rat	PMID:23622064|RGD:13702180
Cellular Component	GO:0098978	glutamatergic synapse	Flot2	IDA		Rat	PMID:23622064|RGD:13702180
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	FLOT2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0030027	lamellipodium	FLOT2	IDA		Human	PMID:24046456
Cellular Component	GO:0016020	membrane	FLOT2	HDA		Human	PMID:19946888
Cellular Component	GO:0016020	membrane	Flot2	IDA		Mouse	PMID:15886206
Cellular Component	GO:0045121	membrane raft	Flot2	IDA		Mouse	PMID:17416589
Cellular Component	GO:0045121	membrane raft	Flot2	IDA		Mouse	PMID:12927782
Cellular Component	GO:0048471	perinuclear region of cytoplasm	FLOT2	IDA		Human	PMID:21119006
Cellular Component	GO:0005886	plasma membrane	FLOT2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	FLOT2	IMP		Human	PMID:21696602
Cellular Component	GO:0048787	presynaptic active zone membrane	Flot2	EXP		Rat	PMID:23622064|RGD:13702180
Cellular Component	GO:0048787	presynaptic active zone membrane	Flot2	IDA		Rat	PMID:23622064|RGD:13702180
Cellular Component	GO:0045202	synapse	Flot2	EXP		Rat	PMID:21797867|RGD:13702258
Cellular Component	GO:0045202	synapse	Flot2	IDA		Rat	PMID:21797867|RGD:13702258
Cellular Component	GO:0001931	uropod	FLOT2	IDA		Human	PMID:21696602
Cellular Component	GO:0031982	vesicle	FLOT2	IDA		Human	PMID:21119006
Biological Process	GO:0098937	anterograde dendritic transport	Flot2	IMP		Mouse	PMID:27993509
Biological Process	GO:0098937	anterograde dendritic transport	Flot2	IDA		Mouse	PMID:27993509
Biological Process	GO:1902992	negative regulation of amyloid precursor protein catabolic process	FLOT2	IMP		Human	PMID:24612608
Biological Process	GO:0010629	negative regulation of gene expression	FLOT2	IMP		Human	PMID:24612608
Biological Process	GO:1903905	positive regulation of establishment of T cell polarity	FLOT2	IMP		Human	PMID:21696602
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	FLOT2	IMP		Human	PMID:23319823
Biological Process	GO:0072659	protein localization to plasma membrane	FLOT2	IMP		Human	PMID:24612608
Biological Process	GO:0044860	protein localization to plasma membrane raft	FLOT2	IMP		Human	PMID:21696602
Biological Process	GO:0050821	protein stabilization	FLOT2	IMP		Human	PMID:24612608
Biological Process	GO:2000047	regulation of cell-cell adhesion mediated by cadherin	flot2a	IMP	ZFIN:ZDB-MRPHLNO-170627-1	Zfish	PMID:28225561
Biological Process	GO:1904086	regulation of epiboly involved in gastrulation with mouth forming second	flot2a	IMP	ZFIN:ZDB-MRPHLNO-170627-1	Zfish	PMID:28225561
Biological Process	GO:0045661	regulation of myoblast differentiation	FLOT2	IEP		Human	PMID:25105415
Biological Process	GO:0045661	regulation of myoblast differentiation	Flot2	IEP		Mouse	MGI:MGI:5634873|PMID:25105415
Biological Process	GO:0099072	regulation of postsynaptic membrane neurotransmitter receptor levels	Flot2	IDA		Mouse	PMID:27993509
Biological Process	GO:0099072	regulation of postsynaptic membrane neurotransmitter receptor levels	Flot2	IMP		Mouse	PMID:27993509

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern