Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Flt4

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes FLT4
- Mouse genes Flt4
- Rat genes Flt4
- Zfish genes flt4
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Flt4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0019838	growth factor binding	FLT4	IPI	UniProtKB:O43915	Human	PMID:9435229
Molecular Function	GO:0019838	growth factor binding	Flt4	IMP		Rat	PMID:11683876\|RGD:727326
Molecular Function	GO:0042802	identical protein binding	flt4	IPI	ZFIN:ZDB-GENE-980526-326	Zfish	PMID:27621059
Molecular Function	GO:0005515	protein binding	FLT4	IPI	UniProtKB:P35968	Human	PMID:16530705
Molecular Function	GO:0005515	protein binding	FLT4	IPI	UniProtKB:P35968	Human	PMID:20224550
Molecular Function	GO:0005515	protein binding	FLT4	IPI	UniProtKB:P35968	Human	PMID:21130043
Molecular Function	GO:0005515	protein binding	FLT4	IPI	UniProtKB:P49767	Human	PMID:21130043
Molecular Function	GO:0005515	protein binding	FLT4	IPI	UniProtKB:P08238	Human	PMID:22939624
Molecular Function	GO:0005515	protein binding	FLT4	IPI	UniProtKB:P49767	Human	PMID:23878260
Molecular Function	GO:0005515	protein binding	FLT4	IPI	UniProtKB:Q86T13	Human	PMID:27991863
Molecular Function	GO:0005515	protein binding	FLT4	IPI	UniProtKB:P08238	Human	PMID:35384245
Molecular Function	GO:0005515	protein binding	Flt4	IPI	UniProtKB:P35918	Mouse	MGI:MGI:5508571\|PMID:20224550
Molecular Function	GO:0005515	protein binding	Flt4	IPI	UniProtKB:P35918\|UniProtKB:P98078\|UniProtKB:Q99NH2-1	Mouse	MGI:MGI:5476876\|PMID:23354168
Molecular Function	GO:0005515	protein binding	Flt4	IPI	PR:P97946	Mouse	PMID:11279005
Molecular Function	GO:0005515	protein binding	Flt4	IPI	PR:P97953	Mouse	PMID:9247316
Molecular Function	GO:0005515	protein binding	Flt4	IPI	PR:Q7TQI0	Mouse	PMID:20439428
Molecular Function	GO:0042803	protein homodimerization activity	FLT4	IDA		Human	PMID:23878260
Molecular Function	GO:0019903	protein phosphatase binding	FLT4	IPI	UniProtKB:Q15678	Human	PMID:20826270
Molecular Function	GO:0004714	transmembrane receptor protein tyrosine kinase activity	FLT4	IMP		Human	PMID:7898938
Molecular Function	GO:0005021	vascular endothelial growth factor receptor activity	FLT4	IMP		Human	PMID:11532940
Molecular Function	GO:0005021	vascular endothelial growth factor receptor activity	FLT4	IMP		Human	PMID:19779139
Molecular Function	GO:0005021	vascular endothelial growth factor receptor activity	FLT4	IDA		Human	PMID:23878260
Molecular Function	GO:0005021	vascular endothelial growth factor receptor activity	FLT4	IDA		Human	PMID:9012504
Molecular Function	GO:0005021	vascular endothelial growth factor receptor activity	Flt4	IGI	MGI:MGI:109124	Mouse	PMID:9247316
Molecular Function	GO:0005021	vascular endothelial growth factor receptor activity	Flt4	IMP		Rat	PMID:11683876\|RGD:727326
Cellular Component	GO:0005829	cytosol	FLT4	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	FLT4	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	FLT4	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	FLT4	IDA		Human	PMID:7898938
Cellular Component	GO:0043235	receptor complex	FLT4	IDA		Human	PMID:23382219
Biological Process	GO:0001525	angiogenesis	flt4	IGI	ZFIN:ZDB-MRPHLNO-060515-1,ZFIN:ZDB-MRPHLNO-111104-5	Zfish	PMID:22007135
Biological Process	GO:0001525	angiogenesis	flt4	IMP	ZFIN:ZDB-MRPHLNO-060515-1	Zfish	PMID:22007135
Biological Process	GO:0001525	angiogenesis	flt4	IGI	ZFIN:ZDB-GENO-040827-1,ZFIN:ZDB-MRPHLNO-060515-1	Zfish	PMID:16617120
Biological Process	GO:0001525	angiogenesis	flt4	IGI	ZFIN:ZDB-GENE-050407-1	Zfish	PMID:28071661
Biological Process	GO:0001525	angiogenesis	flt4	IMP	ZFIN:ZDB-MRPHLNO-060515-1	Zfish	PMID:16617120
Biological Process	GO:0001525	angiogenesis	flt4	IGI	ZFIN:ZDB-GENO-040827-1,ZFIN:ZDB-MRPHLNO-060515-1,ZFIN:ZDB-MRPHLNO-060515-2	Zfish	PMID:16617120
Biological Process	GO:0001525	angiogenesis	flt4	IMP	ZFIN:ZDB-MRPHLNO-100205-4	Zfish	PMID:25171174
Biological Process	GO:0001525	angiogenesis	flt4	IMP	ZFIN:ZDB-MRPHLNO-060515-1	Zfish	PMID:17259972
Biological Process	GO:0036302	atrioventricular canal development	flt4	IMP	ZFIN:ZDB-GENO-100208-3	Zfish	PMID:32668254
Biological Process	GO:0048514	blood vessel morphogenesis	Flt4	IMP		Mouse	MGI:MGI:1309699\|PMID:9794766
Biological Process	GO:0061026	cardiac muscle tissue regeneration	flt4	IMP	ZFIN:ZDB-GENO-220407-10	Zfish	PMID:31702554
Biological Process	GO:0035924	cellular response to vascular endothelial growth factor stimulus	FLT4	IMP		Human	PMID:19779139
Biological Process	GO:0035924	cellular response to vascular endothelial growth factor stimulus	FLT4	IDA		Human	PMID:9435229
Biological Process	GO:0048286	lung alveolus development	Flt4	IMP	MGI:MGI:1856694	Mouse	PMID:24733830
Biological Process	GO:0001945	lymph vessel development	Flt4	IMP		Mouse	MGI:MGI:4436974\|PMID:19903896
Biological Process	GO:0001945	lymph vessel development	Flt4	IGI	MGI:MGI:3039635	Mouse	PMID:20439428
Biological Process	GO:0001945	lymph vessel development	flt4	IMP	ZFIN:ZDB-GENO-100208-3	Zfish	PMID:19906867
Biological Process	GO:0001945	lymph vessel development	flt4	IMP	ZFIN:ZDB-GENO-160816-22	Zfish	PMID:25533206
Biological Process	GO:0001945	lymph vessel development	flt4	IGI	ZFIN:ZDB-GENE-070810-6	Zfish	PMID:28087639
Biological Process	GO:0001945	lymph vessel development	flt4	IMP	ZFIN:ZDB-GENO-160919-20	Zfish	PMID:27621059
Biological Process	GO:0001945	lymph vessel development	flt4	IMP	ZFIN:ZDB-GENO-170131-1	Zfish	PMID:27621059
Biological Process	GO:0001945	lymph vessel development	flt4	IGI	ZFIN:ZDB-GENO-180824-8,ZFIN:ZDB-MRPHLNO-090112-4	Zfish	PMID:29550364
Biological Process	GO:0036303	lymph vessel morphogenesis	flt4	IMP	ZFIN:ZDB-GENO-160919-20	Zfish	PMID:27621059
Biological Process	GO:0036303	lymph vessel morphogenesis	flt4	IMP	ZFIN:ZDB-GENO-170131-1	Zfish	PMID:27621059
Biological Process	GO:0001946	lymphangiogenesis	FLT4	IMP		Human	PMID:19779139
Biological Process	GO:0001946	lymphangiogenesis	Flt4	IMP		Mouse	MGI:MGI:5294901\|PMID:20697430
Biological Process	GO:0001946	lymphangiogenesis	flt4	IMP	ZFIN:ZDB-GENO-200608-2	Zfish	PMID:31433980
Biological Process	GO:0001946	lymphangiogenesis	flt4	IGI	ZFIN:ZDB-GENO-200608-4	Zfish	PMID:31433980
Biological Process	GO:0001946	lymphangiogenesis	flt4	IGI	ZFIN:ZDB-GENO-200604-10	Zfish	PMID:31433980
Biological Process	GO:0001946	lymphangiogenesis	flt4	IMP	ZFIN:ZDB-GENO-220407-10	Zfish	PMID:31702554
Biological Process	GO:0001946	lymphangiogenesis	flt4	IMP	ZFIN:ZDB-GENO-220407-5	Zfish	PMID:31702554
Biological Process	GO:0001946	lymphangiogenesis	flt4	IMP	ZFIN:ZDB-MRPHLNO-100205-4	Zfish	PMID:24903752
Biological Process	GO:0001946	lymphangiogenesis	flt4	IMP	ZFIN:ZDB-GENO-100208-3	Zfish	PMID:24523457
Biological Process	GO:0001946	lymphangiogenesis	flt4	IMP	ZFIN:ZDB-GENO-170131-1	Zfish	PMID:27621059
Biological Process	GO:0001946	lymphangiogenesis	flt4	IMP	ZFIN:ZDB-GENO-100208-3	Zfish	PMID:24903752
Biological Process	GO:0001946	lymphangiogenesis	flt4	IMP	ZFIN:ZDB-GENO-160919-20	Zfish	PMID:27621059
Biological Process	GO:0060836	lymphatic endothelial cell differentiation	flt4	IMP	ZFIN:ZDB-GENO-160919-20	Zfish	PMID:27621059
Biological Process	GO:0060836	lymphatic endothelial cell differentiation	flt4	IMP	ZFIN:ZDB-GENO-170131-1	Zfish	PMID:27621059
Biological Process	GO:0008045	motor neuron axon guidance	flt4	IMP	ZFIN:ZDB-MRPHLNO-060515-1	Zfish	PMID:24046321
Biological Process	GO:0043066	negative regulation of apoptotic process	FLT4	IMP		Human	PMID:11532940
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	FLT4	IDA		Human	PMID:7898938
Biological Process	GO:0030307	positive regulation of cell growth	Flt4	IDA		Rat	PMID:7898938\|RGD:708324
Biological Process	GO:0008284	positive regulation of cell population proliferation	FLT4	IMP		Human	PMID:19779139
Biological Process	GO:0008284	positive regulation of cell population proliferation	FLT4	IMP		Human	PMID:7675451
Biological Process	GO:0008284	positive regulation of cell population proliferation	Flt4	IGI	MGI:MGI:109124	Mouse	PMID:9247316
Biological Process	GO:0010595	positive regulation of endothelial cell migration	FLT4	IMP		Human	PMID:11532940
Biological Process	GO:0001938	positive regulation of endothelial cell proliferation	FLT4	IMP		Human	PMID:11532940
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	FLT4	IMP		Human	PMID:11532940
Biological Process	GO:0046330	positive regulation of JNK cascade	FLT4	IMP		Human	PMID:16076871
Biological Process	GO:0043410	positive regulation of MAPK cascade	FLT4	IMP		Human	PMID:19779139
Biological Process	GO:0090037	positive regulation of protein kinase C signaling	FLT4	IMP		Human	PMID:11532940
Biological Process	GO:0001934	positive regulation of protein phosphorylation	FLT4	IMP		Human	PMID:11532940
Biological Process	GO:0001934	positive regulation of protein phosphorylation	FLT4	IMP		Human	PMID:19779139
Biological Process	GO:0010575	positive regulation of vascular endothelial growth factor production	FLT4	IMP		Human	PMID:19779139
Biological Process	GO:0046777	protein autophosphorylation	FLT4	IDA		Human	PMID:23878260
Biological Process	GO:0046777	protein autophosphorylation	FLT4	IDA		Human	PMID:7675451
Biological Process	GO:0046777	protein autophosphorylation	FLT4	IDA		Human	PMID:9435229
Biological Process	GO:0060312	regulation of blood vessel remodeling	Flt4	IMP		Mouse	MGI:MGI:1309699\|PMID:9794766
Biological Process	GO:0030947	regulation of vascular endothelial growth factor receptor signaling pathway	flt4	IGI	ZFIN:ZDB-GENO-150506-3,ZFIN:ZDB-MRPHLNO-100205-4	Zfish	PMID:25294789
Biological Process	GO:1900746	regulation of vascular endothelial growth factor signaling pathway	flt4	IGI	ZFIN:ZDB-GENO-180824-8,ZFIN:ZDB-MRPHLNO-090112-4	Zfish	PMID:29550364
Biological Process	GO:0007585	respiratory gaseous exchange by respiratory system	Flt4	IMP	MGI:MGI:1856694	Mouse	PMID:24733830
Biological Process	GO:0003016	respiratory system process	Flt4	IMP	MGI:MGI:1856694	Mouse	PMID:24733830
Biological Process	GO:0035474	selective angioblast sprouting	flt4	IMP	ZFIN:ZDB-MRPHLNO-060515-1	Zfish	PMID:19815777
Biological Process	GO:0002040	sprouting angiogenesis	Flt4	IMP		Mouse	MGI:MGI:3805424\|PMID:18594512
Biological Process	GO:0002040	sprouting angiogenesis	flt4	IGI	ZFIN:ZDB-GENE-040303-4,ZFIN:ZDB-MRPHLNO-060515-1	Zfish	PMID:22340502
Biological Process	GO:0048010	vascular endothelial growth factor receptor signaling pathway	FLT4	IDA		Human	PMID:9012504
Biological Process	GO:0048010	vascular endothelial growth factor receptor signaling pathway	FLT4	IMP		Human	PMID:11532940
Biological Process	GO:0048010	vascular endothelial growth factor receptor signaling pathway	FLT4	IMP		Human	PMID:19779139
Biological Process	GO:0048010	vascular endothelial growth factor receptor signaling pathway	Flt4	IMP		Rat	PMID:11683876\|RGD:727326
Biological Process	GO:0048010	vascular endothelial growth factor receptor signaling pathway	flt4	IGI	ZFIN:ZDB-MRPHLNO-060515-1,ZFIN:ZDB-MRPHLNO-111104-5	Zfish	PMID:22007135
Biological Process	GO:0038084	vascular endothelial growth factor signaling pathway	FLT4	IDA		Human	PMID:23878260
Biological Process	GO:0001944	vasculature development	Flt4	IMP		Mouse	MGI:MGI:1309699\|PMID:9794766
Biological Process	GO:0001944	vasculature development	flt4	IMP	ZFIN:ZDB-GENO-160816-22	Zfish	PMID:25533206
Biological Process	GO:0060841	venous blood vessel development	flt4	IMP	ZFIN:ZDB-GENO-100208-6	Zfish	PMID:19906867
Biological Process	GO:0060855	venous endothelial cell migration involved in lymph vessel development	flt4	IMP	ZFIN:ZDB-MRPHLNO-100205-4	Zfish	PMID:24523457

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.