Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes FOLR1
  • Mouse genes Folr1
  • Rat genes Folr1
  • Zfish genes folr
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Folr1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005542	folic acid binding	FOLR1	IDA		Human	PMID:10787414
Molecular Function	GO:0005542	folic acid binding	FOLR1	IDA		Human	PMID:14722620
Molecular Function	GO:0005542	folic acid binding	FOLR1	IDA		Human	PMID:19116913
Molecular Function	GO:0005542	folic acid binding	FOLR1	IDA		Human	PMID:23851396
Molecular Function	GO:0005542	folic acid binding	FOLR1	IDA		Human	PMID:2527252
Molecular Function	GO:0005542	folic acid binding	Folr1	IDA		Rat	PMID:10751329|RGD:1358236
Molecular Function	GO:0061714	folic acid receptor activity	FOLR1	IMP		Human	PMID:8033114
Molecular Function	GO:0005515	protein binding	FOLR1	IPI	UniProtKB:Q8N357	Human	PMID:32296183
Cellular Component	GO:0016324	apical plasma membrane	FOLR1	IDA		Human	PMID:10787414
Cellular Component	GO:0016323	basolateral plasma membrane	FOLR1	IDA		Human	PMID:10787414
Cellular Component	GO:0005903	brush border	Folr1	IDA		Rat	PMID:10751329|RGD:1358236
Cellular Component	GO:0031526	brush border membrane	Folr1	IDA		Rat	PMID:8447363|RGD:7244265
Cellular Component	GO:0009986	cell surface	FOLR1	HDA		Human	PMID:19581412
Cellular Component	GO:0009897	external side of plasma membrane	FOLR1	IDA		Human	PMID:2527252
Cellular Component	GO:0009897	external side of plasma membrane	FOLR1	IDA		Human	PMID:8033114
Cellular Component	GO:0070062	extracellular exosome	FOLR1	HDA		Human	PMID:19199708
Cellular Component	GO:0070062	extracellular exosome	FOLR1	HDA		Human	PMID:23533145
Cellular Component	GO:0005634	nucleus	FOLR1	IDA		Human	PMID:23243496
Biological Process	GO:0061713	anterior neural tube closure	Folr1	IMP		Mouse	MGI:MGI:3721767|PMID:17286298
Biological Process	GO:0031103	axon regeneration	Folr1	IMP		Mouse	MGI:MGI:4460071|PMID:20424322
Biological Process	GO:0003253	cardiac neural crest cell migration involved in outflow tract morphogenesis	Folr1	IMP		Mouse	MGI:MGI:3721767|PMID:17286298
Biological Process	GO:0071231	cellular response to folic acid	FOLR1	IDA		Human	PMID:14722620
Biological Process	GO:0046655	folic acid metabolic process	Folr1	IMP	MGI:MGI:2383986	Mouse	PMID:12854656
Biological Process	GO:0015884	folic acid transport	FOLR1	IMP		Human	PMID:8033114
Biological Process	GO:0001947	heart looping	Folr1	IMP		Mouse	MGI:MGI:3721767|PMID:17286298
Biological Process	GO:0003147	neural crest cell migration involved in heart formation	Folr1	IMP		Mouse	MGI:MGI:3721767|PMID:17286298
Biological Process	GO:0061626	pharyngeal arch artery morphogenesis	Folr1	IMP		Mouse	MGI:MGI:3721767|PMID:17286298
Biological Process	GO:0060828	regulation of canonical Wnt signaling pathway	Folr1	IMP		Mouse	MGI:MGI:5644149|PMID:21649587
Biological Process	GO:0017015	regulation of transforming growth factor beta receptor signaling pathway	Folr1	IMP		Mouse	MGI:MGI:5644149|PMID:21649587
Biological Process	GO:0070293	renal absorption	Folr1	IEP		Rat	PMID:10751329|RGD:1358236
Biological Process	GO:0048678	response to axon injury	Folr1	IMP		Mouse	MGI:MGI:4460071|PMID:20424322
Biological Process	GO:0051593	response to folic acid	Folr1	IEP		Rat	PMID:10751329|RGD:1358236

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern