Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Foxa1

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes FOXA1
- Mouse genes Foxa1
- Rat genes Foxa1
- Zfish genes foxa1
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Foxa1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003682	chromatin binding	Foxa1	IDA		Mouse	PMID:22780989
Molecular Function	GO:0003677	DNA binding	FOXA1	IDA		Human	PMID:9931457
Molecular Function	GO:0003677	DNA binding	Foxa1	IDA		Mouse	PMID:15485926
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Foxa1	IDA		Rat	PMID:10024498\|RGD:1627570
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Foxa1	IDA		Rat	PMID:20735474\|RGD:8553707
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Foxa1	IDA		Mouse	PMID:10049364
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Foxa1	IDA		Rat	PMID:17220277\|RGD:8554147
Molecular Function	GO:0003690	double-stranded DNA binding	Foxa1	IDA		Rat	PMID:10024498\|RGD:1627570
Molecular Function	GO:0005515	protein binding	FOXA1	IPI	UniProtKB:P10275	Human	PMID:22722839
Molecular Function	GO:0005515	protein binding	FOXA1	IPI	UniProtKB:P10275	Human	PMID:23260764
Molecular Function	GO:0005515	protein binding	FOXA1	IPI	UniProtKB:P10275	Human	PMID:33640491
Molecular Function	GO:0019904	protein domain specific binding	Foxa1	IDA		Rat	PMID:18003659\|RGD:2314176
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	FOXA1	IDA		Human	PMID:25802280
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Foxa1	IDA		Mouse	PMID:10049364
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	Foxa1	IPI	UniProtKB:P43699	Rat	PMID:17220277\|RGD:8554147
Molecular Function	GO:0043565	sequence-specific DNA binding	Foxa1	IDA		Mouse	PMID:8306889
Molecular Function	GO:0043565	sequence-specific DNA binding	Foxa1	IDA		Mouse	PMID:22737085
Molecular Function	GO:0043565	sequence-specific DNA binding	Foxa1	IDA		Rat	PMID:2227418\|RGD:632942
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	FOXA1	IDA		Human	PMID:28473536
Molecular Function	GO:0000976	transcription cis-regulatory region binding	FOXA1	IDA		Human	PMID:16087863
Molecular Function	GO:0000976	transcription cis-regulatory region binding	FOXA1	IDA		Human	PMID:16331276
Molecular Function	GO:0000976	transcription cis-regulatory region binding	FOXA1	IDA		Human	PMID:19127412
Molecular Function	GO:0000976	transcription cis-regulatory region binding	foxa1	IDA		Zfish	PMID:27222589
Cellular Component	GO:0001650	fibrillar center	FOXA1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005902	microvillus	Foxa1	IDA		Mouse	PMID:23266329
Cellular Component	GO:0005654	nucleoplasm	FOXA1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	FOXA1	IDA		Human	PMID:20160041
Cellular Component	GO:0005634	nucleus	FOXA1	IDA		Human	PMID:9931457
Cellular Component	GO:0005634	nucleus	Foxa1	IDA		Mouse	PMID:15987773
Cellular Component	GO:0005634	nucleus	Foxa1	IDA		Mouse	PMID:8306889
Cellular Component	GO:0005634	nucleus	Foxa1	IDA		Mouse	PMID:15567715
Cellular Component	GO:0005634	nucleus	Foxa1	IDA		Mouse	PMID:15389796
Cellular Component	GO:0005634	nucleus	Foxa1	IDA		Rat	PMID:10024498\|RGD:1627570
Cellular Component	GO:0005634	nucleus	Foxa1	IDA		Rat	PMID:2227418\|RGD:632942
Biological Process	GO:0061144	alveolar secondary septum development	Foxa1	IMP	MGI:MGI:2653543	Mouse	PMID:16214823
Biological Process	GO:0048646	anatomical structure formation involved in morphogenesis	Foxa1	IGI	MGI:MGI:1347476	Mouse	PMID:23383217
Biological Process	GO:0048319	axial mesoderm morphogenesis	foxa1	IGI	ZFIN:ZDB-MRPHLNO-050228-2,ZFIN:ZDB-MRPHLNO-060321-4,ZFIN:ZDB-MRPHLNO-110304-2,ZFIN:ZDB-MRPHLNO-110304-3	Zfish	PMID:21172337
Biological Process	GO:0006338	chromatin remodeling	Foxa1	IDA		Mouse	MGI:MGI:4456944\|PMID:15748903
Biological Process	GO:0061448	connective tissue development	Foxa1	IGI	MGI:MGI:1347476	Mouse	PMID:23383217
Biological Process	GO:0071542	dopaminergic neuron differentiation	Foxa1	IMP	MGI:MGI:2653543	Mouse	PMID:17596284
Biological Process	GO:0071542	dopaminergic neuron differentiation	Foxa1	IGI	MGI:MGI:1347476	Mouse	PMID:17596284
Biological Process	GO:0021904	dorsal/ventral neural tube patterning	Foxa1	IGI	MGI:MGI:1347476	Mouse	PMID:23383217
Biological Process	GO:0060743	epithelial cell maturation involved in prostate gland development	Foxa1	IMP	MGI:MGI:2384404	Mouse	PMID:15987773
Biological Process	GO:0060441	epithelial tube branching involved in lung morphogenesis	Foxa1	IGI	MGI:MGI:1347476	Mouse	PMID:15668254
Biological Process	GO:0060738	epithelial-mesenchymal signaling involved in prostate gland development	Foxa1	IGI	MGI:MGI:98297	Mouse	PMID:15987773
Biological Process	GO:0042593	glucose homeostasis	Foxa1	IMP	MGI:MGI:2653543	Mouse	PMID:10049364
Biological Process	GO:0042445	hormone metabolic process	Foxa1	IMP	MGI:MGI:2653543	Mouse	PMID:10049364
Biological Process	GO:0030324	lung development	Foxa1	IGI	MGI:MGI:1347476	Mouse	PMID:15668254
Biological Process	GO:0060487	lung epithelial cell differentiation	Foxa1	IGI	MGI:MGI:1347476	Mouse	PMID:15668254
Biological Process	GO:0060425	lung morphogenesis	Foxa1	IMP	MGI:MGI:2653543	Mouse	PMID:16214823
Biological Process	GO:0010719	negative regulation of epithelial to mesenchymal transition	FOXA1	IMP		Human	PMID:20160041
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Foxa1	IMP		Mouse	PMID:17220277
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Foxa1	IGI	UniProtKB:O14956	Rat	PMID:17220277\|RGD:8554147
Biological Process	GO:0030182	neuron differentiation	Foxa1	IGI	MGI:MGI:1347476	Mouse	PMID:17596284
Biological Process	GO:0030182	neuron differentiation	Foxa1	IMP	MGI:MGI:2653543	Mouse	PMID:17596284
Biological Process	GO:0048665	neuron fate specification	Foxa1	IGI	MGI:MGI:1347476	Mouse	PMID:17596284
Biological Process	GO:0007219	Notch signaling pathway	Foxa1	IDA		Mouse	PMID:25446530
Biological Process	GO:0043065	positive regulation of apoptotic process	FOXA1	IDA		Human	PMID:19127412
Biological Process	GO:0051091	positive regulation of DNA-binding transcription factor activity	FOXA1	IMP		Human	PMID:16087863
Biological Process	GO:1904340	positive regulation of dopaminergic neuron differentiation	Foxa1	IMP	MGI:MGI:2653543	Mouse	PMID:17596284
Biological Process	GO:1904340	positive regulation of dopaminergic neuron differentiation	Foxa1	IGI	MGI:MGI:1347476	Mouse	PMID:17596284
Biological Process	GO:1901300	positive regulation of hydrogen peroxide-mediated programmed cell death	Foxa1	IMP		Rat	PMID:19649697\|RGD:151665511
Biological Process	GO:0033148	positive regulation of intracellular estrogen receptor signaling pathway	FOXA1	IMP		Human	PMID:16087863
Biological Process	GO:0045931	positive regulation of mitotic cell cycle	FOXA1	IMP		Human	PMID:16087863
Biological Process	GO:0045880	positive regulation of smoothened signaling pathway	Foxa1	IGI	MGI:MGI:1347476	Mouse	PMID:23383217
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	FOXA1	IMP		Human	PMID:16087863
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	FOXA1	IDA		Human	PMID:16331276
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	FOXA1	IDA		Human	PMID:19127412
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	FOXA1	IDA		Human	PMID:20160041
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Foxa1	IGI	MGI:MGI:95664	Mouse	PMID:15539431
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Foxa1	IDA		Mouse	PMID:10049364
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Foxa1	IDA		Rat	PMID:10024498\|RGD:1627570
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Foxa1	IDA		Rat	PMID:20735474\|RGD:8553707
Biological Process	GO:0060740	prostate gland epithelium morphogenesis	Foxa1	IMP	MGI:MGI:2384404	Mouse	PMID:15987773
Biological Process	GO:0060741	prostate gland stromal morphogenesis	Foxa1	IMP	MGI:MGI:2384404	Mouse	PMID:15987773
Biological Process	GO:0051726	regulation of cell cycle	Foxa1	IMP		Mouse	PMID:22737085
Biological Process	GO:0051726	regulation of cell cycle	Foxa1	IDA		Mouse	PMID:22737085
Biological Process	GO:0010468	regulation of gene expression	Foxa1	IGI	MGI:MGI:1347476	Mouse	PMID:17596284
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	Foxa1	IMP	MGI:MGI:2653543	Mouse	PMID:16214823
Biological Process	GO:1902691	respiratory basal cell differentiation	Foxa1	IMP	MGI:MGI:2653543	Mouse	PMID:16214823
Biological Process	GO:0032355	response to estradiol	FOXA1	IDA		Human	PMID:16087863
Biological Process	GO:0060528	secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development	Foxa1	IMP	MGI:MGI:2384404	Mouse	PMID:15987773
Biological Process	GO:0007224	smoothened signaling pathway	Foxa1	IGI	MGI:MGI:1347476	Mouse	PMID:23383217
Biological Process	GO:0035239	tube morphogenesis	Foxa1	IMP	MGI:MGI:2384404	Mouse	PMID:15987773

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.